原著論文・総説(〜2001)        雑誌名をクリックするとPubMedにリンクします


Fukunaga, K., Ishii, S., Asano, K., Yokomizo, T., Shiomi, T., Shimizu, T., and Yamaguchi, K. (2001) Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation.  J. Biol. Chem. 276, 43025-43030. 

Wu, C., Stojanov, T., Chami, O., Ishii, S., Shimizu, T., Li, A., and O'Neill, C. (2001) Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J. Biol. Chem. 276, 26962-26968.


Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y. and Shimizu, T. (2000) Acute lung injury by sepsis and acid aspiration: a key role of cytosolic phospholipase A2. Nature Immunol. 1, 42-46. 

Shindou, H., Ishii, S., Uozumi, N. and Shimizu, T. (2000) Roles of cytosolic phospholipase A2 and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. Biochem. Biophys. Res. Commun. 271, 812-817. 

Aihara, M., Ishii, S., Kume, K. and Shimizu, T. (2000) Interaction between neurone and glia mediated by platelet-activating factor. Genes Cells 5, 397-406. 

*Ishii, S. and Shimizu, T. (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39, 41-82. (Invited Review) 


Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi, Y. and Shimizu, T. (1999) Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. J. Clin. Invest. 104, 1071-1076. 

Sato, S., Kume, K., Ito, C., Ishii, S. and Shimizu, T. (1999) Accelerated proliferation of the epidermal keratinocytes by the transgenic expression of the platelet-activating factor receptor. Arch. Dermatol. Res. 291, 614-621. 

Kobayashi, K., Ishii, S., Kume, K., Takahashi, T., Shimizu, T. and Manabe, T. (1999) Platelet-activating factor is not required for long-term potentiation in the hippocampal CA1 region. Eur. J. Neurosci. 11, 1313-1316.


Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W.-H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M. and Shimizu, T. (1998) Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187, 1779-1788.


Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J. and Shimizu, T. (1997) Role of cytosolic phospholipase A2 in allergic response and parturition. Nature 390, 618-622.

Tabuchi, S., Kume, K., Aihara, M., Ishii, S., Mishina, M. and Shimizu, T. (1997) Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. Neurosci. Lett. 237, 13-16.

Nagase, T., Ishii, S., Katayama, H., Fukuchi, Y., Ouchi, Y. and Shimizu, T. (1997) Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor: roles of thromboxanes and leukotrienes. Am. J. Resp. Crit. Care Med. 156, 1621-1627.

Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga, I., Kume, K., Miyazaki, J. and Shimizu, T. (1997) Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J. 16, 133-142.


Ishii, S., Matsuda, Y., Nakamura, M., Waga, I., Kume, K., Izumi, T. and Shimizu, T. (1996) A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem. J. 314, 671-678.


Mutoh, H., Ishii, S., Izumi, T., Kato, S. and Shimizu, T. (1994) Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-{kappa}B. Biochem. Biophys. Res. Commun. 205, 1137-1142. 


Ishii, S., Murakami, T. and Shishido, K. (1992) A pSC101-par sequence-mediated study on the intracellular state of supercoiling of the pBR322 genome in Escherichia coli DNA topoisomerase I deletion mutant. FEMS Microbiol. Lett. 93, 115-120.

Murakami, T., Ishii, S. and Shishido, K. (1992) Synthesis of the N-terminal half of the tetracycline resistance protein of pBR322 is responsible for a high level of plasmid DNA supercoiling in Escherichia coli. J. Gen. Appl. Microbiol. 38, 379-383.

Ishii, S., Noguchi, M., Miyano, M., Matsumoto, T. and Noma, M. (1992) Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase. Biochem. Biophys. Res. Commun. 182, 1482-1490.


Ishii, S., Murakami, T. and Shishido, K. (1991) Gyrase inhibitors increase the content of knotted DNA species of plasmid pBR322 in Escherichia coli. J. Bacteriol. 173, 5551-5553.


Shishido, K., Ishii, S. and Komiyama, N. (1989) The presence of the region on pBR322 that encodes resistance to tetracycline is responsible for high levels of plasmid DNA knotting in Escherichia coli DNA topoisomerase I deletion mutant. Nucleic Acids Res. 17, 9749-9759.