平成１３年９月より、田島陽太郎前教授の後任として当講座の教授に就任致しました。
　当講座は　'細胞増殖・細胞 死・細胞分化・発がん'　をテーマに主に遺伝子改変動物の作成解析の手法により、種々の分子の生体における機能を明らかにしたいと考えております。
　また平成１４年には、文部科学省２１世紀COEプロジェクト '細胞の運命決定制御'　のコアメンバーに選ばれました。
　今後も世界に通用する研究を発信し続けることを目標とし、日々研究に励んでおります。
　今後とも、皆様の御指導の程をよろしくお願いいたします。

48)Wijesekara N, Konrad D, Edeida M, Jefferies C, Liadis N, Giacca A, Crockower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
MOLECULAR AND CELLULAR BIOLOGY 25(3), 1135-1145, 2005

47)Horie Y, Suzuki A (equal first and corresponding author), Kataoka Ei, Sasaki T, Hamada K, Junko Sasaki, MIzuno K, Hasegawa G, Kishimoto H, Iizuka M, Naito M, Enomoto K, Watanabe S, Mak TW, Nakano T
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
JOURNAL OF CLINICAL INVESTIGATION 113(12), 1774-1783, 2004
(私達のものが表紙を飾りました）

46)Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, Hennighausen L, Suzuki A, Tsao MS, Chapman WB, Stambolic V, Mak TW.
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.
PROC NATL ACAD SCI USA. 101(6), 1725-30, 2004

45)Nishita M, Yan W, Goto K,Tomizawa C, Suzuki A, Niwa R, Umekura T, Mizuno K
PI3-kinase-Mediated Activation of Cofilin Phosphatase Slingshot-1L Controls Insulin-induced Membrane Protrusion
JOURNAL OF BIOLOGICAL CHEMISTRY 279(8), 7193-7198, 2004

44)Komazawa N, Matsuda M, Kondoh G, Mizunoya W, Iwaki M, Takagi T, Sumikawa Y, Inoue K, Suzuki A, Mak TW, Nakano T, Fushiki T, Takeda J, Shimomura I
Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.
NATURE MEDICINE 10(11), 1208-15, 2004

42)Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM, Nishina H, Katada T
Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stressinduced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells
JOURNAL OF BIOLOGICAL CHEMISTRY 278(19), 16595-16601, 2003

41)Suzuki A, Itami S, Ohishi M, Yamaguchi MT, Hamada K, Inoue T, Komazawa N, Senoo H, Sasaki T, Takeda J, Manabe M, Mak TW, Nakano T
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
CANCER RESEARCH 63(3), 674-681, 2003
(私達のものが表紙を飾りました）

40)Suzuki A, Kaisho T, Ohishi M, Yamaguchi MT, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
JOURNAL of EXPERIMANTAL MEDICINE 197(5), 657-667, 2003

39)Kimura T, Suzuki A, Fujita Y, Yomogida Y, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, Nakano T
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
DEVELOPMENT 130(8), 1691-1700, 2003

38)Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sasaki T, Suzuki A, Sasaki JI, Sah R, Cheng HYM, Oliveira-dos-Santos AO, Benovic JL, Kahn CR,
Izumo S, Steinberg SF, Backx PH, Penninger J
Regulation of heart muscle contractility by the PI3Kg-PTEN signaling pathway
CELL 110(6) 737-749, 2002

37)Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K, Suzuki A, Nakano T and Honjo T
Notch / RBP-J signaling is involved in cell fate determination of Marginal Zone B cells
NATURE IMMUNOLOGY 3(5), 443-50, 2002

36)Cheung AM, Hande MP, Jalali F, Tsao MS, Skinnider B, Hirao A, McPherson JP, Karaskova J, Suzuki A, Wakeham A, You-Ten A, Elia A, Squire J,Bristow R, Hakem R, Mak TW.
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
CANCER RESEARCH 62(21), 6194-204, 2002

35)Itoh H, Komatsuda A, Ohtani H, Wakui H, Imai H, Sawada K, Otaka M, Ogura M, Suzuki A, Hamada F
Mammalian HSP60 is quickly sorted into the mitchondria under dehydration
EUROPEAN JOURNAL of BIOCHEMISTRY 269(23), 5931-5938, 2002

34) Matsumori M, Itoh H, Toyoshima I, Komatsuda A, Sawada K, Fukuda J, Tanaka T, Okubo A, Kinouchi H, Mizoi K., Hama T, Suzuki A, Hamada F, Shoji Y, Takada G
Characterization of the 105-kDa molecular chaperone: Identification, biochemical properties, and lozalization
EUROPEAN JOURNAL of BIOCHEMISTRY 269(22), 5632-5641, 2002

33)Higuchi, M., Masuyama, N., Fukui, Y., Suzuki, A. and Gotoh, Y.
Akt mediates Rac/Cdc42-Regulated Cell Motility in Growth Factor-Stimulated Cells and in Invasive PTEN-Knockout Cells.
CURRENT BIOLOGY 11(24), 1958-1962, 2001.

32)Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, Tsao MS, Shannon P, Bolon B, Ivy GO, Mak TW.
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.
NATURE GENETICS 29(4), 396-403, 2001.

31)Sasaki T, Wada T, Kishimoto H, Irie-Sasaki J, Matsumoto G, Goto T, Yao Z, Wakeham A, Mak TW, Suzuki A, Cho SK, Zuniga-Pflucker JC,
Oliveira-dos-Santos AJ, Katada T, Nishina H, Penninger JM.
The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in
hematopoietic cells.
JOURNAL of EXPERIMANTAL MEDICINE194(6), 757-768, 2001.

30)Suzuki A, Yamaguchi MT, Ohteki T, Sasaki T, Kaisho T, KimuraY, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi P, Koyasu S, Penninger JM, Nakano T and Mak TW
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
IMMUNITY 14, 523-534, 2001

29)Sasaki T, Sasaki JI, Horie Y,Bachmaier K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S , Khokha R, Mak TW, Hawkins PT, Stephens L, Scherer SW, Tsao M, Penninger JM
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K-gammma
NATURE 406, 897-902, 2000

28)Stambolic V, Tsao MS, Macpherson D, Suzuki A, Chapman WB, Mak TW
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
CANCER RESEARCH 60(13), 3605-11, 2000

27)Sasaki T, Sasaki JI, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi
PS, Suzuki A, Penninger JM
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
SCIENCE 287(5455), 1040-1046, 2000

26)Suzuki-A, de la Pompa-JL, Stambolic-V, Elia-AJ, Sasaki-T, Barrantes-IB, Ho-A, Wakeham-A, ltie-A, Khoo-W, Fukumoto-M, Mak-TW
High cancer susceptibility and embryonic lethality associated with mutation of
the PTEN tumor suppressor gene in mice.
CURRENT BIOLOGY 8(21),1169-78,1998

25)Stambolic-V, Suzuki-A(equal first contributor), de la-Pompa JL, Brothers-GM, Mirtsos-C, Sasaki-T, Ruland-J, Penninger-JM, Siderovski-DP, Mak-TW
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
CELL 95(1),29-39 ,1998

24)Suzuki-A. de-la-Pompa-JL. Hakem-R. Elia-A. Yoshida-R. Mo-R. Nishina-H. Chuang-T. Wakeham-A. Itie-A. Koo-W. Billia-P. Ho-A. Fukumoto-M.
Hui-CC. Mak-TW.
Brca2 is required for embryonic cellular proliferation in the mouse.
GENES AND DEVELOPMENT 11(10), 1242-52, 1997.
(私達のものが表紙を飾りました）

23)Suzuki-A. Andrew-DP. Gonzalo-JA. Fukumoto-M. Spellberg-J. Hashiyama-M. Takimoto-H. Gerwin-N. Webb-I. Molineux-G. Amakawa-R. Tada-Y. Wakeham-A. Brown-J. McNiece-I. Ley-K. Butcher-EC. Suda-T. Gutierrez-Ramos-JC. Mak-TW.
CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.
BLOOD 87(9), 3550-62, 1996.

22)Grossman-A. Mittruecker-HW. Nicholl-J. Suzuki-A. Chung-S. Antonio-L. Suggs-S. Sutherland-GR. Siderovski-DP. Mak-TW.
Cloning of human lymphocyte-specific interferon regulatory factor(hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.
GENOMICS 37(2), 229-33, 1996.

21)Tsuyuoka-R. Takahashi-T. Suzuki-A. Sasaki-Y. Nakamura-K. Fukumoto-M. Ohmori-K. Ohno-Y. Nakao-K.
A newly established megakaryoblastic/erythroid cell line that differentiates to red cells in the presence of erythropoietin and produces platelet-like particles.
STEM CELLS 13(1), 54-64, 1995.

20)TAKAHASHI T, SUZUKI A.
LIVER-DAMAGE IN PATIENTS WITH CSF-PRODUCING TUMORS - REPLY
AMERICAN JOURNAL OF MEDICINE
98 (6): 601-602 JUN 1995

19)Suzuki-A. Takahashi-T. Okuno-Y. Tsuyuoka-R. Sasaki-Y. Fukumoto-M. Katakami-H. Kita-K. Shibuya-T.
Production of parathyroid hormone-related protein by cultured human myeloma cells.
AMERICAN JOURNAL OF HEMATOLOGY. 45(1), 88-90, 1994.

18)Tsuyuoka-R. Takahashi-T. Sasaki-Y. Taniguchi-Y. Fukumoto-M. Suzuki-A. Nakamura-K. Kobayashi-S. Kudo-T. Nakao-K.
Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production.
EUROPEAN JOURNAL OF CANCER 30A(14), 2130-6, 1994.

17)Suzuki-A. Takahashi-T. Okuno-Y. Seko-S. Fukuda-Y. Nakamura-K. Fukumoto-M. Konaka-Y. Imura-H.
Liver damage in patients with colony-stimulating factor-producing tumors.
AMERICAN JOURNAL OF MEDICINE 94(2), 125-32, 1993.

16)Fukumoto-M. Suzuki-A. Inazawa-J. Yoshimura-T. Arao-S. Takahashi-T. Nomura-H. Hiai-H.
Chromosomal location and structure of amplicons in two human cell lines with coamplification of c-myc and Ki-ras oncogenes.
SOMATIC CELL AND MOLECULAR GENETICS 19(1), 21-8, 1993.

15)Suzuki-A. Takahashi-T. Nakamura-K. Tsuyuoka-R. Okuno-Y. Enomoto-T. Fukumoto-M. Imura-H.
Thrombocytosis in patients with tumors producing colony-stimulating factor.
BLOOD 80(8), 2052-9, 1992.

14)Suzuki-A. Takahashi-T. Okuno-Y. Tsuyuoka-R. Fukumoto-M. Nakamura-K. Imura-H.
IL-1 production as a regulator of G-CSF and IL-6 production in CSF-producing cell lines.
BRITISH JOURNAL OF CANCER 65(4), 515-8, 1992.

13)Takahashi-T. Nakamura-K. Nishikawa-S. Tsuyuoka-R. Suzuki-A. Murakami-M. Amenomori-M. Okuno-Y. Imura-H.
Interleukin-5 in eosinophilic gastroenteritis.
AMERICAN JOURNAL OF HEMATOLOGY 40(4), 295-8, 1992.

12)Okuno-Y. Takahashi-T. Suzuki-A. Fukumoto-M. Nakamura-K. Fukui-H. Koishihara-Y. Ohsugi-Y. Imura-H.
Acquisition of growth autonomy and tumorigenicity by an interleukin 6-dependent human myeloma cell line transfected with interleukin 6 cDNA.
EXPERIMENTAL HEMATOLOGY 20(4), 395-400, 1992.

11)Suzuki-A. Takahashi-T. Okuno-Y. Nakamura-K. Tashiro-H. Fukumoto-M. Konaka-Y. Imura-H.
Analysis of abnormal expression of g-csf gene in a novel tumor cell line (KHC 287) elaborating G-CSF, IL-1 and IL-6 with co-amplification of c-myc and
c-ki-ras.
INTERNATIONAL JOURNAL OF CANCER 48(3), 428-33, 1991.

10)Suzuki-A. Takahashi-T. Taniguchi-A. Kotake-C. Seo-T. Toda-T. Kobayashi-K. Tsukamoto-N. Fukumoto-M.
Pure red cell aplasia associated with non-Hodgkin's lymphoma and hemolytic anemia.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY 21(5), 384-7, 1991.

9)Suzuki-A. Takahashi-T. Okuno-Y. Fukumoto-M. Fukui-H. Koishihara-Y. Ohsugi-Y. Ohno-Y. Imura-H.
Estimation of interleukin 6 production by reverse transcriptase-polymerase chain reaction in four human myeloma cell lines.
LEUKEMIA RESEARCH 15(11), 1043-50, 1991.

8)Nakamura-K. Takahashi-T. Tsuyuoka-R. Ueda-Y. Suzuki-A. Okuno-Y. Ihara-Y. Seko-S. Okada-T. Kumagai-N. Oyaizu-T, Nishimura-T
Identification of colony-stimulating factor activity in patients with malignant tumors associated with excessive leukocytosis.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY 21(6), 395-9, 1991.

7)Takahashi-T. Suzuki-A. Ichiba-S. Okuno-Y. Sugiyama-H. Imura-H. Nakamura-K. Iho-S. Hoshino-T.
Effect of 1,25(OH)2D3 on normal human CFU-GM: target cells of the agent in the suppression of colony formation and induction of macrophage colonies.
INTERNATIONAL JOURNAL OF HEMATOLOGY 54(1), 57-63, 1991.

6)Okuno-Y. Takahashi-T. Suzuki-A. Ichiba-S. Nakamura-K. Okada-T. Okada-H. Imura-H.
In vitro growth pattern of myeloma cells in liquid suspension or semi-solid culture containing interleukin-6.
INTERNATIONAL JOURNAL OF HEMATOLOGY 54(1), 41-7, 1991.

5)Takahashi-T. Tsuyuoka-R. Ueda-Y. Suzuki-A. Ichiba-S. Okuno-Y. Nakamura-K. Imura-H.
Megakaryocyte potentiating activity of IL-1, IL-6 and GM-CSF as evaluated by their action on in vitro human megakaryocytic colonies.
BRITISH JOURNAL OF HAEMATOLOGY 78(4), 480-7, 1991.

4)Okuno-Y. Takahashi-T. Suzuki-A. Fukumoto-M. Nakamura-K. Imura-H.
Co-production of interleukin-1 and interleukin-6 in tumor cell lines elaborating colony-stimulating factors.
JAPANESE JOURNAL OF CANCER RESEARCH 82(8), 890-2, 1991.

3)Okuno-Y. Takahashi-T. Suzuki-A. Ichiba-S. Nakamura-K. Fukumoto-M. Okada-T. Okada-H. Imura-H.
Establishment and characterization of four myeloma cell lines which are responsive to interleukin-6 for their growth.
LEUKEMIA 5(7), 585-91, 1991.

2)Okuno-Y. Suzuki-A. Ichiba-S. Takahashi-T. Nakamura-K. Hitomi-K. Sasaki-R. Tada-K. Imura-H.
Establishment of an erythroid cell line (JK-1) that spontaneously differentiates to red cells.
CANCER 66(7), 1544-51, 1990.

1)Okuno-Y. Takahashi-T. Suzuki-A. Ichiba-S. Nakamura-K. Hitomi-K. Sasaki-R. Imura-H.
Expression of the erythropoietin receptor on a human myeloma cell line.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 170(3), 1128-34, 1990.

総説 

29)堀江泰夫、鈴木　聡、片岡　英、後藤　隆、芳野竜太郎、佐藤　亘、渡辺純夫
脂肪肝から肝がんへ・・・NASHの新展開
内科　2005　印刷中

28)河原崎哲、夏井美幸、松田幸久、佐々木雄彦、仲野徹、鈴木　聡
PTEN欠損マウスによる疾患モデルマウス
分子細胞治療、in press、2005

27)堀江泰夫、片岡　英、佐々木雄彦、渡辺純夫、仲野　徹、鈴木　聡
肝臓における癌抑制遺伝子PTENの機能解析
細胞療法の基礎と臨床、p146-p156, 2004

26)渡辺純夫、堀江泰夫、鈴木　聡
Nonalcoholic Steatohepatitis (NASH)への実験医学的アプローチ
肝臓45(11), 568-580, 2004

25)Suzuki A, Sasaki T, Mak TW, Nakano T
Functional  analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes
BIOCHEMICAL JOURNAL (BIOCHEMICAL SOCIETY TRANSACTION), 32 (2), 362-365, 2004

24)佐々木雄彦、水野克典、仲野徹、鈴木聡
PTENホスファターゼとその生体における機能
細胞工学、23(5), 556-561, 2004

23)岸本恕征、佐々木雄彦、仲野徹、鈴木聡
PI3Kキナーゼ関連遺伝子欠損と免疫異常
Molecular Medicine, 41(5), 58-63, 2004

22)河原崎哲、濱田浩一、松田幸久、佐々木雄彦、仲野徹、鈴木聡
ＰＴＥＮとアポトーシス
Biotherapy, 18(2), 151-160, 2004

21)堀江泰夫、佐々木雄彦、飯塚政弘、渡邊純夫、鈴木 聡
炎症とアポトーシス
２１世紀の胃の炎症学　, 2004 in press

20)濱田浩一、佐々木雄彦、仲 野徹、鈴木聡　
血液細胞における癌抑制遺伝子PTEN
血液・腫瘍科, 48(2), 190-195, 2004

19)岸本恕征、改正恒康、佐々 木雄彦、仲野徹、鈴木聡
ＰＴＥＮによるＢ細胞の分化と機能制御
臨床免疫　41(2), 121-127, 2004

18)井上多恵、真鍋求、板見智、佐々木雄彦、仲野徹、鈴木聡
がん抑制遺伝子ＰＴＥＮと皮膚疾患
日本皮膚科学会雑誌　113(1), 1641-1650, 2003

17)Kishimoto H, Hamada K, Saunders M, Sasaki T, Nakano T, Mak TW and Suzuki A
Physiological Functions of PTEN in Various Tissues~ Analysis of the tissue specific PTEN mutant mice ~
CELL STRUCTURE and FUNCTION 28, 9-19, 2003

16)木村透、鈴木聡、仲野徹
始原生殖細胞から全能性細胞へ：テラトーマのEG細胞
細胞工学　21 (8)、836-838、2002 秀潤社

15)Sasaki T, Suzuki A, Sasaki J, Penninger JM.
Phosphoinositide 3-kinases in immunity: lessons from knockout mice.
JOURNAL of BIOCHEMISTRY 131(4):495-501, 2002

14)佐々木雄彦、山崎正和、鈴木聡
PI3Kによる極性発生
細胞骨格と細胞運動，169-174，2002　シュプリンガー・ フェアラーク社

13)Suzuki A, Nakano T
Development of Hematopoietic Cells from embryonic stem cells
INTERNATIONAL JOURNAL of HEMATOLOGY 73, 1-5, 2001

12)佐々木雄彦、鈴木聡
PI3Kによる細胞遊走の制御
医学のあゆみ199 (13)，871-875，2001　医歯薬出版

11)大石美奈子、仲野徹、鈴木聡
組織特異的なPTENの不活化とT細胞トレランスの破綻
Molecular Medicine臨時増刊号 免疫2002ﾕ 38, 85-93, 2001

10)鈴木聡、佐々木雄彦、仲野徹
癌抑制遺伝子PTENの機能解析　生化学的・生理学的な役割
実験医学別冊‘アポトーシス研究の新たな挑戦’19(13), 1713-1719, 2001

9)鈴木聡、仲野徹
PTEN変異と自己免疫疾患
実験医学別冊‘免疫総集編2001’19(5), 688-693, 2001

8)鈴木聡、山口麻奈絵、大石美奈子、仲野徹
癌抑制遺伝子PTENと自己寛容
Annual Review免疫2002, 201-207,中外医学社

7)山口麻奈絵、鈴木聡、仲野徹
トレランス形成におけるPTENの意義
臨床免疫 35(6), 675-682, 2001

6)佐々木雄彦、鈴木聡、佐々木純子、Josef M.Penninger
PI3キナーゼとPIホスファターゼの免疫応答、糖代謝、腫瘍形成 における役割
蛋白質核酸酵素46(12) 1820-1829, 2001

5)Akira Suzuki and Tak Wah Mak: CD34. In 'The gene knockout facts Book'(A-H).
(ed)Tak Wah Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders.
p 168- 170. Academic Press, San Diego, USA, 1998

4)Akira Suzuki and Tak Wah Mak: BRCA2. In 'The gene knockout facts Book'(A-H).
(ed)Tak Wah Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders.
p 95- 96. Academic Press, San Diego, USA, 1998

3)鈴木聡、須田年生：CD34. ノックアウトマウスデ-タブック、Molecular Medicine 34（臨時増刊号）92-93、1997

2)鈴木聡、福本学、須田年生：CD34欠損マウス.　実験医学　14、1869-71、1996

1)高橋隆幸、鈴木聡、福本学、坂根剛：CSF産生腫瘍における肝障害.　日常診療と血液2、1090-93, 1992

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