動物実験部門を利用した各講座の2009年度研究業績

 

 

 

病態制御医学系

形態解析学・器官構造学講座（旧解剖学第一講座）

 

1.           Suzuki, R., Saino-Saito, S., Sakagami, H., Toshimori, K., Abe, H., Kondo, H. (2009) Localization of EFA6A, a guanine nucleotide exchange factor for ARF6, in spermatogenic cells of testes of adult mice. J Mol Histol., 40, Issue1, 77-80.

2.           Suzuki, R., Nourani, MR., Saino-Saito, S., Abe, H., Nochi, T., Kiyono, H., Spener, F., Kondo, H., Owada, Y. (2009) Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol., 132, (6), 577-584.

3.           Zhou, M., He, HJ., Hirano, M., Tanaka, O., Sekiguchi, M., Kawahara, K., Abe, H. (2009) Localization of ATP channel subunits in rat submandibular gland. J Histochem Cytochem, DOI: 10.1369/jhc.2009.955047.

4.           周　明，賀 恵経，鈴木良地，阿部　寛（2009）, ラット脳におけるスルホニル尿素受容体の発現, 解剖学雑誌，84(2)，p.48.

 

学会発表　2

 

病態制御医学系

細胞生物学講座（旧剖学第二講座）

 

1.           Mezaki, Y., Yamaguchi, N., Yoshikawa, K., Miura, M., Imai, K., Itoh, H., Senoo, H. (2009) Insoluble, speckled cytosolic distribution of retinoic acid receptor alpha protein as a marker of hepatic stellate cell activation in vitro. J Histochem Cytochem., 57, 687-699.

 

総説　2、学会発表　17、セミナー　3、報告書　2

 

病態制御医学系

細胞生理学講座（旧生理学第一講座）

 

1.           Ohba, T., Takahashi, E., Murakami, M. (2009) Modified autonomic regulation in mice with a P/Q-type calcium channel mutation. Biochemical and Biophysical Research Communications, 381, 27–32.

2.           Ohba, T, Watanabe, H., Murakami, M., Sato, T., Ono, K., and Ito, H. (2009) Essential role of STIM1 in the development of cardiomyocyte hypertrophy. Biochemical & Biophysical Research Communications, 389, 172-176.

3.           佐藤紳一，神林崇，近藤英明，松渕浪子，尾野恭一，清水徹男（2009）ＲＥＭ睡眠時呼吸数増大の解析．不眠研究，三原医学社，東京，pp.9-14．

 

学会発表　14

 

病態制御医学系

器官病態学講座（旧病理学第二講座）

 

1.           Komori, C., Okada, K., Kawamura, K., Chida, S., Suzuki, T. (2009) The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro. Anticancer Res., 29, 2411-2415.

2.           Komori, C., Okada, K., Kawamura, K., Suzuki, N., Chida, S., Suzuki, T. (2009) 　Sonodynamic effects of lomefloxacin derivatives conjugated with methoxy polyethylene glycol on sarcoma 180 cells. Anticancer Res., 29, 243-248.

 

著書　1、学会発表　4、報告書　1

 

病態制御医学系

分子機能学・代謝機能学講座（旧生化学第一講座）

 

1.           Wang, J.S., Koyota, S., Zhou, X.P., Ueno, Y., Ma, L., Kawagoe, M., Koizumi, Y., Okamoto, H. and Sugiyama, T. (2009) Expression and localization of Regenerating gene I in a rat liver regeneration model. Biochem. Biophys. Res. Commun., 380, 472–477.

2.           Arany, S., Koyota, S. and Sugiyama, T. (2009) Nerve growth factor promotes differentiation of odontoblast-like cells. J. Cell Biochem., 106, 539-545.

3.           Arany, S., Kawagoe, M. and Sugiyama, T. (2009) Application of spontaneously immortalized odontoblast cells in tooth regeneration. Biochem. Biophys. Res. Commun., 381, 84-89.

4.           Kawagoe, M., Zhou, X.P., Kumagai, A., Wang, J.S., Ma, L., Wang, D.D., Koizumi, Y., Koyota, S. and Sugiyama, T. (2009) The preventive effect of high blood pressure and hyperlipidemia by MCM water intake. Akita J. Med., 36, 165-170.

5.            増田　豊, 石郷岡清基, 杉山俊博 (2009) 動物実験従事者におけるマウス尿に対するアレルギーの発症について. 秋田県医師会雑誌59, 96-100.

 

学会発表　8

 

病態制御医学系

生体防御学講座（旧寄生虫学講座）

 

1.           Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. and Ohteki, T. (2009) Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat. Med., 15, 696-700.

2.           Asano, J., Tada, H., Onai, N., Sato, T., Horie, Y., Fujimoto, Y., Fukase, K., Suzuki, A., Mak,T.W.and Ohteki, T. (2010) Nucleotide oligomerization binding domain-like receptor signaling　enhances dendritic cell-mediated cross-priming in vivo. J. Immunol., 184, 736-745.

 

総説　3、学会発表　12、報告書　10

 

病態制御医学系

微生物学講座（旧微生物学講座）

 

1.           Nishikimi, A., Fukuhara, H., Su, W., Hongu, T., Takasuga, S., Mihara, H., Cao, Q., Sanematsu, F., Kanai, M., Hasegawa, H., Tanaka, Y., Shibasaki, M., Kanaho, Y., Sasaki, T., Frohman, M.A., Fukui, Y. (2009) Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science, 324, 384-387.

2.           Takeda, M., Ito, W., Tanabe, M., Ueki, S., Kato, H., Kihara, J., Tanigai, T., Chiba, T., Yamaguchi, K., Kayaba, H., Imai, Y., Okuyama, K., Ohno, I., Sasaki, T., Chihara, J. (2009) Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. J Allergy Clin Immunol., 123, 805-812.

3.           Mogi, C., Tobo, M., Tomura, H., Murata, N., He, XD., Sato, K., Kimura, T., Ishizuka, T., Sasaki, T., Sato, T., Kihara, Y., Ishii, S., Harada, A., Okajima, F. (2009) Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in　 peritoneal macrophages. J Immunol., 182, 3243-3251.

4.           Anezaki, Y., Ohshima, S., Ishii, H., Kinoshita, N., Dohmen, T., Kataoka, E., Sato, W., Iizuka, M., Goto, T., Sasaki, J., Sasaki, T., Suzuki, A., Ohnishi, H., Horie, Y. (2009) Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol. Res., 39, 609-618.

 

総説　1、学会発表11、その他講演2

 

病態制御医学系

内分泌・代謝・老年内科学講座，老年科（旧老年医学講座）

 

1.           Fujita, H., Fujishima, H., Chida, S., Takahashi, K., Qi, Z., Kanetsuna, Y., Breyer, MD., Harris, RC., Yamada, Y. and Takahashi, T. (2009) Reduction of renal superoxide dismutase in a murine model of progressive diabetic nephropathy. J. Am. Soc. Nephrol., 20, 1303-1313.

 

病態制御医学系

感染・免疫アレルギー・病態検査学講座（旧臨床検査医学講座）

 

1.           Takeda, M., Ito, W., Tanabe, M., Ueki, S., Kato, H., Kihara, J., Tanigai, T., Chiba, T., Yamaguchi, K., Kayaba, H., Imai, Y., Okuyama, K., Ohno, I., Sasaki, T., Chihara, J.（2009）Phosphatidylinositide 3-kinaseg deficient Mice Fail to Develop Allergic Airway Hyperresponsiveness, Inflammation, and Remodeling. J. Allergy. Clin. Immunol., 123, 805-812.

 

総説　1、　学会発表　20

 

病態制御医学系

麻酔・蘇生・疼痛管理学講座，麻酔科（旧麻酔学講座）

 

1.           Goyagi, T., Nishikawa, T., Tobe, Y., Masaki, Y. (2009) The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats. Acta Anaesthesiologica Scandinavica, 53, 1176-1183.

2.            木村哲, 佐藤浩司, 西川俊昭 (2009) ラット一過性前脳虚血モデルにおけるRhoキナーゼ（ファルジル）とデクスメデトミジン併用療法の脳保護効果.　第13回日本神経麻酔・集中治療研究会プロシーディング, 23-25.

3.            合谷木徹, 西川俊昭 (2009) ラット局所脳虚血における選択的β1遮断薬の脳保護効果.　第13回日本神経麻酔・集中治療研究会プロシーディング, 26-29.

4.            堀口剛, 真崎容子, 西川俊昭 (2009) セボフルラン麻酔後の脳内・血液内のセボフルラン量. 第13回日本神経麻酔・集中治療研究会プロシーディング, 59-60.

 

学会発表　21

 

病態制御医学系

眼科学講座，眼科（旧眼科学講座）

 

学会発表　8

 

腫瘍制御医学系

分子病態学・腫瘍病態学講座（旧病理学第一講座）

 

1.           Nishikawa, Y., Ohi, N., Yagisawa, A., Doi, Y., Yamamoto, Y., Yoshida, M., Tokairin, T., Yoshioka, T., Omori, Y. and Enomoto, K. (2009) Suppressive effect of orthovanadate on hepatic stellate cell activation and liver fibrosis in rats. Am. J. Pathol., 174: 881-890.

 

学会発表　13

 

腫瘍制御医学系

消化器内科学・神経内科学講座，消化器内科・神経内科（旧内科学第一講座）

 

1.           Ishii, H., Horie,Y., Ohshima, S., Anezaki, Y., Kinoshita, N., Dohmen ,T., Kataoka , E., Sato, W., Goto, T., Sasaki ,J., Sasaki, T., Watanabe, S., Suzuki, A., Ohnishi, H.(2009) Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol., 50, 562-571.

2.           Anezaki, Y., Ohshima, S., Ishii, H., Kinoshita, N., Dohmen, T., Kataoka, E., Sato, W., Iizuka , M., Goto, T., Sasaki, J., Sasaki, T., Suzuki, A., Ohnishi, H., Horie, Y. (2009) Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol Res., 39, 609-618.

3.           Koizumi, S., Odashima, M., Otaka, M., Jin, M., Linden, J., Watanabe, S., Ohnishi, H. (2009) Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. J Gastroenterol., 44, 419-425

 

総説　1、学会発表　7

 

腫瘍制御医学系

消化器外科学講座，消化器外科（旧外科学第一講座）

 

1.           Satoh, K., Kume, M., Abe, Y., Uchinami, H., Yakubouski, S.V., Takahashi, T., Sato, T., Yamamoto, Y. (2009) Implication of Protein Kinase A for a Hepato-Protective Mechanism of Milrinone Pretreatment. Journal of Surgical Research., 155, 32-39.

 

学会発表　9

 

腫瘍制御医学系

呼吸器・乳腺内分泌外科学講座，呼吸器・食道・内分泌外科（旧外科学第二講座）

 

1.           Ito, A., Saito, H., Mitobe, K., Minamiya, Y., Takahashi, N., Maruyama, K., Motoyama, S., Katayose, Y., Ogawa, J. (2009) Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature. Cancer Sci,. 100, 558-564.

 

学会発表　1

 

機能展開医学系

器官・統合生理学講座（旧生理学第二講座）

 

1.           Wang, X., Matsumoto-Miyai, K., Yoshizumi, M., Ito, T., Yanase, H., Momota, Y., Tsujimoto, G., Tanoue, K., Nimura, T., Kawatani, M. (2009) Urothelial α１D receptor is predominantly involved in the adrenergic facilitation of micturition reflex. LUTS, 1, S10-S14.

2.           Matsumoto-Miyai, K., Kagase, A., Murakawa. Y., Momota, Y., Kawatani, M. (2009) Extracellular Ca2+ regulates the stimulus-elicited ATP release from urothelium. Autonomic Neuroscience: Basic and Clinical, 150, 94-99.

 

著書　1、学会発表　9

 

機能展開医学系

整形外科学講座，整形外科（旧整形外科学講座）

 

1.           Kamo, K., Miyakoshi, N., Kasukawa, Y., Sasaki, H., Shimada, Y. (2009) Effects of single and cyclical local injections of basic fibroblast growth factor on cancellous bone defects in rabbits. J Orthop Sci, 14, 811-819.

2.           Chida, S., Okada, K., Suzuki, N., Komori, C., Shimada, Y. (2009) Infiltration by macrophages and lymphocytes in transplantable mouse sarcoma after irradiation with high-intensity focused ultrasound. Aniticancer Res., 29, 3877-3882.

 

学会発表　1

 

機能展開医学系

皮膚科学・形成外科学講座，皮膚科（旧皮膚科学講座）

 

1.           Kato, M., Osada, S., Hasunuma, N., Nakayama, R., Takeda, J., Itami, S., Taira, M., Manabe. M.（2009）Progranulin, a Secreted Tumorigenesis and Dementia-related Factor, Regulates Mouse Hair Growth. J Dermatol Sci., 53, 234-236.

2.           Tsuda, M., Inoue-Narita, T., Suzuki, A., Itami, S., Blumenberg, M., Manabe, M.（2009）Induction of gene encoding FABP4 in Pten-null keratinocytes. FEBS Letters., 583, 1319-1322.

3.           Yamakawa, T., Inoue-Narita, T., Tsuda, M., Hatakeyama, S., Fujita, S., Sasaki, T., Suzuki, A., Manabe, M. (2009) Suppression of spontaneous carcinogenesis in keratinocyte-specific Pten-deficient mice with selective inhibition of PI3K isoforms. Akita J Med., 36, 19-23.

4.           Kato, M., Hasunuma, N., Itami, S., Manabe, M., Osada, S.（2009）Overexpression of Progranulin Increases Cells in Growth Phase, but is Insufficient to Induce Skin Tumor Formation. Akita J Med., 36, 35-43.

5.           Kawamura, K., Kawamura, N., Sato, W., Fukuda, J., Kumagai, J., Tanaka, T. (2009) Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival. Endocrinology, 150, 3774-3782.

6.           Ye, Y., Kawamura, K., Sasaki, M., Kawamura, N., Groenen, P., Gelpke, MD., Rauch, R., Hsueh, AJ., Tanaka, T.（2009）Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes. Reprod Biol Endcrinol., 7, 26.

7.           Kawamura, K., Ye, Y., Liang, CG., Kawamura, N., Gelpke, MS., Rauch, R., Tanaka, T., Hsueh, AJ.（2009）Paracrine regulation of the resumption of oocyte meiosis by endothelin-1. Dev Biol., 327, 62-70.

 

機能展開医学系

耳鼻咽喉科・頭頸部外科学講座，耳鼻咽喉科（旧耳鼻咽喉科学講座）

 

1.           Fukui, N., Honda, K., Ito, E., Ishikawa, K (2009) Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice. Allergology International, 58, 247-253.

 

学会発表　1

 

機能展開医学系

循環器内科学・呼吸器内科学講座，循環器内科・呼吸器内科（旧内科学第二講座）

 

1.           Ohba, T., Takahashi, E., Murakami, M. (2009) Modified autonomic regulation in mice with a PIQ–type calcium channel mutation. Biochem Biophys Res Commun., 381, 27-32 .

2.           Ohba, T., Watanabe, H., Murakami, M., Sato, T., Ono, K., Ito, H. (2009) Essential role of STIM1 in the development of cardiomyocyte hypertrophy. Biochem Biophys Res Commun. 389, 172-176.

3.           Koyama, T., Ono, K., Watanabe, H., Ohba, T., Murakami, M., Iino, K., Ito, H. (2009) Molecular and Electrical Remodeling of L-and T-type Ca2+ Channels in Rat Right Atrium with Monocrotaline -Induced Pulmonary Hypertension. Circ J., 73, 256-263.

 

機能展開医学系

小児科学講座，小児科（旧小児科学講座）

 

1.           Miura, S., Ishida-Nakajima, W., Ishida, A., Kawamura, M., Ohmura, A., Oguma, R., Sato, Y., Takahashi, T. (2009) Ascorbic acid protects the newborn rat brain from hypoxic-ischemia. Brain Dev., 31, 307-317.

 

機能展開医学系

産婦人科学講座，産婦人科（旧産婦人科学講座）

 

1.           Kawamura, K., Ye, Y., Liang, CG., Kawamura, N., Gelpke, MS., Rauch, R., Tanaka, T., Hsueh, AJ.（2009）Paracrine regulation of the resumption of oocyte meiosis by endothelin-1. Developmental Biology, 327 (1),62-70．

2.           Kawamura, K., Kawamura, N., Sato, W., Fukuda, J., Kumagai, J., Tanaka, T. (2009) Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival. Endocrinology, 150 (8), 3774-3782.

3.           Ye, Y., Kawamura, K., Sasaki, M., Kawamura, N., Groenen, P., Gelpke, MD., Rauch, R., Hsueh, AJ., Tanaka, T. (2009) Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes. Reproductive Biology and Endocrinology, 7, 26.

4.           Ye, Y., Kawamura, K., Sasaki, M., Kawamura, N., Groenen, P., Sollewijn., Gelpke, MD., Kumagai, J., Fukuda, J., Tanaka, T. (2009) Leptin and ObRa/MEK signalling in mouse oocyte maturation and preimplantation embryo development. Reproductive Biomedicine Online, 19 (2), 181-190.

 

総説　4、学会発表　10

 

臨床教育協力部門

歯科口腔外科学（旧歯科口腔外科）

 

1.           Yamamoto, O., Alvarez, K., Kikuchi, T. and Fukuda, M. (2009) Fabrication and characterization of oxygen-diffused titanium for biomedical applications. Acta Biomaterialia, 59(9), 3605-3615.

 

学会発表　7

 

医学部

総合地域医療推進学講座

 

1.           Kato, M., Osada, S., Hasunuma, N., Nakayamam, R., Takeda, J., Itami, S., Taira, M., Manabe, M.（2009）Progranulin, a Secreted Tumorigenesis and Dementia-related Factor, Regulates Mouse Hair Growth．J Dermatol Sci., 53, 234-236．

2.           Kato, M., Hasunuma, N., Itami, S., Manabe, M., Osada, S.（2009）Overexpression of Progranulin Increases Cells in Growth Phase, but is Insufficient to Induce Skin Tumor Formation. Akita J Med., 36, 35-43.

 

バイオサイエンス教育・研究センター

動物実験部門

1.           増田　豊，石郷岡清基，杉山俊博（2009）動物実験従事者におけるマウス尿に対するアレルギーの発症について，秋田県医師会雑誌，第59巻2号

 

学会発表　4

 

中央診療施設等

 

中央検査部

 

1.           Takeda, M., Ito, W., Tanabe, M., Ueki, S., Kato, H., Kihara, J., Tanigai, T., Chiba, T., Yamaguchi, K., Kayaba, H., Imai, Y., Okuyama, K., Ohno, I., Sasaki, T., Chihara, J.（2009）Phosphatidylinositide 3-kinaseg deficient Mice Fail to Develop Allergic Airway Hyperresponsiveness, Inflammation, and Remodeling. J. Allergy. Clin. Immunol,, 123, 805-812.

 

総説　1、学会発表19

 

中央手術部

 

1.            堀口　剛，真崎容子，西川俊昭（2009）セボフルラン麻酔後の脳内・血液内のセボフルラン量．神経麻酔・集中治療2009：59-60.（Proceedings）

 

学会発表　7

 

病理部

 

1.           Nishikawa, Y., Ohi, N., Yagisawa, A., Doi, Y., Yamamoto, Y., Yoshida, M., Tokairin, T., Yoshioka, T., Omori, Y. and Enomoto, K. (2009) Suppressive effect of orthovanadate on hepatic stellate cell activation and liver fibrosis in rats. Am. J. Pathol., 174, 881-890.

 

緩和ケアセンター

 

1.            Ito, A., Saito, H., Mitobe, K., Minamiya, Y., Takahashi, N., Maruyama, K., Motoyama, S., Katayose, Y., Ogawa, J. (2009) Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature. Cancer Sci., 100, 558-564.