Department of Biochemistry and Metabolic Science, Graduate School of Medicine, Akita University

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Assistant Professor

Yukio KOIZUMI

Email: ykoizumi（at）med.akita-u.ac.jp

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Introduction

　Hello, everyone.
　My name is Yukio Koizumi, and I am a member of the Department of Biochemistry and Metabolic Science. Since my undergraduate studies, I have been fascinated by the potential of microorganisms and have been conducting research aimed at microbial drug discovery.
　Microorganisms produce secondary metabolites with highly unique molecular structures that often defy human ingenuity, and some of these metabolites exhibit significant biological activities. My research focuses on identifying microbial metabolites with potential as seeds for drug development. To date, our team has discovered various compounds with anti-tumor activity, fibrinolytic activity, antibacterial activity, and more. Additionally, we conduct chemical biology research to elucidate the molecular mechanisms underlying these biological activities.
　Moving forward, I would like to continue exploring novel bioactive substances, leveraging microbial resources isolated from the nature-rich environment of Akita.

Biography
Mar. 2002:
Completed the Doctoral course at the United Graduate School of Agricultural Sciences, Tokyo University of Agriculture and Technology
Apr. 2002:
Postdoctoral fellow, Center for Basic Research, Kitasato Institute
Oct. 2004:
Research Assistant, Department of Biochemistry, Akita University School of Medicine
Apr. 2007:
Assistant Professor, same as above
Apr. 2009:
Assistant Professor, Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
Favorite things
  • Watching sports (especially football)
Research specialties
  • Microbial isolation
  • HPLC (High-Performance Liquid Chromatography)
  • Multichannel pipetting
Research themes
  • Study of fibrinolysis-enhancing substances
  • Discovery of antibacterial substances
  • Discovery of brown adipose tissue-activating substances
Representative published papers (*Corresponding author, #Co-first author)
  1. Koizumi Y*, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K*.
    Genome-scale CRISPR/Cas9 screening revealed squalene epoxidase as susceptibility factor for cytotoxicity of malformin A1.
    Chem Bio Chem (2019) 20, 1563-1568.
  2. Koizumi Y*, Nagai K, Gao L, Koyota S, Yamaguchi T, Natsui M, Imai Y, Hasumi K, Sugiyama T, Kuba K.
    Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity.
    Sci Rep (2018) 8, 5472.
  3. Koizumi Y*#, Nagai K#, Hasumi K, Kuba K, Sugiyama T.
    Structure–activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers.
    Bioorg Med Chem Lett (2016) 26, 5267-5271.
  4. Zhou X#、Koizumi Y*#, Zhang M, Natsui M, Koyota S, Yamada M, Kondo Y, Hamada F, Sugiyama T.
    Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice.
    Cancer Sci (2015) 106, 635-641.
  5. Koizumi Y, Tomoda H, Kumagai A, Zhou XP, Koyota S, Sugiyama T*.
    Simaomicin α, a polycyclic xanthone, induces G1 arrest with suppression of pRb phosphorylation.
    Cancer Sci (2009) 100, 322-326.
Affiliated Academic Societies