Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes.
Journal of Inflammation Research (2024) 2024:17, 5415-5425.
Ryo Ozawa sensei completed his doctoral course at the Graduate school of Medicine and obtained his doctor degree.
Under the guidance of former Professor Kuba and former Assistant Professor Yamaguchi, he used a mouse model of hydrochloric acid inhalation-induced lung injury and demonstrated that Cnot3, a component of the CCR4-NOT complex, protects against acute lung injury through transcription and RNA degradation. The research results were published in the Journal of Inflammation Research.