Department of Biochemistry and Metabolic Science, Graduate School of Medicine, Akita University

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Professor

Yoshihiro MATSUMURA

Email: ymatsumura（at）med.akita-u.ac.jp

※Please change (at) to @ when sending.

Introduction

　My name is Yoshihiro Matsumura, and I have been heading the Department of Biochemistry and Metabolic Science from November 2023. As a graduate student and postdoctoral researcher, I conducted research on proteins and genetic diseases. I became fascinated with the epigenome, which determines whether genes are turned on or off, and have been researching the epigenome since 2011. I would like to understand biological phenomena and disease onset that cannot be explained by genome sequence alone from the perspective of the epigenome. I would like to clarify the mechanisms by which living environment, eating habits, and exercise habits rewrite the epigenome, and use the knowledge gained from research to improve metabolism and create healthy bodies that are less susceptible to disease.

Biography
Mar. 1998:
Graduated from the Department of Chemical and Biomolecular Engineering, Tohoku University
Mar. 2001:
Completed master’s course at the Department of Chemistry, Graduate School of Science, Tohoku University
Mar. 2004:
Completed the Doctoral course at the Department of Chemistry, Graduate School of Science, Tohoku University
Jun. 2004:
Postdoctoral researcher, Department of Physiology, Akita University of Medicine
Jan. 2008:
Postdoctoral researcher, Department of Biochemistry and Molecular Biology, Oregon Health and Science University, USA
Sep. 2011:
Project assistant professor, Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The Univ. of Tokyo
Apr. 2012:
Assistant professor, same as above
Apr. 2017:
Associate professor, same as above
Apr. 2022:
Associate professor, Division of Molecular Metabolism and Physiology, Graduate School of Medicine, Tohoku University
Nov. 2023:
Professor, Department of Biochemistry and Metabolic Science, Graduate School of Medicine, Akita University
Favorite things
  • Fishing
  • Visiting hot springs
  • Cooking
Research specialties
  • Chromatin immunoprecipitation
  • Next-Generation Sequencing analysis
  • Protein interaction analysis
Research themes
  • Research into fat burning/accumulation constitutions and the epigenome
  • Research into intergenerational transmission of constitutions and the epigenome
  • Research on the interaction between the epigenome and RNA modifications
Representative published papers (*Corresponding author, #Co-first author)
  1. Matsumura Y#, Wei FY#, Sakai J*.
    Epitranscriptomics in metabolic disease.
    Nat Metab (2023) 5, 370-384.
  2. Takahashi H#, Yang G#, Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J, Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y, Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y, Matsumura Y*, Sakai J*.
    MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
    Nat Commun (2022) 13, 5715.
  3. Matsumura Y*#, Ito R#, Yajima Y#, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue S, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J*.
    Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.
    Nat Commun (2021) 12, 7045.
  4. Mol_Cell_2015 Matsumura Y*, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J*.
    H3K4/H3K9me3 bivalent chromatin domains targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
    Mol Cell (2015) 60, 584-596 (selected as a cover).
  5. Matsumura Y, Sakai J, Skach WR*.
    Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.
    J Biol Chem (2013) 288, 31069-31079.
  6. Matsumura Y, Ban N, Ueda K, Inagaki N*.
    Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency.
    J Biol Chem (2006) 281, 34503-34514.
Affiliated Academic Societies