Koch (1843-1910)

German physician and bacteriologist (founder of modern bacteriology) Invented agar culture media, Petri dishes, and microscope slides, and succeeded in obtaining pure bacterial cultures Used synthetic dyes for bacterial staining (published in 1877) Koch discovered the anthrax bacillus through animal experiments (1876: infection experiments on mice and rabbits), and the tubercle bacillus (1882: infection experiments on guinea pigs, mice, rats, hedgehogs, hamsters, pigeons, frogs, and dogs) 1905: Awarded the Nobel Prize in Physiology or Medicine

1876 1880 1882 1883 1884 1884 1884 1886 1894 1897 1905

Anthrax bacillus Typhoid bacillus Tubercle bacillus Diphtheria bacillus Cholera vibrio Tetanus bacillus Streptococcus Pneumococcus Plague bacillus Dysentery bacillus Treponema pallidum

Koch Eberth and Gaffky Koch Klebs and Loeffler Koch Nicolaier Rosenbach Frenkel Shibasaburo Kitasato and Yersin (independently) Kiyoshi Shiga Schaudinn and Hoffmann

Germany Germany Germany Germany Germany Germany Germany Germany Japan, France Japan Germany