▶︎原著論文・総説(2010〜)    ▶原著論文・総説（〜2001）　　▶総説（日本語）　　▶特許

2009

Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., *Ishii, S., and *Shimizu, T. (2009) Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 106, 21807-21812. (Direct submission)

Hikiji, H., *Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T. (2009) A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc. Natl. Acad. Sci. U. S. A. 106, 21294-21299. (Direct submission)

*Ishii, S., Noguchi, K., and Yanagida, K. (2009) Non-Edg family lysophosphatidic acid (LPA) receptors. Prostaglandins Other Lipid Mediat. 89, 57-65. (Invited Review)

Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu T., and *Ishii, S. (2009) Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J. Biol. Chem. 284, 17731-17741.

Mogi, C., Tobo, M., Tomura, H., Murata, N., He, X.-d., Sato, K., Kimura, T., Ishizuka, T., Sasaki, T., Sato, T., Kihara, Y., Ishii, S., Harada, A., and Okajima, F. (2009) Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages. J. Immunol. 182, 3243–3251.

Welch, E.J., Naikawadi, R.P., Li, Z., Lin, P., Ishii, S., Shimizu, T., Tiruppathi, C., Du, X., Subbaiah, P.V., and Ye, R.D. (2009) Opposing effects of platelet-activating factor and lyso-platelet activating factor on neutrophil and platelet activation. Mol. Pharmacol. 75, 227-234.

Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., Miyano, M., Shimizu, T., and Nakamura, M. (2009) Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum.  FASEB J. 23, 1470-1481.

2008

Moos, M.P.W., Mewburn, J.D., Kan, F.W.K., Ishii, S., Abe, M., Sakimura, K., Noguchi, K., Shimizu, T., and Funk, C.D. (2008) Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport. FASEB J. 22, 4352-4362.

Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., and Shimizu, T. (2008) Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic PLA2-LysoPAFAT axis. J. Immunol. 181, 5008-5014.

Jiang, W., Hall, S.R., Moos, M.P.W., Cao, R.Y., Ishii, S., Ogunyankin, K.O., Melo, L.G., and Funk, C.D. (2008) Endothelial cysteinyl leukotriene 2 receptor (CysLT2R) expression mediates myocardial ischemia-reperfusion injury. Am. J. Pathol. 172, 592-602.

Hikiji, H., Takato, T., Shimizu, T., and *Ishii, S. (2008) The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. Prog. Lipid Res. 47, 107-126. (Invited Review)

2007

Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Tozaki-Saito, H., Yoshimura, M., Koizumi, S., Shimizu, T., and Inoue, K. (2007) Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. J. Neurochem. 102, 1658-1668.

Witzenrath, M., Gutbier, B., Owen, J.S., Schmeck, B., Mitchell, T.J., Mayer, K., Thomas, M.J., Ishii, S., Rosseau, S., Suttorp, N., and Schütte, H. (2007) Role of platelet-activating factor in pneumolysin-induced acute lung injury. Crit. Care Med. 35, 1756-1762.

Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S., Taguchi, R., and Shimizu, T. (2007) A single enzyme catalyzes both PAF production and membrane biogenesis of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase. J. Biol. Chem. 282, 6532–6539.

Yanagida, K., *Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. (2007) LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. J. Biol. Chem. 282, 5814-5824.

Schaefer, M.B., Ott, J., Mohr, A., Bi, M.H., Grosz, A., Weissmann, N., Ishii, S., Grimminger, F., Seeger, W., and Mayer, K. (2007) Immunomodulation by n-3- vs. n-6-rich lipid emulsions in murine acute lung injury – role of platelet-activating factor receptor. Crit. Care Med. 35, 544-554.

2006

Doi, K., Okamoto, K., Negishi, K., Suzuki, Y., Nakao, A., Fujita, T., Toda, A., Yokomizo, T., Kita, Y., Kihara, Y., Ishii, S., Shimizu, T., and Noiri, E. (2006) Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. Am. J. Pathol. 168, 1413-1424.

van der Sluijs, K.F., van Elden, L.J.R., Nijhuis, M., Schuurman, R., Florquin, S., Shimizu, T., Ishii, S., Jansen, H.M., Lutter, R., and van der Poll, T. (2006) Involvement of the platelet activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. Am. J. Physiol. 290, L194-L199.

2005

Toyo-oka, K., Sasaki, S., Yano, Y., Mori, D., Kobayashi, T., Toyoshima, Y.Y., Tokuoka, S.M., Ishii, S., Shimizu, T., Muramatsu, M., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A., and Hirotsune, S. (2005) Recruitment of katanin p60 by phosphorylated NDEL1, a LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum. Mol. Genet. 14, 3113-3128.

Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., and Shimizu, T. (2005) Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J. Exp. Med. 202, 853-863.

Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani, M., Billings, S.D., Perkins, S.M., Howard, K.M., Ishii, S., Shimizu, T., and Travers, J.B. (2005) Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. J. Clin. Invest. 115, 2855-2861.

Shindou, H., *Ishii, S., Yamamoto, M., Takeda, K., Akira, S., and Shimizu, T. (2005) Priming effect of lipopolysaccharide on acetyl-CoA:lyso-PAF acetyltransferase is MyD88 and TRIF independent. J. Immunol. 175, 1177-1183. 

Lang, P.A., Kempe, D.S., Tanneur, V., Eisele, K., Klarl, B.A., Myssina, S., Jendrossek, V., Ishii, S., Shimizu, T., Waidmann, M., Hessler, G., Huber, S.M., Lang, F., and Wieder, T. (2005) Stimulation of erythrocyte ceramide formation by platelet activating factor. J. Cell Sci. 118, 1233-1243. 

*Ishii, S., Kihara, Y., and Shimizu, T. (2005) Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J. Biol. Chem. 280, 9083-9087.

2004

Branger, J., Wieland, C.W., Florquin, S., Maris, N.A., Pater, J.M., Speelman, P., Shimizu, T., Ishii, S., and van der Poll, T. (2004) Platelet-activating factor receptor deficient mice show an unaltered clearance of Haemophilus influenzae from their respiratory tract. Shock 22, 543-547.

Angeli, V, Llodrá, J., Rong, J.X., Satoh, K, Ishii, S., Shimizu, T., Fisher, E.A., and Randolph, G.J. (2004) Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21, 561-574.

Hikiji, H., *Ishii, S., Shindou, H., Takato, T., and Shimizu, T. (2004) Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J. Clin. Invest. 114, 85-93.

*Ishii, S., Nagase, T., Shindou, H., Takizawa, H., Ouchi, Y., and Shimizu, T. (2004) Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J. Immunol. 172, 7095-7102.

Lu, D.P., Chandrakanthan, V., Cahana, A., Ishii, S., and O'Neill, C. (2004) Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. J. Cell Sci. 117, 1567-1576.

Rijneveld, A.W., Weijer, S., Florquin, S., Speelman, P., Shimizu, T., Ishii, S., and van der Poll, T. (2004) Platelet activating factor receptor deficient mice have an improved host defense against pneumococcal pneumonia. J. Infect. Dis. 189, 711-716.

2003

Weijer, S., Leemans, J.C., Florquin, S., Shimizu, T., Ishii, S., and van der Poll, T. (2003) Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis. Immunology 109, 552-556.

Souza, D.G., Pinho, V., Soares, A.C., Shimizu, T., Ishii, S., and Teixeira, M.M. (2003) Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. Br. J. Pharmacol. 139, 733-740.

Talvani, A., Santana, G., Barcelos, L.S., Ishii, S., Shimizu, T., Romanha, Á.J., Silva, J.S., Soares, M.B.P., and Teixeira, M.M. (2003) Experimental Trypanosoma cruzi infection in platelet-activating factor-deficient mice. Microb. Infect. 5, 789-796.

Tokuoka, S.M., Ishii, S., Kawamura, N., Satoh, M., Shimada, A., Sasaki, S., Hirotsune, S., Wynshaw-Boris, A., and Shimizu, T. (2003) Involvement of platelet-activating factor and LIS1 in neuronal migration. Eur. J. Neurosci. 18, 563-570. 

Noguchi, K., *Ishii, S., and Shimizu, T. (2003) Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278, 25600-25606.

Nagase, T., Uozumi, N., Aoki-Nagase, T., Terawaki, K., Ishii, S., Tomita, T., Yamamoto, H., Hashizume, K., Ouchi, Y., and Shimizu, T. (2003) A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am. J. Physiol. 284, L720-L726.

Vogensen, S.B., Strømgaard, K., Shindou, H., Jaracz, S., Suehiro, M., Ishii, S., Shimizu, T., and Nakanishi, K. (2003) Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J. Med. Chem. 46, 601-608.

2002

Soares, A.C., Pinho, V.S., Souza, D.G., Shimizu, T., Ishii, S., Nicoli, J.R., and Teixeira, M.M. (2002) Role of the platelet-activating factor (PAF) receptor during pulmonary infection with gram negative bacteria. Br. J. Pharmacol. 137, 621-628.

Strømgaard, K., Saito, D.R., Shindou, H., Ishii, S., Shimizu, T., and Nakanishi, K. (2002) Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. J. Med. Chem. 45, 4038-4046.

*Ishii, S., Nagase, T., and Shimizu, T. (2002) Platelet-activating factor receptor. Prostaglandins Other Lipid Mediat. 68-69, 599-609. (Review)

Honda, Z., Ishii, S., and Shimizu, T. (2002) Platelet-activating factor receptor. J. Biochem. 131, 773-779. (Review) 

Ogasawara, H., Ishii, S., Yokomizo, T., Kakinuma, T., Komine, M., Tamaki, K., Shimizu, T., and Izumi, T. (2002) Characterization of mouse cysteinyl leukotriene receptors; mCysLT1 and mCysLT2. Differential pharmacological properties and tissue distribution. J. Biol. Chem. 277, 18763-18768. 

Barbuti, A., Ishii, S., Shimizu, T., Robinson, R.B., and Feinmark, S.J. (2002) Block of the background K+ channel, TASK-1, contributes to the arrhythmogenic effects of platelet-activating factor. Am. J. Physiol. 282, H2024-H2030. 

Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y., and Shimizu, T. (2002) A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis. Nature Med. 8, 480-484. 

Ohshima, N., Ishii, S., Izumi, T., and Shimizu, T. (2002) Receptor-dependent metabolism of platelet-activating factor in murine macrophages. J. Biol. Chem. 277, 9722-9727.

Klein, A., Pinho, V., Alessandrini, A.L., Shimizu, T., Ishii, S., and Teixeira, M.M. (2002) Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. Br. J. Pharmacol. 135, 1213-1218.

Nagase, T., Ishii, S., Shindou, H., Ouchi, Y., and Shimizu, T. (2002) Airway hyperresponsiveness in transgenic mice overexpressing platelet-activating factor receptor is mediated via an atropine sensitive pathway. Am. J. Resp. Crit. Care Med. 165, 200-205. 

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