動物実験施設を利用した各講座の2002年度研究業績


秋田大学医学部動物実験施設を使用し得られた研究成果のうち，2002年中に公表された論文．

原著論文

第一解剖
  1. Zhou, M., Tanaka, O., Suzuki, M., Sekiguchi, M., Takata, K., Kawahara, K. and Abe, H. （2002）　Localization of pore‐forming subunit of the ATP‐sensitive K＋‐channel, Kir6.2, in rat brain neurons and glial cells.　Molecular Brain Research, 101, 23‐32.
第二解剖
  1. Satoh, S., Suzuki, A., Kojima, N., Sato, M., Asari, Y., Senoo, H. and Kato, T. （2002）　Expression of CD80 and CD86 in the rat kidney with ischemia/reperfusion injury.　Lab. Invest., 82, 1209‐1217.
  2. 鈴木　明， 佐藤　滋， 土屋順彦， 加藤哲郎， 佐藤　充， 妹尾春樹 （2002）　ラット腎虚血における副刺激シグナル系細胞接着分子 CD80 の発現亢進． 日泌尿会誌 93, 33‐38.
第一病理
  1. Tokairin, T., Nishikawa, Y., Doi, Y., Watanabe, H., Yoshioka, T., Su, M., Omori, Y. and Enomoto, K. （2002）　A highly specific isolation of rat sinusoidal endothelial cells by the immunomagnetic bead method using SE‐1 monoclonal antibody.　J. Hepatol., 36, 725‐733.
第二病理
  1. Ebina, T., Hoshi, N., Kobayashi, M., Kawamura, K., Nanjo, H., Sugita, A., Sugiyama, T., Masuda, H. and Xu, C. （2002）　Physiological angiogenesis in electrically stimulated skeletal muscle in rabbits : Characterization of capillary sprouting by ultrastructural 3‐D reconstruction study. Pathology International, 52, 702‐712.
第一生理
  1. Zhou, C.‐J., Inagaki, N., Pleasure, S.J., Zhao, L.‐X., Kikuyama, S. and Shioda, S. （2002）　ATP‐binding cassette transporter ABCA2 （ABC2） expression in the developing spinal cord and PNS during myelin-ation.　J. Comp. Neurol., 451, 334‐345.
第二生理
  1. Miura, A., Kawatani, M., Maruyama, T., and de Croat, W.C. (2002) Effect of prostaglandins on parasympathetic neurons in the rat Iumbosacral spinal cord. Neuroreport, 13, 1557-1562.
  2. Sato, M. and Kawatani, M., (2002) Effects of noradrenaline on cytosolic concentrations of Ca2+ in cultured corpus cavernosum smooth muscel cells of the rabbit. Neuroscience Lett., 324, 89-92.
  3. Kimura, H., Kawatani, M., Sato, M., Ito, E. and Ishikawa, K. (2002) GDNF increases in peripheral target muscle following facial nerve transection in guinea pig. Akita J. Med., 29, 155-160.
第一生化学
  1. Nagai, H., Terada, K., Watanabe, G. et al. （2002）　Differentiation of liver epithelial （stem‐like） cells into hepatocytes induced by coculture with hepatic stellate cells. Biochem. Biophys. Res. Commun., 293, 1420‐1425.
  2. Kameda, T., Hatakeyama, S., Ma, Y‐Z., Kawarada, Y., Kawamata, M., Terada, K., and Sugiyama, T. （2002）　Targeted elimination of the follicular label‐retaining cells by photo‐induced cell killing caused a defect on follicular renewal on mice. Genes Cells, 7, 923‐931.
  3. 寺田邦彦 （2002）　未分化肝臓由来細胞を利用した胆管癌の発生過程の解明． 成人病と生活習慣病 32, 1346‐1347.
衛生学
  1. E, X., Wada, Y., Dakeishi, M., Hirasawa, F., Murata, K., Masuda, H., Sugiyama, T., Nikaido, H. and Koizumi, A. （2002） Age‐associated cardiomyopathy in hetero-zygous carrier mice of a pathological mutation of carnitine transporter gene, OCTN2.　J. Gerontol. （Biol. Sci. Med. Sci.）, 57, B270‐278
生体防御
  1. Sugaya, H., Yamashita, K., Ishida, K., Matsuda, S. and Yoshimura, K. （2002） The eosinophil is an important effector cell for the protective immunity to Angio-strongylus cantonensis infection in mice. Proceedings of the 10th International Congress of Parasitology‐ICOPA X: Symposia, Workshop and Contributed Papers, 689‐695. （Proceeding）
  2. Murata, Y., Ohteki, T., Koyasu, S., and Hamuro, J., (2002) IFN-γ and pro-inflammatory cytokine production by antigen presenting cells is dictated by intracellular thiol redox status regulated by oxygen tention. Eur. J. Immunol.23:2866-2873
  3. Ohteki, T., (2002)Critical role for IL-15 in innate immuity. Curr. Mol. Med.2: 371-380 Review.
  4. Garza, K., McKall-Faienza, K., Ohteki, T., Zakarian, A., Odermatt, B., and Ohashi, P.,(2002) Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur. J. Immunol. 32:885-894
  5. Sugaya. H., Graeff-Teixeira, C., Ishida, K., Matsuda, S., Katahira, K., and Yoshimura, K., (2002)Interleukin-5 transgenic mice show an augmented resistance to Angiostrongylus costaricensis. Parasitol. Res 88:350-355
  6. Maurer, R.L., Graeff-Teixeira, C., Thome, J.V., Chiaradia, L.A., Sugaya, H., and Yoshimura, K., (2002)Natural infection of Deroceras laeva (Mollusca, Gastropoda) with metastrongylid larvae in a transmission focus of abdominal angiostrongyliasis. Revista do Instituto de Medicina Tropical de Sao Paulo 44:43-44
第二内科
  1. Saito,T., Fujiwara,Y., Fujiwara,R., Hase-gawa,H.,Kibira,S.,Miura,H. and Miura,M. （2002）　Role of augmented expression of intermediate conductance Ca２＋‐Activated K＋ channels in post‐is chemic heart. Clin. Exp. Pharmacol Physiol, 29, 324‐329.
  2. Saito, T., Fushimi, E., Tamura, T., Fu-jiwara, Y., Miura, H., Watanabe, H., Ki-bira, S., Hasegawa, H. and Miura, M. （2002）　L‐nitro‐arginine inhibits increase in endothelin binding sites induced by ischemia and reperfusion.　J. Mol. Cell Cardiol., 34, 1041‐1047.
  3. the antitussive effect of azelastine in guinea pigs.　Arzneim. Forsch. Drug. Res., 52（6）, 441‐447.
  4. Nakajima, I., Watanabe, H., Iino, K., Saito, T. and Miura, M . （2002）　Ca２＋‐overload evokes the transient outward current in guinea‐pig ventricular myocytes. Circulation Journal, 66（1）, 87‐92.
精神科
  1. Masuda, Y., Sugawara, J., Ohnuma, S. and Sugiyama, T. （2002）　Humoral GalNAcα1‐3GalNAc‐Lipid reactivity of humans in hypomanic state.　Tohoku J. Exp. Med., 197, 115‐118.
  2. Masuda, Y., Ohnuma, S., Sugawara, J., Kawarada, Y. and Sugiyama, T. （2002） Behavioral Effect of Herbal Glycoside in the Forced Swimming Test. Methods Find Exp.　Clin. Pharmacol., 24（1）, 19‐21.
  3. Masuda, Y., Ohnuma, S., Sugawara, J., Kawarada, Y. and Sugiyama, T. （2002） Fragment of human beta‐fibrinogen induces a behavioral effect on mouse forced swimming.　Peptides, 23, 409‐411.
第一外科
  1. Asanuma, Y., Sato, T., Kato, T., Nanjo, H., Kurokawa, T., Yasui, O. and Koyama, K. （2002）　Continuous arterial infusion of prostaglandin E1 via the superior mesenteric artery in the treatment of postoperative liver failure.　Therapeutic Apheresis， 6， 89‐92.
  2. Shindo, Y., Asanuma, Y., Furuya, T., Shibata, S., Sato, T., Itoh, H. and Koyama, K. （2002）　Pretransplant heat loading on pancreatic graft reduces posttransplant ischemia‐reperfusion injury.　Transplant Proc., 34, 1329‐1334.
  3. Hatakeyama, Y., Asanuma, Y., Sato, T. and Koyama, K. （2002）　Regional and general effects of hepatic lobes with impaired blood flow after hepatic resection. Hepato‐Gastroenterol， 49, 487‐491.
  4. Sato, T., Kurokawa, T., Kusano, T. et al. （2002）　Uptake of indocyanine green by hepatocytes under inflow occlusion of the liver.　J. Surg. Res., 105, 81‐85.
  5. Miyazawa, H., Furuya, T., Iida, M., Kotanagi, H. and Koyama, K. （2002） Graft immunomodulation by donor irradiation and recipient‐specific bone marrow cells in rat small bowel transplantation. Transplant Proc., 34, 1349‐1354.
  6. Nagai, H., Terada, K. Watanabe, G. et al. （2002）　Differentiation of liver epithelial （stem‐like） cells into hepatocyte induced by coculture with hepatic stellate cells, BBRC, 293, 1420‐1425.
  7. 安藤秀明， 柴田　聡， 黒川敏昭， 安井應紀， 佐藤　勤， 小山研二 （2002）　バイポーラシザーズを用いた膵切離． 外科 64（6）, 628‐631.
  8. 安藤秀明， 伊藤雅仁， 佐藤　勤， 小山研二 （2002）　遠隔手術ライブカンファランス． 手術 56, 1445‐1449.
第二外科
  1. Minamiya, Y., Saito, S., Nakamura, M., Tozawa, K., Saito, H., Matsuzaki, I. and Ogawa, J. （2002）　Nafamostat mesilate attenuates radical formation in the rat lung infused with endotoxin.　Shock, 18（3）, 255‐260.
整形外科
  1. Okada, K., Itoi, E., Miyakoshi, N., Na-kajima, M., Suzuki, T. and Nishida, J. （2002）　Enhanced antitumor effect of ultrasound in the presence of piroxicam in a mouse air pouch model.　Jpn. J. Cancer Res., 93, 216‐222.
泌尿器科
  1. Satoh, S., Suzuki, A., Asari, Y., Sato, M., Kojima, N., Sato, T., Tsuchiya, N., Sato, K., Senoo, H.and Kato, T. （2002） Glomerular endothelial exhibits enhanced expression of costimulatory adhesion molecules, CD80 and CD86, by warm ischemia/reperfusion injury in rats.　Lab. Invest., 82, 1209‐1217.
  2. 鈴木　明， 佐藤　滋， 土谷順彦， 加藤哲郎， 佐藤　充， 妹尾春樹 （2002）　ラット虚血腎における副刺激シグナル系細胞接着因子 CD80 の発現亢進． 日泌尿会誌 93, 33‐38.
産婦人科
  1. Kumagai, A., Kodama, H., Kumagai, J., Fukuda, J., Kawamura, K., Tanikawa, H., Sato, N. and Tanaka, T. （2002） Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.　Mol. Hum. Reprod., 8（1）, 118‐123.
  2. Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Nakamura, A. and Tanaka, T. （2002） Leptin promotes the development of mouse preimplantaion embryos in vitro.　Endocrinology, 143, 1922‐1931.
  3. Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Murata, M. and Tanaka, T. （2002）　The role of leption during the development of mouse preimplantation embryos.　Mol. Cell Endocrinol., （in press）
  4. Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Shimizu, Y. and Tanaka, T. （2002） Survivin acts as an anti‐apoptotic factor during the development of mouse preimplantation embryos.　Dev. Biol., （in press）
  5. Sato, N., Kawamura, K., Fukuda, J., Honda, Y., Sato, T., Tanikawa, H., Kodama, H. and Tanaka, T. （2002）　Expression of LDL receptor （LDLR） and uptake of LDL in mouse preimplantation embryos.　Molecuar and cellular Endocrinology, （in press）
  6. 村田昌功， 佐藤宏和， 安田師仁， 滝沢　淳， 河村和弘， 清水　靖， 高橋　道， 児玉英也， 太田博孝， 田中俊誠 （2002）　Protein Kinase C （PKC） の活性化はヒト黄体化顆粒膜細胞 （GC） の LDL receptor （R） 発現を増強する． 日本産科婦人科栄養・代謝研究会誌 8（1）, 8‐10.
小児科
  1. Matsumori, M., Itoh, H., Toyoshima, I. et al （2002）　Characterization of the 105‐kDa molecular chaperone : Identification, biochemical properties, and localization. Eur. Journal of Biochem., 269（22）, 5632‐5641.
薬剤部
  1. Tada, H., Nakashima, A., Awaya, A., Fujisaki, A., Inoue, K., Kawamura, K., Itoh, K., Masuda, H. and Suzuki, T.(2002) Effects o thymic hormone on reactive oxygen species-scavengers and renal function in tacrolimus-induced nephrotoxicity. Life Sci., 70, 1213-1223.