Research
Elucidation of the role of ion channels in physiology and pathophysiology
We aim to fundamentally understand the "principle of how ion channels work and function" rather than using individual techniques. For example, based on functional analysis centered on electrophysiology, we will promote it by integrating computational science and chemical engineering in addition to molecular biology, biochemistry, crystal structure, and imaging methods.
The functional analysis of ion channels expands our understanding of cell death by advancing the study of the cell volume regulation mechanism as a basis. Furthermore, by using inhibitors targeting ion channels and genetically modified animals, we comprehensively elucidate the physiological/pathological significance of sepsis, epilepsy, etc., in multiple levels (molecules, cells, tissues, individuals).
Elucidating drug targets and mechanisms of action
We are studying the effects of natural substances such as compounds in existing drugs and Kampo drugs(herbal medicine) on ion channels.
For example, drug resistance of the anticancer drug cisplatin, cold irritation hypersensitivity seen as a side effect of oxaliplatin, and liver damage seen as a side effect of acetaminophen are caused by altered expression of ion channels, modification by redox, and hydroxylation reaction.
We will elucidate the mechanism of action of natural substances such as Kampo drugs(herbal medicine) found empirically and the side effects of existing drugs. This result not only enables people to use it as a safe drug by providing scientific support but also leads to the possibility of expanding the adaptation of the drug.
Development of New treatment methods, drug discovery research
So far, we have collaborated with researchers in a wide range of fields such as medicine, dentistry, chemistry, pharmacy, and engineering. These achievements are shown as a drug discovery search by high-throughput function measurement technology based on light intensity and cell excitation technology due to the temperature rise of gold particles by light stimulation.
In addition to the applied and function control technology we have cultivated so far, we would like to utilize our experience in interdisciplinary research to expand the possibilities of study for the development of future treatment technology.
We are studying the effects of natural substances such as compounds in existing drugs and Kampo drugs(herbal medicine) on ion channels.
For example, drug resistance of the anticancer drug cisplatin, cold irritation hypersensitivity seen as a side effect of oxaliplatin, and liver damage seen as a side effect of acetaminophen are caused by altered expression of ion channels, modification by redox, and hydroxylation reaction.
We will elucidate the mechanism of action of natural substances such as Kampo drugs(herbal medicine) found empirically and the side effects of existing drugs. This result not only enables people to use it as a safe drug by providing scientific support but also leads to the possibility of expanding the adaptation of the drug.
Development of New treatment methods, drug discovery research
So far, we have collaborated with researchers in a wide range of fields such as medicine, dentistry, chemistry, pharmacy, and engineering. These achievements are shown as a drug discovery search by high-throughput function measurement technology based on light intensity and cell excitation technology due to the temperature rise of gold particles by light stimulation.
In addition to the applied and function control technology we have cultivated so far, we would like to utilize our experience in interdisciplinary research to expand the possibilities of study for the development of future treatment technology.
So far, we have collaborated with researchers in a wide range of fields such as medicine, dentistry, chemistry, pharmacy, and engineering. These achievements are shown as a drug discovery search by high-throughput function measurement technology based on light intensity and cell excitation technology due to the temperature rise of gold particles by light stimulation.
In addition to the applied and function control technology we have cultivated so far, we would like to utilize our experience in interdisciplinary research to expand the possibilities of study for the development of future treatment technology.