秋田大学大学院医学系研究科 消化器外科学講座(旧第一外科)

研究の紹介

原著論文(英文のみ)

2016年

1) Kumagai, K., Yoshioka, M., Iida, M., Kudoh, K., Uchinami, H., Watanabe, T., Yamamoto, Y. (2016) Usefulness of Oblique Multiplanar Images on Multi-Detector Computed Tomography for Diagnosing Intersigmoid Hernia. Visceral Medicine., 32,437-440

2) Takahashi, K., Yoshioka, M., Uchinami, H., Watanabe, G., Kudoh, K., Yagi, F., Saito, H., Minamiya, Y., Yamamoto, Y. (2016) Appraisal of Aggressive Excisional Biopsy for a Possible Isolated Lung Metastasis of Pancreatic Cancer: Repeated Extirpation Contributes to Long Survival. International Surgery., 101,257-262

3) Siegmund, SV., Schlosser, M., Schildberg, FA., Seki, E., De Minicis,S ., Uchinami, H., Kuntzen, C., Knolle, PA., Strassburg, CP., Schwabe, RF. (2016) Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cell. PLOS ONE., 11(3)

2015年

1) Mederacke, I., Dapito, DH., Affo, S., Uchinami, H., Schwabe, RF. (2015) High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse liver. Nature protocols., 10(2),305-315

2) Yamamoto, Y., Yoshioka, M., Watanabe, G., Uchinami, H. (2015) Opportunistic use of a Foley catheter to provide a common electrocautery with a water-irrigating channel for hepatic parenchymal transaction. Surgery Today., 45(11),1457-1462

3) Yoshioka, M., Uchinami, H., Watanabe, G., Sato, T., Shibata, S., Kume, M., Ishiyama, K., Takahashi, S., Hashimoto, M., Yamamoto, Y. (2015) F-18 fluorodeoxyglucose positron emission tomography for differential diagnosis of pancreatic tumors. Springer Plus., 4,154

4) Yoshioka, M., Shibata S., Uchinami, H., Watanabe, G., Miyazawa, H., Iida, M., Yoshida, M., Yoshioka, T., Nanjo, H., Yamamoto, Y. (2015) The Transformation of a Nonfunctioning Islet Cell Tumor of the Pancreas into a Proinsulinoma under Conditions of Lung Metastasis. Internal Medicine., 54(7),785-790

5) Yoshioka, M., Watanabe, G., Uchinami, H., Kudoh, K., Hiroshima, Y., Yoshioka, T., Nanjo, H., Funaoka, M., Yamamoto, Y. (2015) Hepatic angiomyolipama:differential diagnosis from other liver tumors in a special reference to vascular imaging-importance of early drainage vein. Surgical Case Reports., 1(1),11

6) Takahashi, K., Yoshioka, M., Uchinami, H., Watanabe, G., Kudoh, K., Yagi, F., Saito, H., Minamiya, Y., Yamamoto, Y. (2015) Appraisal of Aggressive Excisional Biopsy for a Possible Isolated Lung Metastasis of Pancreatic Cancer: Repeated Extirpation Contributes to Long Survival. International Surgery., (In press)

2014年

1) Tolba, R., Fet, N., Yonezawa, K., Taura, K., Nakajima, A., Hata, K., Okamura, Y., Uchinami, H., Klinge, U., Minor, T., Yamaoka, Y., Yamamoto, Y. (2014) Role of preferential cyclooxygenase-2 inhibition by meloxicam in ischemia/reperfusion injury of the rat liver. European Surgical Research, 53(1-4),11-24.

2) Watanabe, G., Uchinami, H., Yoshioka, M., Nanjo, H., Yamamoto, Y. (2014) Prognosis analysis of sarcomatous intrahepatic cholangiocarcinoma from a review of the literature. International Journal of Clinical Oncology, 19(3),490-496.

3) Yoshioka, M., Watanabe, G., Ise, M., Uchinami, H., Nakagawa, Y., Kudoh, K., Ryo, Morita., Andoh, H., Yamamoto, Y. (2014) High-dose corticosteroid therapy for erlotinib-induced interstitial lung disease in Japanese patient with advanced pancreatic cancer. Journal of the Pancreas, 15(6),611-614.

4) Kudoh, K., Uchinami, H., Yoshioka, M., Seki, E., Yamamoto, Y. (2014) Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Annals of Surgery , 260(1),118-127.

5) Sakai, T., Mashima, H., Yamada, Y., Goto, T., Sato, W., Dohmen, T., Kamada, K., Yoshioka, M., Uchinami, H., Yamamoto, Y. Ohnishi, H. (2014) The roles of interferon regulatory factors 1 and 2 in the progression of human pancreatic cancer. Pancreas, 43(6),909-916.

6) Soeda, H., Shimodaira, H., Gamoh, M., Ando, H., Isobe, H., Suto, T., Takahashi, S., Kakudo, Y., Amagai, K., Mori, T., Watanabe, M., Yamaguchi, T., Kato, S., Ishioka, C. (2014) Phase II trial of cetuximab plus irinotecan for oxaliplatin- and irinotecan-based chemotherapy-refractory patients with advanced and/or metastatic colorectal cancer: evaluation of efficacy and safety based on KRAS mutation status (T-CORE0801). Oncology, 87(1), 7-20.

7) Hirata, K., Nagata, N., Kato, T., Okuyama, Y., Ando, H., Takahashi, K., Oba, K., Sakamoto, J., Hazama, S., Mishima, H. (2014) Prospective phase II trial of second-line FOLFIRI in patients with advanced colorectal cancer including analysis of UGT1A1 polymorphisms: FLIGHT 2 study. Anticancer research, 34(1), 195-201.

2013年

1) Yamamoto, Y. (2013) Ante-situm hepatic resection for tumors involving the confluence of hepatic veins and IVC. Journal of Hepato-Biliary-Pancreatic Sciences.,20(3),313-323.

2) Yoshioka, M., Watanabe, G., Uchinami, H., Miyazawa, H,. Abe, Y., Ishiyama, K., Hashimoto, M., Nakamura, A., Yamamoto, Y. (2013). Diffusion-weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut-Off values. Hepato-Gastroenterology., 60,692-698.

3) Sawaguchi, M., Jin, M., Matsuhashi, T., Ohba, R., Hatakeyama, N., Koizumi, S., Onochi, K., Tawaraya, S., Watanabe, N., Uchinami, H., Yamamoto, Y., Ohnishi, H., Mashima, H. (2013). Duodenocolic Fistula Caused by a Paptic Stomal Ulcer Following Distal Gastrectomy. Internal Medicine., 52,1579-1583

4) Hazama S, Mishima H, Tsunedomi R, Okuyama Y, Kato T, Takahashi K, Nozawa H, Andoh H, Kobayashi M, Takemoto H, Nagata N, Kanekiyo S, Inoue Y, Hamamoto Y, Fujita Y, Hinoda Y, Okayama N, Oba K, Sakamoto J, Oka M. (2013). UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan. Cancer Science, 104, 1662-1669.

2012年

1) Watanabe, G., Uchinami, H., Yoshioka, M., Abe, Y., Kikuchi, I., Iwasaki, W., Kume, M., Yamamoto, Y. (2012) Transfection of Naked Nuclear Factor-κB Decoy Oligodeoxynucleotides into Liver by Rapid Portal Vein Infusion in Rats: Its Effect on Ischemia-Reperfusion Injury of Liver. HUMAN GENE THERAPY., 23, 428-436.

2) Uchinami, H., Yamamoto, Y. (2012) Optimizing the Liver for Resection in patients Undergoing Extended Hepatectomy or Receiving Chemotherapy. Viszeralmedizin., 2012;28, 60-67.

3) Nakagawa, Y., Yoshioka, M., Abe, Y., Uchinami, H., Ohba, T., Ono, K., Yamamoto, Y. (2012) Enhancement of Liver Regeneration by Adenosine Triphosphate-Sensitive K+ Channel Opener(Diazoxide)After Partial Hepatectomy. Transplantation., 93;11,1094-1100.

4) Yoshioka, M., Uchinami, H., Watanabe, G., Takahashi, T., Nakagawa, Y., Andoh, H., Yoshioka, T., Nanjo, H., Yamamoto, Y. (2012) Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus. Internal Medicine., 2012;51,2145-2150.

5) Kato, S., Andoh, H., Gamoh, M., Yamaguchi, T., Murakawa, Y., Shimodaira, H., Takahashi, S., Mori, T., Ohri, H., Maeda, S., Suzuki, T., Kato., S., Akiyama, S., Sasaki, Y., Yoshioka, T., Ishioka.C. (2012) Safety verification trials of mFOLFIRI and sequential IRIS+Bevacizumab as first- or Second-line therapies for metastatic colorectal cancer in Japanese Patients. Oncology., 2012; 82, 101-107.

6) Otsuka, K., Satoyoshi, R., Nanjo, H., Miyazawa, H., Abe, Y., Tanaka, M., Yamamoto, Y., Shibata, H. (2012) Acquired/Intratumoral Mutation of KRAS during metastatic progression of colorectal carcinogenesis. Oncology Letters., 2012;3,649-653.

7) Abe, Y., Uchinami, H., Kudoh, K., Nakagawa, Y., Ise, N., Watanabe, G., Sato, T., Seki, E., Yamamoto, Y. (2012) Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes. Surgery., 152;5,869-878.

2011年

1) Watanabe, G., Nanjo, H., Nagai, H., Wang, J., Koyota, S., Yamamoto, Y., Sugiyama, T. (2011) A novel monoclonal antibody identified hepatic stem-like cells in rats. Clinical Molecular Morphology., 44, 103-110.

2) Stoffels, B., Yonezawa, K., Yamamoto, Y., Schäfer, N., Overhaus, M., Klinge, U., Kalff, J.C., Minor, T., Tolba, R.H. (2011) Meloxicam, a COX-2 inhibitor, ameliorates ischemia/reperfusion injury in non-heart-beating donor livers. European Surgical Research., 47, 109-117.

3) Otsuka, K., Takahashi, M., Nanjo, H., Miyazawa, H., Iida, M., Abe, Y., Jin, M., Onishi, H., Hashimoto, M., Yamamoto, Y., Shibata, H. (2011) 18FDG-PET at 1-month intervals is a better predictive marker for GISTs that are difficult to be diagnosed histopathologically: A case report. Case Reports in Oncological Medicine., 2011, 5pagesdoi:10.1155.

4) Kodama, M., Kume, M., Miyazawa, H., Satoh, S., Yamamoto, Y., Ito, T., Asanuma, Y. (2011) Pigmentary complication of the peristomal skin in colorectal cancer patients under systemic chemotherapy using S-1: Report of cases. J Wound Ostomy Continence Nurs., 38, 280-285.

5) Inoue, S., Endoh, M., Fukushima, T., Nakadate, T., Karouji, K., Shioya, A., Ohsato, M., Itoh, T., Shida S., Nakachi, H., Narumi, S., Hakamada, K., Sasaki, M., Ebina, Y., Umehara, Y., Andoh, H., Fukuyama, S., Segami, H., Konn, M., Seki, T., Tabuse K. (2011) Long-term survival of over 4 years after micromave tissue coagulation (MTC) therapy via percutaneous transhepatic cholangioscopy in men with jaundice and bile duct carcinoma in the far advanced stage. Journal of Micromave Surgery., 29, 51-57.

2010年

1) Iwasaki, W., Kume, M., Kudo, K., Uchinami, H., Kikuchi, I., Nakagawa, Y., Yoshioka, M., Yamamoto, Y. (2010) Changes in the fatty acid composition of the liver with the administration of N-3 polyunsaturated fatty acids and the effects on warm ischemia/reperfusion injury in the rat liver. Shock., 33, 306-314.

2) Watanabe, D., Miura, K., Goto, T., Nanjo, H., Yamamoto, Y., Ohnishi, H. (2010) Solid pseudopapillary tumor of the pancreas with concomitant pancreas divisum. A case report. Journal of the Pancreas (Online)., 11, 45-48

3) Sato, T., Narita, T., Hosoba, M., Kakei, M., Nanjo, H., Uchinami, H., Satoh, K., Yamamoto, Y., Yamada, Y. (2010) A case of insulinoma following total gastrectomy−Effects of an alpha-glucosidase inhibitor on suppressing GIP and GLP-1 elevations. Diabetes Research and Clinical Practice., 88, e4-e6.

4) Kubota, H., Yamamoto, S., Itoh, E., Abe, Y., Nakamura, A., Izumi, Y., Okada, H., Iida, M., Nanjo, H., Itoh, H., Yamamoto, Y. (2010) Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma. Cell Stress and Chaperones., 15, 1003-1011.

5) Motoyama, S., Yamamoto, Y., Maruyama, K., Uchinami, H., Hasegawa, M., Shindo, Y., Ogawa, J. (2010) A new two-stage esophagectomy followed by pancreaticoduodenectomy. The American Surgeon., 76, 1442-1444.

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