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α2受容体作動薬の麻酔・鎮痛効果についての基礎・臨床研究

α2-アドレナリン受容体作動薬に関する業績

  • Horikoshi Y, Kimura T, Nishikawa T, Horiguchi T, Sato K, Ohbuchi M: Neuroprotecitve effects of combination of dexmedetomidine and hypothermia after asphyxia cardiac arrest in rats. Japanese Journal of Reanimatology 2015; 34:14-21.
  • 木村哲, 西川俊昭: 6 α2受容体アゴニスト, E.鎮痛補助薬, I 身体的苦痛に対する薬物療法. 「誰にでも理解できる緩和ケアの実践書」, 花岡一雄編, 131-138頁, 克誠堂出版, 東京, 2015.
  • 合谷木徹: 第Ⅱ章 麻酔前投薬としての有用性, 第2節 鎮痛効果.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 65-70頁, 克誠堂出版, 東京, 2012.
  • 合谷木徹: 第Ⅱ章 麻酔前投薬としての有用性, 第4節 麻酔薬必要量の減少作用.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 74-79頁, 克誠堂出版, 東京, 2012.
  • 西川俊昭: 第Ⅲ章 全身麻酔における有用性と留意点, 第1節 麻酔補助効果 –鎮静•鎮痛作用-.第2節 循環安定化作用. 第3節 虚血性心疾患における利点. 第4節 うっ血性心不全における利点. 第5節 呼吸への影響. 第6節 内分泌への影響. 第7節 代謝•消化管運動への影響. 第8節 脳循環•頭蓋内圧•眼内圧への影響. 第9節 利尿作用. 第10節 薬物代謝への影響. 第11節 筋弛緩効果への影響. 第12節 麻酔覚醒への影響. 第13節 制吐作用•シバリング防止効果•咳嗽抑制効果. 第14節 離脱•退薬症状. 第15節 副作用と留意点 –低血圧、徐脈、伝導障害など-.第16節 投与経路.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 99-161頁, 克誠堂出版, 東京, 2012.
  • 西川俊昭: 第Ⅳ章 心血管薬との相互作用, 第1節 はじめに.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 165-166頁, 克誠堂出版, 東京, 2012.
  • 西川俊昭: 第Ⅳ章 心血管薬との相互作用, 第3節 副交感神経遮断薬との相互作用. 第4節 血管拡張薬との相互作用.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 177-180頁, 克誠堂出版, 東京, 2012.
  • 西川俊昭: 第Ⅴ章 硬膜外麻酔における有用性と留意点, 第1節 局所麻酔薬の代謝への影響. 第2節 鎮静作用. 第3節 鎮痛作用. 第4節 循環への影響. 第5節 呼吸への影響. 第6節 全身麻酔の補助効果•循環安定化作用. 第7節 制吐作用•シバリング防止効果.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 183-207頁, 克誠堂出版, 東京, 2012.
  • 合谷木徹: 第Ⅶ章 術後急性痛における有用性と留意点, 第1節 局所麻酔薬の代謝への影響. 第2節 硬膜外投与による鎮痛効果. 第3節 くも膜下投与による鎮痛作用.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 243-266頁, 克誠堂出版, 東京, 2012.
  • 西川俊昭: 第XI章 危機的病態における有用性と留意点, 第1節 低酸素症•高二酸化炭素症における作用. 第2節 頭蓋内圧亢進症における作用.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 321-330頁, 克誠堂出版, 東京, 2012.
  • 木村哲: 第XI章 危機的病態における有用性と留意点, 第3節 虚血性脳傷害の軽減効果.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 331-339頁, 克誠堂出版, 東京, 2012.
  • 西川俊昭: 第XI章 危機的病態における有用性と留意点, 第5節 麻薬•アルコール中毒からの離脱における効用.「麻酔•疼痛管理•集中治療領域におけるα2受容体作動薬」, 西川俊昭編, 346頁, 克誠堂出版, 東京, 2012.
  • Kudo R, Horiguchi T, Nishikawa T: Diuretic effect of oral clonidine premedication during hypotensive anesthesia. Circulation Control 2011;32:172-180.
  • Nakajima M, Horiguchi T, Nishikawa T: Effects of oral clonidine premedication on the hypotensive response to nicardipine during isoflurane and nitrous oxide anesthesia. Circulation Control 2011;32:32-37.
  • Sato K, Kimura T, Nishikawa T, Tobe Y, Masaki Y: Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats.  Acta Anaesthesiologica Scandinavica 2010; 54:377-382.
  • Goyagi T, Nishikawa T, Tobe Y, Masaki Y: The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica 2009; 53:1176-1183.
  • Kumagai M, Horiguchi T, Nishikawa T, Masaki Y, Tobe Y: Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats. Anesthesia and Analgesia 2008, 107: 643-647.
  • Kimura T, Sato K, Nishikawa T, Tobe Y, Masaki Y: Effects of mivazerol, an α2-agonist, on striatal norepinephrine concentration during transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica 2008; 52: 997-1002.
  • Kimura T, Sato K, Nishikawa T, Tobe Y, Masaki Y: Small dose of dexmedetomidine, an alpha2-agonist, does not enhance the neuroprotective effects of mild hypothermia after transient forebrain ischemia in rats. Akita Journal of Medicine 2007; 34: 185-198.
  • Kimura T, Sato M, Nishikawa T, Tanaka M, Tobe Y, Masaki Y: Neuroprotective effect of mivazerol, an α2-agonist, after transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica 2005; 49: 1117-1123.
  • 西川俊昭 : α2受容体作動薬の麻酔前投与. Anesthesia 21 Century 2002; 4: 719-723.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces propofol requirement for laryngeal mask airway insertion. Canadian Journal of Anesthesia 2000; 47: 627-630.
  • 合谷木徹, 西川俊昭: α2-アゴニスト(クロニジン)とオピオイドの相互鎮痛効果. 臨床麻酔 2000; 24: 7-15.
  • Handa F, Tanaka M, Nishikawa T, Toyooka H: Effects of oral clonidine premedication on side effects of intravenous ketamine anesthesia: a randomized, double-blind, placebo-controlled study. Journal of Clinical Anesthesia 2000; 12: 19-24.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces induction dose and prolongs awakening time from propofol-nitrous oxide anesthesia. Canadian Journal of Anesthesia 1999; 46: 894-896.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances postoperative analgesia by epidural morphine. Anesthesia and Analgesia 1999; 89: 1487-1471.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces the awakening concentration of isoflurane. Anesthesia and Analgesia 1998; 86: 410-413.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances the pressor response to ephedrine during spinal anesthesia.  Anesthesia and Analgesia 1998; 87: 1136-1139.
  • Kimura T, Tanaka M, Nishikawa T: Effects of oral clonidine on heart rate changes after neostigmine-atropine administration.  Anesthesiology 1998; 88: 1507-1510.
  • Takahashi H, Nishikawa T, Mizutani T, Handa F: Oral clonidine premedication decreases energy expenditure in human volunteers. Canadian Journal of Anaesthesia 1997; 44: 268-272.
  • Tanaka M, Nishikawa T, Takahashi S, Matsumiya N: Oral clonidine premedication does not alter the efficacy of epidural test doses in adult patients anesthetized with isoflurane. Journal of Anesthesia 1997; 11: 88-93.
  • Tanaka M, Nishikawa T: Oral clonidine premedication does not alter the efficacy of simulated intravenous test dose containing low dose epinephrine in awake volunteers. Anesthesiology 1997; 87: 285-288.
  • 西川俊昭, 土肥修司: 臨床麻酔におけるα2-アドレナリン受容体作動薬の有用性と使用上の問題点.  II. 伝達麻酔における効果および鎮痛作用について.   麻酔 1997; 46: 64-72.
  • Kimura T, Nishikawa T, Sato K, Wada K: Oral clonidine reduces thiamylal requirement for anesthesia induction in adults.  Journal of Anesthesia 1996; 10:1-4.
  • Tanaka M, Nishikawa T: Enhancement of pressor response to ephedrine following clonidine medication.  Anaesthesia 1996; 51:123-127.
  • Nishikawa T, Naito H: Clonidine modulation of hemodynamic and catecholamine responses to hypoxia or hypercapnia.  Anesthesiology 1996; 84:672-685.
  • Goyagi T, Nishikawa T: Oral clonidine premedication enhances the quality of postoperative analgesia by intrathecal morphine.  Anesthesia and Analgesia 1996; 82:1192-1196.
  • Nishikawa T, Satsumae T, Uemura A, Hoshi T: Oral clonidine medication partially suppresses transient pressor response to a rapid increase in isoflurane concentration.  Circulation Control 1996; 17:368-373.
  • Nishikawa T, Tajima K, Kimura T, Satsumae T: Hemodynamic effects of oral clonidine premedication in lumbar epidural anesthesia.  Journal of Anesthesia 1996; 10:248-251.
  • 西川俊昭, 土肥修司 : 臨床麻酔におけるα2-アドレナリン受容体作動薬の有用性と使用上の問題点.  1. 麻酔前投薬, 麻酔補助効果および循環作用について.  麻酔 1996; 45: 1490-1502.
  • Tanaka M, Nishikawa T: Effects of clonidine premedication on the pressor response to α-adrenergic agonists. British Journal of Anaesthesia 1995; 75:593-597.
  • Takahashi H, Nishikawa T: Oral clonidine does not alter vecuronium neuromuscular blockade in anaesthetized patients.  Canadian Journal of Anaesthesia 1995; 42:511-515.
  • Anzai Y, Nishikawa T: Thoracic epidural clonidine and morphine for postoperative analgesia.  Canadian Journal of Anaesthesia 1995; 42:292-297.
  • Inomata S, Nishikawa T, Kihara S, Akiyoshi Y: Enhancement of pressor response to intravenous phenylephrine following oral clonidine medication in awake and anaesthetized patients.  Canadian Journal of Anaesthesia 1995; 42:119-125.
  • Tanaka M, Nishikawa T: Oral clonidine premedication attenuates the hypertensive response to ketamine.  British Journal of Anaesthesia 1994; 73:758-762.
  • Hamaya Y, Nishikawa T, Dohi S: Diuretic effects of clonidine during isoflurane, nitrous oxide, and oxygen anesthesia.  Anesthesiology 1994; 81:811-819.
  • Nishikawa T, Goyagi T, Kimura T, Dai M, Naito H: Oral clonidine preanaesthetic medication does not alter plasma lidocaine elimination during epidural anaesthesia in lightly anaesthetized patients. Canadian Journal of Anaesthesia 1992; 39:521-522.
  • Nishikawa T, Dohi S: Oral clonidine blunts the heart rate response to intravenous atropine in humans. Anesthesiology 1991; 75:217-222.
  • Nishikawa T, Kimura T, Taguchi N, Dohi S: Oral clonidine preanesthetic medication augments the pressor responses to intravenous ephedrine in awake or anesthetized patients.  Anesthesiology 1991; 74:705-710.
  • Nishikawa T, Dohi S: Clinical evaluation of clonidine added to lidocaine solution for epidural anesthesia. Anesthesiology 1990; 73:853-859.

脳脊髄虚血に対する薬物効果に関する基礎研究

脳脊髄虚血・脳脊髄循環・脳神経機能に関する業績

  • 西川俊昭: 第XII部各論・麻酔管理, 第19章合併症, A電解質異常. 「神経麻酔」, 内野博之, 川口昌彦編, 337-339頁, 克誠堂, 東京, 2016.
  • 西川俊昭: 第ⅩⅡ部各論・麻酔管理, 第19章合併症, B静脈空気塞栓症. 「神経麻酔」, 内野博之, 川口昌彦編, 340-342頁, 克誠堂, 東京, 2016.
  • 西川俊昭: 第6章麻酔と脳神経機能.「麻酔科学レビュー2016」, 澄川耕二, 岩崎寛監修, 36-41頁, 総合医学社, 東京, 2016.
  • Horikoshi Y, Kimura T, Nishikawa T, Horiguchi T, Sato K, Ohbuchi M: Neuroprotecitve effects of combination of dexmedetomidine and hypothermia after asphyxia cardiac arrest in rats. Japanese Journal of Reanimatology 2015; 34:14-21.
  • 西川俊昭: 第7章麻酔と脳神経機能.「麻酔科学レビュー2015」, 天羽敬祐監修, 42-46頁, 総合医学社, 東京, 2015.
  • 西川俊昭: 第Ⅱ部麻酔管理, 第11章各科手術の麻酔, D脳神経外科手術の麻酔. 「TEXT 麻酔・蘇生学」第4版, 土肥修司, 澄川耕二編, 265-271頁, 南山堂, 東京, 2014.
  • 西川俊昭: 第7章麻酔と脳神経機能.「麻酔科学レビュー2014」, 天羽敬祐監修, 43-47頁, 総合医学社, 東京, 2014.
  • 西川俊昭: 周術期における脳傷害の原因と防止策. 秋田県医師会雑誌 2013; 64: 1-19.
  • Nagasaki G, Horiguchi T, Nishikawa T, Masaki Y, Tobe Y: Long-term effects of post-ischaemic oestrogen on brain injury in a rat forebrain ischaemia model. Acta Anaesthesiologica Scandinavica 2013; 57:1245-1252.
  • 西川俊昭: 第7章麻酔と脳神経機能.「麻酔科学レビュー2013」, 天羽敬祐監修, 42-45頁, 総合医学社, 東京, 2013.
  • Kimura T, Nishikawa T: A biomarker panel: an additional resource in acute stroke evaluation? (Editorial) Minerva Anesthesiologica 2013; 79:711-712.
  • Goyagi T, Tobe Y, Nishikawa T: Long-term and spatial memory effects of selective β-1-antagonist after transient focal ischaemia in rats. British Journal of Anaesthesia 2012; 109: 399-406.
  • 西川俊昭: 1.脳循環, III.臓器循環の構造,機能,病態. 「周術期循環管理」, 澄川耕二編, 59-80頁, 克誠堂出版, 東京, 2011.
  • 木村哲, 西川俊昭: 周術期の新しい臓器保護戦略「Rhoキナーゼ阻害薬と臓器保護」. 日本臨床麻酔学会誌 2011; 31: 124-133.
  • Goyagi T, Nishikawa T, Tobe Y: Neuroprotective effects and suppression of ischemia-induced glutamate elevation by β1-adrenoreceptor antagonists administered before transient focal ischemia in rats. Journal of Neurosurgical Anesthesiology 2011;23:131-137.
  • 合谷木徹, 西川俊昭: 選択的β遮断薬の局所脳虚血保護効果. 蘇生2010; 29: 17-22.
  • Goyagi T, Horiguchi T, Nishikawa T, Tobe Y: Post-treatment with selective beta1 adrenoceptor antagonists provides neuroprotection against transient focal ischemia in rats. Brain Research 2010; 1343:213-217.
  • Umehara S, Goyagi T, Nishikawa T, Tobe Y, Masaki Y: Esmolol and landiolol, selective β-1-adrenoreceptor antagonists, provide neuroprotection against spinal cord ischemia and reperfuison in rats. Anesthesia and Analgesia 2010; 110:1133-1137.
  • Sato K, Kimura T, Nishikawa T, Tobe Y, Masaki Y: Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats.  Acta Anaesthesiologica Scandinavica 2010; 54:377-382.
  • 西川俊昭: 新しい循環系モニタリング – その有用性と限界 -「脳灌流指標:局所脳酸素飽和度(NIRS, INVOSTM )」. 麻酔 2009; 58: 866-871.
  • 西川俊昭: 各種麻酔中の危機管理「脳神経外科手術」. 麻酔 2009; 58: 545-551.
  • Goyagi T, Nishikawa T, Tobe Y, Masaki Y: The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica 2009; 53:1176-1183.
  • Kimura T, Sato K, Nishikawa T, Tobe Y, Masaki Y: Effects of mivazerol, an α2-agonist, on striatal norepinephrine concentration during transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica 2008; 52: 997-1002.
  • Kimura T, Sato K, Nishikawa T, Tobe Y, Masaki Y: Small dose of dexmedetomidine, an alpha2-agonist, does not enhance the neuroprotective effects of mild hypothermia after transient forebrain ischemia in rats. Akita Journal of Medicine 2007; 34: 185-198.
  • Goyagi T, Kimura T, Nishikawa T, Tobe Y, Masaki Y: β-Adrenoreceptor antagonists attenuate brain injury following transient focal ischemia in rats.   Anesthesia and Analgesia 2006; 103: 658-663.
  • Kimura T, Sato M, Nishikawa T, Tanaka M, Tobe Y, Masaki Y: Neuroprotective effect of mivazerol, an α2-agonist, after transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica 2005; 49: 1117-1123.
  • Goyagi T, Bhardwaj A, Koehler RC, Traystman RJ, Hurn PD, Kirsch JR: Potent σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats. Anesthesia and Analgesia 2003; 96:532-538.
  • Goyagi T, Toung TJK, Kirsch JR, Traystman RJ, Koehler RC, Hurn PD, and Bhardwaj A: Neuroprotective κ-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke 2003; 34:1533-1538.
  • Geocadin RG, Sherman DL, Christian H, Kimura T, Niedermyer E, Thakor NV, Hanley DF: Neurological recovery by EEG bursting after resuscitation from cardiac arrest in rats. Resuscitation 2002; 55:193-200.
  • Muthuswamy J, Kimura T, Ding MC, Geocadin R, Hanley DF, Thakor NV: Vulnerability of the thalamic somatosensory pathway after prolonged global hypoxic-ischemic injury. Neuroscience 2002; 115:917-929.
  • Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, Hurn PD: Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.  Stroke 2002; 33:1677-1684.
  • Goyagi T, Goto S, Bhardwaj A, Dawson VL, Hurn PD, Kirsch JR: Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production. Stroke 2001; 32:1613-1620.
  • Geocadin RG, Ghodadra R, Kimura T, Lei H, Sherman DL, Hanley DF, Thakor NV: A novel quantitative EEG injury measure of global cerebral ischemia. Clinical Neurophysiology 2000; 111: 1779-1787.
  • Terada H, Ohta S, Nishikawa T, Mizunuma T, Iwasaki Y, Masaki Y: The effect of intravenous or subarachnoid lidocaine on glutamate accumulation during transient forebrain ischemia in rats. Anesthesia and Analgesia 1999; 89: 957-961.
  • Miyabe M, Kirsch JR, Nishikawa T, Koehler RC, Traystman RJ: Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats. Critical Care Medicine 1997; 25: 1037-1043.
  • Ulatowski JA, Bucci E, Nishikawa T, Razynska A, Williams MA, Takeshima R, Traystman RJ, Koehler RC: Cerebral O2 transport with hematocirt reduced by cross-linked hemoglobin transfusion.   American Journal of Physiology 1996; 270, H466-H475.
  • Ulatowski JA, Nishikawa T, Matheson-Urbaitis B, Bucci E, Traystman RJ, Koehler RC: Regional blood flow alterations after bovine fumaryl ββ-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition. Critical Care Medicine 1996; 24,558-565.
  • Nishikawa T, Kirsch JR, Koehler RC, Miyabe M, Traystman RJ: Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats.  Stroke 1994; 25:2258-2264.
  • Nishikawa T, Kirsch JR, Koehler RC, Miyabe M, Traystman RJ: Nitric oxide synthase inhibition reduces caudate injury following transient focal ischemia in cats.  Stroke 1994; 25:877-885.
  • Nishikawa T, Kirsch JR, Koehler RC, Bredt DS, Snyder SM, Traystman RJ: Effect of nitric oxide synthase inhibition on cerebral blood flow and injury volume during focal ischemia in cats.  Stroke 1993; 24:1717-1724.
  • Nishikawa T, Dohi S: Haemodynamic and cerebral blood flow alterations after reduction of increased cerebrospinal fluid pressure in dogs.  Canadian Journal of Anaesthesia 1991; 38:234-238.
  • Nishikawa T, Namiki A: The effects of verapamil on cerebrospinal fluid pressure in surgical patients.  Journal of Anesthesia 1987; 1:132-136.
  • Nishikawa T, Omote K, Namiki A, Takahashi T: The effects of nicardipine on cerebrospinal fluid pressure in humans.  Anesthesia and Analgesia 1986; 65:507-510.

術後鎮痛法に関する臨床研究

術後鎮痛に関する業績

  • Imai Y, Imai K, Kimura T, Horiguchi T, Goyagi T, Saito H, Sato Y, Motoyama S, Nishikawa T, Minamiya Y: Evaluation of postoperative pregabalin for attenuation of postoperative shoulder pain after thoracotomy in patients with lung cancer, a preliminary result. General Thoracic and Cardiovascular Surgery 2015; 63:99-104.
  • Nitta R, Goyagi T, Nishikawa T: Combination of oral clonidine and intravenous low-dose ketamine reduces the consumption of postoperative patient-controlled analgesia morphine after spine surgery. Acta Anaesthesiologica Taiwanica 2013; 51:14-17.
  • Komatsu H, Matsumoto S, Mitsuhata H: Comparison of patient-controlled epidural analgesia with and without night-time infusion following gastrectomy. British Journal of Anaesthesia 2001; 87:633-635.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances postoperative analgesia by epidural morphine. Anesthesia and Analgesia 1999; 89: 1487-1491.
  • Komatsu H, Matsumoto S, Mitsuhata H, Abe K, Toriyabe S: Comparison of patient-controlled epidural analgesia with and without background infusion after gastrectomy.  Anesthesia and Analgesia 1998; 87:907-910.
  • Tanaka M, Watanabe S, Matsumiya N, Okada M, Kondo T, Takahashi S: Enhanced pain management for post-gastrectomy patients with combined epidural morphine and fentanyl. Canadian Journal of Anaesthesia 1997: 25:615-620.
  • Goyagi T, Nishikawa T: Oral clonidine premedication enhances the quality of postoperative analgesia by intrathecal morphine.  Anesthesia and Analgesia 1996; 82:1192-1196.
  • Goyagi T, Nishikawa T: The addition of epinephrine enhances postoperative analgesia by intrathecal morphine.   Anesthesia and Analgesia 1995; 81:508-513.
  • Anzai Y, Nishikawa T: Thoracic epidural clonidine and morphine for postoperative analgesia.  Canadian Journal of Anaesthesia 1995; 42:292-297.
  • Tanaka M, Watanabe S, Naito H: Comparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia.  Journal of Anesthesia 1994; 8:150-153.
  • Tanaka M, Watanabe S, Ashimura H, Akiyoshi Y, Nishijima Y, Sato S, Naito H: Minimum effective combination dose of epidural morphine and fentanyl for posthysterectomy analgesia: a randomized, prospective, double-blind study.  Anesthesia and Analgesia 1993; 942-946.
  • Tanaka M, Watanabe S, Endo T, Okane M, Hamaya Y: Combination of epidural morphine and fentanyl for postoperative analgesia.  Regional Anesthesia 1991; 16:214-217.

麻酔薬及び麻酔補助薬が呼吸循環に及ぼす影響についての基礎・臨床研究

循環に関する業績

  • Sato T, Horiguchi T, Nishikawa T: Sevoflurane-nitrous oxide anesthesia attenuates the heart rate response to intravenous isoproterenol infusion. Circulation Control 2015; 36:179-184.
  • 長崎剛, 西川俊昭: 5.ジソピラミド, 3-3抗不整脈薬, 3章 全身麻酔薬. 「麻酔科医のための周術期の薬物使用法」, 川真田樹人編, 251-253頁, 中山書店, 東京, 2015.
  • 長崎剛, 西川俊昭: 7.ジギタリス, 3-3抗不整脈薬, 3章 全身麻酔薬. 「麻酔科医のための周術期の薬物使用法」, 川真田樹人編, 256-257頁, 中山書店, 東京, 2015.
  • Adachi M, Horiguchi T, Nishikawa T: Landiolol, an ultra-short acting β1-adrenoreceptor antagonist, for treatment of an abrupt tachycardia in patient undergoing total knee arthroplasty under general anesthesia. Circulation Control 2012; 33: 104-111.
  • Kudo R, Horiguchi T, Nishikawa T: Diuretic effect of oral clonidine premedication during hypotensive anesthesia. Circulation Control 2011; 32: 172-180.
  • Nakajima M, Horiguchi T, Nishikawa T: Effects of oral clonidine premedication on the hypotensive response to nicardipine during isoflurane and nitrous oxide anesthesia. Circulation Control 2011; 32: 32-37.
  • Kumagai M, Horiguchi T, Nishikawa T, Masaki Y, Tobe Y: Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats. Anesthesia and Analgesia 2008, 107: 643-647.
  • Umehara S, Tanaka M, Nishikawa T: Effects of sevoflurane anesthesia on carotid-cardiac baroreflex responses in humans. Anesthesia and Analgesia 2006; 102: 38-44.
  • Goyagi T, Tanaka M, Nishikawa T: Landiolol attenuates the cardiovascular response to tracheal intubation. Journal of Anesthesia 2005; 19: 282-286.
  • Nagata H, Horiguchi T, Enzan K, Nishikawa T, Suzuki K: Inhibition of poly (ADP-ribose) synthetase improves pulmonary arterial endothelium-dependent relaxation after ischemic-reperfusion injury of splanchnic artery in rats.   Anesthesia and Analgesia 2005; 101: 1799-1804.
  • Tanaka M, Nishikawa T: The concentration-dependent effects of general anesthesia on spontaneous baroreflex indices and their correlations with pharmacological gains. Anesthesia and Analgesia 2005; 100: 1325-1332.
  • Sato M, Tanaka M, Umehara S, Nishikawa T: Baroreflex control of heart rate during and after propofol infusion in humans. British Journal of Anaesthesia 2005; 94: 577-581.
  • Tanaka M, Nishikawa T : Effects of nitrous oxide on baroreflex gain and heart rate variability. Acta Anaesthesiologica Scandinavica 2004; 48: 1163-1167.
  • Tanaka M, Goyagi T, Kimura T, Nishikawa T: The effects of cervical and lumbar epidural anesthesia on heart rate variability and spontaneous sequence baroreflex sensitivity. Anesthesia and Analgesia 2004; 99: 924-929.
  • Tanaka M, Kimura T, Goyagi T, Nishikawa T: Gender differences in baroreflex response and heart rate variability in anaesthetized humans. British Journal of Anaesthesia 2004; 92: 831-835.
  • Tanaka M, Nishikawa T: Hemodilution does not alter arterial baroreflex control of heart rate in anesthetized dogs. Anesthesia and Analgesia 2003; 96: 28-32.
  • Horiguchi T, Nishikawa T: Propofol-nitrous oxide anesthesia enhances the heart rate response to intravenous isoproterenol infusion. Anesthesia and Analgesia 2003; 96:132-135.
  • Tanaka M, Sato M, Umehara S, Nishikawa T: Influence of menstrual cycle on baroreflex control of heart rate: comparison with male volunteers. American Journal of Physiology Regulatory Integrative and Comparative Physiology 2003; 285: R1091-R1097.
  • 西川俊昭: 心拍出量測定上の諸問題. Cardiovascular Anesthesia 2002; 6: 63-65.
  • Kimura T, Tanaka M, Nishikawa T: Comparison of heart rate changes after neostigmine-atropine administrations during recovery from propofol-N2O and isoflurane-N2O anesthesia. Journal of Anesthesia 2002; 16:23-27.
  • Horiguchi T, Nishikawa T: Heart rate response to intravenous atropine during propofol anesthesia. Anesthesia and Analgesia 2002; 95:389-392.
  • Boardman A, Schlindwein FS, Thakor NV, Kimura T, Geocadin RG: Detection of asphyxia using heart rate variability. Medical and Biological Engineering and Computing 2002; 40:618-624.
  • Tanaka M, Nagasaki G, Nishikawa T: Moderate hypothermia depresses arterial baroreflex control of heart rate during, and delays its recovery after, general anesthesia in humans. Anesthesiology 2001; 95:51-55.
  • Nagasaki G, Tanaka M, Nishikawa T: The recovery profile of baroreflex control of heart rate after isoflurane or sevoflurane anesthesia in humans.  Anesthesia and Analgesia 2001; 93:1127-1131.
  • Tanaka M, Nishikawa T: Arterial baroreflex function in humans anaesthetized with sevoflurane. British Journal of Anaesthesia 1999; 82:350-354.
  • Tanaka M, Nishikawa T: Sevoflurane speeds recovery of baroreflex control of heart rate after minor surgical procedures compared with isoflurane.  Anesthesia and Analgesia 1999; 89:284-289.
  • Tanaka M, Ishikawa T, Nishikawa T, Goto K, Sato S: Influence of acidosis on cardiotonic effects of milrinone. Anesthesiology 1998; 88:725-734.
  • Kimura T, Tanaka M, Nishikawa T: Effects of oral clonidine on heart rate changes after neostigmine-atropine administration.  Anesthesiology 1998; 88: 1507-1510.
  • Komatsu H, Enzan K, Matsuura S, Kurosawa S, Mitsuhata H: Systemic hypotensive response to protamine following chronic inhibition of nitric oxide synthase in rats.  Canadian Journal of Anaesthesia 1998; 45:1186-1189.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances the pressor response to ephedrine during spinal anesthesia.  Anesthesia and Analgesia 1998; 87: 1136-1139.
  • Tanaka M, Nishikawa T: Acute haemodynamic effects of sodium bicarbonate administration in respiratory and metabolic acidosis in anaesthetized dogs. Anaesthesia and Intensive Care 1997; 25:615-620.
  • Taguchi N, Nishikawa T, Inomata S, Taguchi M, Yamashita S, Naito H: Hemodynamic effects of intravenous ephedrine in infants and children anesthetized with halothane and nitrous oxide.  Anesthesia and Analgesia 1996; 82:568-573.
  • Tanaka M, Nishikawa T, Mizutani T: Normovolaemic haemodilution attenuates cardiac depression by sodium bicarbonate in canine metabolic acidosis. British Journal of Anaesthesia 1996; 77:408-412.
  • Tanaka M, Nishikawa T: Enhancement of pressor response to ephedrine following clonidine medication.  Anaesthesia 1996; 51:123-127.
  • Nishikawa T, Naito H: Clonidine modulation of hemodynamic and catecholamine responses to hypoxia or hypercapnia.  Anesthesiology 1996; 84:672-685.
  • Horiguchi T, Enzan K, Kawamura K, Suzuki M: Pulmonary responses to heparin-protamine complexes: the effects of age and species.  Journal of Applied Physiology 1996; 80:56-61.
  • Yanase T, Enzan K, Mitsuhata H, Horiguchi T: Dibutyryl cAMP improves systemic vasoconstriction caused by endotoxin in dogs.  Shock 1996; 5:284-288.
  • Horiguchi T, Enzan K, Mitsuhata M, Murata M, Suzuki M: Heparin-protamine complexes cause pulmonary hypertension in goats.  Anesthesiology 1995; 83:786-791.
  • Inomata S, Nishikawa T, Kihara S, Akiyoshi Y: Enhancement of pressor response to intravenous phenylephrine following oral clonidine medication in awake and anaesthetized patients.  Canadian Journal of Anaesthesia 1995; 42:119-125.
  • Naganuma T, Nishikawa T, Nakayama H, Yaguchi Y, Naito H: Comparative hemodynamic responses to intravenous ephedrine during halothane, enflurane, or isoflurane anesthesia.  Circulation Control 1995; 16:533-537.
  • Ulatowski JA, Koehler RC, Nishikawa T, Traystman RJ, Razynka A, Kwansa H, Urbaitis B, Bucci E: Role of nitric oxide scavenging in peripheral vasoconstrictor response to ββ cross-linked hemoglobin.  Artificial Cells Blood Substitutes Immobilization Biotechnology 1995; 23:263-269.
  • Nishikawa T, Tanaka M, Naganuma T, Naito H: Determinants for the pressor effect of ephedrine in awake or anesthetized humans: effects of age, general anesthesia, or basal blood pressure.   Circulation Control 1995; 16:212-217.
  • Tanaka M, Nishikawa T: Effects of clonidine premedication on the pressor response to α-adrenergic agonists. British Journal of Anaesthesia 1995; 75:593-597.
  • Inomata S, Nishikawa T, Taguchi M: Continuous monitoring of mixed venous oxygen saturation for detecting alterations in cardiac output after discontinuation from cardiopulmonary bypass.   British Journal of Anaesthesia 1994; 72:11-16.
  • Tanaka M, Dohi S: Effects of phenylephrine and ephedrine on pulmonary arterial pressure in patients with cervical or lumbar epidural anesthesia, or enflurane anesthesia.  Journal of Anesthesia 1994; 8:125-131.
  • Tanaka M, Nishikawa T: Oral clonidine premedication attenuates the hypertensive response to ketamine.  British Journal of Anaesthesia 1994; 73:758-762.
  • Nishikawa T, Dohi S: Errors in the measurement of cardiac output by thermodilution.  Canadian Journal of Anaesthesia 1993; 40:142-153.
  • Nishikawa T: Acute haemodynamic effect of sodium bicarbonate in canine respiratory or metabolic acidosis.   British Journal of Anaesthesia 1993; 70:196-200.
  • Nishikawa T: Haemodynamic changes associated with thermodilution cardiac output determination in canine acute blood loss or endotoxaemia.  Acta Anaesthesiologica Scandinavica 1993; 37:602-606.
  • Nishikawa T, Dohi S: Hemodynamic changes associated with thermodilution cardiac output determination during metabolic acidosis or hypoxic hypoxia in dogs.  European Journal of Anaesthesia 1993; 10:321-329.
  • Nishikawa T, Dohi S: Haemodynamic changes associated with thermodilution cardiac output determination during myocardial ischaemia or pulmonary oedema in dogs.  Acta Anaesthesiologica Scandinavica 1992; 36:679-683.
  • Nishikawa T, Dohi S: Oral clonidine blunts the heart rate response to intravenous atropine in humans. Anesthesiology 1991; 75:217-222.
  • Anzai Y, Nishikawa T: Heart rate responses to body tilt during spinal anesthesia. Anesthesia and Analgesia 1991; 73:385-390.
  • Nishikawa T, Kimura T, Taguchi N, Dohi S: Oral clonidine preanesthetic medication augments the pressor responses to intravenous ephedrine in awake or anesthetized patients.  Anesthesiology 1991; 74:705-710.
  • Omote K, Namiki A, Nishikawa T, Hagiwara T, Iwasaki H, Tsuchida H:  Haemodynamic effects of famotidine and cimetidine in critically ill patients.  Acta Anaesthesiologica Scandinavica 1990; 34:576-578.
  • Nishikawa T, Dohi S: Hemodynamic status susceptible to slowing of heart rate during thermodilution cardiac output determination in anesthetized patients.  Critical Care Medicine 1990; 18:841-844.
  • Anzai Y, Nishikawa T, Namiki A: Attenuated sympathetic tone augments nitrous oxide-induced myocardial depression during high-dose fentanyl anaesthesia in dogs.  Canadian Journal of Anaesthesia 1990; 37:245-249.
  • 西川俊昭, 土肥修司: スワンガンツカテーテル使用時の合併症と測定上の諸問題 1. カテーテル挿入・留置による合併症.  呼吸と循環 1989; 37:603-615.
  • 西川俊昭, 土肥修司: スワンガンツカテーテル使用時の合併症と測定上の諸問題  2. 測定上の諸問題. 呼吸と循環 1989; 37:835-843.
  • Nishikawa T, Namiki A: Attenuation of the pressor response to laryngoscopy and tracheal intubation with intravenous verapamil.  Acta Anaesthesiologica Scandinavica 1989; 33:232-234.
  • Nishikawa T, Namiki A: Mechanism for slowing of heart rate and associated changes in pulmonary circulation elicited by cold injectate during thermodilution cardiac output determination in dogs.  Anesthesiology 1988; 68:221-225.
  • Nishikawa T, Dohi S: A correlation between extrasystoles and relative decreases in stroke volume during general anesthesia.  Anesthesiology Review 1985; 12:27-32.
  • Dohi S, Nishikawa T, Ujike Y, Mayumi T: Circulatory responses to airway stimulation and cervical epidural blockade.  Anesthesiology 1982; 57:359-363.

呼吸に関する業績

  • 西川俊昭: 第28章人工呼吸依存患者. 「ICUブック第4版(日本語版)」, 稲田英一監修, 434-447頁, メディカル・サイエンス・インターナショナル社, 東京, 2015.
  • 西川俊昭: 第30章人工呼吸からのウィーニング. 「ICUブック第4版(日本語版)」, 稲田英一監修, 462-474頁, メディカル・サイエンス・インターナショナル社, 東京, 2015.
  • 西川俊昭: 第Ⅰ部全身管理の基礎, 第1章呼吸管理, E気道確保法. 「TEXT 麻酔・蘇生学」第4版, 土肥修司, 澄川耕二編, 35-39頁, 南山堂, 東京, 2014.
  • Kumagai M, Horiguchi T, Nishikawa T, Masaki Y, Tobe Y: Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats. Anesthesia and Analgesia 2008, 107: 643-647.
  • Inomata S, Nishikawa T, Saito S, Kihara S: "Best" PEEP during one-lung ventilation. British Journal of Anaesthesia 1997; 78:754-756.
  • Matsumiya N, Tanaka M, Iwai M, Kondo T, Takahashi S, Sato S: Elevated amylase is related to the development of respiratory failure in organophosphate poisoning.  Human Experimental Toxicology 1996; 15:250-253.

硬膜外麻酔及び脊髄くも膜下麻酔に関する臨床研究

硬膜外麻酔・脊髄くも膜下麻酔に関する業績

  • Ogasawara K, Tanaka M, Nishikawa T: Choice of electrocardiography lead does not affect the usefulness of the T-wave criterion for detecting intravascular injection of an epinephrine test dose in anesthetized children.  Anesthesia and Analgesia 2003; 97: 372-376.
  • Takahashi S, Tanaka M, Toyooka H: The efficacy of hemodynamic and T-wave criteria for detecting intravascular injection of epinephrine test dose in propofol-anesthetized adults.  Anesthesia and Analgesia 2002; 94:717-722.
  • Tanaka M, Nishikawa T: Does the choice of electrocardiography lead affect the efficacy of the T-wave criterion for detecting intravascular injection of an epinephrine test dose?  Anesthesia and Analgesia 2002; 95:1408-1411.
  • 田中誠: 硬膜外テストの実施法と効果について.  Pharmacoanesthesiology 2002;14:23-28.
  • Tanaka M, Nishikawa T: The T-wave amplitude as an indicator for detecting intravascular injection of epinephrine test dose in awake and anesthetized elderly patients.  Anesthesia and Analgesia 2001; 93: 1332-1337.
  • Tanaka M, Sato M, Kimura T, Nishikawa T: Efficacy of simulated intravascular test dose in sedated patients.  Anesthesia and Analgesia 2001; 93:1612-1617.
  • Tanaka M, Nitta R, Nishikawa T: Increased T-wave amplitude after accidental intravascular injection of lidocaine plus bupivacaine without epinephrine in sevoflurane-anesthetized child.  Anesthesia and Analgesia 2001; 92:915-917.
  • Tanaka M, Nishikawa T: Aging reduces the efficacy of the simulated epidural test dose in anesthetized adults.  Anesthesia and Analgesia 2000; 91:657-661.
  • Tanaka M, Kimura T, Goyagi T, Ogasawara K, Nitta R, Nishikawa T: Evaluating hemodynamic and T-wave criteria of simulated intravascular test doses using bupivacaine or isoproterenol in anesthetized children.  Anesthesia and Analgesia 2000; 91:567-572.
  • Tanaka M, Goyagi T, Kimura T, Nishikawa T: Efficacy of hemodynamic and T wave criteria for detecting intravascular injection of epinephrine test doses in anesthetized adults: a dose-response study.  Anesthesia and Analgesia 2000; 91:1196-1202.
  • Tanaka M, Nishikawa T: Evaluating T-wave amplitude as a guide for detecting intravascular injection of a test dose in anesthetized children.  Anesthesia and Analgesia 1999; 88:754-758.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances postoperative analgesia by epidural morphine.  Anesthesia and Analgesia 1999; 89: 1487-1497.
  • Tanaka M, Nishikawa T: Efficacy of simulated intravenous test dose in the elderly during general anesthesia.  Regional Anesthesia and Pain Medicine 1999; 24: 393-398.
  • Tanaka M, Nishikawa T: A comparative study of hemodynamic and T-wave criteria for detecting intravascular injection of the test dose (epinephrine) in sevoflurane-anesthetized adults.  Anesthesia and Analgesia 1999; 89:32-36.
  • Tanaka M, Nishikawa T: The efficacy of a simulated intravascular test dose in sevoflurane-anesthetized children: a dose-response study.  Anesthesia and Analgesia 1999; 89:632-637.
  • Takahashi S, Tanaka M, Toyooka H: Fentanyl pretreatment does not impair the reliability of an epinephrine-containing test dose during propofol-nitrous oxide anesthesia.  Anesthesia and Analgesia 1999; 89: 743-747.
  • Takahashi S, Tanaka M: Reduced efficacy of simulated epidural test doses in sevoflurane-anesthetized adults.  Canadian Journal of Anesthesia 1999; 46:433-438.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances the pressor response to ephedrine during spinal anesthesia.  Anesthesia and Analgesia 1998; 87: 1136-1139.
  • Tanaka M, Nishikawa T: Simulation of an epidural test dose with intravenous epinephrine in sevoflurane-anesthetized children.  Anesthesia and Analgesia 1998; 86:952-957.
  • Tanaka M, Nishikawa T: The combination of epinephrine and isoproterenol as a simulated epidural test dose in isoflurane-anesthetized adults. Anesthesia and Analgesia 1998; 86:1312-1317.
  • Tanaka M, Nishikawa T, Takahashi S, Matsumiya N: Oral clonidine premedication does not alter the efficacy of epidural test doses in adult patients anesthetized with isoflurane. Journal of Anesthesia 1997; 11:88-93.
  • Tanaka M, Nishikawa T: Oral clonidine premedication does not alter the efficacy of simulated intravenous test dose containing low dose epinephrine in awake volunteers.  Anesthesiology 1997;87: 285-288.
  • Tanaka M: Simulation of an epidural test dose with intravenous isoproterenol in isoflurane-anesthetized adults.  Anesthesia and Analgesia 1997; 85:639-643.
  • Tanaka M, Nishikawa T, Takahashi S, Matsumiya N: Oral clonidine premedication does not alter the efficacy of epidural test doses in adult patients anesthetized with isoflurane. Journal of Anesthesia 1997; 11: 88-93.
  • Tanaka M: Epidural test dose: Isoproterenol is a reliable marker for intravascular injection in anesthetized adults.  Anesthesia and Analgesia 1996; 82:1056-1059.
  • Goyagi T, Nishikawa T: Oral clonidine premedication enhances the quality of postoperative analgesia by intrathecal morphine.  Anesthesia and Analgesia 1996; 82:1192-1196.
  • Tanaka M, Takahashi S, Kondo T, Matsumiya N: Efficacy of simulated epidural test doses in adult patients anesthetized with isoflurane: a dose-response study. Anesthesia and Analgesia 1995; 81:987-992.
  • Tanaka M, Yamamoto S, Ashimura H, Iwai M, Matsumiya N: Efficacy of epidural test dose in adult patients anesthetized with isoflurane: lidocaine containing 15 μg epinephrine reliably increases blood pressure, but not heart rate.  Anesthesia and Analgesia 1995; 80:310-314.
  • Sato S, Baba Y, Tajima K, Kimura T, Tsuji MH, Koda Y, Sato Y: Prolongation of epidural anesthesia using biodegradable copolymer paste containing lidocaine in the rabbit.  Anesthesia and Analgesia 1995; 80:97-101.
  • Anzai Y, Nishikawa T: Thoracic epidural clonidine and morphine for postoperative analgesia.  Canadian Journal of Anaesthesia 1995; 42:292-297.
  • Yamashita M, Goyagi T: The drip and tube method for single-shot lumbar epidural anaesthesia in infants and children.  Paediatric Anaesthesia 1993; 3:387-389.
  • Nishikawa T, Inomata S, Igarashi M, Goyagi T, Naito H: Plasma lidocaine concentrations during epidural blockade with isoflurane or halothane anesthesia.  Anesthesia and Analgesia 1992; 75:885-888.
  • Nishikawa T, Goyagi T, Kimura T, Dai M, Naito H: Oral clonidine preanaesthetic medication does not alter plasma lidocaine elimination during epidural anaesthesia in lightly anaesthetized patients. Canadian Journal of Anaesthesia 1992; 39:521-522.
  • Anzai Y, Nishikawa T: Heart rate responses to body tilt during spinal anesthesia. Anesthesia and Analgesia 1991; 73:385-390.
  • Nishikawa T, Dohi S: Clinical evaluation of clonidine added to lidocaine solution for epidural anesthesia.  Anesthesiology 1990; 73:853-859.
  • Dohi S, Nishikawa T, Ujike Y, Mayumi T: Circulatory responses to airway stimulation and cervical epidural blockade.  Anesthesiology 1982; 57:359-363.

その他

麻酔前投薬に関する業績

  • Tanaka M, Sato M, Saito A, Nishikawa T: Reevaluation of rectal ketamine premedication in children: comparison with rectal midazolam.  Anesthesiology 2000; 93:1217-1224.

筋弛緩薬に関する業績

  • Kimura T, Tanaka M, Nishikawa T: Effects of oral clonidine on heart rate changes after neostigmine-atropine administration.  Anesthesiology 1998; 88: 1507-1510.
  • Takahashi H, Nishikawa T: Oral clonidine does not alter vecuronium neuromuscular blockade in anaesthetized patients.  Canadian Journal of Anaesthesia 1995; 42:511-515.

静脈麻酔薬に関する業績

  • Goyagi T, Tanaka M, Nishikawa T : Fentanyl decreases propofol requirement for laryngeal mask airway insertion. Acta Anaesthesiologica Scandinavica 2003; 47: 771-774.
  • Tanaka M, Nishikawa T: Propofol requirement for insertion of cuffed oropharyngeal airway versus laryngeal mask airway with and without fentanyl: a dose-finding study.  British Journal of Anaesthesia 2003; 90: 14-20.
  • Masaki Y, Tanaka M, Nishikawa T: Physicochemical compatibility of propofol-lidocaine mixture.  Anesthesia and Analgesia 2003; 97: 1646-1651.
  • Goyagi T, Tanaka M, Nishikawa T: Fentanyl decreases propofol requirement for laryngeal mask airway insertion.  Acta Anaesthesiologica Scandinavica 2003; 47: 771-774.
  • Horiguchi T, Nishikawa T: Heart rate response to intravenous atropine during propofol anesthesia.  Anesthesia and Analgesia 2002; 95:389-392.
  • Masaki Y, Tanaka M, Nishikawa T: Changes in propofol concentration in a propofol-lidocaine 9:1 volume mixture.  Anesthesia and Analgesia 2000; 90:989-992.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces propofol requirement for laryngeal mask airway insertion.  Canadian Journal of Anesthesia 2000; 47: 627-630.
  • Handa F, Tanaka M, Nishikawa T, Toyooka H: Effects of oral clonidine premedication on side effects of intravenous ketamine anesthesia: a randomized, double-blind, placebo-controlled study.  Journal of Clinical Anesthesia 2000; 12: 19-24.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces induction dose and prolongs awakening time from propofol-nitrous oxide anesthesia.  Canadian Journal of Anesthesia 1999; 46: 894-896.
  • Kimura T, Nishikawa T, Sato K, Wada K: Oral clonidine reduces thiamylal requirement for anesthesia induction in adults.  Journal of Anesthesia 1996; 10:1-4.
  • Tanaka M, Nishikawa T: Oral clonidine premedication attenuates the hypertensive response to ketamine.  British Journal of Anaesthesia 1994; 73:758-762.
  • Anzai Y, Nishikawa T, Namiki A: Attenuated sympathetic tone augments nitrous oxide-induced myocardial depression during high-dose fentanyl anaesthesia in dogs.  Canadian Journal of Anaesthesia 1990; 37:245-249.

吸入麻酔薬に関する業績

  • Kimura T, Nishikawa T: Minimum alveolar concentration needed to block adrenergic response of sevoflurane with nitrous oxide varies depending on the stimulation sites in adult patients.  Journal of Anesthesiology and Critical Care Medicine 2015; 2:1-4.
  • Nagasaki G, Tanaka M, Nishikawa T: The recovery profile of baroreflex control of heart rate after isoflurane or sevoflurane anesthesia in humans.  Anesthesia and Analgesia 2001; 93:1127-1131.
  • Tanaka M, Nishikawa T: Arterial baroreflex function in humans anaesthetized with sevoflurane.  British Journal of Anaesthesia 1999; 82:350-354.
  • Tanaka M, Nishikawa T: Sevoflurane speeds recovery of baroreflex control of heart rate after minor surgical procedures compared with isoflurane.  Anesthesia and Analgesia 1999; 89:284-289.
  • Tanaka M, Watanabe S, Nishikawa T: Minimum alveolar sevoflurane concentrations required for insertion of the cuffed oropharyngeal airway and the laryngeal mask airway: a comparative study.  Anaesthesia 1999; 54:1155-1160.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces the awakening concentration of isoflurane. Anesthesia and Analgesia 1998; 86: 410-413.
  • Inomata S, Nishikawa T: Determination of end-tidal sevoflurane concentration for tracheal intubation in children with the rapid method.  Canadian Journal of Anaesthesia 1996; 43:806-811.
  • Nishikawa T, Satsumae T, Uemura A, Hoshi T: Oral clonidine medication partially suppresses transient pressor response to a rapid increase in isoflurane concentration.  Circulation Control 1996; 17:368-373.
  • Naganuma T, Nishikawa T, Nakayama H, Yaguchi Y, Naito H: Comparative hemodynamic responses to intravenous ephedrine during halothane, enflurane, or isoflurane anesthesia.  Circulation Control 1995; 16:533-537.
  • Kimura T, Watanabe S, Asakura N, Inomata S, Okada M, Taguchi M: Determination of end-tidal sevoflurane concentration for tracheal intubation and minimum alveolar anesthetic concentration in adults.  Anesthesia and Analgesia 1994; 79:378-381.
  • Nishikawa T, Inomata S, Igarashi M, Goyagi T, Naito H: Plasma lidocaine concentrations during epidural blockade with isoflurane or halothane anesthesia. Anesthesia and Analgesia 1992; 75:885-888.

産科麻酔に関する業績

  • Tanaka M, Watanabe S: The obese parturient. In Textbook of Obstetric Anesthesia. Birnbach DJ, Gatt SP, Datta S eds. Churchill-Livingstone. New York, 2000, pg 527-539.
  • Tanaka M, Watanabe S, Nishikawa T: Anesthetic management in obese parturients.  Journal of Anesthesia 1999; 13:217-229.

小児麻酔に関する業績

  • Ogasawara K, Tanaka M, Nishikawa T: Choice of electrocardiography lead does not affect the usefulness of the T-wave criterion for detecting intravascular injection of an epinephrine test dose in anesthetized children.  Anesthesia and Analgesia 2003; 97: 372-376.
  • Suga A, Tanaka M, Toyooka H: Effects of i.v. metoclopramide, atropine and their combination on gastric insufflation in children anaesthetized with sevoflurane and nitrous oxide.  Paediatric Anaesthesia 2001; 11:151-156.
  • Tanaka M, Nitta R, Nishikawa T: Increased T-wave amplitude after accidental intravascular injection of lidocaine plus bupivacaine without epinephrine in sevoflurane-anesthetized child.  Anesthesia and Analgesia 2001; 92:915-917.
  • Tanaka M, Kimura T, Goyagi T, Ogasawara K, Nitta R, Nishikawa T: Evaluating hemodynamic and T-wave criteria of simulated intravascular test doses using bupivacaine or isoproterenol in anesthetized children.  Anesthesia and Analgesia 2000; 91:567-572.
  • Tanaka M, Sato M, Saito A, Nishikawa T: Reevaluation of rectal ketamine premedication in children: comparison with rectal midazolam.  Anesthesiology 2000; 93:1217-1224.
  • Tanaka M, Nishikawa T: The efficacy of a simulated intravascular test dose in sevoflurane-anesthetized children: a dose-response study.  Anesthesia and Analgesia 1999; 89:632-637.
  • Tanaka M, Nishikawa T: Simulation of an epidural test dose with intravenous epinephrine in sevoflurane-anesthetized children.  Anesthesia and Analgesia 1998; 86:952-957.
  • Taguchi N, Nishikawa T, Inomata S, Taguchi M, Yamashita S, Naito H: Hemodynamic effects of intravenous ephedrine in infants and children anesthetized with halothane and nitrous oxide.  Anesthesia and Analgesia 1996; 82:568-573.
  • Yamashita M, Goyagi T: The drip and tube method for single-shot lumbar epidural anaesthesia in infants and children.  Paediatric Anaesthesia 1993; 3:387-389.

サイトカインに関する業績

  • Sato T, Asanuma Y, Masaki Y, Sato Y, Hatakeyama Y, Kusano T, Koyama K: Changes in tumor necrosis factor-α and interleukin-β production following liver surgery on cirrhotic patients.  Hepato-Gastroenterology 1996; 43:1148-1153.

中毒に関する業績

  • Matsumiya N, Tanaka M, Iwai M, Kondo T, Takahashi S, Sato S: Elevated amylase is related to the development of respiratory failure in organophosphate poisoning.  Human Experimental Toxicology 1996; 15:250-253.
  • Mizutani T, Kobayashi T, Tanaka M, Naito H: Significance of thromboxane A2 in NaOCl-induced airway hyper-responsiveness in guinea pigs.  Inhalation Toxicology 1994; 6:139-149.
  • Mizutani T, Yamashita M, Okubo N, Tanaka M, Naito H: Efficacy of whole bowel irrigation using solution with or without absorbent in the removal of paraquat in dogs.  Human Experimental Toxicology 1992; 11:495-504.

心肺蘇生に関する業績

  • Watanabe S, Kimura K, Asakura N: End-tidal O2 and CO2 after resuscitation.  Canadian Journal of Anaesthesia 1994; 41:354-355.
  • Sato S, Kimura T, Okubo N, Naganuma T, Tanaka M: End-tidal CO2 and plasma lactate level: a comparison of their use as parameter for evaluating successful CPR.  Resuscitation 1993; 26:133-139.

気道確保に関する業績

  • Tanaka M, Nishikawa T: Propofol requirement for insertion of cuffed oropharyngeal airway versus laryngeal mask airway with and without fentanyl: a dose-finding study.  British Journal of Anaesthesia 2003; 90: 14-20.
  • Goyagi T, Tanaka M, Nishikawa T: Fentanyl decreases propofol requirement for laryngeal mask airway insertion.  Acta Anaesthesiologica Scandinavica 2003; 47: 771-774.
  • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication reduces propofol requirement for laryngeal mask airway insertion.  Canadian Journal of Anesthesia 2000; 47: 627-630.
  • Watanabe S, Suga A, Asakura N, Takeshima R, Kimura K, Taguchi N, Kumagai M: Determination of the distance between the laryngoscope blade and the upper incisors during direct laryngoscopy: Comparisons of a curved, an angulated straight, and two straight blades.  Anesthesia and Analgesia 1994; 79:638-641.
  • Dohi S, Inomata S, Tanaka M, Ishizawa Y, Matsumiya N: End-tidal carbon dioxide monitoring during awake blind naasotracheal intubation.  Journal of Clinical Anesthesia 1990; 2:415-419.
  • Nishikawa T, Namiki A: Attenuation of the pressor response to laryngoscopy and tracheal intubation with intravenous verapamil.  Acta Anaesthesiologica Scandinavica 1989; 33:232-234.

症例報告

  • Sato K, Horiguchi T, Nishikawa T: Pulmonary aspiration during induction of anesthesia in a patient with a past history of esophagectomy.  Japanese Journal of Reanimatology 2014; 33:10-12.
  • Sato K, Nakajima M, Kimura T, Nishikawa T: Vecuronium was safely used in a patient with Engelmann’s disease without muscle weakness.  Journal of Anesthesia 2012; 26: 471-472.
  • Abe K, Horiguchi T, Nishikawa T: Anesthetic management of pulmonary atresia in a patient with left bronchial compression by a patent ductus arteriosus. Journal of Cardiothoracic and Vascular Anesthesia ; 22: 102-104.
  • Sato Y, Horiguchi T, Nishikawa T: Intraoperative occurrence of bradyarrhythmia in a patient with asymptomatic bifascicular block. Journal of Anesthesia 2008; 22: 104.
  • Sato K, Horiguchi T, Nishikawa T: Unsuspected subglottic stenosis in a 5-year-old scheduled for elective surgery.  Journal of Clinical Anesthesia 2005; 17: 470-472.
  • Sato Y, Horiguchi T, Nishikawa T : Anesthetic management of cardiac tamponade after dual-chamber implantable cardioverter defibrillator implantation in a patient with dilated cardiomyopathy.  Journal of Clinical Anesthesia 2004; 16: 554-556.
  • Tanaka M, Nishikawa T: Decrease in T-wave amplitude without hemodynamic changes after intravascular injection of an epinephrine test dose.  Anesthesiology 2001; 94:365-367.
  • Sato Y, Tanaka M, Nishikawa T: Reversible catecholamine-induced cardiomyopathy by subcutaneous injection of epinephrine solution in an anesthetized patient.  Anesthesiology 2000; 92:615-619.
  • Takahashi S, Matsumiya N, Tanaka M, Kondo T, Sato S, Toyooka H: Ruptured superior mesenteric artery aneurysms during treatment of tetanus: a case report.  Journal of Anesthesia 2000; 14:204-206.
  • Komatsu H, Matsumoto S, Mitsuhata H, Abe K: Airway management in an infant with Tessier type 3 cleft.  Anesthesiology 1999; 90:1800.
  • Tanaka M, Harukuni I, Naito H: Intraoperative cardiovascular collapse in an infant with Arnold-Chiari malformation.  Paediatric Anaesthesia 1997; 7:163-166.
  • Inomata S, Nishikawa T, Suga A, Yamashita S: Transient bilateral vocal cord paralysis following insertion of a laryngeal mask airway. Anesthesiology 1995; 82:787-788.
  • Inomata S, Nishikawa T: Bleeding from the Sv02 monitoring port of PA catheter during cardiac surgery.  Canadian Journal of Anaesthesia 1994; 41:877-878.
  • Tanaka M, Sato S, Naito H, Nakayama H: Anaesthetic management of a neonate with prenatally diagnosed cervical tumor and upper airway obstruction.  Canadian Journal of Anaesthesia 1994; 41:236-240.
  • Watanabe S, Tanaka M, Endo T: Myoclonus of hand and arm after ipsilateral stellate ganglion block.  Regional Anesthesia 1991; 16:186-187.
  • Mizutani T, Kimura T, Mizuyama K, Saito S, Naito H: Use of pulse oximeter in new SaO2-oriented technique for bronchopulmonary lavage.  Chest 1991; 100:1477.
  • Matsumiya N, Dohi S, Kimura T, Naito H: Reexpansion pulmonary edema after mediastinal tumor removal.  Anesthesia and Analgesia 1991; 73:646-648.
  • Nishikawa T, Anzai Y, Namiki A: Asystole during spinal anaesthesia after change from Trendelenburg to horizontal position.  Canadian Journal of Anaesthesia 1989; 35:406-408.
  • Anzai Y, Nishikawa T, Namiki A, Takahashi T: Cannulation of an AV fistula as a cause of falsely low oxygen tension during anesthesia.  Anesthesia and Analgesia 1987; 66:919-920.
  • Nishikawa T, Dohi S, Anzai Y: Recurrence of bronchial asthma after adrenalectomy for phaeochromocytoma.  Canadian Anaesthetists' Society Journal 1986; 33:109-111.
  • Nishikawa T, Dohi S: Baroreflex function in a patient with Bartter's syndrome.  Canadian Anaesthetists' Society Journal 1985; 32:646-650.
  • Nishikawa T, Dohi S: Slowing of heart rate during cardiac output measurement by thermodilution. Anesthesiology 1982; 57:538-539.

学会発表

国際学会

  1. 16th World Congress of Anaesthesiologists, August 2016 (Hong Kong, China)
    • Masaki Y, Horiguchi T, Kawamura K, Nishikawa T: Ultrastructural changes in the liver after sevoflurane anesthesia in rats.
    • Nagasaki G, Masaki Y, Horiguchi T, Nishikawa T, Takahashi M: Neuroprotective effect of hydrogen gas on brain injury in a rat transient forebrain ischemia model.
  2. Euroanaesthesia 2016, May 2016 (London, UK)
    • Horiguchi T, Masaki Y, Kawamura K, Nishikawa T: Angiogenesis in the brain after sevoflurane anesthesia in rats.
  3. 27th International Symposium on Cerebral Blood Flow, Metabolism, and Function, June 2015 (Vancouver, Canada)
    • Goyagi T, Horiguchi T, Nishikawa T: Pretreatment with dexmedetomidine or erythropoietin had no effect on the long-term cognitive function after sevoflurane exposure in neonatal rats.
  4. Euroanaesthesia 2015, June 2015 (Berlin, Germany)
    • Horiguchi T, Shimizu M, Hikita Y, Nishikawa T: Water-repellent moisturizing cream protects a patient against pressure injury of skin during prone position surgery: A prospective, double-blind, randomized study.
  5. Euroanaesthesia 2014, June 2014 (Stockholm, Sweden)
    • Yoshimoto M, Horiguchi T, Nishikawa T: Efficacy of lipid resuscitation in cardiac arrest induced by bupivacaine-glucose mixture in rats.
    • Obuchi M, Kimura T, Tobe Y, Masaki Y, Fukuda M, Nishikawa T: Neuroprotective effects of pre- and post-treatment with fasudil (a Rho-kinase inhibitor) in a rat transient spinal cord ischemia-reperfusion model.
    • Horiguchi T, Masaki Y, Kawamura K, Nishikawa T: Ultrastructural changes in the brain cells after discontinuation of sevoflurane anesthesia in rats.
  6. Annual Meeting of the American Society of Anesthesiologists, October 2013 (San Francisco, USA)
    • Horikoshi Y, Goyagi T, Horiguchi T, Nishikawa T: The suppressive effects of landiolol administration on the plasma IL-6 elevations and occurrences of arrhythmias in patients undergoing esophageal surgery.
    • Goyagi T, Masaki Y, Horiguchi T, Nishikawa T: Sevoflurane exposure-induced neural apoptosis and impairment of long-term spatial cognitive function in neonatal rats.
  7. International Union of Physiological Sciences, July 2013 (Birmingham, UK)
    • Adachi T, Ono K, Nishikawa T: Postnatal change of heart rate and sinoatrial node pacemaker activity in mice.
  8. Euroanaesthesia 2013, June 2013 (Balcelona, Spain)
    • Horiguchi T, Abe K, Nishikawa T: Propofol anesthesia enhances the systemic arterial pressor response and attenuates the pulmonary arterial pressor response to intravenous phenylephrine.
    • Yoshimoto M, Horiguchi T, Nishikawa T: Comparative efficacy of lipid resuscitation from local anesthetics (levobupivacaine, ropivacaine) toxicity in rats.
  9. The 3rd Conference of The Asian Society for Neuroanesthesia and Critical Care, February 2013 (Bali,Indonesia)
    • Goyagi T, Nishikawa T:Dexmedetomidine improves neurological and histological outcomes after transient spinal ischemia in rats.
    • Ohubuchi M, Fukuda M, Kimura T, Goyagi T, Tobe Y, Masaki Y, Nishikawa T: Neuroprotective effects of pre-treatment with fasudil (Rho-kinase inhibitor) in a rat transient spinal cord ischemia-reperfusion model.
    • Sato T, Goyagi T, Nishikawa T: The effect of nitrous oxide on the intraocular pressure during sevoflurane and remifentanil anesthesia.
  10. Annual Meeting of the American Society of Anesthesiologists, October 2012 (Washington DC, USA)
    • Goyagi T, Nishikawa T: Dexmedetomidine improves neurological and histological outcomes after transient spinal ischemia in rats.
    • Kimura T, Nishikawa T: Minimum alveolar concentration needed to block adrenergic response of sevoflurane with nitrous oxide varies depending on the stimulation sites in adult surgical patients.
    • Horiguchi T, Masaki Y, Muto H, Nishikawa T, Tobe Y: Comparative residual concentrations of isoflurane and sevoflurane in blood and brain after anesthesia in rats.
  11. 15th World Congress of Anaesthesiologists, March 2012 (Buenos Aires, Argentina)
    • Horiguchi T, Masaki Y, Nishikawa T: Residual concentrations of propofol in the blood and brain after administration in rats.
    • Yoshimoto M, Horiguchi T, Nishikawa T: Comparative effects of lipid emulsion on the recovery from levobupivacaine-induced or from ropivacaine-induced cardiac arrest in rats.
    • Yoshimoto M, Horiguchi T, Nishikawa T: The incidence of desaturation in patients undergoing total knee arthroplasty during anesthesia: comparison of general anesthesia combined with epidural anesthesia and general anesthesia alone.
  12. Annual Meeting of the American Society of Anesthesiologists, October 2011 (Chicago, IL, USA)
    • Kimura T, Tobe Y, Masaki Y, Nishikawa T: Neuroprotective effects of a Rho-kinase inhibitor (fasudil) in a rat transient spinal cord ischemia-reperfusion model.
    • Abe K, Horiguchi T, Enzan K, Nishikawa T, Tobe Y: The soluble guanylyl cyclase inhibitor blocks the beneficial effect of nicorandil on ischemia-reperfusion injury in isolated rat lungs.
    • Horiguchi T, Masaki Y, Muto H, Nishikawa T: Residual concentration of sevoflurane in blood after sevoflurane anesthesia in humans.
    • Masaki Y, Horiguchi T, Nishikawa T, Tobe Y: Sevoflurane concentraions in spleen, liver kidney and brain after anesthesia in rats.
  13. 25th International Symposium on Cerebral Blood Flow, Metabolism, and Function, May 2011 (Barcelona, Spain)
    • Goyagi T, Nishikawa T: Selective β1-adrenoreceptor antagonists provide neuroprotection against transient forebrain ischemia in rats.
  14. The 2nd Conference of The Asian Society for Neuroanesthesia and Critical Care, February 2011 (New Delhi, India)
    • Yoshimoto M, Horiguchi T, Nishikawa T: Systemic toxicity of bupivacaine, levobupivacaine or ropivacaine in awake rats.
    • Goyagi T: The role of beta-adrenoreceptor antagonists for neuroprotection.
  15. Annual Meeting of the American Society of Anesthesiologists, October 2010 (San Diego, CA, USA)
    • Nagasaki G, Horiguchi T, Tobe Y, Nishikawa T: Long-term effects of post-treatment with estrogen on brain injury in a rat forebrain ishemia model.
    • Yoshimoto M, Goyagi T, Nishikawa T: Induction dose of propofol cause profound decrease in blood pressure following tracheal intubation.
    • Abe K, Horiguchi T, Enzan K, Masaki Y, Nishikawa T: Nicorandil attenuates ischemia-reperfusion injury in isolated rat lungs.
    • Goyagi T, Nishikawa T: Selective β1 antagonists provide neuroprotection against forebrain ischemia in rats.
    • Horiguchi T, Masaki Y, Nishikawa T, Tobe Y: Residual concentration of sevoflurane in brain after anesthesia differed among ages in rats.
  16. The 13th Asian Australasian Congress of Anesthesiologists, June 2010 (Fukuoka, Japan)
    • Goyagi T, Nishikawa T: Selective beta 1-adrenoreceptor antagonists provide neuroprotection against transient forebrain ischemia in rats.
    • Yoshimoto M, Goyagi T, Nishikawa T: The dose-effect of propofol on the cardiovascular responses associated with tracheal intubation.
  17. International Anesthesia Research Society 2010 Annual Meeting, March 2010 (Honolulu, HI, USA)
    • Kimura T, Tobe Y, Masaki Y, Nishikawa T: Neuroprotective effects of a Rho-kinase inhibitor alone or combined with an a2 adrenoceptor agonist in a rat transient forebrain ischemia-reperfusion model.
    • Kudo R, Umehara S, Horiguchi T, Nishikawa T: Landiolol, an ultra-short acting β1 adrenoreceptor antagonist, for treatment of tachycardia in patients undergoing total knee arthroplasty under general anesthesia.
  18. Annual Meeting of the American Society of Anesthesiologists, October 2009 (New Orleans, LA, USA)
    • Horiguchi T, Nishikawa T: Heart rate response to intravenous remifentanil during propofol anesthesia.
    • Horiguchi T, Masaki Y, Nishikawa T, Tobe Y: Residual concentration of sevoflurane in blood and brain after sevoflurane anesthesia in rats.
    • Horiguchi T, Masaki Y, Nishikawa T, Tobe Y: Histological changes and acquisition of spatial memory after sevoflurane anesthesia in rats.
    • Kimura T, Sato K, Nishikawa T, Tobe Y, Masaki Y: Neuroprotective effect of fasudil, a Rho-kinase inhibitor, after transient forebrain ischemia in rats.
    • Umehara S, Goyagi T, Nishikawa T: Neuroprotective effects of selective β1-adrenoreceptor antagonists in a rat spinal ischemia-reperfusion model.
    • Goyagi T, Nishikawa T: Landiolol, a β1-adrenoreceptor antagonist, improves the spatial memory after transient focal ischemia in rats.
  19. The 9th Indonesian Society of Neuroanesthesia and Critical Care in conjunction with 2nd Joint Symposium Indonesia – Singapore, January 2009 (Jogjakarta, Indonesia).
    • Nishikawa T: Neuroprotective effects of pharmacological agents.
    • Horiguchi T: Cognitive dysfunction after general anesthesia.
    • Goyagi T: The neuroprotective effects of β-adrenoceptor antagonists.
  20. The 1st Congress of Asian Society for Neuroanesthesia and Critical Care, November 2008 (Beijing, China).
    • Nishikawa T, Kimura T, Sato K, Tobe Y, Masaki Y: Neuroprotective effect of fasudil, a Rho-kinase inhibitor, after transient forebrain ischemia in rats.
    • Goyagi T, Nishikawa T: The neuroprotective effect of β1-adrenoreceptor antagonists after transient focal ischemia in rats.
  21. Annual Meeting of the American Society of Anesthesiologists, October 2007 (San Francisco, CA, USA)
    • Goyagi T, Nishikawa T: The neuroprotective effect of post-treatment with β1-antagonists after focal ischemia in rats.
  22. Annual Meeting of the American Society of Anesthesiologists, October 2006 (Chicago, IL, USA)
    • Goyagi T, Kimura T, Nishikawa T: Selective β1-adrenoceptor antagonists provide neuroprotection after focal ischemia in rats.
    • Kimura T, Goyagi T, Nishikawa T: Sevoflurane concentration needed to suppress bispectral index increase following noxious stimulation.
    • Kumagai M, Horiguchi T, Nishikawa T: Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats.
  23. Euroanaesthesia 2006, June 2006 (Madrid, Spain)
    • Horiguchi T, Nishikawa T: Heart rate response to intravenous landiolol during propofol anesthesia.
  24. The 2nd Japan-China-Korea Joint Symposium for Neuroanesthesia, April 2006 (Osaka, Japan)
    • Goyagi T, Kimura T, Nishikawa T: Adrenoceptor antagonists attenuate the brain infarction after transient focal ischemia in rats.
    • Sato K, Kimura T, Nishikawa T: Neuroprotective effects of combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats.
    • Kumagai M, Horiguchi T, Nishikawa T: Intravenous dexmedetomidine attenuates cardiac collapse and decreases lung permiability induced by intracranial hypertension in rats.
    • Kimura T, Sato K, Nishikawa T: Sevoflurane concentration needed to suppress bispectral index increase in response to noxious stimulation.
  25. 22nd International Symposium on Cerebral Blood Flow, Metabolism, and Function, June 2005 (Amsterdam, Netherlands)
    • Goyagi T, Nishikawa T: Beta-adrenoceptor antagonists attenuate brain injury following transient focal ischemia in rats.
    • Kimura T, Goyagi T, Tanaka M, Tobe Y, Masaki Y, Nishikawa T: Neuroprotective effects of dexmedetomidine - hypothermia after asphyxial cardiac arrest in rats.
  26. International Anesthesia Research Society 2005 Annual Meeting, March 2005 (Honolulu, HI, USA)
    • Masaki Y, Tanaka M, Nishikawa T: Decreased pH and lidocaine are prerequisite for emulsion instability of propofol-lidocaine mixture.
    • Nitta R, Goyagi T, Nishikawa T: The effect of intra- and postoperative administration of low-dose ketamine and oral clonidine premedication on postoperative analgesia after spinal surgery.
  27. 8th America−Japan Anesthesia Congress, March 2005 (Honolulu, HI, USA)
    • Masaki Y, Tanaka M, Nishikawa T: Decreased pH and lidocaine are prerequisite for emulsion instability of propofol-lidocaine mixture.
  28. Annual Meeting of the American Society of Anesthesiologists, October 2004 (Las Vegas, NV, USA)
    • Kimura T, Sato M, Tanaka M, Nishikawa T: Neuroprotective effect of mivazerol, an α2-agonist, after transient forebrain ischemia in rats.
    • Tanaka M, Masaki Y, Nishikawa T: Influence of acidosis on cardiotonic effects of colforsin in rats: in vivo preparation.
    • Tanaka M, Umehara S, Nishikawa T: Effects of sevoflurane on carotid-cardiac baroreflex function.
    • Tanaka M, Masaki Y, Nishikawa T: Influence of acidosis on inotropic effect and increase in myocardium cAMP content by colforsin in in vitro rat preparation.
  29. The 1st China-Japan-Korea Joint Symposium for Neuroanesthesia, August 2004 (Jeju, Korea)
    • Nishikawa T: Alpha-2 adrenoceptor agonists during mild hypothermia.
    • Kimura T, Sato M, Tanaka M, Nishikawa T, Tobe Y, Masaki Y: Effect of mivazerol after transient forebrain ischemia in rats.
    • Sato M, Kimura T, Nishikawa T, Tobe Y, Masaki Y: Neuroprotective effect of mivazerol and hypothermia after transient forebrain ischemia in rats.
  30. 13th World Congress of Anaesthesiologists, April 2004 (Paris, France)
    • Goyagi T, Nishikawa T: Neuroprotective effects by coadministration of lidocaine and dexmedetomidine after transient forebrain ischemia.
    • Umehara S, Tanaka M, Nishikawa T: Effects of induced hypotension on cardiovagal baroreflex sensitivity in anaesthetized humans.
  31. Annual Meeting of the American Society of Anesthesiologists, October 2003 (San Francisco, CA, USA)
    • Sato S, Tanaka M, Nishikawa T: Recovery profile of baroreflex sensitivity after propofol anesthesia.
    • Tanaka M, Nishikawa T: Influences of sevoflurane anesthesia on spontaneous sequence baroreflex sensitivity and heart rate variability.
    • Horiguchi T, K Abe, T Nishikawa: Sevoflurane anesthesia enhances the systemic arterial pressor response and attenuates pulmonary arterial pressor response to intravenous phenylephrine.
  32. 86th Annual Meeting of the Federation of American Societies for Experimental Biology, April 2002 (New Orleans, LA, USA)
    • Alkayed NJ, Goyagi T, Narayanan J, Harder DR, Koehler RC: Role of P450 arachidonic acid epoxides in ischemic preconditioning in brain.
  33. International Anesthesia Research Society 2002 Annual Meeting, March 2002 (San Diego, CA, USA)
    • Kimura T, Tanaka M, Nishikawa T: Effects of stimulation sites on minimum alveolar anesthetic concentration needed to block adrenergic response of sevoflurane.
    • Goyagi T, Bhardwaj A, Koehler RC, Traystman RJ, Hurn PD, Kirsch JR: Potent σ1-receptor ligand, PPBP provides ischemic neuroprotection without altering dopminergic neurotransmission In vivo.
  34. 27th International Stroke Conference, February 2002 (San Antonio, TX, USA)
    • Goyagi T, Klaus J, Koehler RC, Hurn PD, Harder DR, Traystman RJ, Alkayed NJ: Cerebral ischemic preconditioning via P450 epoxygenase.
  35. Annual Meeting of the Society for Neuroscience, November 2001, (San Diego, CA, USA)
    • Alkayed NJ, Goyagi T, Klaus J, Narayanan J, Bhardwaj A, Koehler RC, Harder DR, Traystman RJ, Hurn PD: P450 arachidonic acid (AA) epoxides are endogenous neuroprotectants in experimental cerebral ischemia.
  36. Annual Meeting of the American Society of Anesthesiologists, October 2001 (New Orleans, LA, USA)
    • Tanaka M, Nishikawa T: Effects of cervical and lumbar epidural anesthesia on spontaneous cardiac baroreflex sensitivity and heart rate variability.
    • Tanaka M, Nishikawa T: Does the choice of electrocardiography lead affect the efficacy of T-wave criterion for detecting intravascular injection of epinephrine test dose in anesthetized adults ?
  37. 57th Annual Meeting of the Canadian Anesthesiologists' Society, June 2001 (Halifax, Canada)
    • Goyagi T, Bhardwaj A, Hurn PD, Traystman RD, Kirsch JR: Neuroprotective σ1-receptor ligand, PPBP [4 phenyl-1- (4-phenylbutyl) piperidine] attenuates ischemia-evoked striatal nitric oxide production in vivo.
  38. 20th International Symposium on Cerebral Blood Flow and Metabolism, June 2001, (Taipei, Taiwan)
    • Goyagi T, Bhardwaj A, Hurn PD, Traystman RJ, Kirsch JR: Neuroprotective sigma1-receptors ligand, PPBP, attenuates ischemia-evoked striatal nitric oxide production in vivo.
  39. International Anesthesia Research Society 2001 Annual Meeting, May 2001 (Ft. Lauderdale, FL, USA)
    • Tanaka M, Sato M, Nishikawa T: Efficacy of simulated intravenous test dose in patients sedated with midazolam plus fentanyl compared with midazolam alone.
    • Nagasaki G, Tanaka M, Nishikawa T: Recovery profile of arterial baroreflex control of heart rate after sevoflurane and isoflurane anesthesia in volunteers.
    • Takahashi S, Tanaka M, Miyabe M, Toyooka H: Efficacy of hemodynamic and T-wave criteria for detecting intravascular injection of the epinephrine test dose during propofol anesthesia: a dose-response study.
  40. Annual Meeting of the American Society of Anesthesiologists, October 2000 (San Francisco, CA, USA)
    • Tanaka M, Nagasaki G, Nishikawa T: Mild Hypothermia depresses arterial baroreflex function and delays its recovery after general anesthesia in humans.
  41. 12th World Congress of Anesthesiologists, June 2000 (Montreal, Canada)
    • Goyagi T, Tanaka M, Nishikawa T: The effect of fentanyl on propofol requirement for laryngeal mask airway insertion.
  42. Annual Meeting of the American Society of Anesthesiologists, October 1999 (Dallas, TX, USA)
    • Tanaka M, Nishikawa T: T-wave amplitude as an indicator for detecting intravascular injection of epinephrine test dose in awake and anesthetized elderly.
    • Tanaka M, Nishikawa T: Comparison of heart rate and T-wave criteria for detecting intravascular injection of epinephrine test dose in anesthetized adults: A dose-response study.
    • Nagasaki G, Tanaka M, Nishikawa T: Recovery profile of arterial baroreflex control of heart rate after sevoflurane anesthesia in volunteers.
    • Horiguchi T, Nishikawa T, Tanaka M, Abe K, Saito A: Propofol anesthesia enhances heart rate response to intravenous isoproterenol infusion.
    • Tanaka M, Nishikawa T: Efficacy of simulated intravascular test dose using hemodynamic and T-wave criteria in anesthetized children: A dose-response study.
  43. International Anesthesia Research Society 1999 Annual Meeting, May 1999 (Los Angeles, CA, USA)
    • Goyagi T, Tanaka M, Nishikawa T: Oral clonidine premedication enhances the postoperative analgesia by epidural morphine.
    • Takahashi S, Tanaka M: Efficacy of simulated intravenous test dose during sevoflurane anesthesia.
  44. Annual Meeting of the American Society of Anesthesiologists, October 1998 (Orlando, FL, USA)
    • Horiguchi T, Nishikawa T, Nagasaki G, Sakai A: Heart rate response to intravenous atropine during propofol anesthesia.
    • Tanaka M, Nishikawa T: T-wave amplitude as an indicator for detecting intravenous injection of test dose in sevoflurane-anesthetized children.
    • Tanaka M, Sato Y, Sato K, Saito A, Nishikawa T: Comparative study of rectal midazolam and ketamine: revisited.
  45. International Anesthesia Research Society 1998 Annual Meeting, May 1998 (Orlando, FL, USA)
    • Iwasaki Y, Tanaka M, Nishikawa T: Intrathecal morphine decreases MAC-awake of sevoflurane in humans.
    • Tanaka M, Nishikawa T: End-tidal sevoflurane concentrations for cuffed oropharyngeal airway (COPA) insertion in the elderly and young adult.
    • Tanaka M, Nishikawa T: Efficacy of epidural test dose in the elderly during general anesthesia.
  46. The 1st Congress of Asian and Oceanic Society for Intravenous Anesthesia, February 1998 (Kyoto, Japan)
    • Terada H, Ohta S, Nishikawa T: Prevention of injection pain by prior continuous infusion of low-dose propofol.
    • Handa F, Tanaka M, Nishikawa T, Toyooka H: Effect of oral clonidine premedication on side effects of intravenous ketamine.
  47. Annual Meeting of the American Society of Anesthesiologists, October 1997 (San Diego, CA, USA)
    • Tanaka M, Nishikawa T: Arterial baroreflex function in humans anesthetized with sevoflurane.
    • Tanaka M, Nishikawa T: Efficacy of simulated epidural test dose in children anesthetized with sevoflurane.
    • Tanaka M, Nishikawa T: Normovolemic hemodilution does not alter arterial baroreflex function in dogs.
  48. 18th International Symposium on Cerebral Blood Flow and Metabolism, June 1997 (Baltimore, MD, USA)
    • Mizunuma T, Ohta S, Nishikawa T: Intravenous and subarachnoid administration of lidocaine reduces the delayed neuronal damage in rats.
  49. International Anesthesia Research Society 1997 Annual Meeting, March 1997 (San Francisco, CA, USA)
    • Takahashi S, Kondo T, Tanaka M, Matsumiya N: Dose-response of preoperative buprenorphine on awakening time and postoperative analgesic requirement in patients undergoing otolaryngeal surgery.
    • Goyagi T, Nishikawa T: Oral clonidine premedication enhances the pressor response to ephedrine during spinal anesthesia.
  50. 6th Annual Meeting of Whistler Winter Anaesthesia, March 1997 (Whistler, Canada)
    • Suga A, Tanaka M: Effects of intravenous metoclopramide and atropine on preventing gastric insufflation in children.
  51. 11th World Congress of Anesthesiologists, April 1996 (Sydney, Australia)
    • Nishikawa T, Inomata S, Goyagi T: Oral clonidine premedication does not enhance the hypotensive effect of nicardipine during isoflurane anesthesia.
    • Goyagi T, Nishikawa T: Oral clonidine premedication reduces the awakening concentration of isoflurane.
  52. Annual Meeting of the American Society of Anesthesiologists, October 1995 (Atlanta, GA, USA)
    • Tanaka M, Nishikawa T, Takahashi S, Sato S: Cardiovascular response to milrinone in canine mild and severe metabolic acidosis.
    • Tanaka M, Takahashi S, Kondo T, Matsumiya N, Okada M, Kihara S, Suga A: Efficacy of epidural test dose in anesthetized patients: effects of epinephrine does and isoflurane concentration.
    • Kimura T, Nishikawa T: effect of oral clonidine on heart rate changes after neostigmine-atropine administration.
    • Tajima K, Nishikawa T: The effects of oral clonidine on plasma ADH level and urine output during prostaglandin E1 induced hypotensive anesthesia.
  53. International Anesthesia Research Society 1995 Annual Meeting, March 1995 (Honolulu, HI, USA)
    • Harukuni I, Nishikawa T: The effects of oral clonidine on requirement of vasodilator, plasma ADH level, and urine output during hypotensive anesthesia.
    • Nishikawa T, Naito H: Systemic clonidine administration modulates the hemodynamic and catecholamine responses associated with hypoxia or hypercapnia in dogs.
    • Tajima K, Nishikawa T: Heart rate response to intravenous atropine in anesthetized patients with diabetic autonomic dysfunction.
    • Goyagi T, Nishikawa T: Addition of epinephrine potentiates postoperative analgesia by intrathecal morphine.
  54. 2nd International Congress of Pathophysiology, November 1994 (Kyoto, Japan)
    • Hamaya Y, Nishikawa T, Dohi S: Arrangement of body fluid homeostasis by α2-adrenergic agonist during anesthesia.
  55. Annual Meeting of the American Society of Anesthesiologists, October 1994 (San Francisco, CA, USA)
    • Tanaka M, Nishikawa T, Yamamato S, Nishijima Y, Ashimura H, Akiyoshi Y, Iwai M, Mastumiya N: Efficacy of an epidural test dose in adult patients anesthetized with isoflurane: Effects of oral clonidine premedication.
    • Tanaka M, Nishikawa T: Acute hemodynamic changes by sodium bicarbonate in respiratory or metabolic acidosis in dogs.
    • Tanaka M, Nishikawa T: Effects of anemia and metabolic acidosis on acute hemodynamic changes by sodium bicarbonate in dogs.
    • Nishikawa T, Kirsch JR, Koehler RC, Miyabe M, Traystman RJ: NPC17742, a competitive N-methyl-D-aspartate receptor antagonist, reduces brain injury following transient focal ischemia in cats.
    • Inomata S, Nishikawa T, Kihara S, Naito H: Enhancement of pressor response to intravenous phenylephrine following oral clonidine medication in awake or anesthetized patients.
  56. 11th Congress of the International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, July 1994 (Boston, MA, USA)
    • Ulatowski JA, Koehler RC, Nishikawa T, Traystman RJ, Bucci E: Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin.
  57. 78th Annual Meeting of the Federation of American Societies for Experimental Biology, April 1994 (Anaheim, CA, USA)
    • Nishikawa T, Kirsch JR, Koehler RC, Miyabe M, Snyder SH, Traystman RJ: NPC17742, an N-methyl-D-aspartate receptor antagonist, reduces brain injury following transient focal ischemia in cats.
  58. International Anesthesia Research Society 1994 Annual Meeting, March 1994 (Orlando, FL, USA)
    • Taguchi N, Nishikawa T, Yamashita S, Naito H: Hemodynamic response to intravenous ephedrine in pediatric patients.
  59. Annual Meeting of the American Society of Anesthesiologists, October 1993 (Washington DC, USA)
    • Nishikawa T, Kirsch JR, Koehler RC, Traystman RJ: Nitric oxide synthase inhibition decreases brain injury following transient focal ischemia.
    • Tanaka M, Nishikawa T: Enhanced pressor response to intravenous ephedrine following oral clonidine premedication.
    • Tanaka M, Nishikawa T: Oral clonidine blunts the pressor response to intravenous ketamine in humans.
  60. 2nd Congress of Asian and Oceanic Society of Regional Anaesthesia, July 1993 (Jakarta, Indonesia)
    • Akiyoshi Y, Goyagi T, Yamashita M: Addition of epidural anaesthesia to general anaesthesia for pyloromyotomy in infants.
  61. 16th International Symposium on Cerebral Blood Flow and Metabolism, May 1993 (Sendai, Japan)
    • Nishikawa T, Kirsch JR, Koehler RC, Bredt DS, Snyder SH, Traystman RJ: N-nitro-L-arginine methyl ester attenuates caudate injury during focal ischemia in cats.
    • Koehler RC, Ulatowski JA, Nishikawa T, Williams M, Bucci E, Traystman RJ: Comparison of albumin and intramolecularly crosslinked hemoglobin transfusion on cerebral blood flow.
  62. 77th Annual Meeting of the Federation of American Societies for Experimental Biology, March 1993 (New Orleans, LA, USA)
    • Nishikawa T, Kirsch JR, Koehler RC, Traystman RJ: Effect of N-nitro-L-arginine (L-NAME) on brain injury following temporary middle cerebral artery occlusion (MCAO) in cats.
    • Williams M, Ulatowski JA, Nishikawa T, Bucci E, Koehler RC, Traystman RJ: Cerebral blood flow differences between crosslinked hemoglobin and albumin induced anemia.
  63. International Anesthesia Research Society 1993 Annual Meeting, March 1993 (San Diego, CA, USA)
    • Goyagi T, Iwai M, Yamashita M: Refined technique for single-shot lumber epidural anesthesia in infants and young children.
  64. Annual Meeting of the American Society of Anesthesiologists, October 1992 (New Orleans, LA, USA)
    • Tanaka M, Watanabe S, Ashimura H, Akiyoshi Y, Nishijima Y, Sato S, Naito H: Optimal dose combination of epidural morphine and fentanyl for postoperative analgesia: a double-blind study.
  65. 10th World Congress of Anaesthesiologists, June 1992 (Hague, Netherlands)
    • Kimura T, Sato S, Okubo N, Naito H: End-tidal CO2 or lactic acid; Which is a better prognostic factor for successful resuscitation ?
  66. 76th Annual Meeting of the Federation of American Societies for Experimental Biology, April 1992 (Anaheim, CA, USA)
    • Nishikawa T, Kirsch JR, Koehler RC, Bredt DS, Snyder SH, Traystman RJ:Effect of N-nitro-L-arginine on blood flow response and caudate injury volume following middle cerebral artery occlusion in cats.
    • Enzan K, Komatsu H, Shouji K, Mitsuhata H, Masaki Y, Tobe Y, Suzuki M, Yoshioka N: Inhibition of pulmonary hypertensive reaction to human erythrocytes in sensitized rabbits.
  67. 2nd America-Japan Anesthesia Congress, January 1992 (Honolulu, HI, USA)
    • Anzai Y, Nishikawa T: Epidural clonidine and morphine in combined use for postoperative pain relief.
  68. 5th Congress of International Association for The Study of Pain 1990 (Adelaide, Australia)
    • Watanabe S, Tanaka M: Postoperative analgesia by epidural morphine and fentanyl combination for those who underwent transabdominal hysterectomy.
  69. 5th World Congress on Intensive and Critical Care Medicine, September 1989 (Kyoto, Japan)
    • Nishikawa T, Dohi S, Naito H: Hemodynamic status susceptible to slowing of heart rate during thermodilution cardiac output determination in anesthetized patients.
  70. International Symposium on Regional Anaesthesia June 1989 (Dusseldorf, Germany)
    • Dohi S, Tanaka M: Cardiopulmonary changes during cervical epidural anaesthesia.
    • Dohi S, Tanaka M: Techniques of cervical epidural anaesthesia in adults.
  71. 14th International Symposium on Cerebral Blood Flow and Metabolism, May 1989 (Bologna, Italy)
    • Nishikawa T, Dohi S, Naito H: Changes in cerebral blood flow and hemodynamics after normalization of increased intracranial pressure.
  72. Annual Meeting of the American Society of Anesthesiologists, October 1988 (San Francisco, CA, USA)
    • Dohi S, Tanaka M, Naito H: Effects of ephedrine and phenylephrine on pulmonary arterial pressure in patients with cervical, lumbar epidural or enflurane anesthesia.
  73. 9th World Congress of Anesthesiologists, May 1988 (Washington DC, USA)
    • Nishikawa T, Namiki A: Mechanism for slowing of heart rate induced by cold injectate during thermodilution.
    • Anzai Y, Nishikawa T, Namiki A: Participation of the autonomic nervous system in nitrous oxide induced myocardial depression during high dose fentanyl anesthesia.
    • Dohi S, Tanaka M, Ishizawa Y, Takahashi H, Matsumiya N, Kondo Y: End-tidal carbon dioxide monitoring during awake blind nasotracheal intubation.
    • Tanaka M, Dohi S, Naito H: Effects of ephedrine and phenylephrine on pulmonary arterial pressure in patients with cervical, lumbar epidural or enflurane anesthesia.
  74. 7th World Congress of Anesthesiologists, September 1980 (Hamburg, West Germany)
    • Dohi S, Ujike Y, Nishikawa T, Takahashi T: Cardiovascular changes following airway stimulation and cervical epidural block.