動物実験施設を利用した各講座の2006年度研究業績
原著論文
構造機能医学講座
分子機能学分野・代謝機能学分野(生化学第一講座)
- Arany, S., Nakata, A., Kameda, T., Koyota, S., Ueno, Y. and Sugiyama, T. (2006) Phenotype properties of a novel spontaneously immortalized odontoblast-lineage cell line. Biochem. Biophys. Res. Commun., 342, 718-724.
分子医科学分野(生化学第二講座)
- Tsuruta, H., Kishimoto, H., Sasaki, T. et al. (2006) Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res., 66, 8389-8396.
- Sato, W., Horie, Y., Kataoka, E. et al. (2006) Hepatocic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res., 34, 256-265.
機能制御医学講座
細胞制御学分野(生理学第一講座)
- Sato, S., Yamada, K. and Inagaki, N. (2006) System for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer. Med. Biol. Eng. Comput., 44,353-362.
- Matsumura, Y., Ban, N., Ueda, K. and Inagaki, N. (2006) Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency. J. Biol. Chem., 281, 34503-34514.
器官制御学分野・統合制御学分野(生理学第二講座)
- 河谷正仁, 百田芳春, 簗瀬晴子, 王 小軍, 石濱寛子(2006)痛みの研究アプローチ. 河谷正仁(編)膀胱痛. 真興交易, 東京, pp.200-206.
- Ishihama, H., Momota, Y., Yanase, H., Wang, X., deGroat W.C. and Kawatani, M. (2006) Activation of α1D adrenergic receptors in the rat urothelium facilitates the micturition reflex. J. Urology, 175, 358-364.
- Ikeda, M., Kawatani, M., Maruyama, T. and Ishihama, H. (2006) Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats. Biomedicial Res., 27, 49-54.
- 河谷正仁(2006)膀胱の機能解剖学−中枢と末梢の神経支配−.神経内科64, 5-9.
情報制御学分野・実験治療学分野(薬理学講座)
- Wu, T.W., Ono, K., Murakami, M. and Iijima, T. (2006) Involvement of voltage-dependent Ca channel β3 subunit in the autonomic control of heart rate variability. Pharmacology. 76, 170-179.
- Murakami, M., Ohba, T., Takahashi, Y., Watanabe, H., Miyoshi, I., Nakayama, S., Ono, K., Ito, H. and Iijima T. (2006) Identification of a cardiac isoform of the murine calcium channel α1C (CaV1.2-a) subunit
and its preferential binding with the β2 subunit. J. Mol. Cell. Cardiol., 41, 115-125.
- Ohba, T., Watanabe, H., Takahashi, Y. et al. (2006) Regulatory role of neuron-restrictive silencing factor in the expression of TRPC1. Biochem. Biophys. Res. Commun. 351, 764-770.
病理病態医学講座
分子病態学分野・腫瘍病態学分野(病理学第一講座)
- Ohi, N., Nishikawa, Y., Tokairin, T., Yamamoto, Y., Doi, Y., Omori, Y. and Enomoto, K. (2006) Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic sinusoidal endothelial cells in vitro and in vivo.
Am. J. Pathol., 168, 1097-1106.
- 西川祐司 (2006) 三次元培養を用いた肝細胞の胆管上皮化生の証明およびそのメカニズムの検討. Akita J. Med., 33, 9-19.
器官病態学分野(病理学第二講座)
- Nanjo, H., Sho, E., Komatsu, M., Sho, M., Zarins, C.K. and Masuda, H.(2006) Intermittent short-duration exposure to low wall shear stress induces intimal thickening in arteries exposed to chronic high
shear stress. Exp. Mol. Pathol., 80,38-45.
生体防御学分野(生体防御学講座)
- Kuwajima, S., Sato, T., Ishida, K., Tada, H., Tezuka, H. and Ohteki, T. (2006) Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat. Immunol., 7, 740-746.
- Ohteki*, T., Tada*, H.(*equal contribution), Ishida, K., Sato, T., Maki, C., Yamada, T., Hamuro, J. and Koyasu, S. (2006) Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J. Exp. Med., 203, 2329-2338.
感染制御学分野(微生物学講座)
- Sato, W., Horie, Y., Kataoka, E. et al.(2006) Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res., 34, 256-265.
- Yogo, K., Mizutamari, M., Mishima, K., Takenouchi, H., Ishida-Kitagawa, N., Sasaki, T. and Takeya, T. (2006) Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and
the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology, 147, 3307-3317.
- Zhao, M., Song, B., Pu, J. et al.(2006) Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-g and PTEN. Nature, 442,457-460.
- Suzuki, T, Kanai, Y., Hara, T. et al.(2006) Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell. Biol., 26, 6149-6156.
- Tsuruta, H., Kishimoto, H., Sasaki, T. et al.(2006) Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res., 66, 8389-8396.
- Kunisaki, Y., Nishikimi, A., Tanaka, Y., Takii, R., Noda, M., Inayoshi, A., Watanabe, K., Sasazuki, T., Sasaki, T. and Fukui, Y. (2006) DOCK2 is a Rac activator that regulates motility and polarity
during neutrophil chemotaxis. J. Cell Biol., 174, 647-652.
内科学講座
消化器内科学分野・神経内科学分野
(内科学第一講座)
- Otaka, M., Odashima, M. and Watanabe, S. (2006) Role of heat shock proteins (molecular chaperones) in intestinal mucosal protection ミ Mini review ミ. Biochem. Biophys. Res. Commun., 348,1 ミ5.
- Otaka, M., Matsuhashi, T., Itoh, H. et al. (2006) Enhancement of cytoprotective ability and restoration in 70-kDa heat shock protein gene-transfected rat gastric mucosal cells. Aliment. Pharmacol. Ther.,
(Symposium ser)2, 272-277.
- Otaka, M., Konishi, N., Odashima, M., Jin, M., Wada, I., Matsuhashi, T., Horikawa, Y., Ohba, R. and Watanabe, S. (2006) Is Mongolian gerbil really adequate host animal for study of Helicobacter
pylori infection-induced gastritis and cancer? Biochem. Biophys. Res. Commun., 347, 297-300.
- Goto,T., Takeuchi,S., Miura,K. et al.(2006)Suramin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of NF-κB activity. Cytokine, 33,28-35.
- Mikami, K., Otaka, M., Watanabe, D. et al. (2006) Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.
J. Gastroenterol. Hepatol., 21, 1669-1674.
- Odashima, M., Otaka, M., Jin, M., Horikawa, Y., Matsuhashi, T., Ohba, R., Linden, J. and Watanabe, S. (2006) A selective adenosine A2A receptor agonist, ATL-146e, prevents
concanavalin A-induced acute liver injury in mice. Biochem. Biophys. Res. Commun., 347, 949-954.
- Odashima, M., Otaka, M., Jin, M., Wada, I., Horikawa, Y., Matsuhashi, T., Ohba, R., Hatakeyama, N., Oyake, J. and Watanabe, S. (2006) Zinc L-carnosine protects colonic mucosal injury
through induction of heat shock protein 72 and suppression of NF-kB activation. Life Sci., 79, 2245-2250.
- Odashima, M., Otaka, M., Jin, M. et al.(2006) Attenuation of gastric mucosal inflammation induced by aspirin through activation of the A2A adenosine receptor in rats.
World J. Gastroenterol., 12, 568-573.
- Shibuya, T., Otaka, M., Mikami, K. et al. (2006) Alteration of heme oxygenase-1 and heat shock protein 72 in the gastric mucosa in fasted streptozotocin-diabetic rats. Akita J. Med., 33, 39-48.
- Ohba, R., Otaka, M., Odashima, M. et al.(2006) A selective type III phosphodiesterase inhibitor, on water-immersion stress-induced gastric mucosal injury in rats. J. Gastroenterol., 41, 34-40.
- Endoh, A., Otaka, M., Goto, T. et al. (2006) Decreased renal expressions of heat shock protein-72 and -25 are associated with renal dysfunction in biliary cirrhotic rats. Hepatol. Res., 34, 273-281.
- Oyake, J., Otaka, M., Jin, M. et al.(2006) Overexpression of 70-kDa heat shock protein confers protection against monochloramine-induced gastric mucosal cell injury. Life Sci., 79, 300-305.
- Hatakeyama, N., Otaka, M., Itoh, H. et al.(2006) 70-kDa heat shock protein protects gastric epithelial cells against ceramide-induced apoptosis. Akita J. Med., 33, 49-56.
- Yoshino,R., Miura,K., Segawa,D. et al.(2006)Epimorphin expression and stellate cell status in mouse liver injury. Hepatol. Res., 34,238-249.
呼吸器内科学分野・循環器内科学分野
(内科学第二講座)
- Ohba, T., Watanabe, H., Takahashi, Y. et al. (2006) Regulatory role of neuron- restrictive silencing factor in the expression of TRPC1. Biochem. Biophys. Res. Commun., 351, 764-770.
- Ohba, T. Watanabe, H. Murakami, M. Takahashi, Y. and Ito, H.(2006) Increased expression of transient receptor potential C1 in rats with hypertensive hypertrophy. Akita J. Med., 32, 201-207.
外科学講座
小児外科学分野(小児外科学講座)
- 蛇口達造, 吉野裕顕, 森井真也子, 蛇口 琢, 加藤哲夫(2006) アルギニン代謝からみた短腸症候群の栄養管理. 小児外科38, 1028-1035.
神経運動器学講座
脳神経外科学分野(脳神経外科学講座)
- Yamaguchi, S.,Sugawara, T.,Oda, M.,Omae, T.,Mizoi, K. and Kinouchi, H. (2006)N-methyl-d-aspartate receptor glycine-binding site antagonist,sm-31900 protects against delayed
neuronal death and reduces neurogenesis.Akita J.Med.,33, 29-37.
精神科学分野(精神科学講座)
- Satoh, S., Matsumura, H., Kanbayashi, T., Yoshida, Y., Urakami, T., Nakajima, T., Kimura, N., Nishino, S. and Yoneda, H. (2006) Expression pattern of FOS in orexin neurons during sleep
induced by an adenosine A2A receptor agonist. Behav. Brain Res., 170, 277-286.
- Yoshida, K., Sugawara, Y. and Higuchi, H. (2006) Dramatic remission of treatment-resistant depression after the cessation of tricyclic antidepressants. Pharmacopsychiatry, 39, 114.
- 神林 崇, 有井潤子, 久保田博昭, 矢野珠巨, 柏木 充, 吉川聡介,遠山 潤, 沢石由記夫(2006)視床下部病変によりオレキシン神経障害を来した2次性過眠症8例の検討. 脳と発達38, 340-345.
感覚器学講座
眼科学分野、眼科(眼科学講座)
- Chen, W., Hara, K., Bu, J., Zhao, K. and Yoshitomi, T. (2006)Existence of small slow-cycling Langerhans cells in the limbal basal eqithelium that express ABCG2. Exp. Eye Res., 83, 1-9.
- Dong, Y.,Ishikawa, H.,Wu, Y., Shimizu, K., Goseki, T. and Yoshitomi, T. (2006) Effect and mechanisms of betaxolol and timolol on vascular relaxation in isolated rabbit ciliary artery.
Jpn. J. Oph.,50, 504-508.
生殖発達医学講座
小児科学分野、小児科(小児科学講座)
- Miura, S., Ishida, A., Nakajima, W., Ohmura, A., Kawamura, M. and Takada, G. (2006) Intraventricular ascorbic acid administration decreases hypoxic-ischemic brain injury
in newborn rats. Brain Res., 1095, 159-166.
産婦人科学分野(産科婦人科学講座)
- 河村和弘,河村七美,Aaron JW Hsueh,田中俊誠(2006)卵巣由来Brain-Derived Neurotrophic Factor(BDNF)による卵成熟機構の解明.日本生殖内分泌学会雑誌11,39-42.
- 田中俊誠(2006)北大から続いている着床前受精卵の研究.北産婦医会報117,2-7
泌尿器科学分野(泌尿器科学講座)
- Matsuura, S., Obara, T., Tsuchiya, N., Suzuki, Y. and Habuchi, T. (2006) Cavernous nerve regeneration by biodegradable alginate gel sponge sheet placement without sutures. Urology, 68, 1366-1371.
- Obara, T., Matsuura, S., Narita, S., Satoh, S., Tsuchiya, N. and Habuchi, T. (2006) Bladder acellular matrix grafting regenerates urinary bladder in the spinal cord injury rat. Urology, 68, 892-897.
- Tsuruta, H., Kishimoto, H., Sasaki, T. et al. (2006) Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients. Cancer Res., 66, 8389-8396.
統合医学講座
麻酔科学・蘇生学分野(麻酔学講座)
- Goyagi, T., Kimura, T., Nishikawa, T., Tobe, Y. and Masaki, Y. (2006) β-Adrenoreceptor antagonists attenuate brain injury following transient focal ischemia in rats. Anesth. Analg., 103, 658-663.
診療科
歯科口腔外科
- Arany, S., Nakata, A., Kameda, T., Koyota, S., Ueno, Y. and Sugiyama, T. (2006) Phenotype properties of a novel spontaneously immortalized odontoblast-lineage cell line.
Biochem. Biophys. Res. Commun., 342, 718-724.
中央診療施設等
病理部
- Nanjo, H., Sho, E., Komatsu, M., Sho, M., Zarins, C.K. and Masuda,H. (2006) Intermittent short-duration exposure to low wall shear stress induces intimal thickening in arteries
exposed to chronic high shear stress. Exp. Mol. Pathol., 80, 38-45.
リハビリテーション部
- Shimada, Y., Sakuraba, T., Matsunaga, T., Misawa, A., Kawatani, M. and Itoi, E. (2006) Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension.
Biomed. Research, 27, 23-27.
- Kobayashi, M., Itoi, E., Minagawa, H., Miyakoshi, N., Takahashi, S., Touheti, Y., Okada, K. and Shimada, Y. (2006) Expression of growth factors in the early phase of supraspinatus tendon
healing in rabbits. J. Shoulder Elbow Surg., 15, 371-377.
- Shimada, Y., Ito, H., Matsunaga, T., Misawa, A., Kawatani, M. and Itoi, E. (2006) Reduction of muscle fatigue by catchlike-inducing intermittent electrical stimulation in rat skeletal muscle.
Biomed. Res., 27, 183-189.
バイオサイエンス教育研究センター
動物実験部門(旧附属動物実験施設)
- 松田幸久 (2006) 特集 動物福祉とサイエンス 私の見る動物実験史(1)、 アニテックス, 18(2), 26-30