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2025
Yoneshiro T# *, Matsushita M# , Fuse-Hamaoka S# , Kuroiwa M,
Kurosawa Y, Yamada Y, Arai M, Wei Y, Iida M, Kuma K, Kameya T, Harada T, Matsumura
Y , Osawa T, Aoki Y, Nakamura H, Hamaoka T*, Sakai J*, Saito M*. Pre-fertilization-origin preservation of brown
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Matsumura Y , Osborne TF, Ito R, Takahashi H, Sakai J*.β-Adrenergic Signal and Epigenomic Regulatory Process for
Adaptive Thermogenesis. Adv Exp Med Biol Ito R# , Xie S# , Tumenjargal M# , Sugahara Y, Yang C,
Takahashi H, Arai M, Inoue SI, Uchida A,
Nakano K, Choi H, Yang G, Zhao Y, Yamaguchi R, Jin H, Sagae H, Wada Y, Tanaka T, Kimura H,
Kodama T, Aburatani H, Takeda K, Inagaki T, Osborne TF, Yoneshiro T, Matsumura
Y* ,
Sakai J*.Mitochondrial biogenesis in white adipose tissue mediated
by JMJD1A-PGC-1 axis limits age-related metabolic disease iScience
Takahashi H, Ito R, Matsumura Y* , Sakai J*.Environmental factor reversibly determines cellular
identity through opposing Integrators that unify epigenetic and transcriptional
pathways. Bioessays
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Nakahara R# , Aki S# , Sugaya M# , Hirose H# , Kato
M, Maeda K, Sakamoto DM, Kojima Y, Nishida
M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y , Yanai H, Takano H,
Yao R,
Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T*. Hypoxia activates SREBP2 through Golgi disassembly in bone
marrow-derived monocytes for enhanced tumor growth. EMBO J
2015-2023（松村教授 着任前）
Matsumura Y# , Wei FY# , Sakai J*. Epitranscriptomics in metabolic disease. Nat Metab Takahashi H# , Yang G# , Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J,
Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae
H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y,
Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y,
Matsumura Y* , Sakai J*. MYPT1-PP1β phosphatase negatively regulates both chromatin
landscape and co-activator recruitment for beige adipogenesis. Nat Commun
Pan M, Zorbas C, Sugaya M, Ishiguro K, Kato M, Nishida M, Zhang HF, Candeias MM, Okamoto A,
Ishikawa T, Soga T, Aburatani H, Sakai J, Matsumura Y , Suzuki T, Proud CG,
Lafontaine DLJ, Osawa T*. Glutamine deficiency in solid tumor cells confers
resistance to ribosomal RNA synthesis inhibitors. Nat Commun
Matsumura Y , Osborne TF, Sakai J*. Epigenetic and environmental regulation of adipocyte
function. J Biochem Murakami K, Sasaki Y, Asahiyama M, Yano W, Takizawa T, Kamiya W, Matsumura
Y , Anai M, Osawa T, Fruchart JC, Fruchart-Najib J, Aburatani H, Sakai J, Kodama
T, Tanaka T* Selective PPARα Modulator Pemafibrate and Sodium-Glucose
Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved
Histopathology in Experimental Mice Model of Non-Alcoholic
Steatohepatitis. Cells
Matsumura Y# * , Ito R# , Yajima A# ,
Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H,
Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S,
Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node
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complex determines enhancer activation for adipogenesis. Nat Commun Zhang J# , Matsumura Y# * , Kano Y# , Yoshida
A, Kawamura T, Hirakawa H, Inagaki T, Tanaka T, Kimura H, Yanagi S, Fukami K, Doi T, Osborne
TF, Kodama T, Aburatani H, Sakai J*. Ubiquitination-dependent and -independent repression of
target genes by SETDB1 reveal a context-dependent role for its methyltransferase
activity during adipogenesis. Genes Cells
Shiono A, Sasaki H, Sekine R, Abe Y, Matsumura Y , Inagaki T, Tanaka T,
Kodama T, Aburatani H, Sakai J, Takagi H*. PPARα activation directly upregulates thrombomodulin in
the diabetic retina. Sci Rep
Sasaki Y# , Asahiyama M# , Tanaka T# *, Yamamoto S, Murakami
K, Kamiya W, Matsumura Y , Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai
J, Kodama T.Pemafibrate, a selective PPARα modulator, prevents
non-alcoholic steatohepatitis development without reducing the hepatic triglyceride
content. Sci Rep
Sasaki Y# , Raza-Iqbal S# , Tanaka T# *, Murakami K, Anai M,
Osawa T, Matsumura Y , Sakai J, Kodama T.Gene Expression Profiles Induced by a Novel Selective
Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα)
Pemafibrate. Int J Mol Sci
Osawa T# *, Shimamura T# *, Saito K, Hasegawa Y, Ishii N, Nishida M,
Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo
K, Yamano S, Kanki Y, Matsumura Y , Minami T, Tanaka T, Anai M, Wada Y,
Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H,
Shibuya M, Hanada K, Miyano S, Soga T*, Kodama T*.Phosphoethanolamine Accumulation Protects Cancer Cells
under Glutamine Starvation through Downregulation of PCYT2. Cell Rep
Nagai N, Ohguchi H, Nakaki R, Matsumura Y , Kanki Y, Sakai J, Aburatani H,
Minami T*.Downregulation of ERG and FLI1 expression in endothelial
cells triggers endothelial-to-mesenchymal transition. PLoS Genet
Abe Y# , Fujiwara Y# , Takahashi H# , Matsumura
Y , Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura
H, Osborne TF, Aburatani H, Kodama T, Inagaki T*, Sakai J*.Histone demethylase JMJD1A coordinates acute and chronic
adaptation to cold stress via thermogenic phospho-switch. Nat Commun
Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y ,
Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T*.Overexpression of p54nrb /NONO induces
differential EPHA6 splicing and contributes to castration-resistant prostate cancer
growth. Oncotarget
Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y , Oishi Y,
Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T*, Ogawa
Y*.The H3K9 methyltransferase Setdb1 regulates TLR4-mediated
inflammatory responses in macrophages. Sci Rep
Matsumura Y* , Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T,
Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J*.H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by
Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Mol Cell Raza-Iqbal S, Tanaka T, Anai M, Inagaki T, Matsumura Y , Ikeda K, Taguchi A,
Gonzalez FJ,
Sakai J, Kodama T*.Transcriptome Analysis of K-877 (a Novel Selective PPARα
Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse
Liver. J Atheroscler Thromb
Abe Y# , Rozqie R# , Matsumura Y , Kawamura T,
Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura
S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T*, Sakai
J*.JMJD1A is a signal-sensing scaffold that regulates acute
chromatin dynamics via SWI/SNF association for thermogenesis. Nat Commun
Inagaki T# *, Iwasaki S# , Matsumura Y , Kawamura
T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K,
Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J*.The FBXL10/KDM2B scaffolding protein associates with novel
polycomb repressive complex-1 to regulate adipogenesis. J Biol Chem
2018-2023（久場教授主宰）
Kemuriyama K, An J , Motoyama S, Nagaki Y, Yamaguchi T, Sato Y, Wakita A,
Minamiya Y,
Kuba K*.Squamous cell carcinoma-derived G-CSF promotes tumor
growth and metastasis in mice through neutrophil recruitment and tumor cell
proliferation, associated with poor prognosis of the patients. Genes Cells
An J , Nagaki Y, Motoyama S, Kuze Y, Hoshizaki M, Kemuriyama K, Yamaguchi T,
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T, Minamiya Y, Suzuki Y, Imai Y, Kuba K*.Identification of Galectin-7 as a crucial metastatic
enhancer of squamous cell carcinoma associated with
immunosuppression. Oncogene
Minato T, Yamaguchi T, Hoshizaki M, Nirasawa S, An J , Takahashi S,
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Y, Kuba K*.ACE2-like enzyme B38-CAP suppresses abdominal sepsis and
severe acute lung injury. PLoS One
Yamaguchi T# , Hoshizaki M# , Minato T# , Nirasawa S, Asaka
MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J , Saku A, Nukiwa R,
Utsumi D,
Kiso M, Yasuhara A, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada
H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K*.ACE2-like carboxypeptidase B38-CAP protects from
SARS-CoV-2-induced lung injury. Nat Commun
Nagaki Y, Motoyama S*, Yamaguchi T, Hoshizaki M, Sato Y, Sato T, Koizumi Y ,
Wakita A,
Kawakita Y, Imai K, Nanjo H, Watanabe H, Imai Y, Minamiya Y, Kuba K*.
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma
associated with poor prognosis. Genes Cells
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Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility
Factor for Cytotoxicity of Malformin A1. Chembiochem
Koizumi Y* , Nagai K, Gao L, Koyota S, Yamaguchi T, Natsui M, Imai Y, Hasumi
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Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic
activity. Sci Rep
Yamaguchi T# , Suzuki T# , Sato T, Takahashi A, Watanabe H, Kadowaki A,
Natsui M, Inagaki H,
Arakawa S, Nakaoka S, Koizumi Y , Seki S, Adachi S, Fukao A, Fujiwara T,
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Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba
K*.
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart
function. Sci Signal
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Koizumi Y# * , Nagai K# , Hasumi K, Kuba K, Sugiyama
T.Structure-activity relationship of cyclic pentapeptide
malformins as fibrinolysis enhancers. Bioorg Med Chem Lett Zhou X# , Koizumi Y# * , Zhang M, Natsui M, Koyota S,
Yamada M,
Kondo Y, Hamada F, Sugiyama T.Cadmium-coordinated supramolecule suppresses tumor growth
of T-cell leukemia in mice. Cancer Sci
Qiao Z, Koizumi Y , Zhang M, Natsui M, Flores MJ, Gao L, Yusa K, Koyota S,
Sugiyama
T*.Anti-melanogenesis effect of Glechoma hederacea L. extract
on B16 murine melanoma cells. Biosci Biotechnol Biochem
Ma L, Koyota S, Myoen Y, Yamashita T, Yatabe N, Koizumi Y , Aosasa M,
Nishimichi N,
Matsuda H, Sugiyama T*.Generation of intracellular single-chain antibodies
directed against polypeptide GalNAc-transferase using a yeast two-hybrid
system. Biophys Res Commun
Yusa K, Yamamoto O, Fukuda M, Koyota S, Koizumi Y , Sugiyama T*.In vitro prominent bone regeneration by release zinc ion
from Zn-modified implant. Biochem Biophys Res Commun
Kuhara M, Wang J, Flores MJ, Qiao Z, Koizumi Y , Koyota S, Taniguchi N,
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T*.Sexual dimorphism in LEC rat liver: suppression of
carbonic anhydrase III by copper accumulation during
hepatocarcinogenesis. Biomed Res
Wang J, Koyota S, Zhou X, Ueno Y, Ma L, Kawagoe M, Koizumi Y , Okamoto H,
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T*.Expression and localization of regenerating gene I in a
rat liver regeneration model. Biochem Biophys Res Commun
Koizumi Y , Tomoda H, Kumagai A, Zhou XP, Koyota S, Sugiyama T*.Simaomicin α, a polycyclic xanthone, induces G₁ arrest
with suppression of retinoblastoma protein phosphorylation. Cancer Sci Hayashi K, Motoyama S*, Koyota S, Koizumi Y , Wang J, Takasawa S,
Itaya-Hironaka A,
Sakuramoto-Tsuchida S, Maruyama K, Saito H, Minamiya Y, Ogawa J, Sugiyama T.REG I enhances chemo- and radiosensitivity in squamous
cell esophageal cancer cells. Cancer Sci
Kawagoe M, Ishikawa K, Wang SC, Yoshikawa K, Arany S, Zhou XP, Wang JS, Ueno Y,
Koizumi Y , Kameda T, Koyota S, Sugiyama T*Acute effects on the lung and the liver of oral
administration of cerium chloride on adult, neonatal and fetal
mice J Trace Elem Med Biol
Hirasawa F, Kawagoe M, Wang JS, Arany S, Zhou XP, Kumagai A, Koizumi Y ,
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Sugiyama T*.Gadolinium chloride suppresses styrene-induced cytochrome
P450s expression in rat liver. Biomed Res
Ueno Y, Nagai H, Watanabe G, Ishikawa K, Yoshikawa K, Koizumi Y , Kameda T,
Sugiyama
T.Transplantation of rat hepatic stem-like (HSL) cells with
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Takahashi S*, Ogasawara H, Hiwatashi K, Hata K, Hori K, Koizumi Y , Sugiyama
T.Amino acid residues conferring the nucleotide binding
properties of N-acetyl-D-glucosamine 2-epimerase (renin binding
protein). Biomed Res
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