2011
2018











Name: Yosuke Okamoto, 岡本 洋介
Publication:
  1. Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K. "Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes." J Biol Chem. 2019 in press
  2. Umehara S, Tan X, Okamoto Y, Ono K, Noma A, Amano A, Himeno Y. "Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study." Int J Mol Sci. 2019;20(12). pii: E2913.
  3. Kashino Y, Obara Y, Okamoto Y, Saneyoshi T, Hayashi Y, Ishii K. "ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells." Int J Mol Sci. 2018;19(7). pii: E2008.
  4. Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JR, Rimmbach C, Okamoto Y, ,..& Ghaffari S. "The γ2 subunit of AMP-activated protein kinase regulates mammalian heart rate." Nat Commun. 2017;8,1258
  5. Yaniv Y, Ahmet I, Tsutsui K, Behar J, Moen JM, Okamoto Y, Guiriba TR, Liu J, Bychkov R and Lakatta EG. "Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age‐associated alterations in heart rate variability in vivo. " Aging cell. 2016;15(4), 716-724. 
  6. Okamoto Y, Kawamura K, Nakamura Y, Ono K. “Pathological impact of hyperpolarization- activated chloride current peculiar to rat pulmonary vein cardiomyocytes. " J Mol Cell Cardiol. 2014;66:53-62. 
  7. Yaniv Y, Ahmet I, Liu J, Lyashkov AE, Guiriba TR, Okamoto Y, Ziman BD, Lakatta EG. "Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals. " Heart Rhythm. 2014. pii: S1547-5271(14):385-3. 
  8. Yaniv Y, Lyashkov AE, Sirenko S, Okamoto Y, Guiriba TR, Ziman BD, Morrell CH, Lakatta EG. "Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells. " J Mol Cell Cardiol. 2014;77:1-10. 
  9. Adachi T, Shibata S, Okamoto Y, Sato S, Fujisawa S, Ohba T, Ono K. "The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice. " J Physiol Sci. 2013;63(2):133-46. 
  10. Okamoto Y, Takano M, Ohba T, Ono K. "Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. " J Mol Cell Cardiol. 2012;52(5):988-97. 
  11. Zhang C, Okamoto Y, Ohba T, Ishibashi K, Yamamoto H, Ono K, Yamamoto F. “Down-regulation of L-type Ca2+ current in left atrial myocytes of rats during experimental cardiac hypertrophy. " Akita J Med. 2012;39:61-71. 
  12. Shibata S, Okamoto Y, Endo S, Ono K. “Direct effects of esmolol and landiolol on cardiac function, coronary vasoactivity, and ventricular electrophysiology in guinea-pig hearts. " J Pharmacol Sci. 2012;118(2):255-65. 
  13. Komatsuda A, Okamoto Y, Hatakeyama T, Wakui H, Sawada K. "Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus." Clin Rheumatol. 2008;27(3):395-7.
  14. Mizukami Y, Ono K, Du CK, Aki T, Hatano N, Okamoto Y, Ikeda Y, Ito H, Hamano K, Morimoto S. "Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion." Cardiovasc Res. 2008;79(4):589-99.
History: College of Literature, Aoyama Gakuin University, Graduated in 2000
Faculity of Medicine, Akita University, Graduated in 2006
Junior resident, Akita University Hospital, 2006 - 2008
Research assistant, Akita Graduate and Faculity of Medicine, 2008 - 2012
PhD, Akita Graduate School of Medicine, Graduated in 2012
Postdoc, National Institute on Aging, NIH in Baltimore, MA, 2012 - 2015
Assistant professor, Hirosaki University Graduate School of Medicine, 2015
Assistant professor, Yamagata University Faculity of Medicine, 2015 - 2017
Assistant professor, Akita University Graduate School of Medicine, 2017 -
Birth Date: 08/June/1977

Assistant Professor
Department of Cell Physiology
Zip 010-8543
Hondo 1-1-1
E-mail: okamoto@med.akita-u.ac.jp
TEL: +81-18-884-6070
FAX: +81-18-836-2604