動物実験部門を利用した各講座の2008年度研究業績


構造機能医学講座

形態解析学分野・器官構築学分野（旧解剖学第一講座）
  1. Zhou, M., He, H-J., Tanaka, O., Suzuki, R., Sekiguchi, M., Yasuoka, Y., Kawahara, K., Itoh, H. and Abe, H. (2008) Localization of the sulfonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium. Tohoku J. Exp. Med., 214, 247-256.
  2. 学会発表　3

細胞生物学分野（旧解剖学第二講座）
  1. Kawagoe, M., Ishikawa, K., Wang, S., Yoshikawa, K., Arany, S., Zhou, X. P., Wang, J. S., Ueno, Y., Koizumi, Y., Kameda, T., Koyota, S. and Sugiyama, T. (2008) Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice. J. Trace Elem. Med. Biol., 22, 59-65.
  2. 学会発表　19、特別講演　1、セミナー　1、報告書　2

分子機能学分野・代謝機能学分野（旧生化学第一講座）
  1. Kawagoe, M., Ishikawa, K., Wang, S.-C., Yoshikawa, K., Arany, S., Zhou, X., Wang, J.-S., Ueno, Y., Koizumi, Y., Kameda, T., Koyota, S. and Sugiyam, T. (2008) Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice. J. Trace Elem. Med. Biol., 22, 59-65.
  2. 学会発表　10

分子医科学分野（旧生化学第二講座）
  1. Inoue-Narita, T., Hamada, K., Sasaki, T., Hatakeyama, S., Fujita, S., Kawahara, K., Sasaki, M., Kishimoto, H., Eguchi, S., Kojima, I., Beermann, F., Kimura, T., Osawa, M., Itami, S., Mak, T.W., Nakano, T., Manabe, M. and Suzuki, A. (2008) Pten deficiency in melanocytes results in resistance to hair graying and susceptiblity to carcinogen-induced melanomagenesis. Cancer Res., 68, 5760-5768.
  2. Kuroda, S., Nishio, M., Sasaki, T., Horie, Y., Kawahara, K., Sasaki, M., Natsui, M., Matozaki, T., Tezuka, H., Ohteki, T., Forster, I., Mak, T.W., Nakano, T. and Suzuki, A. (2008) Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages . Eur. J. Immunol., 38, 1331-1340.
    著書　1、総説　3、学会発表　5

機能制御医学講座

細胞制御学分野（旧第一生理学講座）
  1. Sato, S. (2008) CARDIAC BEAT DETECTOR, A novel analogue circurity for the first heart sound discrimination. Biosignals 2008, 2, 136-140.
  2. Sato, S. (2008) Quantitative evaluation of ontogenetic change in heart rate and its autonomic regulation in newborn mice with the use of a noninvasive piezoelectric sensor. Am. J. Physiol. Heart Circ. Physiol., 294, H1708-H1715
  3. 学会発表　7

器官制御学分野・統合制御学分野（旧生理学第二講座）
  1. Wang, X., Momota,Y., Yanase, H., Narumiya, S., Maruyama, T. and Kawatani, M .(2008) Urothelium EP1 receptor facilitates the micturition reflex in mice. Biomed. Res, 29, 105-111.
  2. Momota,Y, Wang, X. and Kawatani, M. (2008) Adrenergic activation to heal damaged urothelium might contriubute to normal micturition reflex. Neurourol. Urodynam., 27, 707-708.
  3. Yanase, H., Wang, X., Momota, Y., Nimura, T. and Kawatani, M. (2008)The involvement of urothelial _1A adrenergic receptor in controlling the micturition reflex. Biomed. Res., 29?C 239-244.
  4. 学会発表　9

情報制御学分野・実験治療学分野（旧薬理学講座）
  1. その他の講演　１

病理病態医学講座

分子病態学分野・腫瘍病態学分野（旧病理学第一講座）
  1. 総説　1、　学会発表　10、　報告書　2

器官病態学分野（旧病理学第二講座）
  1. 高橋正人，吉田　誠，小林實貴夫，川村公一，南條　博，増田弘毅（2008）　血流負荷ウサギ総頸動脈における 血管内皮細胞の増殖とアポトーシス．脈管学　48, 473-474.
  2. 学会発表　18、特別講演　1

生体防御学分野・病原微生物学分野（旧寄生虫学講座）
  1. Inaba, M. and Ohteki, T. (2008) Induction mechanisms of receptor activator of NF-B ligand on activated T cells. Akita J. Med., 34, 237-244.
  2. 総説　8

感染制御学分野（旧微生物学講座）
  1. Iwasaki, H., Murata, Y., Kim, Y., Hossain, M., Worby, C., Dixon, J., McCormack, T., Sasaki, T. and Okamura, Y. (2008) A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci.,105, 7970-7975.
  2. Wang, Y., Chen, X., Lian, L., Tang, T., Stalker, T., Sasaki, T., Brass, L., Choi, J., Hartwig, J. and Abrams, C. (2008) Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci.,105,14064-14069.
  3. Kuroda, S., Nishio, M., Sasaki, T., Horie, Y., Kawahara, K., Sasaki, M., Natsui, M., Matozaki, T., Tezuka, H., Ohteki, T., Forster, I., Mak, T., Nakano, T. and Suzuki, A. (2008) Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J. Immunol.,38, 1131-1140.
  4. Garcon, F., Patton, D., Emery, J., Hirsch, E., Rottapel, R., Sasaki, T. and Okkenhaug, K. (2008) CD28 provides T cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood, 111,1464-1471.
  5. Wang, Y., Litvinov, R., Xinsheng, D., Bach, T., Lian, L., Petrich, B., Monkley, S., Critcheley, D., Sasaki, T., Birnbaum, M., Weisel, J., Hartwig, J. and Abrams, C. (2008) Loss of PIP5KI_, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J. Clin. Invest.,118, 812-819.
  6. Nakasaki, M, Yoshioka, K, Miyamoto, Y, Sasaki, T., Yoshikawa, H. and Itoh, K. (2008) IGF-I secreted by osteoblasts acts as a poteint chemotactic factor for osteoblast. Bone, 43, 869-879.
  7. Inoue-Narita, T., Hamada, K., Sasaki, T., Hatakeyama, S., Fujita, S., Kawahara, K., Sasaki, M., Kishimoto, H., Eguchi, S., Kojima, I., Beermann, F., Kimura, T., Osawa, M., Itami, S., Mak, T., Nakano, T., Manabe, M. and Suzuki, A. (2008) Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res., 68, 5760-5768.
  8. Hebiguchi, M., Hirokawa, M., Guo, Y.M., Saito, K., Wakui, H., Komatsuda, A., Fujishima, N., Takahashi, N. Sasaki, T., Nunomura, W., Takakuwa, Y. and Sawada, K. (2008) Dynamics of human erythroblast enucleation. Int. J. Hematol., 88, 498-507.
  9. Kuwana, H., Terada, Y., Kobayashi, T., Okado, T., Penninger, J., Sasaki, J., Sasaki, T. and Sasaki, S. (2008) The phosphoinositide-3 kinase-_ - Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int.,73, 430-445.
  10. Tsukamoto, K., Hazeki, K., Hoshi, M., Nigorikawa, K., Inoue. N., Sasaki, T. and Hazeki, O. (2008) Critical roles of the p110_ subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J. Immunol., 180, 2054-2061
  11. 総説　1、学会発表　6

内科学講座

消化器内科学分野・神経内科学分野，第一内科（旧内科学第一講座）
  1. Kuroda, S., Nishio, M., Sasaki, T., Horie, Y., Kawahara, K., Sasaki, M., Natsui, M., Matozaki, T., Tezuka, H., Ohteki, T., Forster, I., Mak, T.W., Nakano, T. and Suzuki, A. (2008) Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur. J. Immunol., 38, 1331-1340.
  2. 総説1、学会発表　1

循環器内科学分野・呼吸器内科学分野, 第二内科（旧内科学第二講座）
  1. Watanabe, H., Murakami, M., Ohba, T., Takahashi, Y. and Ito, H.(2008)　TRP channel and cardiovascular disease. Pharmacol. Ther., 118, 337-351.
  2. Ohba, T., Watanabe, H., Murakami, M., Radovanovic, M., Iino, K., Ishida, M., Tosa, S., Ono, K. and Ito, H. (2008) Amlodipine inhibits cell proliferation via PKD1-related pathway. Biochem. Biophys. Res. Commun., 369,376-381.
  3. Murakami, M., Ohba, T., Xu, F., Satoh, E., Miyoshi, I., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, H., Ono, K., Sasano, H., Kasai, N., Ito, H. and Iijima,T.(2008) Modified sympathetic nerve system activity with over-expression of the voltage-dependent?@calcium channel _3 subunit. J. Biol. Chem., 283, 24554-24560.
  4. 学会発表　13、その他の講演１

内分泌・代謝・老年医学分野（旧老年医学講座）
  1. 学会発表　5

外科学講座

消化器外科学分野, 第一外科（旧外科学第一講座）
  1. 学会発表　3

呼吸器外科学分野，第二外科（旧外科学第二講座
  1. Minamiya, Y., Saito, H., Takahashi, N., Kawai, H., Ito, M., Hosono, Y., Motoyama, S. and Ogawa, J.（2008） Polymorphonuclear leukocytes are activated during atelectasis before lung reexpansion in rat. Shock, 30, 81-86.
  2. Saito, H., Mitobe, K., Ito, A., Sugawara, Y., Maruyama, K., Minamiya, Y., Motoyama, S., Yoshimura, N. and Ogawa, J.(2008) Self-regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperature. Cancer Sci., 99, 805-809.
  3. 学会発表　2

整形外科学分野, 整形外科（旧整形外科学講座）
  1. Nozaka, K., Miyakoshi, N., Kasukawa, Y., Maekawa, S., Noguchi, H. and Shimada, Y. (2008) Intermittent administration of human parathyroid hormone enhances bone formation union at the site of cancellous bone osteotomy in normal and ovariectomized rats. Bone, 42, 90-97.
  2. Maekawa, S, Miyakoshi, N, Kasukawa, Y, Nozaka, K, Noguchi, H. and Shimada, Y. (2008) Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in aged rats. Akita J. Med., 35, 53-58.
  3. 学会発表　4

感覚器学講座

眼科学分野, 眼科（旧眼科学講座）
  1. 1. Dong, Y., Watabe, H., Su, G., Ishikawa, H., Sato, N. and Yositomi, T . (2008) Relaxing effect of tafluprost on isolated rabbit ciliary . Exp. Eye Res ., 87, 251-256.
  2. 学会発表　6

生殖発達医学講座

産婦人科学分野，産科婦人科（旧産科婦人科学講座）
  1. Kawamura,K. (2008) Preimplantation embryo development and its regulatory factors. Akita.J.Med.,35,113-122.
  2. Kawamura,K., Ye,Y., Kawamura,N., Jing,L., Groenen,P., Gelpke,M.S., Rauch,R., Hsueh,A.J. and Tanaka,T. (2008) Completion of meiosis I of preovulatory oocytes and?@facilitation of preimplantation embryo development by glial cellline-derived neurotrophic factor. Dev.Biol.,315,189-202.
  3. Sato,T., Fukuda,J., Kawamura,K., Kodama,H., Kumagai,J. and Tanaka,T.(2008) Dynamics of maternal survivin mRNA in mouse oocytes and pre-implantation embryos. J. Mammal. Ova Res.,25,184-192.
  4. 4. Sato,M., Kawamura,K., Fukuda,J. and Tanaka,T.(2008) Promotion of mouse preimplantation embryo development by vascular endothelial growth factor. Akita J.Med.,35,155-163.
  5. 河村和弘，河村七美，佐藤亘，熊谷仁，福田淳，田中俊誠（2008） 新規母胎由来卵成熟・胚発育調節因子の同定：glial cell-line derived neurotrophic factor(GDNF). J.Mammal.Ova Res., 25,159
  6. 総説　3、学会発表　8、その他の講演　１

泌尿器科分野，泌尿器科(旧泌尿器科学講座)
  1. Narita, S., Tsuchiya, N., Saito, M., Inoue, T., Kumazawa, T., Yuasa, T., Nakamura, A. and Habuchi, T. (2008) Candidate genes involved in enhanced growth of human prostate cancer under high fat feeding identified by microarray analysis. Prostate, 68, 321-335.

統合医学講座

麻酔科学・蘇生学分野，麻酔科（旧麻酔学講座）
  1. Kimura, T., Sato, K., Nishikawa, T., Tobe, Y. and Masaki, Y. (2008) Effects of mivazerol, a _2-agonist, on striatal norepinephrine concentration during transient forebrain ischemia in rats.　 Acta Anaesthesiol. Scand., 52, 997-1002.
  2. Kumagai, M., Horiguchi, T., Nishikawa, T., Masaki, Y. and Tobe, Y. (2008) Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats.　Anesth. Analg., 107, 643-647.
  3. 合谷木徹, 西川俊昭(2008) _遮断薬によるラット局所脳虚血の脳保護効果 - 用量反応関係 -.　第12回日本神経麻酔・集中治療研究会プロシーディング 37-40.
  4. 梅原志乃, 合谷木徹, 西川俊昭(2008) 虚血性脊髄障害に対する_受容体遮断薬の保護効果.第12回日本神経麻酔・集中治療研究会プロシーディング 41-43.
  5. 5. 木村哲, 佐藤浩司, 西川俊昭(2008) ラット一過性前脳虚血モデルにおけるRhoキナーゼ（ファスジル）の脳保護効果.　 第12回日本神経麻酔・集中治療研究会プロシーディング 44-45.
  6. 学会発表　15

臨床検査医学分野（旧臨床検査医学講座）
  1. 学会発表　7

歯科口腔外科
  1. 1. Yamamoto, O., Ohira, T., Mohan, D.J., Fukuda M., ?zkal, B., Sawai J. and Nakagawa, Z.(2008) Antibacterial characteristics of carbon-coated CaCO3/MgO powder let by the pyrolysis of poly?ivinyl alcohol?j-dolomite mixture. TANSO, 232, 77-81.
  2. 学会発表　3

中央検査部
  1. 学会発表　7

中央手術部
  1. Kumagai, M., Horiguchi, T. and Nishikawa, T. (2008) Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats. Anesth. Analg., 107, 643-647.
  2. 学会発表　2

バイオサイエンス教育研究センター

動物実験部門(旧附属動物実験施設)
  1. 学会発表　1、その他の講演　2