Faroese Birth Cohort Study (フェロー出生コーホート研究)



フェロー出生コホート研究



Grandjean P, Weihe P, Jorgensen PJ, Clarkson T, Cemichiari E, Videro T: Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health 47: 185-195, 1992

Grandjean P, Weihe P: Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias. Environ Res 61: 176-183, 1993

Olsen SF, Grandjean P, Weihe P, Videro T: Frequency of seafood intake in pregnancy as a determinant of birth weight: evidence for a dose dependent relationship. J Epidemiol Community Health 47: 436-440, 1993

Grandjean P, Jorgensen PJ, Weihe P: Human milk as a source of methylmercury exposure in infants. Environ Health Perspect 102: 74-77, 1994

Grandjean P, Weihe P, Nielsen JB: Methylmercury: significance of intrauterine and postnatal exposures. Clin Chem 40: 1395-1400, 1994

Grandjean P, Weihe P, White RF: Milestone development in infants exposed to methylmercury from human milk. Neurotoxicology 16: 27-33, 1995

Grandjean P, Weihe P, Needham LL, Burse VW, Patterson DG Jr, Sampson EJ, Jorgensen PJ, Vahter M: Relation of a seafood diet to mercury, selenium, arsenic, and polychlorinated biphenyl and other organochlorine concentrations in human milk. Environ Res 71: 29-38, 1995

Grandjean P, White RF, Weihe P: Neurobehavioral epidemiology: application in risk assessment. Environ Health Perspect 104(Suppl 2): 397-400, 1996

Dahl R, White RF, Weihe P, Sorensen N, Letz R, Hudnell HK, Otto DA, Grandjean P: Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year-old children. Neurotoxicol Teratol 18: 413-419, 1996

Weihe P, Grandjean P, Debes F, White R: Health implications for Faroe islanders of heavy metals and PCBs from pilot whales. Sci Total Environ 186: 141-148, 1996

Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ: Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19: 417-428, 1997

Grandjean P, Weihe P, White RF, Debes F: Cognitive performance of children prenatally exposed to "safe" levels of methylmercury. Environ Res 77: 165-172, 1998

Sorensen N, Murata K, Budtz-Jorgensen E, Weihe P, Grandjean P: Prenatal methylmercury exposure as a cariovascular risk factor at senven years of age. Epidemiology 10: 370-375, 1999

Grandjean P, Budtz-Jorgensen E, White RF, Jorgensen PJ, Weihe P, Debes F, Keiding N: Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years. Am J Epidemiol 150: 301-305, 1999

Murata K, Weihe P, Araki S, Budtz-Jorgensen E, Grandjean P: Evoked potentials in Faroese children prenatally exposed to methylmercury. Neurotoxicol Teratol 21: 471-472, 1999

Budtz-Jorgensen E, Grandjean P, Keiding N, White RF, Weihe P: Benchmark dose calculations of methylmercury-associated neurobehavioral deficits. Toxicol Lett 112-113: 193-199, 2000

Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, Budtz-Jorgensen E, Grandjean P: Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr 136: 599-605, 2000

Grandjean P, White RF, Sullivan K, Debes F, Murata K, Otto DA, Weihe P: Impact of contrast sensitivity performance on visually presented neurobehavioral tests in mercury-exposed children. Neurotoxicol Teratol 23: 141-146, 2001

Grandjean P, Weihe P, Burse VW, Needham LL, Storr-Hansen E, Heinzow B, Debes F, Murata K, Simonsen H, Ellefsen P, Budtz-Jorgensen E, Keiding N, White RF: Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol 23: 305-317, 2001

Grandjean P, Bjerve KS, Weihe P, Steuerwald U: Birthweight in a fishing community: significance of essential fatty acids and marine food contaminants. Int J Epidemiol 30: 1272-1278, 2001

Mol NM, Sorensen N, Weihe P, Andersson AM, Jorgensen N, Skakkebaek NE, Keiding N, Grandjean P: Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls. Eur J Endocrinol 146: 357-363, 2002

Weihe P, Hansen JC, Murata K, Debes F, Jorgensen P, Steuerwald U, White RF, Grandjean P: Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury. Int J Circumpolar Health 61: 41-49, 2002

Fangstrom B, Athanasiadou M, Grandjean P, Weihe P, Bergman A: Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women. Environ Health Perspect 110: 895-899, 2002

Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P: Estimation of health effects of prenatal methylmercury exposure using structural equation models. Environ Health 1: 2, 2002

Grandjean P, White RF, Weihe P, Jorgensen PJ: Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. Ambul Pediatr 3: 18-23, 2003

Grandjean P, Budtz-Jorgensen E, Steuerwald U, Heinzow B, Needham LL, Jorgensen PJ, Weihe P: Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls. FASEB J 17: 699-701, 2003

Grandjean P, Weihe P: Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure. Am J Clin Nutr 77: 715-719, 2003

Budtz-Jorgensen E, Keiding N, Grandjean P, Wiehe P, White RF: Consequences of exposure measurement error for confounder identification in environmental epidemiology. Stat Med 22: 3089-3100, 2003

Rasmussen TH, Nielsen F, Andersen HR, Nielsen JB, Weihe P, Grandjean P: Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts. Environ Health 2: 12, 2003

Grandjean P, Budtz-Jorgensen E, Keiding N, Weihe P: Underestimation of risk due to exposure misclassification. Int J Occup Environ Health 17: 131-136, 2004

Budtz-Jorgensen E, Grandjean P, Jorgensen PJ, Weihe P, Keiding N: Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages. Environ Res 95: 385-393, 2004

Grandjean P, Murata K, Budtz-Jorgensen E, Weihe P: Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese Birth Cohort. J Pediatr 144: 169-176, 2004

Murata K, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Grandjean P: Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury. J Pediatr 144: 177-183, 2004

Barr DB, Weihe P, Davis MD, Needham LL, Grandjean P: Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort. Chemosphere 62: 1167-1182, 2005

Debes F, Budtz-Jorgensen E, Weihe P, White RF, Grandjean P: Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Terato 28: 536-547, 2006

Heilmann C, Grandjean P, Weihe P, Nielsen F, Budtz-Jorgensen E: Reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls. PLoS Med 3: e311, 2006

Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P: Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure. Ann Epidemiol 17: 27-35, 2006

Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brosen K: Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. Eur J Clin Pharmacol 62: 1041-1048, 2006

Budtz-Jorgensen E, Grandjean P, Weihe P: Separation of risks and benefits of seafood intake. Environ Health Perspect 115: 323-327, 2006

Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brosen K: Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activitity in healthy Faroese adults. Toxicol Appl Pharmacol 224: 202-206, 2007

Choi AL, Budtz-Jorgensen E, Jorgensen PJ, Steuerwald U, Debes F, Weihe P, Grandjean P: Selenium as a potential protective factor against mercury developmental neurotoxicity. Environ Res 107: 45-52, 2008

Grandjean P, Bellinger D, Bergman A, Cordier S, Davey-Smith G, Eskenazi B, Gee D, Gray K, Hanson M, van den Hazel P, Heindel JJ, Heinzow B, Hertz-Picciotto I, Hu H, Huang TT, Jensen TK, Landrigan PJ, McMillen IC, Murata K, Ritz B, Schoeters G, Skakkebaek NE, Skerfving S, Weihe P: The faroes statement: human health effects of developmental exposure to chemicals in our environment. Basic Clin Pharmacol Toxicol 102: 73-75, 2008.

Wermuth L, Bech S, Petersen MS, Joensen P, Weihe P, Grandjean P: Prevalence and incidence of Parkinson's disease in the Faroe Islands. Acta Neurol Scand 118: 126-131, 2008

Halling J, Petersen MS, Grandjean P, Weihe P, Brosen K: Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands. Pharmacogenet Genomics 18: 209-212, 2008

Petersen MS, Halling J, Bech S, Wermuth L, Weihe P, Nielsen F, Jorgensen PJ, Budtz-Jorgensen E, Grandjean P: Impact of dietary exposure to food contaminants on the risk of Parkinson's disease. Neurotoxicology 29: 584-590, 2008

Petersen MS, Weihe P, Choi A, Grandjean P: Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease. Neurotoxicology 29: 591-595, 2008

Weihe P, Kato Calafat AM, Nielsen F, Wanigatunga AA, Needham LL, Grandjean P: Serum concentrations of polyfluoroalkyl compounds in Faroese whale meat consumers. Environ Sci Technol 42: 6291-6295, 2008

Grandjean P, Budtz-Jorgensen E, Barr DB, Needham LL, Weihe P, Heinzow B: Elimination half-lives of polychlorinated biphenyl congeners in children. Environ Sci Technol 42: 6991-6996, 2008

Choi AL, Cordier S, Weihe P, Grandjean P: Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafood. Crit Rev Toxicol 38: 877-893, 2008

Coccini T, Manzo L, Debes F, Steuerwald U, Weihe P, Grandjean P: No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphyenyls. Biomarkers 14: 67-76, 2009

Choi AL, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Salonen JT, Tuomainen TP, Murata K, Nielsen HP, Petersen MS, Askham J, Grandjean P: Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 117: 367-372, 2009

Schlezinger JJ, Bermard PL, Haas A, Grandjean P, Weihe P, Sherr DH: Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans. Environ Health Perspect 118: 693-698, 2010

Dalgard C, Petersen MS, Schmedes AV, Brandslund I, Weihe P, Grandjean P: High latitude and marine diet: vitamin D status in elderly Faroese. Br J Nutr 104: 914-918, 2010

Grandjean P, Poulsen LK, Heilmann C, Steuerwald U, Weihe P: Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants. Environ Health Perspect 118: 1429-1433, 2010

Heilmann C, Budtz-Jorgensen E, Nielsen F, Heinzow B, Weihe P, Grandjean P: Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants. Environ Health Perspect 118: 1434-1438, 2010

Spulber S, Rantamaki T, Nikkila O, Castren E, Weihe P, Grandjean P, Ceccatelli S: Effects of maternal smoking and exposure to methylmercury on brain-derived neurotrophic factor concentrations in umbilical cord serum. Toxicol Sci 117: 263-269, 2010

Julvez J, Debes F, Weihe P, Choi A, Grandjean P: Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure. Neurotoxicol Teratol 32: 627-632, 2010

Budtz-Jorgensen E, Debes F, Weihe P, Grandjean P: Structural equation models for meta-analysis in environmental risk assessment. Environmetrics 21: 510-527, 2010

Yorifuji T, Debes F, Weihe P, Grandjean P: Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury. Neurotoxicol Teratol 33: 205-211, 2011

Needham LL, Grandjean P, Heinzow B, Jorgensen PJ, Nielsen F, Patterson DG, Sjodin A, Tumer WE, Weihe P: Partition of environmental chemicals between maternal and fetal blood and tissues. Environ Sci Tehnol 45: 1121-1126, 2011

Grandjean P, Henriksen JE, Choi AL, Petersen MS, Dalgard C, Nielsen F, Weihe P: Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes. Epidemiology 22: 410-417, 2011

Dalgard C, Petersen MS, Weihe P, Grandjean P: Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care 34: 1284-1288, 2011

White RF, Palumbo CL, Yurgelun-Todd DA, Heaton KJ, Weihe P, Debes F, Grandjean P: Functional MRI approach to developmental methylmercury and polychloriated biphenyl neurotoxicity. Neurotoxicology 32: 975-980, 2011

Julvez J, Debes F, Weihe P, Choi AL, Grandjean P: Thyroid dysfunction as a mediator of organochlorine neurotoxicity in preschool children. Environ Health Perspect 119: 1429-1435, 2011

Grandjean P, Andersen EW, Budtz-Jorgensen E, Nielsen F,Molbak K, Weihe P, Heilmann C: Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA 307: 391-397, 2012

Grandjean P, Weihe P, Nielsen F, Heinzow B, Debes F, Budtz-Jorgensen E: Neurobehavioral deficits at 7 years associated with prenatal exposure to toxicants from maternal seafood diet. Neurotoxicol Teratol 34: 466-472, 2012

Grandjean P, Gronlund C, Kjaer IM, Jensen TK, Sorensen N, Andersson AM, Juul A, Skakkebaek NE, Budtz-Jorgensen E, Weihe P: Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls. Reprod Toxicol 34: 498-503, 2012

Halling J, Petersen MS, Jorgensen N, Jensen TK, Grandjean P, Weihe P: Semen quality and reproductive hormones in Faroese men: a cross-sectional population-based study of 481 men. BMJ Open 1: 3, 2013

Yorifuji T, Murata K, Bjerve KS, Choi AL, Weihe P, Grandjean P: Visual evoked potentials in children prenatally epxosed to methylmercury. Neurotoxicology 37: 15-18, 2013

Tang-Peronard JL, Heitmann BL, Andersen HR, Steuerwald U, Grandjean P, Weihe P, Jensen TK: Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands. Am J Clin Nutr 99: 5-13, 2014

Choi AL, Mogensen UB, Bjerve KS, Debes F, Weihe P, Grandjena P, Budtz-Jorgensen E: Negative confounding by essential fatty acids in methylmercury neurotoxicity. Neurotoxicol Teratol 42: 85-92, 2014

Grandjean P, Weihe P, Debes F, Choi AL, Budtz-Jorgensen E: Neurotoxicity from prental and postnatal exposure to methylmercury. Neurotoxicol Teratol 43: 39-44, 2014

Kim BM, Choi AL, Ha EH, Pedersen L, Nielsen F, Weihe P, Hong YC, Budtz-Jorgensen E, Grandjean P: Effect of hemoglobin adjustment on the precision of mercury concentrations in maternal and cord blood. Environ Res 132: 407-412, 2014

Li M, Sherman LS, Blum JD, Grandjean P, Mikkelsen B, Weihe P, Sunderland EM, Shine JP: Assessing sources of human methylmercury exposure using stable mercury isotopes. Environ Sci Technol 48: 8800-8806, 2014

Osuna CE, Grandjean P, Weihe P, El-Fawal HA: Autoantibodies associated with prenatal and childhood exposure to environmental chemicals in Faroese children. Toxicol Sci 142: 158-166, 2014

Kvist L, Giwercman A, Weihe P, Kold Jensen T, Grandjean P, Halling J, Petersen MS, Giwercman YL: Exposure to persistent organic pollutants and sperm sex chromosome ratio in men from the Faroe Islands. Environ Int 73: 359-364, 2014

Petersen MS, Halling J, Weihe P, Jensen TK, Grandjean P, Nielsen F, Jorgensen N: Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls. Environ Res 138: 345-351, 2015

Timmermann CA, Osuna CE, Steuerwald U, Weihe P, Poulsen LK, Grandjean P: Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination. Pediatr Allergy Immunol 26: 742-749, 2015

Mongensen UB, Grandjean P, Heilmann C, Nielsen F, Weihe P, Budtz-Jorgensen E: Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates. Environ Health 14: 47, 2015

Tottenborg SS, Choi AL, Bjerve KS, Weihe P, Grandjean P: Effect of seafood mediated PCB exposure on desaturase activity and PUFA profile in Faroese septuagenarians. Environ Res 140: 699-703, 2015

Tang-Peronard JL, Heitmann BL, Jensen TK, Vinggaard AM, Madsbad S, Steuerwald U, Grandjean P, Weihe P, Nielsen F, Andersen HR: Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls. Environ Res 142: 407-413, 2015

Mogensen UB, Grandjean P, Nielsen F, Weihe P, Budtz-Jorgensen E: Breastfeeding as an exposure pathway for perfluorinated alkylates. Environ Sci Technol 49: 10466-10473, 2015

Debes F, Weihe P, Grandjean P: Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury. Cortex 74: 358-369, 2016

Perry MJ, Young HA, Grandjean P, Halling J, Petersen MS, Martenies SE, Karimi P, Weihe P: Sperm aneuploidy in Faroese men with lifetime exposure to dichlorodiphenyldichloroethylene (p,p-DDE) and polychlorinated biphenyls (PCB) pollutants. Environ Health Perspect 124: 951-956, 2016

Dalgard C, Petersen MS, Steuerwald U, Weihe P, Grandjean P: Umbilical cord serum 25-hydroxyvitamine D concentrations and relation to birthweight, head circumference and infant length at age 14 days. Paediatr Perinat Epidemiol 30: 238-245, 2016

Oulhote Y, Steuerwald U, Debes F, Weihe P, Grandjean P: Behavioral difficulties in 7-year-old children in relation to developmental exposure to perfluorinated alkyl substances. Environ Int 97: 237-245, 2016

Weihe P, Debes F, Halling J, Petersen MS, Muckle G, Odland JO, Dudarev A, Ayotte P, Dewailly E, Grandjean P, Bonefeld-Jorgensen E: Health effects associated with measured levels of contaminants in the Arctic. Int J Circumpolar Health 75: 33805, 2016

Timmermann CAG, Budtz-Jorgensen E, Petersen MS, Weihe P, Steuerwald U, Nielsen F, Jensen TK, Grandjean P: Shorter during of breastfeeding at elevated exposures to perfluoroalkyl substances. Reprod Toxicol 68: 164-170, 2017

Karlsen M, Grandjean P, Weihe P, Steuerwald U, Oulhote Y, Valvi D: Early-life exposures to persistent organic pollutants in relation to overweight in preschool children. Reprod Toxicol 68: 145-153, 2017

Oulhote Y, Shamim Z, Kielsen K, Weihe P, Grandjean P, Ryder LP, Heilmann C: Children's white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants. Reprod Toxicol 68: 207-214, 2017

Oulhote Y, Debes F, Vestergaard S, Weihe P, Grandjean P: Aerobic fitness and neurocognitive function scores in young Faroese adults and potential modification by prenatal methylmercury exposure. Environ Health Perspect 125: 677-683, 2017

Timmermann CA, Budtz-Jorgensen E, Jensen TK, Osuna CE, Petersen MS, Steuerwald U, Nielsen F, Poulsen LK, Weihe P, Grandjean P: Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. J Immunotoxicol 14: 39-49, 2017

Grandjean P, Heilmann C, Weihe P, Nielsen F, Mogensen UB, Budtz-Jorgensen E: Serum vaccine antibody concentrations in adolescents exposed to perfluorinated compounds. Environ Health Perspect 125: 077018, 2017

Valvi D, Oulhote Y, Weihe P, Dalgard C, Bjerve KS, Steuerwald U, Grandjean P: Gestational diabetes and offspring birth size at elevated environmental pollutant exposures. Environ Int 107: 205-215, 2017

Grandjean P, Heilmann C, Weihe P, Nielsen F, Mogensen UB, Timmermann A, Budtz-Jorgensen E: Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years. J Immunotoxicol 14: 188-195, 2017

Timmermann CAG, Choi AL, Petersen MS, Nielsen F, Budtz-Jorgensen E, Weihe P, Grandjean P: Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury. Int J Circumpolar Health 76: 1406234, 2017

Hu XC, Dassuncao C, Zhang X, Grandjean P, Wiehe P, Webster GM, Nielsen F, Sunderland EM: Can profiles of poly- and perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? Environ Health 17: 11, 2018



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