動物実験部門を利用した各講座の2012年研究業績

病態制御医学系

形態解析学・器官構造学講座（旧解剖学第一）

1. Zhou, M., He, H.J., Tanaka, O., Sekiguchi, M.,Kawahara, K. and Abe, H. (2012) Localization of the ATP- sensitive K channel regulatory subunits SUR2A and SUR2B in the rat brain. Neuroscience Res., 74, 91-105.

学会発表　3

病態制御医学系

細胞生物学講座（旧解剖学第二）

1. Mezaki, Y., Morii, M., Yoshikawa, K., Yamaguchi, N., Satoyoshi, K., Miura, M., Imai, K., Hebiguchi, T., Habuchi, T. and Senoo, H. (2012) Elevated expression of transforming growth factor β3 in carbon tetrachloride-treated rat liver and involvement of retinoid signaling.　Int. J. Mol. Med., 29, 18-24.

学会発表　4、特別講義　3

病態制御医学系

細胞生理学講座（旧生理学第一）

1. Okamoto, Y., Takano, M., Ohba, T. and Ono, K. (2012) Arrhythmogenic coupling between the Na⁺ -Ca²⁺ exchanger and inositol 1,4,5 –triphosphate receptor in rat pulmonary vein cardiomyocytes, J.M.C.C., 52, 988-997.

2. Zhang, C., Okamoto, Y., Ohba, T., Ishibashi, K., Yamamoto, H., Ono, K. and Yamamoto, F.(2012) Down- regulation of L- type Ca2+ current in left atrial myocytes of rats during experimental cardiac hypertrophy.　Akita J. Med., 39, 61-71.

3. Shibata, S., Okamoto, Y., Endo, S. and Ono, K. (2012) Direct effects of esmolol and landiolol on cardiac function, coronary vasoactivity, and ventricular electrophysiology in guinea-pig hearts. 　J. Pharmacol. Sci., 118(2), 255-265.

4. Seya, K., Ono, K., Fujiswa, S., Okumura, K., Mo- tomura, S. and Furukawa, K. (2013) Cytosolic Ca2+- induced apoptosis in rat cardiomyocytes via mitochondrial NO- cGMP- protein kinase G pathway.　J. Pharmacol Exp. Ther., 344(1), 77-84, Epub 2012 Oct 25.

学会発表　14

病態制御医学系

器官病態学講座（旧病理学第二）

1. Kawamura, K. (2012) The value of electron microscopy for endomyocardial biopsy. Scientific Instrument News, Volume 3, 11-19.

学会発表　5

病態制御医学系

分子機能学・代謝機能学講座（旧生化学第一）

1. Sone, M., Nishikawa, Y., Nagahama, Y., Kumagai, E., Doi, Y., Omori, Y., Yoshioka, T., Tokairin, T., Yoshida, M., Sugiyama, T. and Enomoto, K. (2012) Recovery of mature hepatocytic phen otype following Bile Ductular Transdifferentiation of rat hepatocytes in vitro.　Am. J. Pathol., 181, 2094-2104.

2. 増田　豊,　杉山俊博(2012) 行動変容をもたらす血中複合糖質の構造主義的検討. 秋田県医師会雑誌63, 8-19.

学会発表　2

病態制御医学系

内分泌・代謝・老年内科学講座（旧老年医学）

1. Fujita, H., Fujishima, H., Morii, T., Sakamoto, T., Komatsu, K., Hosoba, M., Narita, T., Takahashi, K., Takahashi, T. and Yamada, Y. (2012) Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6- Ins2 (Akita) diabetic mice.　Hypertens Res., 35, 213-220.

2. Fujita, H., Fujishima, H., Takahashi, K., Sato, T., Shimizu, T., Morii, T., Shimizu, T., Shirasawa, T., Zhonghua, Q.I., Matthew, D.B., Raymond, C.H., Yamada, Y. and Takahashi, T. (2012) SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6- Ins2 (Akita) diabetic mice. Metaborism, 61, 1714-1724.

病態制御医学系

感染・免疫アレルギー・病態検査学講座（旧臨床検査医学）

学会発表　4

病態制御医学系

麻酔・蘇生・疼痛管理学講座（旧麻酔学）

1. Goyagi, T., Tobe, Y. and Nishikawa, T.(2012) Long-term and spatial memory effects of selective β1-antagonist after transient focal ischaemia in rats.　Br. J. Anaesth., 109, 399-406.

2. Goyagi, T., Horiguchi, T., Nishikawa, T., Tobe, Y. and Masaki, Y. (2012) Neuroprotective effects of selective beta-1 adrenoceptor antagonists, landiolol and esmolol, on transient forebrain ischemia in rats ; a dose-response study.　Brain Res., 1461, 96-101.

学会発表　12

病態制御医学系

眼科学講座（旧眼科学）

著書　2、学会発表　6

病態制御医学系

微生物学講座（旧微生物学）

1. Chida, S., Itoh, R., Kofuji, S., Eguchi, S., Takasuga, S., Sasaki, J. and Sasaki, T. (2012) SHIP1 deletion enhances ROS production and decreases survival of the S. aureus infected mice. Akita J. Med., 39, 95-101.

2. Asanuma, K., Takasuga, S., Sasaki, J. and Sasaki, T. (2012) Phosphatidylinositol 3, 5-bisphosphate is an essential regulator of lysosome morphology.　Akita J. Med., 39, 129-137.

3. Biswas, K., Yoshioka, K., Asanuma, K., Okamoto, Y., Takuwa, N., Sasaki, T. and Takuwa, Y. (2012) Essential role of class II PI3K- C2α in sphingosine-1-phosphate receptor-1 mediated signaling and migration in endothelial cells. J. Biol. Chem., 288, 2325-2339.

4. Ichikawa, A., Kuba, K., Morita, M., et al. (2012) CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Non-viral Origin. Am. J. Respir Crit Care Med., 187, 65-77.

5. Neely, G.G., Rao, S., Costigan, M., et al. (2012) Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet., 8, e1003071.

6. Nishio, M., Hamada, K., Kawahara, K., et al. (2012) Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest., 122, 4505-4518.

7. Lee, H.C., Inoue, T., Sasaki, J., et al. (2012) LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol. Biol. Cell., 23, 4689-4700.

8. Kawamura, N., Sun-Wada, G.H., Aoyama, M., Harada, A., Takasuga, S., Sasaki, T. and Wada, Y. (2012) Delivery of Endosomes to Lysosomes via Microautophagy in the Visceral Endoderm of Mouse Embryos. Nature Commun., 3, 1071. doi : 10.1038/ncomms2069.

9. Yoshioka, K., Yoshida, K., Cui, H., et al. (2012) Essential role of endothelial class II PI3K-C2α in angiogenesis and vascular barrier function. Nature Med., 18, 1560-1569.

10. Shinohara, M., Nakamura, M., Masuda, H., et al. (2012) Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through Akt-mediated vesicle transport. J. Bone Miner Res., 27, 2464-2475.

11. Kurokawa, T., Takasuga, S., Sakata, S., Yamaguchi, S., Horie, S., Homma, K.J., Sasaki, T. and Okamura, Y. (2012) 3’ Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc. Natl. Acad. Sci., 109, 10089-10094.

12. Imae, R., Inoue, T., Nakasaki, Y., Uchida, Y., Ohba, Y., Kono, N., Nakanishi, H., Sasaki, T., Mitani, S. and Arai, H. (2012) LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. J. Lipid Res., 53, 335-347.

著書　2、学会発表　10

腫瘍制御医学系

分子生化学講座，（旧生化学第二）

1. Tanaka, M., Kuriyama, S. and Aiba, N.(2012) Nm23-H1 regulates contact inhibition of locomotion which is affected by ephrin-B1.　J. Cell. Science., 125, 4343-4353.

学会発表　7、報告書　1

腫瘍制御医学系

分子病態学・腫瘍病態学講座（旧病理学第一）

1. Sone, M., Nishikawa, Y., Nagahama, Y., Kumagai, E., Doi, Y., Omori, Y., Yoshioka, T., Tokairin, T., Yoshida, M., Sugiyama, T. and Enomoto, K. (2012) Recovery of mature hepatocytic phenotype following bile ductular transdifferentiation of rat hepatocytes in vitro.　Am. J. Pathol., 181, 2094-2104.

2. Nishikawa, Y., Sone, M., Nagahama, Y., Kumagai, E., Doi, Y., Omori, Y., Yoshioka, T., Tokairin, T., Yoshida, M., Yamamoto, Y., Ito, A., Sugiyama, T. and Enomoto, K. (2012) Tumor necrosis factor-α promotes bile ductular transdifferentiation of mature rat hepatocytes in vitro. J. Cell. Biochem., [Epub ahead of print]

著書　1、総説　1、学会発表　5

腫瘍制御医学系

消化器内科学・神経内科学講座（旧内科学第一）

1. Miura, K., Yang, L., van Rooijen, N., Ohnishi, H. and Seki, E. (2012) Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2.　Am. J. Physiol Gastrointest Liver Physiol., 302, G1310-1321.

2. 眞嶋浩聡, 大西洋英 (2012) インターフェロン制御因子IRF-2は膵調節性外分泌に重要な役割を果たし,急性膵炎モデルIRF2KOマウスを用いて膵炎発症の分子メカニズム解明を目指す. 分子生物学が可能とした個別化医療第19回浜名湖シンポジウム記録集, 106-114. (Proceedings)

学会発表　11、報告書　4、受賞　6

腫瘍制御医学系

血液・腎臓・膠原病内科学講座（旧内科学第三）

1. Liu, J., Guo, Y.M., Hirokawa, M., Iwamoto, K., Ubukawa, K., Michishita, Y., Fujishima, N., Tagawa, H., Takahashi, N., Xiao, W., Yamashita, J., Ohteki, T. and Sawada, K. (2012) A synthetic double-stranded RNA, poly I : C, induces a rapid apoptosis of human CD34+ cells.　Exp. Hematol., 40, 330-341.

学会発表　7

腫瘍制御医学系

消化器外科学講座（旧外科学第一）

1. Watanabe, G., Uchinami, H., Yoshioka, M., Abe, Y., Kikuchi, I., Iwasaki, W., Kume, M. and Yamamoto, Y. (2012) Transfection of Naked Nuclear Factor-κB Decoy Oligodeoxynucleotides into Liver by Rapid Portal Vein Infusion in Rats : Its Effect on Ischemia-Reperfusion Injury of Liver.　HUMAN GENE THERAPY, 23, 428-436.

2. Nakagawa, Y., Yoshioka, M., Abe, Y., Uchinami, H., Ohba, T., Ono, K. and Yamamoto, Y. (2012) Enhancement of Liver Regeneration by Adenosine Triphosphate-Sensitive K+ Channel Opener (Diazoxide) After Partial Hepatectomy.　Transplantation, 93(11), 1094-1100.

学会発表　3

腫瘍制御医学系

呼吸器・乳腺内分泌外科学講座，第二外科（旧外科学第二）

1. Imai, K., Minamiya, Y., Koyota, S., Ito, M., Saito, H., Sato, Y., Motoyama, S., Sugiyama, T. and Ogawa, J. (2012) Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis. J. Exp. Clin. Cancer Res., 31, 3.

学会発表　2

腫瘍制御医学系

腎泌尿器科学講座（旧泌尿器科学）

1. Maita, S., Yuasa, T., Tsuchiya, N., Mitobe, Y., Narita, S., Horikawa, Y., Hatake, K., Fukui, I., Kimura, S., Maekawa, T. and Habuchi, T. (2012) Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function.　Int. J. Cancer, 130, 677-684.

2. Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N. and Habuchi, T. (2012) A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling.　Prostate, 72, 1779-1788.

機能展開医学系

器官・統合生理学講座（旧生理学第二）

1. Matsumoto-Miyai, K., Yamada, E., Yoshizumi, M. and Kawatani, M. (2012) The regulation of distention-induced ATP release from urothelium by the adenylyl cyclase-cyclic AMP pathway. Biomedical Res., 33, 153-157.

2. 松本-宮井和政,河谷正仁(2012) 膀胱上皮からの分泌における貯蔵量作動性Ca2+流入と抑制性アデニル酸シクラーゼの役割. 排尿障害プラクティス

機能展開医学系

整形外科学講座，整形外科（旧整形外科学）

1. Tsuchie, H., Miyakoshi, N., Kasukawa, Y., Aonuma, H. and Shimada, Y. (2012) Intermittent administration of human parathyroid hormone before osteosynthesis stimulates cancellous bone union in ovariectomized rats.　The Tohoku Journal of Experimental Medicine, 229, 19-28.

学会発表　6

機能展開医学系

耳鼻咽喉科・頭頸部外科学講座（旧耳鼻咽喉科学）

1. Koizumi, K., Omi, E., Angunsri, N., Honda, K., Ono, K. and Ishikawa, K. (2012) Age-Related Changes in Electrophysiological Properties in CBA/N Mice Utricular TypeII Hair cells.　Akita J. Med., 39, 81-87.

機能展開医学系

脳神経外科学講座（旧脳神経外科学）

報告書　1

機能展開医学系

循環器内科学・呼吸器内科学講座，循環器内科・呼吸器内科（旧内科学第二）

著書　1、学会発表　11

機能展開医学系

情報制御学・実験治療学講座（旧薬理学）

1. Kuba, K., Imai, Y. and Penninger, J.M. (2012) Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases.　Circ. J., 77(2), 301-308.

2. Ichikawa, A., Kuba, K., Morita, M., Chida, S., Tezuka, H., Hara, H., Sasaki, T., Ohteki, T., Ranieri, V.M., dos Santos, C.C., Kawaoka, Y., Akira, S., Luster, A.D., Lu, B., Penninger, J.M., Uhlig, S., Slutsky, A.S. and Imai, Y. (2013) CXCL10-CX-CR3 enhances the development of neutrophilmediated fulminant lung injury of viral and nonviral origin.　Am. J. Respir. Crit. Care Med., 187(1), 65-77. Epub 2012 Nov 9.

3. Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanebe, T., Sakabe, S., Daidoji, T., Nakamura, S., Kadowaki, A., Ohto, T., Nakanishi, H., Taguchi, R., Nakaya, T., Murakami, M., Yoneda, Y., Arai, H., Kawaoka, Y., Penninger, J.M., Arita, M. and Imai, Y. (2013) The lipid mediator protectin D1 inhibits influenza virus replication and improvessevere influenza. Cell, 153(1), 112-125. Epub 2013 Mar7.

機能展開医学系

産婦人科学講座（旧産婦人科学）

1. Sato, N. and Terada, Y. (2012) Temporal expression of functional low density lipoprotein receptors and catalytic enzymes in steroid hormone synthesis of mouse preimplantation embryos.　Akita J. Med., 39(1), 1-12.

2. Makino, K., Kawamura, K., Sato, W., Kawamura, N., Fujimoto, T. and Terada, Y. (2012) Inhibition of Uterine Sarcoma Cell Growth through Suppression of Endogenous Tyrosine Kinase B Signaling.　PLoS One., 7(7), e41049.

3. Kawamura, K., Kawamura, N., Kawagoe, Y., Kumagai, J., Fujimoto, T. and Terada, Y. (2012) Suppression of hydatidiform molar growth by inhibiting endogenous brain- derived neurotrophic dactor/tyrosine kinase B signaling.　Endocrinology., 153(8), 3972-3981.

学会発表　1

機能展開医学系

小児外科学講座（旧小児外科学）

1. Mezaki, Y., Morii, M., Yoshikawa, K., Yamaguchi, N., Satoyoshi, K., Miura, M., Imai, K., Hebuguchi, T., Habuchi, T. and Senoo, H. (2012) Elevated expression of transforming growth factorβ3in carbon tetrachloride-treated rat liver and involvement of retinoid signaling.　Int. J. Mol. Med., 29, 18-24.

2. Senoo, H., Mezaki, Y., Morii, M., Hebiguchi, T., Miura, M. and Imai, K. (2012) Uptake and storage of vitamin A as lipid droplets in the cytoplasm in cells in lamina propria mucosae of rat intestine.　Cell. Biol. Int., doi : 10.1002/cbin. 10140.

学会発表　3

バイオサイエンス教育・研究センター
動物実験部門

学会発表　5、報告書　3、その他の講演　7

生体情報研究センター

1. Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N. and Habuchi, T. (2012) A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling.　Prostate, 72, 1779-1788.

学会発表　2

中央診療施設等

中央検査部

学会発表　4、報告書　1

中央診療施設等

中央手術部

1. Goyagi, T., Horiguchi, T., Nishikawa, T., Tobe, Y. and Masaki, Y. (2012) Neuroprotective effects of selective beta-1 adrenoceptor antagonists, landiolol and esmolol, on transient forebrain ischemia in rats ; a dose-response study.　Brain Res., 1461, 96-101.

学会発表　7

中央診療施設等

病理部

1. Sone, M., Nishikawa, Y., Nagahama, Y., Kumagai, E., Doi, Y., Omori, Y., Yoshioka, T., Tokairin, T., Yoshida, M., Sugiyama, T. and Enomoto, K. (2012) Recovery of mature hepatocytic phenotype following bile ductular transdifferentiation of rat hepatocytes in vitro.　Am. J. Pathol., 181, 2094-2104.

著書　1、学会発表　5

中央診療施設等

歯科口腔外科

1. 福田雅幸(2012) 生体内微量元素としての亜鉛の利用. 秋田大学環境安全センター報 32, 13-15.

学会発表　1