各講座の研究業績

2015年

1) Omokawa, M., Ayabe, T., Nagai, T., Imanishi, A., Omokawa, A., Nishino, S., Sagawa, Y., Shimizu, T. and Kanbayashi, T.(2015) Decline of CSF orexin (hypocretin) levels in Prader-Willi syndrome. Am. J. Med. Genet. A, 170(5), 1181-1186.


2) Takahashi, Y., Kanbayashi, T., Hoshikawa, M., Imanishi, A., Sagawa, Y., Tsutsui, K., Takeda, Y., Kusanagi, H., Nishino, S. and Shimizu, T.(2015) Relationship of orexin(hypocretin) system and astrocyte activation in Parkinson’s disease with hypersomnolence. Sleep and Biological Rhythms, 13(3), 252-260.


3) 今西 彩,久保田弘樹,鎮西祐美,佐藤 亘,瀬尾東伸,小野大輔,筒井 幸,佐々木倫子,佐川洋平,神林 崇,清水徹男(2015) ナルコレプシーの夜間の中途覚醒やその他レム関連症状に対する様々な薬物による治療法の検討.不眠研究2015, 25-30.


4) Nigorikawa, K., Hazeki, K., Sasaki, J., Omori, Y., Miyake, M., Morioka, S., Guo, Y., Sasaki, T. and Hazeki, O.(2015) Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2. PLoS One, 10(11), e0142091.


5) Hammond, G.R., Takasuga, S., Sasaki, T. and Balla, T.(2015) The ML1Nx2 Phosphatidylinositol 3,5 Bisphosphate Probe Shows Poor Selectivity in Cells. PLoS One, 10(10), e0139957.


6) Kofuji, S., Kimura, H., Nakanishi, H., Nanjo, H., Takasuga, S., Liu, H., Eguchi, S., Nakamura, R., Itoh, R., Ueno, N., Asanuma, K., Huang, M., Koizumi, A., Habuchi, T., Yamazaki, M., Suzuki, A., Sasaki, J. and Sasaki, T.(2015) INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov., 5, 730-739.


7) Li Chew, C., Lunardi, A., Gulluni, F., Ruan, D.T., Chen, M., Salmena, L., Nishino, M., Papa, A., Ng, C., Fung, J., Clohessy, J.G., Sasaki, J., Sasaki, T., Bronson, R.T., Hirsch, E. and Pandolfi, P.P.(2015) In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov., 5, 740-751.


8) Ip, L.R., Poulogiannis, G., Viciano, F.C., Sasaki, J., Kofuji, S., Spanswick, V.J., Hochhauser, D., Hartley, J.A., Sasaki, T. and Gewinner, C.A.(2015) Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget., 6, 10548-10562.


9) Konno, Y., Takahashi, I., Narita, A., Takeda, O., Koizumi, H., Tamura, M., Kikuchi, W., Komatsu, A., Tamura, H., Tsuchida, S., Noguchi, A. and Takahashi, T.( 2015) Elevation of Serum Acid Sphingomyelinase Activity in Acute Kawasaki Disease. Tohoku J. Exp. Med., 237, 133-140.


10) 山下順助,滝澤行雄(2015) 日本酒のX線照射マウスに対する放射線防護効果.日本醸造協会誌110,8-12.

2014年

1) Kume, K., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y., Kamada, M., Touge, T., Takahashi, T., Kanbayashi, T. and Masaki, T. (2014) Neuromyelitis optica spectrum disorder presenting with repeated hypersomnia due to involvement of the hypothalamus and hypothalamus-amygdala linkage. Mult. Scler., 21(7):960-2.


2) 神林 崇,筒井 幸,田中惠子,大森佑貴,高木 学,面川真由,森 朱音,草薙宏明,西野精治,清水徹男 (2014) 精神科におけるanti-NMDAR 脳炎: 悪性緊張病と非定型精神病と電気治療.臨床神経学,54, 1103-1106.


3) 斎藤奈穂子,井上雅人,蓮尾金博,神林 崇,村山繁雄,竹内壯介 (2014) 高体温,過眠症を呈しMRI で両側視床下部病変をみとめモダフィニルが奏功した39 歳女性例.臨床神経学,54, 550-555.


4) 酒井和香,松井尚子,藤田浩司,和泉唯信,西田善彦,高橋利幸,神林 崇,梶 龍兒 (2014)  抗利尿ホルモン分泌異常症候群で発症し,橋中心・橋外髄鞘崩壊症を合併した視神経脊髄炎関連疾患の1 例. 臨床神経学,54, 556-560.


5) 向野晃弘,木下郁夫,福島直美,大坪まゆみ,神林 崇(2014) 髄液オレキシン低値をともない過眠症を合併した単純ヘルペス脳炎の1例.臨床神経学,54, 207-211.


6) 酒井和香,松井尚子,藤田浩司,和泉唯信,西田善彦,高橋利幸,神林 崇,梶 龍兒 (2014)  抗利尿ホルモン分泌異常症候群で発症し,橋中心・橋外髄鞘崩壊症を合併した視神経脊髄炎関連疾患の1 例. 臨床神経学, 54(7), 556-560.


7) 斎藤奈穂子,井上雅人,蓮尾金博,神林 崇,村山繁雄,竹内壯介 (2014) 高体温,過眠症を呈しMRI で両側視床下部病変をみとめモダフィニルが奏功した39 歳女性例. 臨床神経学, 54(7), 550-555.


8) 向野晃弘,木下郁夫,福島直美,大坪まゆみ,神林 崇 (2014) 髄液オレキシン低値をともない過眠症を合併した単純ヘルペス脳炎の1例. 臨床神経学, 54(3), 207-211.


9) Segawa, T., Hazeki, K., Nigorikawa, K., Morioka, S., Guo, Y., Takasuga, S., Asanuma, K. and Hazeki, O. (2014) Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20. Biochem. J., 464(3), 365-375.


10) Ayukawa, T., Akiyama, M., Mummery-Widmer, J.L., Stoeger, T., Sasaki, J., Knoblich, J.A., Senoo, H., Sasaki, T. and Yamazaki, M. (2014) Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep., 8, 610-621.


11) Teshima, K., Nara, M., Watanabe, A., Ito, M., Ikeda, S., Hatano, Y., Oshima, K., Seto, M., Sawada, K. and Tagawa, H. (2014) Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma. Oncogene, 33(17), 2191-2203.


12) Nara, M., Komatsuda, A., Omokawa, A., Togashi, M., Okuyama, S., Sawada, K. and Wakui, H. (2014) Serum interleukin 6 levels as a useful prognostic predictor of clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease. Mod. Rheumatol., 24(4), 633-636.


13) Ito, M., Teshima, K., Ikeda, S., Kitadate, A., Watanabe, A., Nara, M., Yamashita, J., Ohshima, K., Sawada, K. and Tagawa, H. (2014) MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6 in advanced cutaneous T-cell lymphoma. Blood, 123(10), 1499-1511.


14) Ikeda, S. and Tagawa, H. (2014) Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias. Int. J. Hematol., 99(5), 542-552.


15) 蛇口 琢, 目崎喜弘 (2014) 短腸症候群とビタミンA ビタミン 88(12), 618-621.


16) Takizawa, Y., Yamashita, J. and Ishigouka, S. (2014) Protective effect of Japanese sake against lonizing X-irradiation in mice. Radioisotopes, 63, 1-12.

2013年

1) 神林 崇, 筒井 幸, 田中恵子, 朴 秀賢, 菱川泰夫, 清水徹男 (2013) 抗 NMDA 受容体抗体が陽性であった脳炎, 統合失調症, 精神症状をともなうナルコレプシーの症例. 精神薬療研究年報, 45, 35-37.


2) 森 朱音, 筒井 幸, 高橋裕哉, 菊池結花, 細川敬輔, 丸山 史, 八重樫香名子, 近藤英明, 神林 崇, 清水徹男 (2013) 抗 NMDA 受容体抗体陽性が判明したパーキンソン病を合併したナルコレプシーの一例. 睡眠医療, 7(4), 499-505.


3) 岡本健太郎, 伊藤 康, 西川愛子, 七字美延, 石垣景子, 舟塚 真, 神林 崇, 大澤眞木子 (2013) Modafinil が有効であった小児期特発性ナルコレプシーの1例. 東京女子医科大学雑誌, 83巻臨増, 265-268.


4) Takasuga, S. and Sasaki, T.(2013) Phosphatidylinositol-3,5-bisphosphate : metabolism and physiological functions. J. Biochem., 154(3), 211-218.


5) Takasuga, S., Horie, Y., Sasaki, J., Sun-Wada, G.H., Kawamura, N., Iizuka, R., Mizuno, K., Eguchi, S., Kofuji, S., Kimura, H., Yamazaki, M., Horie, C., Odanaga, E., Sato, Y., Chida, S., Kontani, K., Harada, A., Katada, T., Suzuki, A., Wada, Y., Ohnishi, H. and Sasaki, T.(2013) Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. USA, 110(5), 1726-1731.


6) Biswas, K., Yoshioka, K., Asanuma, K., Okamoto, Y., Takuwa, N., Sasaki, T. and Takuwa, Y. (2013) Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. J. Biol. Chem., 288(4), 2325-2339.


7) Teshima, K., Nara, M., Watanabe, A., Ito, M., Ikeda, S., Hatano, Y., Oshima, K., Seto, M., Sawada, K. and Tagawa, H.(2013) Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma. Oncogene, 20, 1-13.


8) Nara, M., Teshima, K., Watanabe, A., Ito, M., Iwamoto, K., Kitabayashi, A., Kume, M., Hatano, Y., Takahashi, N., Iida, S., Sawada, K. and Tagawa, H.(2013) Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells. PLoS One, 8(3), e56954.


9) Michishita, Y., Hirokawa, M., Fujishima, N., Abe, Y., Fujishima, M., Guo, Y.M., Ubukawa, K., Liu, J., Yoshioka, T., Kameoka, Y., Saitoh, H., Tagawa, H., Takahashi, N. and Sawada, K.(2013) CDR3-independent expansion of Vδ1 T lymphocytes in acquired chronic pure red cell aplasia. Immunol. Lett., 150(1-2), 23-29.


10) Sasajima, T., Ono, T., Shimada, N., Doi, Y., Oka, S., Kanagawa, M., Baden, A. and Mizoi, K. (2013) Trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (anti-18F-FACBC) is a feasible alternative to 11C-methyl-L-methionine and magnetic resonance imaging for monitoring treatment response in gliomas. Nucl. Med. Biol., 40, 808-815.