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業績について


業績:2017年

総説・解説

  1.  橋直人(2017) 白血病診療の実際−最新の診断と治療: 白血病治療における薬物血中濃度モニタリング.日本医師会誌雑誌145(12),2578.

原著・論文(審査を経た論文)

  1.  Md. Fahmid Islam, Atsushi Watanabe, Lai Wong, Conor Lazarou, Frederick S. Vizeacoumar, Omar Abuhussein, Wayne Hill, Maruti Uppalapati, C. Ronald Geyer & Franco J. Vizeacoumar.(2017) Enhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens. SCIENTIFIC REPORTS., [Epub ahead of print].
  2.  Ikeda S, Kitadate A, Abe F, Hirobumi S, Michishita Y, Hatano Y, Kawabata Y, Kitabayashi A, Teshima K, Kume M, Takahashi N, Tagawa H.(2017) Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma. Cancer Sci., [Epub ahead of print].
  3.  Abe F, Kitadate A, Ikeda S, Yamashita J, Nakanishi H, Takahashi N, Asaka C, Teshima K, Miyagaki T, Sugaya M, Tagawa H.(2017) Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma. Oncotarget., 8(5), 7572-7585.
  4.  Masato Sawamura, Atsushi Komatsuda, Masaru Togashi, Hideki Wakui, Naoto Takahashi.(2017) Effects of Denosumab on Bone Metabolic Markers and Bone Mineral Density in Patients Treated with Glucocorticoids. Intern Med., 56(6), 631-636.
  5.  Ozawa M, Komatsuda A, Ohtani H, Nara M, Sato R, Togashi M, Takahashi N, Wakui H.(2017) Long-term prognosis of AL and AA renal amyloidosis: a Japanese single-center experience. Clin Exp Nephrol., [Epub ahead of print].
  6.  Jiang ZP, Zhao XL, Takahashi N, Angelini S, Dubashi B, Sun L, Xu P.(2017) Trough concentration and ABCG2 polymorphism are better to predict imatinib response in chronic myeloid leukemia: a meta-analysis. Pharmacogenomics., 18(1),35-56.
  7.  Katsushi Tajima, Naoto Takahashi, Kenichi Ishizawa, Kazunori Murai, Tomoaki Akagi, Hideyoshi Noji, Osamu Sasaki, Masaharu Wano, Jugoh Itoh, Yuichi Kato, Tsutomu Shichishima, Hideo Harigae, Yoji Ishida & for the Tohoku Hematology Forum.(2017) Clinicopathological characteristics of malignant lymphoma in patients with hepatitis C virus infection in the Tohoku district in Eastern Japan. Leukemia & Lymphoma., 58(6), 1509-1511.
  8.  Komatsu N, Kirito K, Shimoda K, Ishikawa T, Ohishi K, Ohyashiki K, Takahashi N, Okada H, Amagasaki T, Yonezu T, Akashi K..(2017) Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis. Int J Hematol., 105(3), 309-317.
  9.  Yokoyama H, Takahashi N, Katsuoka Y, Inomata M, Ito T, Meguro K, Kameoka Y, Tsumanuma R, Murai K, Noji H, Ishizawa K, Ito S, Onishi Y, Harigae H; Tohoku Hematology Forum...(2017) Evaluation of the safety and efficacy of recombinant soluble thrombomodulin for patients with disseminated intravascular coagulation associated with acute leukemia: multicenter prospective study by the Tohoku Hematology Forum. Int J Hematol., [Epub ahead of print].
  10.  Shuntaro Togashi, Kyosuke Takahashi, Arisa Tamura, Ikumi Toyota, Shiori Hatakeyama, Atsushi Komatsuda, Ikuro Kudo, Erina Sasaki Kudoh, Tomoya Okamoto, Asami Haga.(2017) High dose of antibiotic colistin induces oligomerization of molecular chaperone HSP90. J Biochem., [Epub ahead of print].
  11.  伊藤史子、亀岡吉弘、奈良美保、鵜生川久美、藤島眞澄、吉岡智子、藤島直仁、橋直人(2017) 両側副腎出血を合併したTAFRO症候群. 日本内科学会雑誌106(2), 288-294.


業績:2016年

総説・解説

  1.  Miura M, Takahashi N.(2016) Routine therapeutic drug monitoring of tyrosine kinase inhibitors by HPLC-UV or LC-MS/MS methods. Drug Metab Pharmacokinet31(1),12-20.
  2.  橋直人(2016) 慢性期CMLに対するTKI療法 ―晩期副作用としての心血管障害を考える―.臨床血液57(10),1956-1961.
  3.  小松田敦(2016) ネフローゼ症候群: 膜性増殖性糸球体腎炎.腎と透析 診断指針2016,207-211.
  4.  小松田 敦(2016) その他のリウマチ性疾患および関連疾患: リウマチ性多発筋痛症(PMR)、RS3PE. 膠原病・リウマチ・アレルギー 研修ノート,437-439.
  5.  野口晋佐、橋直人(2016) 管理・治療: 慢性骨髄性白血病 治癒への道程.診断と治療のABC113: 慢性骨髄性白血病骨髄増殖性腫瘍,149-156.
  6.  小林敬宏、三浦昌明、橋直人(2016) 特論: 多発性骨髄腫に対する新規薬剤療法のTDM(therapeutic drug monitoring:治療薬物モニタリング). 日本臨牀74(5),573-577.
  7.  藤岡優樹、西川博嘉(2016) がん免疫療法の最前線: がん免疫療法の基礎. 臨床血液57(11),2346-2354.

原著・論文(審査を経た論文)

  1.  Ikeda S, Kitadate A, Ito M, Abe F, Nara M, Watanabe A, Takahashi N, Miyagaki T, Sugaya M, Tagawa H.(2016) Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma. Oncotarget., 7(12), 13563-13574.
  2.  Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H.(2016) MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas. Oncogene., 35(28), 3692-3704.
  3.  Takaya Yamashita, Naohito Fujishima, Masatomo Miura, Takenori Niioka, Maiko Abumiya, Yoshinori Shinohara, Kumi Ubukawa, Nara Miho, Fujishima Masumi, Kameoka Yoshihiro,. (2016) Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation. Cancer Chemother Pharmacol., 78(1), 111-118.
  4.  Takahiro Kobayashi, Takenori Niioka, Masatomo Miura, Naoto Takahashi,.(2016) Therapeutic drug monitoring enables safe and effective lenalidomide therapy in patients with multiple myeloma on hemodialysis. Ann Hematol.,95(12), 2087-2088.
  5.  Kobayashi I, Ubukawa K, Sugawara K, Asanuma K, Guo YM, Yamashita J, Takahashi N, Sawada K, Nunomura W. (2016) Erythroblast enucleation is a dynein-dependent process. Exp Hematol., 44(4), 247-256.
  6.  Liu J, Guo YM, Onai N, Ohyagi H, Hirokawa M, Takahashi N, Tagawa H, Ubukawa K, Kobayashi I, Tezuka H, Minamiya Y, Ohteki T, Sawada K. (2016) Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation. Biol Blood Marrow Transplant., 22(4), 627-636.
  7.  Ayano Saito, Atsushi Komatsuda, Hajime Kaga, Ryuta, Masaru Togashi, Shin Okuyama, Hideki Wakui, Naoto Takahashi. (2016) Different Expression Patterns of Toll-Like Receptor mRNAs in Blood Mononuclear Cells of IgA Nephropathy and IgA Vasculitis with Nephritis. Tohoku J Exp Med., 240(3), 199-208.
  8.  Takahashi N, Kameoka J, Takahashi N, Tamai Y, Murai K, Honma R, Noji H, Yokoyama H, Tomiya Y, Kato Y, Ishizawa K, Ito S, Ishida Y, Sawada K, Harigae H. (2016) Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization. Int J Hematol., 104(3), 344-357.
  9.  Katsushi Tajima, Naoto Takahashi, Kenichi Ishizawa, Kazunori Murai, Tomoaki Akagi, Hideyoshi Noji, Osamu Sasaki, Masaharu Wano, Jugoh Itoh, Yuichi Kato, Tsutomu Scichishima, Yoji Ishida, Hideo Harigae, Kenichi Sawada, Tohoku Hematology Forum. (2016) High prevalence of diffuse large B-cell lymphoma in occult hepatitis B virus-infected patients in the Tohoku district in Eastern Japan. Journal of Medical Virology., 88(12), 2206-2210.
  10.  菅沢邦江、斎藤宗一、濱中純子、小山雄太、橋直人. (2016) エクリズマブの継続と短期抗凝固療法により妊娠と正常分娩が可能であった発作性夜間ヘモグロビン尿症(PNH). 秋田医学43(2), 87-92.


業績:2015年

著書

  1.  Tagawa, H. (2015) microRNA in Malignant Lymphoma. Adv. Exp. Med. Biol., 889, 41-50.

総説・解説

  1.  橋直人(2015) Hematologic Malignancies/Pediatric Malignancies 血液・リンパ系腫瘍造血器腫瘍における新規薬剤─分子標的薬─とその位置付けIV.CML 治療における新たな選択肢─ボスチニブ─.癌と化学療法42(5),563-567.
  2.  橋直人(2015) Multiple myeloma and renal impairment. 日本臨床73(1),38-41.
  3.  橋直人(2015) 白血病の分類と治療と予後: 慢性骨髄性白血病.内科116(2),235-238.
  4.  小松田敦(2015) 各論: 免疫グロブリン関連糸球体沈着症.腎と透析78(5),753-758.
  5.  亀岡吉弘,橋直人(2015) リンパ腫関連血球貪食症候群: Lymphoma-Associated hemophagocytic syndrome. 日本臨牀73(8),455-460.
  6.  池田 翔,田川博之(2015) 骨髄腫幹細胞研究の進展.血液内科70(6),661-667.
  7.  北舘明宏,田川博之(2015) T 細胞リンパ腫におけるmicroRNA の調節異常: Aberrant microRNA expression and its role for T-cell lymphoma development. 日本臨牀73(8),172-176.
  8.  長尾貴代,守時由起,廣川 誠(2015) 悪性貧血.別冊日本臨床免疫症候群(第2 番)I 巻,277-280.

原著・論文(審査を経た論文)

  1.  Takahashi, N.(2015) Hypereosinophilic syndrome in the tyrosine kinase inhibitor era. Intern. Med., 54(6), 551-552.
  2.  Kameoka, Y., Takahashi, N., Itou, S., Kume, M., Noji, H., Kato, Y., Ichikawa, Y., Sasaki, O., Motegi, M., Ishiguro, A., Tagawa, H., Ishizawa, K., Ishida, Y., Ichinohasama, R., Harigae, H. and Sawada, K. (2015) Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma. Int. J. Hematol., 101(6), 536-542.
  3.  Mita, A., Miyamura, K., Hino, M., Watakabe, K., Takahashi, K., Yoshimoto, M. and Takahashi, N.(2015) Evaluating Sensitivity of ipsogen BCRABL1 Mbcr IS-MMR DX Kit for Scoring Molecular Response. J. Blood Disord. Transfus., 6 : 5 : 1000314, 1-5.
  4.  Kaga, H., Komatsuda, A., Omokawa, A., Ito, M., Teshima, K., Tagawa, H., Sawada, K. and Wakui, H.( 2015) Downregulated expression of miR-155, miR-17, and miR-181b, and upregulated expression of activationinduced cytidine deaminase and interferon-α in PBMCs from patients with SLE. Mod. Rheumatol., 25(6), 865-870.
  5.  Togashi, M., Niioka, T., Komatsuda, A., Nara, M., Okuyama, S., Omokawa, A., Abumiya, M., Wakui, H., Takahashi, N. and Miura, M. (2015) Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease. Eur. J. Clin. Pharmacol., 71(9), 1091-1097.
  6.  大八木秀明,久米正晃,篠原良徳,高橋さつき,齊藤昌宏,洞口正志,榎本好恭,斉藤 研,平山 克,橋直人(2015) 門脈腫瘍塞栓の経皮経肝針生検によって診断し得たB 細胞性非ホジキンリンパ腫. 臨床血液56(12),2483-2487.
  7.  Nakaseko, C., Takahashi, N., Ishizawa, K., Kobayashi, Y., Ohashi, K., Nakagawa, Y., Yamamoto, K., Miyamura, K., Taniwaki, M., Okada, M., Kawaguchi, T., Shibata, A., Fujii, Y., Ono, C. and Ohnishi, K. (2015) A phase 1/2 study of bosutinib in Japanese adults with Philadelphia chromosomepositive chronic myeloid leukemia. Int. J. Hematol., 101(2), 154-164.
  8.  Niioka, T., Komatsuda, A., Kato, S., Togashi, M., Okuyama, S., Omokawa, A., Nara, M., Wakui, H., Takahashi, N. and Miura, M. (2015) Effects of CYP3A5 polymorphism and the tacrolimus 12 hconcentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis. Xenobiotica, 45(12), 1147-1153.
  9.  Kato, H., Fujigaki, Y., Asakawa, S., Yamaguchi, Y., Uozaki, H., Komatsuda, A., Nagata, M. and Uchida, S. (2015) Rapid Deterioration of the Renal Function Caused by the Coexistence of Intratubular Amyloidosis and Myeloma Cast Nephropathy. Intern. Med., 54(23), 3023-3028.
  10.  森 健介,涌井秀樹,布村 渉,富樫 賢,小松田敦(2015) 運動後急性腎不全を合併症に持つ遺伝性低尿酸血症患者の尿酸トランスポーター1 の遺伝子解析.秋田腎不全研究会誌18,98-102.

学会発表(国際会議)

  1.  20th Congress of the European Hematology Association, June, Vienna
    1. Takahashi, N., Nakaseko, C., Nishiwaki, K., Ogasawara, H., Wakita, H. and on behalf of STAT study group (2015) Switching to Nilotinib is Associated with Deeper Molecular Responses in Chronic Myeloid Leukemia Chronic Phase with Major Molecular Responses on Imatinib : STAT1 Trial in Japan
    2. Kitadate, A., Ito, M., Ikeda, S., Teshima, K., Hasunuma, N., Miyagaki, T., Makoto, S., Takahashi, N., Komatuda, A. and Tagawa, H.(2015) Silencing progression of tumor suppressive microRNAs essentially contributes to develop aggressive T-cell lymphoma
    3. Yamashita, T., Fujishima, N., Miura, M., Niioka, T., Abumiya, M., Nara, M., Fujishima, M., Kameoka, Y., Hirokawa, M. and Takahashi, N.(2015) Influence of CYP3A5 gene polymorphisms on pharmacokinetics of modified-release tacrolimus
  2.  57th American Society Hematology Annual Meeting and Exposition, December, Orlando
    1. Takahashi, N., Tauchi, T., Kitamura, K., Miyamura, K., Saburi, Y., Miyata, Y., Hatta, Y., Kimura, F., Takada, S., Fukuda, T., Fujimaki, K., Ishikawa, M., Matsumura, I., Usui, N., Usuki, K., Kobayashi, Y. and Naoe, T.( 2015) Around 70% of Japanese CML Patients Could Stop Imatinib According to a-STIM Criteria : The JALSG-STIM213 Study
    2. Kitadate, A., Ikeda, S., Teshima, K., Ito, M., Takahashi, N., Miyagaki, T., Sugaya, M. and Tagawa, H. (2015) Microrna-16 Mediates the Regulation of a Senescence-Apoptosis Switch in Cutaneous T-Cell and Other Non-Hodgkin Lymphomas
    3. Noguchi, S., Nishikawa, H., Saitoh, H., Ohshima, A., Sawada, K., Sakaguchi, S. and Takahashi, N. (2015) Tyrosine Kinase Inhibitor Imatinib Enhances Tumor Immunity By Depleting Functionally Mature Regulatory T Cells
    4. Nakaseko, C., Takahashi, N., Nishiwaki, K., Ogasawara, H. and Wakita, H.( 2015) Switching to Nilotinib and ABCG2 421C/a Genotype Are Associated with Deeper Molecular Responses in Chronic Myeloid Leukemia Chronic Phase with Major Molecular Responses on Imatinib ; STAT1 Trial in Japan
    5. Ko, T.K., Sheila, X.X., Yu, W., Winter, P.S., Pathiraja, T., Javed, A., Malik, S., Tan, J.H.J., Chuah, C., Takahashi, N., Bhatia, R., Chng, W.J., Valent, P., Reiterer, S.C., Ng, K.P., Tennakoon, C., Hoi, Q., Guan, P., Teo, A.S.M., Lee, W.H., Tan, P., Sung, W.K., Ng, P., Hillmer, A.K., Wood, C., Rozen, S. and Ong, S.T. (2015) Functional Analysis of the CML Blast Crisis Transcriptome and Epigenome Using Crispr-CAS9 and Pharmacologic Approaches
  3.  The American Society of Cell Biology 2015 Meeting, December, San Diego
    1. Sugawara, K., Araki, K., Asanuma, K., Yamashita, J., Hayakawa, E., Kobayashi, I., Ubukawa, K., Takahashi, N., Wakui, H., Sawada, K., Mochizuki, H. and Nunomura, W.( 2015)  Biological significance of α-synuclein in human erythroid cells
    2. Goto, T., Sugawara, K., Nakagawa, M., Kobayashi, I., Ubukawa, K., Asanuma, K., Yamashita, J., Sawada, K., Wakui, H. and Nunomura, W.( 2015)Inhibition of lactate dehydrogenase isozymes blocked cell proliferation
    3. Kobayashi, I., Sugawara, K., Asanuma, A., Yamashita, J., Ubukawa, K., Takahashi, N., Wakui, H., Sawada, K. and Nunomura, W.( 2015) Regulation of energy metabolism during human erythropoiesis

学会発表(国内会議−総会・年会)

  1.  第77 回日本血液学会学術集会,10 月,金沢
    1. 橋直人,Mahon, F.X. (2015) 欧州,本邦におけるStop-TKI 試験結果と今後の展望
    2. Kameoka, Y., Ubukawa, K., Nara, M., Yokoyama, H., Ito, S., Ishizawa, K., Ishida, Y., Harigae, H. and Takahashi, N. (2015) R-GDP therapy as salvage treatment of patients with refractory or relapsed DLBCL
    3. Mita, A., Miura, M., Niioka, T., Abumiya, M., Kobayashi, T., Takahashi, S., Kameoka, Y., Yoshioka, T. and Takahashi, N.(2015) Correlation of dasatinib pharmacokinetics with clinical response and adverse events
    4. 小林五十鈴,鵜生川久美,菅原琴美,浅沼 研,山下順助,橋直人,澤田賢一,布村 渉(2015) Enucleation is a process dependent on dynein, a motor protein
    5. 池田 翔,北舘明宏,伊藤 貢,手島和暁,奈良美保,渡部 敦,鵜生川久美,藤島眞澄,藤島直仁,吉岡智子,亀岡吉弘,橋直人,田川博之(2015) Chemokine CCL20 and its receptor CCR6 are new therapeutic targets in cutaneous T-cell lymphoma
    6. 北舘明宏,池田 翔,手島和暁,伊藤 貢,奈良美保,鵜生川久美,渡部 敦,藤島眞澄,藤島直仁,吉岡智子,亀岡吉弘,橋直人,宮垣朝光,菅谷 誠,田川博之(2015) Tumor-suppressor miR-16 induces senescence and apoptosis in aggressive T-cell lymphomas
    7. 劉 嘉嘉,郭 永梅,大八木秀明,廣川 誠,橋直人,鵜生川久美,小林五十鈴,南谷佳弘,手塚裕之,小内伸幸,樗木俊聡,澤田賢一(2015) TLR9 signaling exerts HPS in BMT mice and is effectively treated through TNF-αinhibition
    8. 菅原琴美,小林五十鈴,鵜生川久美,浅沼 研,山下順助,橋直人,涌井秀樹,澤田賢一,布村 渉(2015) Enucleation of human erythroblast requires energy produced by anaerobic glycolysis
  2.  第37 回日本造血細胞移植学会総会,3 月,神戸
    1. 奈良美保,廣川 誠,山下鷹也,鵜生川久美,藤島眞澄,藤島直仁,吉岡智子,亀岡吉弘,田川博之,橋直人(2015) 当院における造血幹細胞移植後ICU 入室患者の適応と予後 Adjustment and prognosis of patients for treatment in ICU after hematopoietic stem cell transplantation in Akita University Hospital
  3.  第58 回日本腎臓学会学術総会,6 月,名古屋
    1. 富樫 賢,新岡丈典,奈良瑞穂,面川 歩,奥山 慎,加藤正太郎,涌井秀樹,三浦昌朋,小松田敦(2015) ループス腎炎患者の急性腎障害発症に及ぼすタクロリムスの血中濃度とCP3A5 遺伝子多型の影響
    2. 阿部史人,小原綾乃,澤村昌人,加賀 一,齋藤雅也,奈良瑞穂,面川 歩,富樫 賢,奥山 慎,涌井秀樹,小松田敦(2015) 微小変化型ネフローゼ症候群の血清ではperforinが高発現する
    3. 加賀 一,小原綾乃,面川 歩,涌井秀樹,小松田敦(2015) IgA 腎症患者,紫斑病性腎炎患者の末梢血単核球でのToll-like receptors mRNA の検討
    4. 澤村昌人,堀口兵剛,小熊悦子,松川岳久,千葉百子,村田勝敬,横山和仁,中村正明,涌井秀樹,小松田敦(2015) 秋田県内の医療機関における腎機能低下患者に対するカドミウム腎症スクリーニング
  4.  第45 回日本腎臓学会東部学術大会,10 月,東京
    1. 面川 歩,富樫 賢,奥山 慎,廣川 誠,橋直人,小松田敦(2015) 早期に診断,治療し得た多発性嚢胞腎に嚢胞内腎細胞癌を合併した1 例
    2. 小原綾乃,澤村昌人,阿部史人,加賀 一,齋藤雅也,奈良瑞穂,富樫 賢,奥山 慎,小松田敦(2015) ネフローゼ症候群を呈した移植後腎症
    3. 齋藤雅也,加賀 一,阿部史人,小原綾乃,奈良瑞穂,面川 歩,富樫 賢,奥山 慎,涌井秀樹,小松田敦(2015) SLE を合併した膜型proliferative glomerulonephritis with monoclonal IgG deposits(PGNMID)
    4. 佐藤隆太,畠山 卓,小原綾乃,小松田敦(2015) 乳癌進行期における化学療法とゾレドロン酸の長期併用療法中に生じた急性尿細管壊死
    5. 伊藤香里,富樫 賢,小原綾乃,小松田敦,橋直人(2015) 放射線療法後に二次性高血圧をきたしたネフローゼ症候群
  5.  第74 回日本癌学会学術総会,10 月,名古屋
    1. 池田 翔,北舘明宏,伊藤 貢,阿部史人,手島和暁,奈良美保,渡部 敦,亀岡吉弘,橋直人, 田川博之(2015) ケモカインCCL20 とケモカインレセプターCCR6 を標的とした皮膚T 細胞性リンパ腫の新規治療戦略
    2. 北舘明宏,池田 翔,手島和暁,伊藤 貢,阿部史人,奈良美保,渡部 敦,亀岡吉弘,橋直人,田川博之(2015) 悪性リンパ腫における癌抑制的microRNA を介したセネッセンス・アポトーシス誘導及び転移浸潤抑制
    3. 阿部史人,田川博之,北舘明宏,池田 翔,奈良美保,亀岡吉弘,橋直人,佐々木雄彦,中西広樹(2015) 悪性リンパ腫におけるイノシトールリン脂質プロファイル
  6.  第22 回日本遺伝子診療学会大会,7 月,神奈川
    1. 橋直人(2015) 血液がん遺伝子検査の臨床応用〜CML の治療効果モニタリングに有用なMajor BCR-ABL1 IS 検査を中心に〜

学会発表(国内会議−地方会)

  1.  第204 回日本内科学会東北地方会,2 月,宮城
    1. 富樫 賢,奈良瑞穂,面川 歩,奥山 慎,小松田敦,涌井秀樹(2015) ポリスチレンスルホン酸Ca(CPS)により著明な高Ca 血症が遷延した慢性腎不全
    2. 長崎博和,奈良美保,鵜生川久美,藤島眞澄,吉岡智子,藤島直仁,亀岡吉弘,田川博之,橋直人,小松田敦(2015) 潰瘍性大腸炎の経過観察中に発症したHLA-DRB 15 : 01 発現再生不良性貧血
  2.  第119 回日本血液学会東北地方会,2 月,宮城
    1. 鈴木貴之,亀岡吉弘,奈良美保,小林敬宏,三田亜紀子,鵜生川久美,藤島眞澄,藤島直仁,吉岡智子,田川博之,橋直人(2015) HLA半合致移植を施行したatypical CML の40歳代男性
  3.  第120 回日本血液学会東北地方会,10 月,福島
    1. 伊藤史子,奈良美保,齋藤雅也,奈良瑞穂,三田亜紀子,篠原良徳,藤島眞澄,吉岡智子,藤島直仁,亀岡吉弘,田川博之,橋直人(2015) Dose-adjusted EPOCH-R 療法が奏功した primary mediastinal large B cell lymphoma
  4.  第25 回日本リウマチ学会北海道・東北支部学術集会,11 月,盛岡
    1. 阿部史人,小原綾乃,加賀 一,齋藤雅也,澤村昌人,奈良瑞穂,面川 歩,手島和暁,鵜生川久美,富樫 賢,藤島眞澄,藤島直仁,奥山 慎,亀岡吉弘,吉岡智子,小松田敦,涌井秀樹,橋直人(2015) Infliximab を含む集学的治療により寛解を得た難治性成人Still病
    2. 齋藤雅也,小原綾乃,阿部史人,加賀 一,奈良瑞穂,面川 歩,富樫 賢,奥山 慎,涌井秀樹,小松田敦(2015) ステロイドパルス療法により視力が回復した高安動脈炎

学会発表(国内会議−研究会−全国規模)

  1.  4th chronic kidney disease frontier meeting,2 月,名古屋
    1. Komatsuda, A. (2015) Monoclonal immunoglobulin deposition desease (MIDD) and proliferative glomerulonephritis with monoclonal IgG deposits( PGNMID)

学会発表(国内会議−研究会−地方規模)

  1.  第19 回秋田県腎不全研究会,11 月,秋田
    1. 小原綾乃,齋藤雅也,加賀 一,富樫 賢,小松田敦(2015) 多発性嚢胞腎に対するトルバプタンの使用経験
  2.  AKITA Multiple Myeloma Seminar,1 月,秋田
    1. 池田 翔(2015) 多発性骨髄腫における低酸素応答とエピジェネティクス

その他

  1.  秋田県がん予防授業,9 月,大舘
    1. 藤島眞澄(2015) 秋田がん予防授業


業績:2014年

著書

  1.  小松田敦 (2014) 腎疾患・透析 最新の治療2014-2016.南江堂,pp.200-202.
  2.  高橋直人 (2014) EBM血液疾患の治療2015-2016.中外医学社,pp.150-153.
  3.  奈良美保,澤田賢一 (2014) 遺伝性出血性末梢血管拡張症の診療マニュアル 2015.中外医学社,pp.92-93.
  4.  廣川誠,澤田賢一 (2014) 「新戦略による貧血治療」 赤芽球癆.中山書店,pp.249-256.
  5.  廣川誠,澤田賢一 (2014) 血液腫瘍とDIC.成人病と生活習慣病 44,pp.937-940.

総説・解説

  1.  小松田敦 (2014) 単クローン性免疫グロブリン関連腎症―特にproliferative glomerulonephritis with monoclonal IgG depositsについて.小児腎臓病学会誌27(2), 86-90.
  2.  高橋直人 (2014) 進行期慢性骨髄性白血病の治療. 臨床血液55(10),1860-1869.
  3.  高橋直人 (2014) 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤療法の中止を成功させるための予測因子. 臨床血液55(5),489-496.
  4.  高橋直人 (2014) CMLに対するTKI 中止の可能性,残存病変に対する免疫学的抗腫瘍効果. 血液内科 69 (2), 165-169.
  5.  高橋直人 (2014) がんサポート.血液がん最新特集 134 , 30-33.
  6.  高橋直人 (2014) がんサポート.7大がんガイド 140 , 126-129.
  7.  田川博之 (2014) 悪性リンパ腫とマイクロRNA. 血液内科 68(6),70-76.
  8.  田川博之 (2014) 骨髄腫Side populationで高発現する治療標的分子. 日本臨床72,1052-1057.
  9.  大八木秀明、小内伸幸、澤田賢一、樗木俊聡 (2014) 樹状細胞による免疫寛容誘導の最新情報:単球に由来する樹状細胞による血球の貪食と新しい免疫寛容誘導の仕組み  surgery frontier vol.21 No.3 251-256.
  10.  大八木秀明、小内伸幸、澤田賢一、樗木俊聡 (2014) 血球貪食症候群の病態解明の進歩:単球に由来する樹状細胞による血球の貪食と新しい免疫寛容誘導の仕組み   血液内科 第69巻第2号 279-284.
  11.  大八木秀明、小内伸幸、澤田賢一、樗木俊聡 (2014) 血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する Akita j Med 41;17-22,
  12.  鵜生川久美 (2014) なぜ?どのように?赤芽球の脱核. 血液フロンティア 24(4), 565-571.
  13.  鵜生川久美, 澤田賢一 (2014) 赤芽球脱核の分子機構と血液疾患. 血液内科 68(5), 585-591.
  14.  奈良美保, 高橋直人 (2014) 成人急性リンパ性白血病の中枢神経再発予防の方法と意義. 血液内科 69 (5), 610-615.
  15.  奈良美保,澤田賢一 (2014) 骨髄異形成症候群. 耳鼻咽喉科・頭頚部外科86(3), 264-268.
  16.  北館明宏,田川博之 (2014) miR-17-92 クラスターと造血器腫瘍. 血液フロンティア 128, 98-101.

原著・論文(審査を経た論文)

  1.  Takahashi, N., Miura, M., Kuroki, J., Mitani, K., Kitabayashi, A., Sasaki, O., Kimura, H., Imai, K., Tsukamoto, N., Noji, H., Kondo, T., Motegi, M., Kato, Y., Mita, M., Saito, H., Yoshida, C., Torimoto, Y., Kimura, T., Wano, Y., Nomura, J., Yamamoto, S., Mayama, K., Honma, R., Sugawara, T., Sato, S., Shinagawa, A., Abumiya, M., Niioka, T., Harigae, H., Sawada, K. (2014) Multicenter phase II clinical trial of nilotinib for patients with imatinib-resistant or -intolerant chronic myeloid leukemia from the East Japan CML study group evaluation of molecular response and the efficacy and safety of nilotinib. Biomark Res., 2(1), 6..
  2.  Togashi, M., Komatsuda, A., Nara, M., Omokawa, A., Okuyama, S., Sawada, K., Wakui, H. (2014) Validation of the 2010 histopathological classification of ANCA-associated glomerulonephritis in a Japanese single-center cohort. Mod Rheumatol., 24(2), 300-303.
  3.  Omokawa, A., Komatsuda, A., Hirokawa, M., Wakui, H. (2014) Membranous nephropathy with monoclonal IgG4 deposits and associated IgG4-related lung disease. Clin Kidney J., 7(5), 475-8.
  4.  Teshima, K., Nara, M., Watanabe, A., Ito, M., Ikeda, S., Hatano, Y., Oshima, K., Seto, M., Sawada, K., Tagawa, H. (2014) Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma. Oncogene., 33(17), 2191-2203.
  5.  Nara, M., Komatsuda, A., Omokawa, A., Togashi, M., Okuyama, S., Sawada, K., Wakui, H. (2014) Serum interleukin 6 levels as a useful prognostic predictor of clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease. Mod Rheumatol., 24(4), 633-636.
  6.  Ito, M., Teshima, K., Ikeda, S., Kitadate, A., Watanabe, A., Nara, M., Yamashita, J., Ohshima, K., Sawada, K., Tagawa, H. (2014) MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6 in advanced cutaneous T-cell lymphoma. Blood., 123(10), 1499-1511.
  7.  Shida, S., Takahashi, N., Niioka, T., Kitabayashi, A., Kawabata, Y., Kume, M., Saitoh, H., Hatano, Y., Ichikawa, Y., Kuroki, J., Motegi, M., Kobayashi, T., Kameoka, Y., Tagawa, H., Fujishima, N., Yoshioka, T., Hirokawa, M., Miura, M., Sawada, K. (2014) Treatment of multiple myeloma in Akita: features and outcomes in the era of novel agents. J Clin Exp Hematop., 54(1), 89-93.
  8.  Shida, S., Takahashi, N., Miura, M., Niioka, T., Matsumoto, M., Hagihara, M., Kobayashi,T., Abumiya, M., Kameoka, Y., Fujishima, N., Tagawa, H., Hirokawa, M., Sawada, K. (2014) A limited sampling model to estimate exposure to lenalidomide in multiple myeloma patients. Ther. Drug Monit., 36(4), 505-509.
  9.  Sato, R., Joh, K., Komatsuda, A., Ohtani, H., Okuyama, S., Togashi, M., Omokawa, A., Nara, M., Nagata, D., Kusano, E., Sawada, K., Wakui, H. (2014) Validation of the Japanese histologic classification 2013 of immunoglobulin A nephropathy for prediction of long-term prognosis in a Japanese single-center cohort. Clin Exp Nephrol., 2014 Jul 8. [Epub ahead of print]
  10.  Ikeda, S., Tagawa, H. (2014) Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias. Int J Hematol., 99(5), 542-552.
  11.  Abumiya, M., Takahashi, N., Niioka, T., Kameoka, Y., Fujishima, N., Tagawa, H., Sawada, K., Miura, M. (2014) Influence of UGT1A1 *6, *27, and *28 Polymorphisms on Nilotinib-induced Hyperbilirubinemia in Japanese Patients with Chronic Myeloid Leukemia. Drug Metab. Pharmacokinet., 29(6), 449-454.
  12.  Imaizumi, C., Tamaki, M., Ueki, S., Takahashi, N. (2014) An unusual cause of abdominal pain: abdominal hematoma. Intern Med., 53(21), 2563.
  13.   Watanabe, R., Ishii, T., Kobayashi, H., Asahina, I., Takemori, H., Izumiyama, T., Oguchi, Y., Urata, Y., Nishimaki, T., Chiba, K., Komatsuda, A., Chiba, N., Miyata, M., Takagi, M., Kawamura, O., Kanno, T., Hirabayashi, Y., Konta, T., Ninomiya, Y., Abe, Y., Murata, Y., Saito, Y., Ohira, H., Harigae, H., Sasaki, T. (2014) Prevalence of hepatitis B virus infection in patients with rheumatic diseases in Tohoku area: a retrospective multicenter survey. Tohoku J Exp Med., 233(2), 129-133.
  14.  Yamamoto, S., Wakui, H., Kubota, H., Komatsuda, A., Itoh, H., Yokota, S. (2014) Aminoglycosides suppress the protein folding activity of the molecular chaperone HSC70: implication of a structure-activity relationship. Chemotherapy., 60(1), 37-46.
  15.  Yokoyama, K., Akiba, T., Fukagawa, M., Nakayama, M., Sawada, K., Kumagai, Y., Chertow, GM., Hirakata, H. (2014) Long-term safety and efficacy of a novel iron-containing phosphate binder, JTT-751, in patients receiving hemodialysis. J Ren Nutr., 24(4), 261-267.
  16.  Yokoyama, K., Hirakata, H., Akiba, T., Fukagawa, M., Nakayama, M., Sawada, K., Kumagai, Y., Block, GA. (2014) Ferric citrate hydrate for the treatment of hyperphosphatemia in nondialysis-dependent CKD. Clin J Am Soc Nephrol., 9(3), 543-552.
  17.  Yokoyama, K., Akiba, T., Fukagawa, M., Nakayama, M., Sawada, K., Kumagai, Y., Chertow, GM., Hirakata, H. (2014) A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis. Nephrol Dial Transplant., 29(5),1053-1060.
  18.  宮村耕一,岡本真一郎,薄井紀子,日野雅之,赤司浩一,中世古知昭,高橋直人,中谷中,高橋啓太,登勉,直江知樹 (2014) キャリブレーターによる国際標準値変換を可能とするMajor BCR-ABL mRNA測定キットの臨床性能評価. 臨床血液 55(5), 534-540.

学会発表(国際会議)

  1.  56th American Society of Hematology Annual Meeting and Exposition, December, San Francisco
    1. Takezako, N., Miura, M., Nagata, A., Sekiguchi, N., Niioka, T., Shida, S., Kobayashi, T., Abumiya, M., Miwa, A., Takahashi, N. (2014) Clarithromycin Elevates the Plasma Concentration of Lenalidomide Via Inhibition of MDR1.
    2. Kyo, T., Tojo, A., Yamamoto, K., Takahashi, N., Nakamae, H., Kobayashi, Y., Tauchi, T., Okamoto, S., Miyamura, K., Iwasaki, H., Hatake, K., Matsumura, I., Usui, N., Yanase, K., Hu, S., Naoe, T., Ohyashiki, K. (2014) Ponatinib Safety and Efficacy in Japanese Patients with Philadelphia Positive Leukemia: Update of a Phase 1/2 Study.
  2.   19th Congress of European Haematology Association, June, Milan
    1. Takahashi, N., Saitoh, H., Nara, M., Fujishima, N., Fujishima, M., Kameoka, Y., Tagawa, H., Sawada, K. (2014) A single-center retrospective analysis of recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome after hematopoietic stem cell transplantation.
    2. Teshima, K., Ito, M., Ikeda, S., Kitadate, A., Nara, M., Ubukawa, K., Fujishima, M., Fujishima, N., Yoshioka, T., Kameoka, Y., Hasunuma, N., Takahashi, N., Hirokawa, M., Sawada, K., Tagawa, H. (2014) MicroRNA-150 Regulates IL-22-CCL20-CCR6 Autocrine Pathway In Metastatic Cutaneous T-Cell Lymphoma.
    3. Takezako, N., Sekiguchi, N., Nagata, A., Miura, M., Niioka, T., Shida, S., Kobayashi, T., Abumiya, M., Takahashi, N. (2014) Blood concentration of lenalidomide would change with the existence of clarithromycin.
    4. Takezako, N., Sekiguchi, N., Nagata, A., Takahashi, N., Miwa, A. (2014) The peripheral blood stem cell collection by EDAP following initial therapy with combining bortezomib and dexamethasone is effective in young multiple myeloma patients.
  3.  105th American Association of Cancer Research annual Meeting, April, San Diego
    1. Tagawa, H., Ito, M., Ikeda, S., Kitadate, A., Sawada, K. (2014) MicroRNA-150Inhibits Tumor Invasion and Metastasis by Targeting IL-22-CC20-CCR6 Autocrine Signaling in Advanced T-Cell Lymphoma.
  4.   47th Annual Meeting American Society of Nephrology, Kidney week 2014, November, Philadelphia, PA
    1. Sato,R., Wakui,H., Joh,K., Komatsuda,A. (2014) Validation of the Japanese histologic classification 2013 of immunoglobulin a nephropathy for prediction of long-term prognosis in a Japanese single center cohort.

学会発表(国内会議−総会・年会)

  1.  第76回日本血液学会学術集会,10月,大阪
    1. 高橋直人 (2014) 教育講演:進行期慢性骨髄性白血病の治療
    2. 亀岡吉弘、高橋直人、赤木智昭、奈良美保、井根省二、加藤裕一、横山寿行、野地秀義、伊藤薫樹、石田陽治、張替秀郎、澤田賢一 (2014) Analysis of the MCNU-based high dose chemotherapy followed by ASCT for relapsed or refractory DLBCL.
    3. Kobayashi, T., Takahashi, N., Miura, M., Ohara, A., Mitishita, Y., Niioka, T., Abumiya, M., Shida, S., Ubukawa, K., Fujishima, N., Kameoka, Y., Tagawa, H., Sawada, K. (2014) Pharmacokinetcis of lenalidomide in patients with multiple myeloma on hemodialysis.
    4. Abumiya, M., Takahashi, N., Niioka, T., Kameoka, Y., Fujishima, N., Tagawa, H., Sawada, K., Miura, M. (2014) Influence of UGT1A1 polymorphisms on nilotinib-induced hyperbilirubinemia in Japanese CML patients.
    5. Takezako, N., Sekiguchi, N., Nagata, A., Miura, M., Niioka, T., Shida, S., Kobayashi, T., Abumiya, M., Takahashi, N. (2014) Blood concentration of lenalidomide would change with the existence of clarithromycin.
    6. 氷室真仁、鎌田真弓、亀岡吉弘、高橋直人、沖津庸子、福原規子、大西康、石澤賢一、張替秀郎、石田陽治、澤田賢一 (2014) FR therapy followed by 90Y-ibritumomab tiuxetan for relapsed indolent B cell lymphoma, phase 1 study.
  2.  第36回日本造血細胞移植学会総会,3月,沖縄
    1. 奈良美保, 廣川誠, 山下鷹也, 鵜生川久美, 藤島眞澄, 藤島直仁, 吉岡智子, 亀岡吉弘,  田川博之, 高橋直人, 澤田賢一 (2014) 同種造血幹細胞移植の治療成績に及ぼすHLA-DRB1ミスマッチの影響:単一施設における後方視的解析.
    2. 山下鷹也,藤島直仁,新岡丈典,三浦昌朋,藤島眞澄,藤岡優樹,小林敬宏,三田亜紀子,手島和暁,奈良美保,鵜生川久美,亀岡吉弘,田川博之,高橋直人,廣川誠,澤田賢一(2014)造血幹細胞移植患者のCYP3A5遺伝子多型がタクロリムス徐放製剤代謝に及ぼす影響に関する検討.
  3.   第57回日本腎臓学会学術総会,7月, 横浜
    1. 奈良瑞穂,小松田敦,面川歩,富樫賢,奥山慎,涌井秀樹 (2014) マンスリーステロイドパルス(MSP)とその他ステロイドパルス群との有効性・腎予後の比較.
    2. 加賀一,阿部史人,小原綾乃,齋藤雅也,澤村昌人,面川歩,奈良瑞穂,富樫賢,奥山慎,小松田敦,涌井秀樹,澤田賢一 (2014) 当科における特発性膜性腎症患者のphospholipase A2 receptor sequence variants.
    3. 齋藤雅也,小松田敦,阿部史人,澤村昌人,加賀一,小原綾乃,奈良瑞穂,面川歩,富樫賢,奥山慎,涌井秀樹,澤田賢一 (2014) 半月体形成を認めた慢性腎症44症例の臨床病理的学検討.
    4. 4) 小原綾乃,面川歩,阿部史人,齋藤雅也,加賀一,澤村昌人,奈良瑞穂,富樫賢,奥山慎,小松田敦,涌井秀樹,澤田賢一 (2014) IgA腎症患者の末梢血単核球でのToll-like-receptors 5および9 mRNAの検討.
    5. 阿部史人,小松田敦,小原綾乃,加賀一,齋藤雅也,奈良瑞穂,面川歩,富樫賢,奥山慎,涌井秀樹,澤田賢一 (2014) 微小変化型ネフローゼ症候群発症期の末梢血単核球ではperforin-1が高発現する.
  4.   第44回日本腎臓学会東部学術大会,10月,東京
    1. 小松田敦 (2014) よくわかるシリーズ1,パラプロティミアと腎障害.
    2. 加賀一,澤村昌人,奥山慎,阿部史人,小原綾乃,齋藤雅也,奈良瑞穂,面川歩,富樫賢,小松田敦,涌井秀樹 (2014) Rituximab (RTX)によりステロイドを減量しえたステロイド抵抗性微小変化型ネフローゼ症候群(MCNS).
    3. 齋藤雅也,小山雄太,奈良瑞穂,面川歩,富樫賢,奥山慎,小松田敦,涌井秀樹 (2014) SLE経過中に発症した1型クリオグロブリン血症性糸球体腎炎.
    4. 阿部史人,小松田敦,小原綾乃,加賀一,齋藤雅也,澤村昌人,奈良瑞穂,面川歩,富樫賢,奥山慎,涌井秀樹 (2014) 生体腎移植後に巣状糸球体硬化症の発症と移植後リンパ増殖性疾患を認めた1例.
    5. 澤村昌人,富樫賢,齋藤雅也,阿部史人,小原綾乃,加賀一,奈良瑞穂,面川歩,奥山慎,小松田敦,涌井秀樹 (2014) Light and heavy chain disease(LHCDD)との鑑別が困難だったproliferative glomerulonephritis with monoclonal IgG deposits (PGNMID).
  5.   第57回日本腎臓学会学術総会オフィシャル サテライトシンポジウム,7月, 福島
    1. 小松田敦 (2014) 低たんぱく食介入研究オーバービュー.
  6.   第9回臨床ストレス応答学会,11月,岡山
    1. 小原綾乃,三瓶杏,小松田敦,布村渉,涌井秀樹 (2014) IgA関連糸球体疾患におけるIgA型抗分子シャペロン自己抗体.
  7.   第49回日本小児腎臓病学会学術集会,6月,秋田
    1. 小松田敦 (2014) 教育講演:単クローン性免疫グロブリオン関連腎症.
  8.   第103回日本病理学会,4月,広島
    1. 廣嶋優子, 高橋正人, 南條博, 鵜生川久美, 亀岡吉弘, 伊藤行信, 吉田誠, 川村公一, 大田泰徳, 後藤明輝 (2014) EBV陽性大型異型リンパ球の増生が目立ったAITLの一剖検例..
  9.   第15回日本検査血液学会,7月,宮城
    1. 菊地優子, 藤田詳子, 小林毅, 永沼綾子, 齊藤由紀子, 亀岡吉弘, 高橋直人, 澤田賢一, 廣川誠(2014)本態性血小板血症として経過観察1年3ヵ月後に病型の変化を認めたPh染色体陰性非定型慢性骨髄性白血病.
  10.   第22回クリニカルファーマシーシンポジウム,6月,東京
    1. 新岡丈典,高橋直人,志田青慈,小林敬宏,鐙屋舞子,澤田賢一,三浦昌朋(2014)レナリドマイドのTDMの有用性〜TM-Rev 試験からの報告2014〜.

学会発表(国内会議−地方会)

  1.   第201回日本内科学会東北地方会,2月,宮城
    1. 黒木淳,郭永梅,猪又美佳,西成民夫,朝倉健一、廣川誠、澤田賢一 (2014) Mycobacterium abscessによる腸腰筋冷膿瘍を合併した急性骨髄性白血病の1例.
  2.   第201回日本内科学会東北地方会,6月,宮城
    1. 澤村昌人,富樫賢,齋藤雅也,小林敬宏,藤島眞澄,藤島直仁,小松田敦,澤田賢一 (2014) 高齢発症したneuropsychiatric systemic lupus erythematosus(NPSLE).
  3.   第203回日本内科学会東北地方会,9月,秋田
    1. 富樫賢,小原綾乃,阿部史人,齋藤雅也,澤村昌人,奈良瑞穂,面川歩,奥山慎(2014)右眼窩蜂巣炎で発症した再発性多発性軟骨炎.
    2. 齋藤雅也,阿部史人,加賀一,小原綾乃,澤村昌人,奈良瑞穂,富樫賢,小松田敦、面川歩,奥山慎 (2014) 外耳病変で発症した限局型Wegener肉芽腫症.
    3. 鈴木貴之,奈良美保,鵜生川久美,藤島眞澄,吉岡智子,藤島直仁,亀岡吉弘,田川博之,高橋直人 (2014) ins(21;8)(q22;q13q22)を有してAML1/MTG8融合遺伝子が検出された急性骨髄性白血病.
  4.   秋田医学会学術奨励賞受賞記念講演,2月,秋田
    1. 大八木秀明 (2014) 血球貪食を行う単球由来樹状細胞は過剰な免疫応答を制御する.
  5.   第117回日本血液学会東北地方会,2月,宮城
    1. 森本友里子, 鵜生川久美, 高橋直人, 奈良美保, 藤島眞澄, 藤島直仁, 吉岡智子, 亀岡吉弘, 田川博之, 澤田賢一(2014)血小板増加症で発症したatypical CML..
  6.   第118回日本血液学会東北地方会,9月,秋田
    1. 奈良美保,齋藤雅也,澤村昌人,小林敬宏,三田亜紀子,鵜生川久美,藤島眞澄,吉岡智子,藤島直仁,亀岡吉弘,田川博之,高橋直人,廣川誠 (2014) 右腸腰筋血腫で発症した後天性血友病.
    2. 長谷川純郎,手島和暁,道下吉広,阿部史人,小原綾乃,奈良美保,鵜生川久美,富樫賢,藤島眞澄,藤島直仁,吉岡智子,亀岡吉弘,田川博之,高橋直人 (2014) エクリズマブ投与を行った非典型溶血性尿毒症症候群
  7.   第24回日本リウマチ学会北海道・東北支部学術集会,11月,札幌
    1. 小松田敦 (2014) シンポジウム:『リウマチ治療;基礎から応用へ』,「高齢者・ハイリスク症例での診療の工夫」.
    2. 富樫賢,奥山慎,涌井秀樹,小松田敦 (2014) 維持透析中にセルトリズマブペゴル(CZP)で寛解を得たベーチェット病(BD)合併関節リウマチ(RA).
    3. 富樫賢,奥山慎,涌井秀樹,小松田敦 (2014) アダリムマブ(ADA)導入後 ギラン・バレー症候群(GBS)を発症した関節リウマチ.
    4. 小原綾乃,富樫賢,奥山慎,涌井秀樹,小松田敦 (2014) 乳腺に肉芽腫性病変を認めた多発血管炎性肉芽腫症

学会発表(国内会議−研究会−全国規模)

  1.   第1回Tsurui Lymphoma Workshop,7月,北海道
    1. 田川博之,久米正晃,高橋直人 (2014) PTCLに対する薬剤開発の可能性 (TCR signaling pathwayを中心に).
  2.   第2回赤血球研究会,10月,大阪
    1. 小林五十鈴 (2014) 赤芽球の脱核における中心体の役割.
  3.   第17回癌と骨病変研究会,11月,東京
    1. 田川博之 (2014) マイクロRNAデリバリーによる進行性リンパ腫の骨髄浸潤抑制.

学会発表(国内会議−研究会−地方規模)

  1.   第8回TOHOKU HEMATOLOGY FORUM,2月,宮城
    1. 亀岡吉弘 (2014) 「THF共同研究23再発・治療抵抗性の悪性リンパ腫に対するゲムシタビン、デキサメサゾン、シスプラチン(GDP)療法2第相試験」の紹介.
  2.   市民公開講座:STOP!CKD,11月,秋田
    1. 富樫賢 (2014) 腎臓の検査 Q&A..
  3.   秋田大学高校生対象公開講演会,5月,秋田
    1. 涌井秀樹 (2014) 生命科学への招待.
    2. 鵜生川久美 (2014) 赤血球ができる仕組み.
    3. 布村歩 (2014) 赤血球の構造と機能.
    4. 藤島直仁 (2014) 血液型と性格との関係.
  4.   Akita Thrombomodulin Seminar,3月,秋田
    1. 奈良美保 (2014) 造血幹細胞移植後肝類洞閉塞症候群の単一施設における後ろ向き解析:トロンボモジュリン製剤の有効性.
  5.   血友病研究会,12月,秋田
    1. 奈良美保,齋藤雅也,小林敬宏, 三田亜紀子,鵜生川久美,藤島眞澄,吉岡智子,藤島直仁,亀岡吉弘,田川博之,高橋直人,小松田敦, 廣川誠 (2014) 右腸腰筋血腫で発症した後天性血友病.
  6.   多発性骨髄腫研究会,5月,仙台
    1. 奈良美保 (2014) 特異的遺伝子を標的とした多発性骨髄腫の治療.
  7.   トロンボモジュリン研究会,3月,秋田
    1. 奈良美保,高橋直人,藤島直仁,斉藤宏文,藤島眞澄,亀岡吉弘,田川博之,澤田賢一 (2014) 造血幹細胞移植後肝類洞閉塞症候群の単一施設における後ろ向き解析:トロンボモジュリン製剤の有効性.
  8.   理系女子をめざそう in 秋田2014,12月,秋田
    1. 奈良美保(2014)パネラー: 理系女子をめざそう..
  9.   MM Round Meeting, 1月,秋田
    1. 小林敬宏,高橋直人,志田青慈,澤田賢一 (2014) IgD型多発性骨髄腫に対するRd療法の経験.
  10.   第3回生体情報研究シンポジウム, 8月, 秋田
    1. 北舘明宏,伊藤貢,池田翔,手島和暁,澤田賢一,田川博之(2014) マイクロRNAデリバリーによる悪性リンパ腫の臓器浸潤抑制.
  11.   第13回東北臨床免疫研究会,8月,福島
    1. 加賀一(2014) 関節リウマチの治療経過中に低蛋白血症、両側胸水をきたし、その後多臓器不全、脳出血で死亡した一例.
  12.   第24回腎と血管研究会,4月,秋田
    1. 小原綾乃 (2014) ネオーラルが有効だった膜性腎症の症例.
    2. 澤村昌人 (2014) LHCDDかPGNMIDか鑑別困難であったMIDD.
    3. 齋藤雅也 (2014) C3のdominantな沈着を認めたMPGN様病変の症例.
  13.   第25回東北腎フォーラム,7月,福島
    1. 澤村昌人,富樫賢,齋藤雅也,阿部史人,小原綾乃,加賀一,奈良瑞穂,小松田敦,面川歩,奥山慎,涌井秀樹 (2014) 絨毛性疾患によるThrombotic microangiopathyで発症したネフローゼ症候群.
  14.   第18回秋田腎不全研究会,11月,秋田
    1. 森健介,涌井秀樹,布村渉,富樫賢,小松田敦 (2014) 運動後急性腎不全を合併症に持つ低尿酸血症患者のURAT1の遺伝子解析.

 

 

業績:2013年

原著論文

  1. Ohyagi,H., Onai,N., Sato,T., Yotsumoto,S., Liu,J., Akiba,H., Yagita, H., Atarashi,K., Honda,K., Roers,A., Muller,W., Kurabayashi,K., Hosoi-Amaike,M., Takahashi,N., Hirokawa,M., Matsushima,K., Sawada,K., Ohteki,T.(2013) Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity., 19,39(3),584-98.
  2.   Saitoh,H., Takahashi,N., Nanjo,H., Kawabata,Y., Hirokawa,M., Sawada, K.(2013) Varicella-zoster virus-associated fulminant hepatitis following allogeneic hematopoietic stem cell transplantation for multiple myeloma. Intern.Med., 52(15),1727-30.
  3.   Shinohara,Y., Takahashi,N., Nishiwaki,K., Hino,M., Kashimura,M., Wakita,H., Hatano,Y., Hirasawa,A., Nakagawa,Y., Itoh,K., Masuoka,H., Aotsuka,N., Matsuura,Y., Takahara,S., Sano,K., Kuroki,J., Hata,T., Nakamae,H., Mugitani,A., Nakane,T., Miyazaki,Y., Niioka,T., Miura,M., Sawada,K.(2013) A multicenter clinical study evaluating the confirmed complete molecular response rate in imatinib-treated patients with chronic phase chronic myeloid leukemia by using the international scale of real-time quantitative polymerase chain reaction. Haematologica., 98(9),1407-13.
  4.   Teshima,K., Nara,M., Watanabe,A., Ito,M., Ikeda,S., Hatano,Y., Oshima,K., Seto,M., Sawada,K., Tagawa,H.(2013) Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma. Oncogene., 20, 1-13.
  5.  Hirokawa,M., Fukuda,T., Ohashi,K., Hidaka,M., Ichinohe,T., Iwato,K., Kanamori,H., Murata,M., Sakura,T., Imamura,M., Adachi,S., Suzuki,R., Morishima,Y., Sakamaki,H., PRCA,Collaborative,Study,Group.(2013) Efficacy and long-term outcome of treatment for pure red cell aplasia after allogeneic stem cell transplantation from major ABO-incompatible donors. Biol.Blood.Marrow.Transplant.,19(7),1026-32.
  6.  Tagawa,H., Ikeda,S., Sawada,K.(2013) Role of microRNA in the pathogenesis of malignant lymphoma. Cancer.Sci.,104(7),801-9.
  7.  Nara,M., Teshima,K., Watanabe,A., Ito,M., Iwamoto,K., Kitabayashi,A., Kume,M., Hatano,Y., Takahashi,N., Iida,S., Sawada,K,, Tagawa,H.(2013) Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells. PLoS.One.,8(3),e56954.
  8.  Komatsuda,A., Ohtani,H., Sawada,K., Joh,K., Wakui,H.(2013) Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin γ1 CH 2 heavy chain and κ light chain: a new variant of monoclonal immunoglobulin deposition disease. Pathol.Int.,63(1),63-7.
  9.   Nara,M., Takahashi,N., Miura,M., Niioka,T., Kagaya,H., Fujishima,N., Saitoh,H., Kameoka,Y., Tagawa,H., Hirokawa,M., Sawada,K.(2013) Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants. Eur.J.Clin.Pharmacol.,69(6),1321-9.
  10.   Michishita,Y., Hirokawa,M., Fujishima,N., Abe,Y., Fujishima,M., Guo,Y,M., Ubukawa,K., Liu,J., Yoshioka,T., Kameoka,Y., Saitoh,H., Tagawa,H., Takahashi,N., Sawada,K.(2013) CDR3-independent expansion of Vδ1 T lymphocytes in acquired chronic pure red cell aplasia. Immunol. Lett.,150(1-2),23-9.
  11.   11) Yokoyama,K., Akiba,T., Fukagawa,M., Nakayama,M., Sawada,K., Kumagai,Y., Chertow,G,M., Hirakata,H.(2013) A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis. Nephrol.Dial.Transplant.,26.
  12.  Guo, Y,M., Ishii, K., Hirokawa, M., Tagawa, H., Ohyagi, H., Michishita, Y., Ubukawa, K., Yamashita, J., Ohteki, T., Onai, N., Kawakami, K., Xiao, W., Sawada, K. (2010) CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood.,3,115,4569-4579.
  13.   Ohmachi,K., Niitsu,N., Uchida,T., Kim,S,J., Ando,K., Takahashi,N., Takahashi ,N., Uike,N., Eom,H,S., Chae,Y,S., Terauchi,T., Tateishi,U., Tatsumi ,M., Kim,W,S., Tobinai,K., Suh,C., Ogura,M.(2013) Multicenter phase II study of bendamustine plus rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma. J.Clin.Oncol.,10,31(17),2103-9.
  14.  Nagao,T., Takahashi,N., Kameoka,Y., Noguchi,S., Shinohara,Y., Ohyagi,H., Kume,M., Sawada,K. (2013) Dasatinib-responsive chronic lymphocytic leukemia in a patient treated for coexisting chronic myeloid leukemia. Intern. Med., 52(15). 2567-2571.
  15.   Saito,Y., Takahashi,N., Ohyagi,H., Shinohara,Y., Kume,M., Sawada,K. (2013) Acquired Philadelphia Chromosome with Transformed Myelodysplastic Syndrome. Journal.of.Case,Reports.in.Medicine., 2, e2..
  16.  Noguchi,S., Takahashi,N., Ito,M., Teshima,K., Yamashita,T., Michishita,Y., Ohyagi,H., Shida,S., Nagao,T., Fujishima,M., Ikeda,S., Ito,I., Fujishima,N., Kameoka,Y., Saitoh,H., Tagawa,H., Hirokawa,M., Sawada,K. (2013) Safety and efficacy of low-dose liposomal amphotericin B as empirical antifungal therapy for patients with prolonged neutropenia. Int.J.Clin.Oncol., 18, 983-987.
  17.  Fujiwara,T., Komatsuda,A., Ohtani,H., Togashi,M., Sawada,K., Wakui,H.(2013) Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia. Clin,Nephrol.,79,(6),494-8.
  18.  藤島眞澄,藤島直仁,道下吉広,奈良美保,亀岡吉弘,吉岡智子,田川博之,高橋直人,廣川誠,澤田賢一 (2013) 同種造血幹細胞移植後ヒトヘルペスウイスル6型脳炎の急性症状の緩和としてステロイドパルス療法の有用性が示唆された2例.日本造血細胞移植学会誌., 2, 75-79.
  19.  大八木秀明,久米正晃,高橋直人,澤田賢一(2013)輸血後GVHDとの鑑別が困難であった中毒性表皮壊死症,日本内科学会雑誌,102(6),1467-1469.

業績:2012年

原著論文

  1. Komatsuda, A., Omokawa, A., Fujiwara, T., Sato, R., Togashi, M., Okuyama, S., Sawada, K., Wakui, H. (2012)  Serum procalcitonin levels in patients with myeloperoxidase-antineutrophil cytoplasmic antibodies-associated glomerulonephritis. Am. J. Med. Sci.,  343,136-40.

  2. Komatsuda, A., Nara, M., Ohtani, H., Nimura, T., Sawada, K., Wakui, H.(2012) Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis. Intern. Med., 51,3273-6.

  3. 3)   Komatsuda, A., Masai, R., Togashi, M., Ohtani, H., Sawada, K., Wakui, H.(2012)Discrete renal deposition of IgM heavy chain and κlight chain in Waldenström macroglobulinemia(IgM-κ).Clin. Kidney. J., 5,438-441.

  4. Kameoka, J., Takahashi, N., Noji, H., Murai, K., Tajima, K., Kameoka, Y., Sato, S., Shichishima, T., Ishida, Y., Harigae, H., Sawada, K. (2012) T-cell prolymphocytic leukemia in Japan: is it a variant?  Int. J. Hematol.,  95,660-7.

  5. Ubukawa, K., Guo, Y,M., Takahashi, M., Hirokawa, M., Michishita ,Y., Nara, M., Tagawa, H., Takahashi, N., Komatsuda, A., Nunomura, W., Takakuwa, Y., Sawada, K. (2012) Enucleation of human erythroblasts involves non-muscle myosin IIB. Blood., 26,119,1036-44.

  6. Omokawa, A., Komatsuda, A., Nara, M., Fujiwara, T., Sato, R., Togashi, M., Okuyama, S., Sawada, K., Wakui, H. (2012) Renal biopsy in patients aged 80 years and older: a single-center experience in Japan. Clin. Nephrol.,  77,461-7.

  7. Maki, N., Komatsuda, A., Ohtani, H., Kuroki, J., Nishinari, T., Asakura, K., Sawada, K., Wakui, H.(2012)Streptococcus pneumoniae-Associated Hemolytic Uremic Syndrome in a Splenectomized Adult Patient. Intern. Med., 51,2001-5.

  8. Tanabe, M., Ishida, R., Izuhara, F., Komatsuda, A., Wakui, H., Sawada, K., Otaka, M., Nakamura, N., Itoh, H. (2012) The ATPase activity of molecular chaperone HSP60 is inhibited by immunosuppressant mizoribine. American. J. Molecular. Biology., 2,93-102.

  9. Yokoyama, K., Hirakata, H., Akiba, T., Sawada, K., Kumagai, Y. (2012) Effect of oral JTT-751 (Ferric citrate) on hyperphosphatemia in hemodialysis patients: results of a randomized, double-blind, placebo-controlled trial. Am. J. Nephrol., 36,478-487.

  10. Nagao, T., Takahashi, N., Saitoh, H., Noguchi, S., Guo, Y,M., Ito, M., Watanabe, A., Fujishima, N., Kameoka, Y., Tagawa, H., Hirokawa, M., Sawada, K. (2012)Adult T-cell leukemia-lymphoma developed from an HTLV-1 carrier during treatment of B-cell lymphoma-associated hemophagocytic syndrome. Rinsho. Ketsueki., 53,2008-12.

  11. Noguchi, S., Takahashi, N., Ito, M., Teshima, K., Yamashita, T., Michishita, Y., Ohyagi, H., Shida, S., Nagao, T., Fujishima, M., Ikeda, S., Ito, I., Fujishima, N., Kameoka, Y., Saitoh, H., Tagawa, H., Hirokawa, M., Sawada, K. (2012) Safety and efficacy of low-dose liposomal amphotericin B as empirical antifungal therapy for patients with prolonged neutropenia. Int. J. Clin. Oncol., 18.

  12. Kameoka, Y., Takahashi, N., Ishizawa, K., Kato, Y., Ito, J., Sasaki, O., Murai, K., Noji, H., Hirokawa, M., Tajima, K., Shichishima, T., Ishida, Y., Harigae, H., Sawada, K. (2012) Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma. Int. J. Hematol., 96,624-30. 

  13. Matsuoka, A., Takahashi, N., Miura, M., Niioka, T., Kawakami, K., Matsunaga, T., Sawada, K. (2012) H2-receptor antagonist influences dasatinib pharmacokinetics in a patient with Philadelphia-positive acute lymphoblastic leukemia. Cancer. Chemother. Pharmacol., 70,351-2.

  14. Takahashi, N., Miura, M., Scott, SA., Niioka, T., Sawada, K. (2012) Pharmacokinetics of Dasatinib for Philadelphia- Positive Acute Lymphocytic Leukemia with Acquired T315I mutation. J. Hematol. Oncol., 15,5(1),23.

  15. Fujimi, A., Takahashi, N., Miura, M., Kanisawa, Y., Ono, K., Sawada, K.(2012)Bile acid is important for gastrointestinal absorption of nilotinib. Eur. J. Clin. Pharmacol., 68,1575-6.

  16. Ng, KP., Hillmer, AM., Chuah, CT., Juan, WC., Ko, TK., Teo, AS., Ariyaratne, PN., Takahashi, N., Sawada, K., Fei, Y., Soh, S., Lee, WH., Huang, JW., Allen, JC. Jr,, Woo, XY., Nagarajan, N., Kumar, V., Thalamuthu, A., Poh, WT., Ang, AL., Mya, HT., How, GF., Yang, LY., Koh, LP., Chowbay, B., Chang, CT., Nadarajan, VS., Chng, WJ., Than, H., Lim, LC., Goh, YT., Zhang, S., Poh, D., Tan, P., Seet, JE., Ang, MK., Chau, NM., Ng, QS., Tan, DS., Soda, M., Isobe, K., Nöthen, MM., Wong, TY., Shahab, A., Ruan, X., Cacheux-Rataboul, V., Sung, WK., Tan, EH., Yatabe, Y., Mano, H., Soo, RA., Chin, TM., Lim, WT., Ruan, Y., Ong, ST. (2012) A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat. Med., 18,18,521-8.

  17. Onaka, T., Takahashi, N., Miura, M., Yonezawa, A., Imada, K., Sawada, K.(2012)Pharmacokinetics of nilotinib in imatinib-resistant/ intolerant chronic myeloid leukemia patients on hemodialysis for chronic renal failure. Am. J. Hematol., 87,451.

  18. Takahashi, N., Miura, M., Kameoka, Y., Abumiya, M., Sawada, K. (2012) Drug interaction between lenalidomide and itraconazole. Am. J. Hematol., 87,338-9.

  19. Liu, J., Guo, YM., Hirokawa, M., Iwamoto, K., Ubukawa, K., Michishita, Y., Fujishima, N., Tagawa, H., Takahashi, N., Xiao, W., Yamashita, J., Ohteki, T., Sawada, K. (2012) A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34+ cells. Exp. Hematol., 40,330-41.

  20. Takahashi, N., Kyo, T., Maeda, Y., Sugihara, T., Usuki, K., Kawaguchi, T., Usui, N., Okamoto, S., Ohe, Y., Ohtake, S., Kitamura, K., Yamamoto, M., Teshima, H., Motoji, T., Tamaki, T., Sawada, K., Ohyashiki, K. (2012) Discontinuation of imatinib in Japanese patients with chronic myeloid leukemia. Haematologica. 97,903-6.

  21. Takahashi, N., Miura, M., Niioka, T., Sawada, K. (2012) Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients. Cancer. Chemother. Pharmacol., 69,999-1004.

  22. Usuki, K., Kurosawa, S., Uchida, N., Yakushiji, K., Waki, F., Matsuishi, E., Kagawa, K., Furukawa, T., Maeda, Y., Shimoyama, M., Ago, H., Yamano, Y., Yano, S., Fujishima, N., Takamatsu, Y., Eto, T., Hidaka, M., Matsuoka, H., Fukuda, T.(2012) Comparison of Autologous Hematopoietic Cell Transplantation and Chemotherapy as Postremission Treatment in Non-M3 Acute Myeloid Leukemia in First Complete Remission. Clin. Lymphoma. Myeloma. Leuk., 12,444-451.

  23. 池田翔,小松田敦,富樫賢,山下鷹也,道下吉広,藤島眞澄,藤島直仁,涌井秀樹,澤田賢一 (2012) 胆嚢動脈のフィブリノイド壊死性血管炎が初発症状となった全身性エ リテマトーデスの1例,日本内科学会雑誌101(11),3229-3232.

 

 

 

 

業績:2011年

原著論文

  1. Sawada, K., Guest editorial.(2011) the seven wonders of erythropoiesis. Int. J. Hematol., 93,1-4.

  2. Takahashi, N., Yoshioka, T., Kameoka, Y., Tagawa, H., Fujishima, N., Saitoh, H., Hirokawa, M., Enomoto, K., Sawada, K. (2011) Fatal hemorrhagic pneumonia caused by Stenotrophomanas maltophilia in a patient with non-Hodgkin lymphoma. J. Infect. Chemother., 17,858-862.

  3. Takahashi, N., Miura, M. (2011) Therapeutic drug monitoring of imatinib for chronic myeloid leukemia patients in the chronic phase. Pharmacology., 87,241-248.

  4. Watanabe, A., Tagawa, H., Yamashita, J., Teshima, K., Nara, M., Iwamoto, K., Kume, M., Kameoka, Y., Takahashi, N., Nakagawa, T., Shimizu, N., Sawada, K. (2011) The role of microRNA-150 as a tumor suppressor in malignant lymphoma. Leukemia.,25,1324-1334.

  5. Michishita, Y., Hirokawa, M., Guo, Y,M., Abe, Y., Liu, J., Ubukawa, K., Fujishima, N., Fujishima, M., Yoshioka, T., Kameoka, Y., Saito, H., Tagawa, H., Takahashi, N., Sawada, K. (2011) Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells. Int. J. Hematol., 94,230-240.

  6.  Nara, M., Komatsuda, A., Fujishima, M., Fujishima, N., Nara, M., Iino, T., Ito, H., Sawada, KI., Wakui, H. (2011) Renal paradoxical embolism in a hypertensive young adult without acute ischemic symptoms. Clin. Exp. Nephrol., 15, 582-585.

  7. Ito, M., Takahashi, N., Saitoh, H., Shida, S., Nagao, T., Kume, M., Kameoka, Y., Tagawa, H., Fujishima, N., Hirokawa, M., Tazawa, H., Minato, T., Yamada, S., Sawada, K.(2011) Successful treatment of necrotizing fasciitis in an upper extremity caused by Clostridium perfringens after bone marrow transplantation. Intern. Med., 50,2213-2217.

  8. Shida, S., Takahashi, N., Fujishima, N., Kameoka, Y., Nara, M., Fujishima, M., Saitoh, H., Tagawa, H., Hirokawa, M., Ichinohasama, R., Sawada, K. (2011) False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. Intern. Med., 50,2383-2387.

  9. Kosaka, M., Takahashi, N., Saitoh, H., Masai, R., Ito, M., Sato, R., Wakui, H., Sawada, K. (2011) Thrombotic thrombocytopenic purpura with severe ADAMTS-13 deficiency in a patient with antiphospholipid antibodies and Charcot-Marie-Tooth disease. Intern. Med.,50,487-493.

  10. Suzuki, K., Miura, N., Kitagawa, W., Suzuki, S., Komatsuda, A., Nishikawa, K., Watanabe, D., Imai, H.(2011) Progressive renal failure despite long-term biweekly enzyme replacement therapy in a patient with Fabry disease secondary to a new α-galactosidase mutation of Leu311Arg (L311R). Clin. Exp. Nephrol., 15,916-920.

  11. Akagi, T., Takahashi, N., Yamaguchi, K., Ishizawa, K., Murai, K., Tajima, K., Ikeda, K., Kameoka, Y., Kameoka, J., Ito, S., Kato, Y., Noji, H., Shichishima, T., Itoh, J., Ichinohasama, R., Harigae, H., Ishida, Y., Sawada, K. (2011) Comparison of Long-Term clinical outcomes of CHOP chemotherapy between Japanese patients with nodal peripheral T- Cell lymphomas and those with diffuse large B-Cell lymphoma in the study group of the Tohoku Hematology Forum. J. Clin. Exp. Hematop., 51,29-35.

  12. Miura, M., Okuyama, S., Kato, S., Kagaya, H., Murata, A., Komatsuda, A., Wakui, H., Sawada, K. (2011) Simultaneous determination of warfarin and 7-hydroxywarfarin enantiomers by high-performance liquid chromatography with ultraviolet detection. Ther. Drug. Monit.,  33,108-114.

  13. Miura, M., Takahashi, N., Sawada, K . (2011) Quantitative determination of imatinib in human plasma with High-Performance liquid chromatographyand ultraviolet detection.  Journal. of. Chromatographic. Science., 49,412-415.

  14. Miura, M., Takahashi, N., Kanno, S., Kato, S., Nara, M., Itoh, M., Saitoh, H., Yoshioka, T., Kameoka, Y., Fujishima, N., Tagawa, H., Hirokawa, M., Sawada, K.(2011) Drug interaction of (S)-warfarin, and not (R)-warfarin, with itraconazole in a hematopoietic stem cell transplant recipient. Clin. Chim. Acta., 412,2002-2006.

  15. Tanaka, R., Kimura, S., Ashihara, E., Yoshimura, M., Takahashi, N., Wakita, H., Itoh, K., Nishiwaki, K.,  Suzuki, K., Nagao, R.,  Yao, H., Hayashi, Y., Satake, S., Hirai, H., Sawada, K., Oliver, G, Ottman., Junia, V, Melo., Maekawa, T.(2011)  Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients.  Cancer. Lett.,   22,228-234.

  16. Nagai, H., Ogura, M., Kusumoto, S., Takahashi, N., Yamaguchi, M., Takayama, N., Kinoshita, T., Motoji, T., Ohyashiki, K., Kosugi, H., Matsuda, S., Ohnishi, K., Omachi, K., Hotta, T. (2011) Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma. Eur. J. Haematol., 86,117-123.

  17. 佐藤隆太,小松田敦,政井理恵,澤田賢一,涌井秀樹(2011) 自己免疫性肝炎による肝機能障害を合併し高度の肺動脈性高血圧症にbosentanが奏効した全身性エリテマトーデスの1例.リウマチ科., 45,560-566.

 

 

業績:2010年

原著論文

  1. Wakui,H., Togashi, M., Omokawa, A., Okuyama, S., Masai, R., Komatsuda,A., Ogasawara, H., Sawada, K. (2010) Simultaneous herpes simplex virus esophagitis and lupus enteritis in a patient with systemic lupus erythematosus. Mod.Rheumatol.,20,98-101.
  2.  Komatsuda, A., Wakui, H., Togashi,M., Sawada, K. (2010) IgA nephropathy associated with Castleman disease with cutaneous involvement. Am.J.Med Sci.,339,486-490.
  3.  Komatsuda, A., Wakui, H., Ohtani, H., Masai, R., Okuyama, S., Nimura, T., Suzuki,N., Sawada, K.(2010) Tubulointerstitial nephritis and renal tubular acidosis of different types are rare but important complications of primary biliary cirrhosis. Nephrol.Dial.Transplant., 25,3575-3579.
  4.  Komatsuda,A., Wakui, H.,Ohtani,H., Nimura,T.,Sawada, K.(2010) Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features. NDT.Plus., 3,357-359.
  5.  Takahashi, N., Wakita, H., Miura, M., Scott, SA., Nishii, K., Masuko, M., Sakai, M., Maeda, Y., Ishige, K., Kashimura, M., Fujikawa, K., Fukazawa, M., Katayama, T., Monma, F., Narita, M., Urase, F., Furukawa, T., Miyazaki, Y., Katayama, N., Sawada, K. (2010) Correlation between imatinib pharmacokinetics and clinical response in Japanese patients with chronic-phase chronic myeloid leukemia. Clin.Pharmacol.Ther., 88,809-813.
  6.  Takahashi, N., Miura, M., Scott, SA., Kagaya, H., Kameoka, Y., Tagawa, H., Saitoh, H., Fujishima, N., Yoshioka, T., Hirokawa, M., Sawada, K. (2010) Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia. J.Hum.Genet.,5,731-737.
  7.  Takahashi, N., Kameoka, Y., Tagawa, H., Saitoh, H., Yoshioka, T., Fujishima, N., Kitabayashi, A., Takahashi, K., Hirokawa,M., Sawada, K. (2010) Early prediction of a long-term outcome by neutrophil-FISH in patients with CML receiving imatinib mesylate. Int.J.Hematol., 92,559-61.
  8.  Takahashi, N. (2010) Can we distinguish chronic myeloid leukemia presenting in the lymphoblastic phase from de novo Philadelphia-positive acute lymphoid leukemia? Intern. Med., 49, 2535-2536
  9.  Kameoka, Y., Takahashi, N., Tagawa, H., Fujishima, N., Yoshioka, T., Saito, H., Hirokawa, M., Ichinohasama, R., Sawada, K. (2010) A case of intravascular large B-cell lymphoma of the cutaneous variant: the first case in Asia. Int.J.Hematol.,91,146-148.
  10.  Togashi, M., Wakui, H., Kodama, K., Kameoka, Y., Komatsuda, A., Nimura, T., Ichinohasama, R., Sawada, K. (2010) Angioimmunoblastic T-cell lymphoma and membranous nephropathy: a still unreported association. Clin.Exp.Nephrol.,14,288-293.
  11.  Guo, Y,M., Hirokawa, M., Takahashi, N., Fujishima, M., Fujishima, N., Komatsuda, A., Tagawa, H., Ohyagi, H., Michishita, Y., Ubukawa, K., Hebiguchi, M., Xiao, W., Sawada, K.(2010) Delayed addition of tumor necrosis factor (TNF) antagonists inhibits the generation of CD11c+ dendritic cells derived from CD34+ cells exposed to TNF-alpha. Int.J. Hematol.,91,61-68.
  12.  Guo, Y,M., Ishii, K., Hirokawa, M., Tagawa, H., Ohyagi, H., Michishita, Y., Ubukawa, K., Yamashita, J., Ohteki, T., Onai, N., Kawakami, K., Xiao, W., Sawada, K. (2010) CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood.,3,115,4569-4579.
  13.  Nara, M., Takahashi, N., Miura, M., Saitoh, H., Kagaya, H., Sawada, K. (2010) Effect of oral itraconazole on the pharmacokinetics of tacrolimus in a hematopoietic stem cell transplant recipient with CYP3A5*3/*3.Am.J. Hematol.,85,634-635.
  14.  Ohtani, H., Wakui, H., Komatsuda, A., Goto, H., Tada, M., Ozawa, M., Kobayashi, R., Sawada, K. (2010) Progressive glomerulopathy with unusual deposits of striated structures: a new disease entity? Nephrol.Dial. Transplant.,25,2016-2019.
  15.  Yamamoto, S., Nakano, S., Owari, K., Fuziwara, K., Ogawa, N., Otaka, M., Tamaki, K., Watanabe, S., Komatsuda, A., Wakui, H., Sawada, K., Kubota, H., Itoh, H. (2010) Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. FEBS.Lett., 584,645-651.
  16.  Shichishima, T., Ikeda, K., Takahashi, N., Kameoka, J., Tajima, K., Murai, K., Tamai, Y., Shichishima-Nakamura, A., Akutsu, K., Noji, H., Okamoto, M., Kimura, H., Harigae, H., Oyamada, T., Kamesaki, T., Takeishi ,Y., Sawada, K. (2010) Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes. Int.J.Hematol.,91,602-610.
  17.  Miura, M., Takahashi, N., Sawada, KI. (2010) High-performance liquid chromatography with solid-phase extraction for the quantitative determination of nilotinib in human plasma. Biomed.Chromatogr., 24,789-793.

 

 

業績:2009年

原著論文

  1. Sawada, K., Hirokawa, M., Fujishima, N.(2009) Diagnosis and management of acquired pure red cell aplasia. Hematol Oncol Clin North Am., A23, 249-259. 
  2. Hirokawa, M., Sawada, K., Fujishima, N., Kawano, F., Kimura, A., Watanabe, T., Arai, A., Matsui, T., Nakao, S., Urabe, A., Omine, M., Ozawa, K.(2009) Acquired pure red cell aplasia associated with malignant lymphomas : A nationwide cohort study in Japan for PRCA Collaborative Study Group. Am J Hematol., 84, 144-148. 
  3. Komatsuda, A., Wakui, H., Iwamoto, K., Togashi, M., Masai, R., Maki, N., Sawada, K.(2009) GATA-3 is upregulated in peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome. Clin Nephol., 71, 608-616. 
  4. Komatsuda, A., Wakui, H., Iwamoto, K., Sawada, K. (2009) Up-regulated expression of suppressor of cytokine signaling (SOCS) proteins mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Rheumatol., 27, 1060.
  5.  Kameoka, Y., Takahashi, N., Komatsuda, A., Tagawa, H., Hamai, K., Hirokawa, M., Wakui, H., Ichinohasama, R., Sawada, K.(2009) Kidney-limited intravascular large B cell lymphoma : a distinct variant of IVLBCL? . Int J Hematol., 89, 533-537.
  6.  Masai, R., Wakui, H., Togashi, M., Maki, N., Ohtani, H., Komatsuda, A., Sawada, K.(2009) Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. Clin Nephrol., 71, 9-20.
  7.  Masai, R., Wakui, H., Komatsuda, A., Togashi, M., Maki, N., Ohtani, H., Oyama, Y., Sawada, K.(2009) Characteristics of proliferative glomerulonephritis with monoclonal IgG deposits associated with membranoproliferative features. Clin Nephrol., 72, 46-54.
  8.  Yamanaka, Y., Tagawa, H., Takahashi, N., Watanabe, A., Y, G, Mei., Iwamoto, K., Yamashita, J., Saitoh, H., Kameoka, Y., Shimizu, N., Ichinohasama, R., Sawada, K.(2009) Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lympoma/leukemia. Blood., 114, 3265- 3275.
  9.  Inomata, M., Tagawa, H., Y, M, Guo., Kameoka, Y., Takahashi, N., Sawada, K.(2009) MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes. Blood.,396- 402.
  10.  Satoh, K., Yoshida, N., Imaizumi, K., Yajima, M., Wakui, H., Sawada, K., Komatsuda, A.(2009) Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis. Am J Med Sci., 338, 334-335.
  11.  Satoh, S., Saito, M., Inoue, T., Kagaya, H., Miura, M., Inoue, K., Komatsuda, A., Tsuchiya, N., Suzuki, T., Habuchi, T. (2009) CYP3A5 *1 allele associated with tacrolimus trough concentration but not subclinical acute rejection or chronic allograft nephropathy in Japanese renal transplant recipients. Eur J Clin Pharmacol., 65, 473-481.
  12.  Lakshmikuttyamma, A., Takahashi, N., Pastural, E., Torlakovic, E., Amin, H,M., Garcia-Manero, G., Voralia, M., Czader, M., Decoteau, J,F., Geyer ,C,R.(2009) RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. J Hematol Oncol., 14, 2-28.
  13.  Nakagawa, M., Nakagawa-Oshiro, A., Karnan, S., Tagawa, H., Utsunomiya, A., Nakamura, S., Takeuchi, I., Ohshima, K., Seto, M. (2009) Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma. Clin Cancer Res., 15, 30-38.
  14.  Takeuchi, I., Tagawa, H., Tsujikawa, A., Nakagawa, M., Katayama-Suguro, M., Guo, Y., Seto, M. (2009) The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis. Haematologica., 94, 61-69.
  15.  Honma, K., Tsuzuki, S., Nakagawa, M., Tagawa, H., Nakamura, S., Morishima, Y., Seto, M. (2009) TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood., 114, 2467-2475.
  16.  Yoshida, M., Nishikawa, Y., Yamamoto, Y., Doi, Y., Tokairin, T., Yoshida, T., Omori, Y., Watanabe, A., Takahashi, N., Yoshioka, T., Miura, I., Sawada, K., Enomoto, K. (2009) Mast cell leukemia with rapidly progressing portal hypertension. Pathology International., 56, 817-822.

業績:2008年

原著論文

  1. Hirokawa, M., Sawada, K., Fujishima, N., Nakao, S., Urabe, A., Dan, K., Fujisawa, S., Yonemura, Y., Kawano, F., Omine, M., Ozawa, K., for the PRCA collaborative study group. (2008) Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia : a nationwide cohort study in Japan by the PRCA collaborative study group. Hamatologica., 931, 27-33.
  2.  Komatsuda, A., Wakui, H., Iwamoto, K., Ozawa, M., Togashi, M., Masai, R., Maki, N., Hatakeyama, T., Sawada, K. (2008) Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol., 152, 482-487.
  3.  Komatsuda, A., Wakui, H., Iwamoto, K., Harada, M., Okumoto, Y., Sawada, K. (2008) Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays. Am J Nephrol., 28, 539-547.
  4. Sawada K, Fujishima N, Hirokawa M.  Acquired pure red cell aplasia: updated review of treatment.
    Br J Haematol. 2008 Aug;142 (4):505-14. Epub 2008 May 28. Review.
  5.  Komatsuda, A., Wakui, H., Nimura, T., Sawada, K. (2008) Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis. Mod Rheumatol., 18, 315-318.
  6.  Komastuda, A., Masai, R., Ohtani, H., Togashi, M., Maki, N., Sawada, K., Wakui, H. (2008) Monoclonal immunoglobulin deposition disease associated with membranous features. Nephrol Dial Transpl., 23, 3888-3894.
  7.  Komatsuda, A., Okamoto, Y., Hatakeyama, T., Wakui, H., Sawada, K. (2008) Sulfasalazine- induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus. Clin Rheumatol., 27,395-397.
  8.  Komatsuda, A., Kinoshita, K., Togashi, M., Maki, N., Masai, R., Niitsu, H., Ohtani, S., Sageshima, M., Sawada, K., Wakui, H. (2008) Cutaneous polyarteritis nodosa in a patient with Crohn's disease. Mod Rheumatol., 18, 639-642.
  9.  Takahashi, N., Kameoka, Y., Yamanaka, Y., Ubukawa, K., Saito, K., Fujishima, M., Fujishima, N., Saito, H., Hirokawa, M., Stuart, A, Scott., Sawada, K. (2008) Itraconazole oral solution enhanced vincristine neurotoxicity in five patients with malignant lymphoma. Inter Med., 47, 651-653.
  10.  Hatakeyama, T., Komatsuda, A., Matsuda, M., Togashi, M., Maki, N., Masai, R., Sawada, K., Wakui, H. (2008) Renal amyloidosis associated with extracapillary glomerulonephritis and vasculitis in a patient with inflammatory bowel disease treated with infliximab. Clin Nephrol., 70, 240-244.
  11.  Fujishima, N., Sawada, K., Hirokawa, M., Oshimi, K., Sugimoto, K., Matsuda, A., Teramura, M., Karasawa, M., Arai, A., Yonemura, Y., Nakao, S., Urabe, A., Omine, M., Ozawa, K. (2008) Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia : a nationwide cohort study in Japan for the PRCA collaborative study group. Haematologica. Haematologica., 93, 1555-1559.
  12.  Okuyama, S., Wakui, H., Maki, N., Kuroki, J., Nishinari, T., Asakura, K., Komatsuda, A., Sawada K. (2008) Successful treatment of post-MRSA infection glomerulonephritis with steroid therapy. Clin Nephrol., 70, 344-347.
  13.  Saito, Y., Y, M, Guo., Hirokawa, M., Saito, K., Komatsuda, A., Takahashi, N., Fujishima, M., Fujishima, N., Yamashita, J., Sawada, K. (2008) Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34+ cells with granulocyte colonystimulating factor and tumor necrosis factor-α. Int J Hematol., 88, 64-72.
  14.  Togashi, M., Komatsuda, A., Masai, R., Maki, N., Hatakeyama, T., Wakui, H., Sawada, K. (2008) Hypertrophic cranial pachymeningitis in a patient with Cogan’s syndrome. Clin Rheumatol., 27(suppl 1), S33-S35.
  15.  Omokawa, A., Wakui, H., Okuyama, S., Togashi, M., Ohtani, H., Komatsuda, A., Ichinohasama, R., Sawada, K. (2008) Predominant tubulointerstitial nephritis in a patient with systemic lupus erythematosus: phenotype of infiltrating cells. Clin Nephrol., 69, 436-444.
  16.  Hebiguchi, M., Hirokawa, M., Y, M, Guo., Saito, K., Wakui, H., Komatsuda, A., Fujishima, N., Takahashi, N., Takahashi, T., Sasaki, T., Nunomura, W., Takakuwa, Y., Sawada, K. (2008) Dynamics of human erythroblast enucleation. Int J Hematol., 88, 498-507.
  17.  Tamai, H., Yamaguchi, H., Hamaguchi, H., Yagasaki, F., Bessho, M., Kobayashi, T., Akiyama, H., Sakamaki, H., Takahashi, S., Tojo, A., Ohmine, K., Ozawa, K., Okumura, H., Nakao, S., Arai, A., Miura, O., Toyota, S., Gomi, S., Murai, Y., Usui, N., Miyazawa, K., Ohyashiki, K., Takahashi, N., Sawada, K., Kato, A., Oshimi, K., Inokuchi, K., Dan, K. (2008) Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study. Int J Hematol., 87, 195-202.
  18.  Lakshmikuttyamma, A., Pastural, E., Takahashi, N., Sawada, K., Sheridan, DP., DeCoteau, JF., Geyer, CR. (2008) Bcr-Abl induces autocrine IGF-1 signaling. Oncogene., 1-14.
  19.  Kimura, F., Sato, K., Kobayashi, S., Ikeda, T., Sao, H., Okamoto, S., Miyamura, K., Mori, S., Akiyama, H., Hirokawa, M., Ohto, H., Ashida, H., Motoyoshi, K., for The Japan Marrow Donor Program. (2008) Impact of ABO-blood group incompatibility on the outcome of recipients of bone marrow transplants from unrelated donors in the Japan Marrow Donor Program. Haematologica., 9311, 1686-1693.
  20.  Ishida, R., Takaoka, Y., Yamamoto, S., Miyazaki, T., Otaka, M., Watanabe, S., Komatsuda, A., Wakui, H., Sawada, K., Kubota, H., Itoh, H. (2008) Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP90. FEBS Lett., 582, 3879-3883.
  21.  Kitagawa, W., Imai, H., Komatsuda, A., Maki, N., Wakui, H., Hiki, Y., Sugiyama, S. (2008) The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease. Nephrol Dial Transplant., 23, 3126-3129.
  22.  Karube, K., Ying, G., Tagawa, H., Niino, D., Aoki, R., Kimura, Y., Hashikawa, K., Suefuji, N., Sugita, Y., Nomura, Y., Shimizu, K., Yoshida, S., Seto, M., Ohshima, K. (2008) BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristis among follicular lymphoma without BCL2 gene translocation. Mod Pathol,, 21, 973-978.

業績:2007年

原著論文

  1. Sawada, K., Hirokawa, M., Fujishima, N., Teramura, M., Bessho, M., Dan, K., Tsurumi, H., Nakao, S., Urabe, A., Omine, M., Ozawa, K., for the PRCA collaborative study group. (2007) Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A.A nationwide cohort study in Japan for the PRCA collaborative study group. Haematologica., 92: 1021-1028.
  2.  Hirokawa, M., Kawabata, Y., Fujishima, N.,Yoshioka, T., Sawada, K. (2007) Prolonged reactivation of cytomegalovirus infection following successful rituximab therapy for Epstein-Barr virus associated posttransplantation lymphoproliferative disorder. Int J Hematol., 86: 291-292.
  3.  Komatsuda, A., Wakui, H., Iwamoto, K., Togashi, M., Maki, N., Masai, R., Hatakeyama, T., Sawada, K. (2007) Up-regulation of TRAIL m RNA expression in peripheral blood mononuclear cells from patients with active systemic lupus erythematosus. Clin Immunol., 125: 26-29.
  4.  Ohtani, H., Wakui, H., Komatsuda, A., Chyzh, KA., Hatakeyama, T., Masai, R., Okuyama, S., Togashi, M., Sawada, K. (2007) Differences between myeloperoxidase-specific and -nonspecific P-ANCA-associated renal disease. Ren Fail., 29: 183-187.
  5.  Takahashi, N., Pastural, E., Dong, WF., Bainbridge, M., Hull, A., Pearson, D., Huang, S., Lowsky, R., DeCoteau, JF., Geyer, CR. (2007) RIZ1 repression is associated with insulin-like growth factor-1 signaling activation in chronic myeloid leukemia cell lines. Oncogene., 8: 26(11)1586-1594.
  6.  Fujishima, N., Hirokawa, M., Fujishima, M., Yamashita, J., Saitoh, H., Ichikawa, Y., Horiuchi, T., Kawabata, Y., Sawada, K. (2007) Skewed T cell receptor repertoire of Vδ1+ γδT lymphocytes after human allogeneic heamatopoietic stem cell transplantation and the potential role for Epstein-Barr virus-infected B cells in clonal restriction. Clin Exp Imm., 149: 70-79.
  7.  Fujishima, N., Komatsuda, A., Ohyagi, H., Fujishima, M., Tada, M., Ohtani, H., Wakui, H., Hirokawa, M., Sawada, K. (2007) Adrenal insufficiency complicated with antipholipid syndrome (APS). Internal Medicine., 45: 963-966.
  8.  Okuyama, S., Hamai, K., Fujishima, M., Ohtani, H., Komatsuda, A., Sawada, K., Wakui, H. (2007) Focal segmental glomerulosclerosis associated with polycythemia vera : report of a case and review of the literature. Clin Nephrol., 68: 412-415.
  9.  Togashi, M., Okuyama, S., Wakui, H., Komatsuda, A., Suzuki, D., Toyoda, M., Sawada, K. (2007) Interaction of alpha-actinin-4 with class I PxxP motif-containing OK/SW-CL.16 protein. Nephron Exp Nephrol., 107: e65-e72.
  10.  Takatoku, M., Uchiyama, T., Okamoto, S., Kanakura, Y., Sawada, K., Tomonaga, M., Nakao, S., Nakahata, T., Harada, M., Murata, T., Ozawa, K., on behalf of the Japanese National Research Group on I diopathic Bone Marrow Failure Syndromes. (2007) Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Eur J Hematol., 78: 487-494.
  11.  Sada, A., Katayama, Y., Yamamoto, K., Okuyama, S., Nakata, H., Shimada, H., Oshimi, K., Mori, M., Matsui, T., Japanese Elderly Leukemia and Lymphoma Study Group (JELLSG). (2007) A multicenter analysis of the FIP1L1-αPDGER fusion gene in Japanese idiopathic hypereosinophilic syndrome : an aberrant splicing the αPDGER exon 12. Ann Hematol., 86: 855-863.
  12.  Saito, M., Saitoh, S., Inoue, T., Yuasa, T., Komatsuda, A., Tsuchiya, N., Habuchi, T. (2007) Clinical course and pathologic findings of successful second ABO-incompatible renal transplantation in a patient with donor-specifc anti-HLA antibody. Clin Transplant., 21(18)54-59.
  13.  Akihama, S., Sato, K., Satoh, S., Tsuchiya, N., Kato, T., Komatsuda, A., Hirokawa, M., Sawada, K., Nanjo, H., Habuchi, T. (2007) Bone marrow-derived cells mobilized by granulocyte-colony stimulating factor facilitate vascular regeneration in mouse kidney after ischemia / reperfusion Injury. Tohoku J Exp Med., 213: 341-349.
  14.  藤島直仁, 藤島眞澄, 猪又美佳, 山中康生, 斉藤邦江, 亀岡吉弘, 吉岡智子, 斉藤宏文, 高橋直人, 廣川誠, 澤田賢一 (2007) Rituximabを併用したCODOX-M/IVAC療法後に早期再発したt(8;14)とt(14;18)の染色体異常を有するバーキットリンパ腫, 臨床血液., 48, 326-331.
  15.  富樫賢、奥山慎、政井理恵、畠山卓、大谷浩、小松田敦、涌井秀樹、澤田賢一(2007)副腎皮質ステロイドにより難聴が改善したCogan症候群の1例,日本内科学会雑誌., 96, 986-987.

業績:2006年

原著論文

  1. Mizoroki F, Hirose Y, Sano M, Fukuda H, Tobinai K, Nakata M, Taniwaki M, Kawano F, Uozumi K, Sawada K, Fukuhara S, Nasu K, Ohno Y, Toki H, Togawa A, Kikuchi M, Hotta T, Shimoyama M, for the Japan clinical oncology group-lymphoma study group (JCOG-LSG)
    A phase II study of VEPA/FEPP chemotherapy for aggressive lymphoma in elderly patients: Japan clinical oncology group study JCOG9203.
    Int J Hematol 83:55-62
  2. Hirokawa M., Saito H, Kawabata Y, Sawada K
    Vaginal outflow tract obstruction associated with chronic graft-versus-host disease following allogeneic peripheral blood stem cell transplantation.
    Int J Hematol 83:181-182
  3. Saito K, Hirokawa M, Inaba K, Fukaya H, Kawabata Y, Komatsuda A, Yamashita J, Sawada K
    Phagocytosis of co-developing megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-{alpha} and its possible role in hemophagocytic syndrome.
    Blood15,107:1366-1374
  4. Komatsuda A, Iwamoto K, Wakui H, Sawada K
    Analysis of mutations in the urate transporter 1 (URAT1) gene of Japanese patients with hypouricemia in Northern Japan and review of the literature.
    Renal failure 28:223-227
  5. Komatsuda A, Kawabata Y, Horiuchi T, Motegi M, Ozawa M, Fujishima N, Kume M, Hirokawa M, Wakui H, Yamaguchi A, Sawada K
    Successful autologous peripheral blood stem cell transplantation using thiotepa in a patient with systemic sclerosis and cardiac involvement.
    Tohoku J Exp Med 209:61-67
  6. Komatsuda, A., Masai, R., Wakui, H., Iwamoto, K., Aiba, N., Ohtani, H., Saitoh, K., Hasayama, T., Imai, H., Nakamoto, Y., Sawada, K
    Anaysis of the NPHP genes in two Japanese patients with suspected sporadic juvenile or adolescent nephronophthisis.
    Clin Nepl 65(5)364-369
  7. Ito M, Minamiya Y, Kawa H, Saito S, Saito H, Nakagawa T, Imai K., Hirokawa M, Ogawa J
    Tumor-derived TGFβ-1 induces dendritic cell apoptois in the sentinel lymph node.
    J Imm 176:5637-5643
  8. Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K
    Nodular mesangial lesions, marked mesangiolysis, and fingerprint deposits of unknown origin in a patient with nephrotic syndrome : a unique combination of glomerular lesions.
    Clin Exp Nephrol 10:140-145
  9. Komatsuda A, Ohtani H, Wakui H, K.A.Chyzh., Hatakeyama T, Iwamoto K, Maki N, Kimura J, Hitomi J, Sawada K
    Increased serum levels of S100A12 in patients with MPO-ANCA-associated glomerulonephritis.
    Clin Nephrol 66:315-321
  10. Endoh, A., Ohtaka, M., Goto, T., Mikami, K., Watanabe, D., Miura, K., Ohshima, S., Yoneyama, K., Shibuya, T., Wakui, H., Komatsuda, A., Watanabe, S
    Decreased renal expressions of heat shock protein-72 and ?25 are associated with renal dysfunction in biliary cirrhotic rets.
    Hepatology Research 34:273-281
  11. Kawabata, Y., Hirokawa, M., Saitoh, Y., Kosugi, S., Yoshioka, T., Fujishima, M., Fujishima, N., Kameoka, Y., Saitoh, H., Kume, M., Takahashi, N., Sawada, K
    Late-onset fatal epstein-barr virus-associated hemophagocytic syndrome following cord blood cell transplantaion for adult acute lymphoblastic leukemia.
    Int J Hematol 84:445-448
  12. Fujishiama N, Hirokawa M, Fujishima M, Wada C, Toyoshima I, Watanabe S, Sawada K
    Oligoclonal T cell expansion in blood but not in the thymus from a patient with thymoma-associated pure red cell aplasia.
    Hematologica91:9-12

著書/総説

  1. 澤田賢一
    なんでも健康相談 「骨髄異形成症候群」で輸血を受けています
    NHKきょうの健康,日本放送出版協会2006.1.1 p125
  2. 涌井秀樹,小松田敦
    原発性糸球体疾患 微小変化型ネフローゼ症候群
    日本臨床64:408-412
  3. 廣川誠,澤田賢一
    慢性赤芽球癆 特集・難治性貧血?分子病態と治療戦略?
    最新医学61:22-28
  4. 澤田賢一
    再生不良性貧血・赤芽球癆の診断と治療
    臨床血液47(3)176-189
  5. 山口昭彦,佐藤美由紀,渡辺智子,相馬琢也,奥田哲士,小松田敦,涌井秀樹,澤田賢一
    定期健診の中から尿酸トランスポーター遺伝子解析より見出された腎性低尿酸血症の4例
    逓信医学58(2)48-53
  6. 澤田賢一,浦部晶夫,中尾眞二,別所正美,唐沢正光,石田陽治,小松則夫,増田道彦,廣川誠,茂木睦仁,小峰光博
    赤芽球癆診療の参照ガイド (厚生労働科学研究費補助金 難治性疾患克服研究事業 特発性造血障害に関する調査研究班 主任研究者 小峰光博)
    PRCAの診断基準と診療の参照ガイド作成のためのワーキンググループ
    臨床血液47(4)316-330
  7. 小杉成樹
    第2回認定内科専門医会東北支部教育セミナーまとめ
    症例:血球貪食症候群の1例
    内科専門医会誌17(3)367-384
  8. 今井裕一(委員長),石村英治,井関邦敏,井上亨,内田啓子,内田俊也,遠藤正之,大石哲也,大野岩男,岡田一義,小原まみ子,小山雄太,柏原直樹,加藤哲夫,鎌田貢壽,河田哲也,菅野義彦,北川渡,小松田敦,佐々木環,重松隆,篠田俊雄,柴垣有吾.須藤博,竹本文美,田村展一,南学正臣,西慎一,堅村信介,八田和大,早野恵子,平方秀樹,平和伸史,藤垣嘉秀,藤田芳郎,福本真也,松村正巳,宮崎正信,武曾恵理,守村敏樹,門川俊明,安田隆,山縣邦弘,山田明,吉田篤博,頼健光,渡辺毅(委員)
    腎臓専門医の研修単位認定のためのセルフトレーニング問題の正解と解説
    日本腎臓学会会誌48(8)別736-762

業績:2005年

原著論文

  1. Komatsuda, A., Maki, N., Wakui, H., Ohtani, H., Hatakeyama, T., Yasuda, T., Nakamoto, Y., Imai, H., Sawada, K
    Development of systemic λ-light chain amyloidosis in a patient with γ-heavy chain deposition disease during long-term follow-up.
    Nephrol Dial Transplant 20:434-437.
  2. Yoshioka , T., Miura, I., Kume, M., Takahashi, N., Okamoto, M., Ichinohasama, R., Yoshino, T., Yamaguchi, M., Hirokawa, M., Sawada, K., Nakamura, S
    Cytogenetic Features of de novo CD5-positive diffuse large B-cell lymphoma : chromosome aberrations affecting 8p21 and 11q13 constitute major subgroups with different overall survival.
    Genes, Chromosomes & Cancer 42:149-157.
  3. Okuyama, S., Komatsuda, A., Wakui, H., Kaneko, J., Masai, R., Ohtani, H., Komatsuda, A., Sawada, K
    Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with minimal-change nephritic syndrome.
    Nephrol Dial Transplant 20:539-544.
  4. Mori, M., Kitamura, K., Masuda, M., Hotta, T., Miyazaki, T., Miuta, A, B., Mizoguchi, H., Shibata, A., Saito, H., Matsuda, T., Masaoka,T., Harada, M., Niho, Y., Takaku, F., JGTLE.
    Long-term results of a multicenter randomized, comparative trial of modified CHOP versus THP-COP versus THP-COPE regiments in elderly patients with non-hodgkin’s lymphoma.
    Int J Hematol 81:246-254.
  5. Takahashi, N., Miura, I., Kobayashi, Y., Kume, M., Yoshioka, T., Otane, W., Ohtsubo, K., Takahashi, K., Kitabayashi, A., Kawabata, Y., Hirokawa, M., Nishijima, H., Ichinohasama, R., J, DeCoteau., Miura, A,B., Sawada, K. (2005)
    Fluorecence in situ hybridization monitoring of BCR-ABL-positive neutrophils in chronic-phase chronic myeloid leukemia patients during the primary stage of imatinib mesylate therapy.
    Int J Hematol 81:235-241
  6. Wakui H, Masai R, Okuyama S, Ohtani H, Komatsuda A, Toyoshima I, Watanabe S, Sawada K
    Development of lupus nephritis in a patient with human T-Cell lymphotropic virus type I-associated myelopathy.
    American J Kidney Diseases 46(2)25-29
  7. Fujishima, M., Hirokawa, M., Fujishima, N., Sawada, K
    TCRαβ repertoire diversity of human naturally occurring CD4+CD25+regulatory T cells.
    Imm Letters 99:193-197
  8. Tsuchiya, N., Ssaitoh, S., Narita, S., Shimoda, N., Matsuura, S., Ohyama, C., Sato, K., Kato, T., Ohtani, H., Komatsuda, A., Habuchi, T
    Successful renal transplantation in the right iliac fossa 2 years after serious deep venous thrombosis in a patient with systemic lupus erythematosus.
    Int J Urology 12:912-916
  9. Komatsuda A, Wakui H
    Nephronophthisis : difficulties and recent advancec in molecular genetic diagnostics.
    Clin Exp Nephrol 9:340-342

著書/総説

  1. 廣川誠,三浦偉久男,澤田賢一
    CLLの分子病態解明の進歩
    血液・腫瘍科51:237-241
  2. 涌井秀樹
    腎機能が週の単位で低下した症例に血痰が突然出現したが!?
    腎疾患を探る,編著者今井裕一,永井書店pp148-151
  3. 小松田敦
    上気道炎症後に全身の浮腫と体重増加がみられて受診したが?
    腎疾患を探る,編著者今井裕一,永井書店pp144-147
  4. 澤田賢一
    幹細胞・造血因子
    森眞由美編,高齢者の血液疾患,医薬ジャーナル社,pp22-35
  5. 小松田敦,澤田賢一
    リウマチ患者によくみられる合併疾患=診断と治療のコツ 貧血
    リウマチ科34(2)155-159
  6. 澤田賢一
    外来診療と治りにくい貧血への対応
    日本医事新報4256:1-6

業績:2004年

原著論文

  1. Okuyama S, Wakui H., Kaneko J., Masai R., Ohtani H., Komatsuda A., Sawada K
    49,XXXXY syndrome with unilateral renal aplasia, proteinuria, and venous thromboembolism.
    Intern Med 43:1186-1190.
  2. Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K., Imai H
    Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy.
    Nephrol Dial Transplant 19:574-579.
  3. Maki N, Komatsuda A, Wakui H, Oyama Y, Kodama T, Ohtani H, Kigawa A, Aiba N, Imai H, Motegi M, Yamaguchi A, Sawada K
    A nonsense mutation (R220X) in the α-galactosidase A gene causes typical Fabry disease in both genders.
    Clin Nephrol 61:185-190.
  4. Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K
    Immune complex-type glomerulonephritis with unusual giant deposits in a patients with active rheumatoid arthritis.
    Clin Exp Nephrol 8:63-67.
  5. Ichikawa Y, Hirokawa M, Aiba N, Fujishima N, Komatsuda A, Saitoh H, Kume M, Miura I, Sawada K
    Monitoring the expression profiles of Doxorubicin-Resistant K562 human leukemia cells by serial analysis of gene expression.
    Int J Haematol 79:276-282.
  6. Miyazaki T, Sagawa R, Honma T, Noguchi S, Harada T, Komatsuda A, Ohtani H, Wakui H, Sawada K, Otaka M, Watanabe S, Jikei M, Ogawa N, Hamada F, Itoh H
    73-kDa Molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
    J Biol Chem 279:17295-17300.
  7. Nishimura H, Hirokawa M, Fujishima N, Fujishima M, Miura I, Sawada K
    Contribution of complementarity-determining region 3 of the T-cell receptor Vδ2 chain to the recognition of aminobisphosphonates by human γδ T-cells.
    Int J Hematol 79:369-376.
  8. Fukaya H, W Xiao, Inaba K, Suzuki Y, Hirokawa M, Kawabata Y, Komatsuda A, Endo T, Kishimoto H, Takada G, Sawada K
    Codevelopment of dendritic cells along with erythroid differentiation from human CD34+ cells by tumor necrosis factor-α.
    Experimental Hematology 32:450-460.
  9. Maki, N., Komatsuda, A., Wakui, H., Ohtani, H., Kigawa, A., Aiba, N., Hamai, K., Motegi, M., Yamaguchi, A., Imai, H., Sawada, K
    Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome.
    Nephrol Dial Transplant 19:1761-1766.
  10. Fujishima N, Hirokawa M, Ishikawa H, Fujishima M, Kume M, Miura I, Sawada K
    May-Hegglin anomaly developing myelodysplasia and acute myeloid leukemia.
    Int J Hematol 79:505-506.
  11. Kimura H, Komatsuda A, Sawada K, Mimori A, Baba S, Minota S
    Rapidly progressed secondary amyloidosis in a patient with mixed connective tissue disease.
    Intern Med 43(9)878-882.
  12. Fujishima N, Hirokawa M, Aiba N, Ichikawa Y, Fujishima M, Komatsuda A, Suzuki Y, Kawabata Y, Miura I, Sawada K
    Gene expression profiling of human erythroid progenitors by Micro-Serial analysis of gene expression.
    Int J Hematol 80:239-245.
  13. Kigawa, A., Wakui, H., Maki, N., Okuyama, S., Masai, R., Ohtani, H., Komatsuda, A., Suzuki, D., Toyoda, M., Kobayashi, R., Sawada, K
    Interaction of the spectrin-like repeats of alpha-actinin-4 with human peptide.
    Clin Exp Nephrol 8:331-338.
  14. Koizumi K, Fujimoto K, Haseyama Y, Endo T, Nishio M, Yokota K, Itoh T, Sawada K, Koike T
    Effective high- dose chemotherary combined with CD34+-selected peripheral blood stem cell transplantation in a patient with cutaneous involvement of nasal NK/T-cell lymphoma.
    Eur J Haematol 72(2)140-144

著書/総説/セミナー

  1. 澤田賢一,小松田敦,廣川誠
    自己免疫疾患に対する造血幹細胞移植
    血液フロンティア14(9)77-84.
  2. 小松田敦
    腎型ファブリー病.症例T;αガラクトシダーゼ遺伝子のナンセンス変異(R220X)により発症したファブリー病の1家系
    ファブリー病,基礎から臨床までの最近の知見.衛藤義勝編,ブレーン出版,東京,pp128-132.
  3. 三浦偉久男
    血球のクローン性。新しい診断と治療のABC19,骨髄異形成症候群,第2章 骨髄異形成症候群の病理・病態生理
    最新医学,pp43-50.
  4. 澤田賢一
    樹状前駆細胞と自己造血前駆細胞のinteraction
    秋田医誌55:1-11.
  5. 廣川誠
    アポトーシス感受性機構
    生体の科学55(5)448-449
  6. 小松田敦,澤田賢一,涌井秀樹,大谷浩
    エリスロポエチン抵抗性腎性貧血における造血抑制因子:赤芽球形前駆細胞を用いた検討.
    腎性貧血治療研究会 平成15年度研究報告集48-49.
  7. 澤田賢一
    鉄欠乏性貧血
    血液の事典,朝倉書店初版,pp66-67.
  8. 澤田賢一
    自家末梢血幹細胞移植を併用した悪性リンパ腫の集学的治療.
    エントーニ41 全日本病院出版会41:57-65.
  9. 廣川誠
    同種造血幹細胞移植後の免疫再構築におけるT-cell peripheral expansionの役割
    第2回先端血液学セミナー,6月,東京
  10. 小松田敦
    腎型ファブリー病.症例T;αガラクトシダーゼ遺伝子のナンセンス変異(R220X)により発症したファブリー病の1家系.
    ファブリー病,基礎から臨床までの最近の知見.衛藤義勝編,ブレーン出版,東京,pp128-132.
  11. 廣川誠,三浦偉久男,澤田賢一
    造血器疾患 GVHD
    日本臨床62(5)478-481.