動物実験施設を利用した各講座の研究業績

秋田大学医学部動物実験施設を使用し得られた研究成果のうち，2001年中に公表された論文．

原著論文

解剖学第二講座
  1. Sato, M., Miura, M., Kojima, N., et al.(2001) Nuclear deviation in heptic parenchymal cells on sinusoidal surface in arctic animals. Cell Struct. Func., 26, 71-77.
  2. Sato,T., Sato,N., Aota, T.,et al. (2001) Hepatic stellate cells proliferats in rotary culture system. Cells HepaticSinusoid., 8, 317-318
  3. Kojima, N., Sato, M., Suzuki, A., Sato, T., Satoh, S., Kato, T. and Senoo, H. (2001) Enhanced expression of B7-1, B7-2, and ICAM-1 in sinusoidal endothelial cells by ischemia/reperfution injury in rat liver. Hepatology, 34, 751-757.
  4. Sato,M,. Sato, T,. Kojima, N,. Miura, M,. Imai, K. and Senoo, H. (2001) Induction of cellular process elongation mediated by microtubule-associated protein 2 in hepatic stellate cells cultured on type 1 collagen gel. Cells Heepatic Sinusoid., 8, 205-206
  5. Kojima, N., Sato, M., Suzuki, A., Sato, T., Satoh, S., Kato, T. and Senoo, H. (2001) Upregulation of cell adhesion molecules, B7-1, B7-2, and ICAM-1, in hepatic sinusoidal endothelial cells after ischemia/reperfusion. Cells Hepatic Sinusoid.,8, 43-46
病理学第一講座
  1. Ichihara, T,. Komagata, Y,. Lang, XL., Uezato, T., Enomoto, K., Koyama, K., Miyazaki, J., Sugiyama, T. and Miura, N. (2001) Resistance to fulminant Hepatitis and carcinogenesis conferred by overexpression of retionblastoma protein in mouse liver. Hepatology, 33, 948-955.
病理学第二講座
  1. Sho, E., Sho, M., Singh, TM., Xu, C., Zarins, CK. and Masuda, H. (2001) Blood Flow Decrease Induces Apoptosis of Endothelial Cells in Previously dilatated Arteries Resulting from Chronic Higy Blood Flow. Arterioscler Thromb Vasc Biol., 21<, 1139-1145.
  2. Nanjo, H., Kobayashi, M., Murakami, M., Sugita, A., Asari, Y., Sugiyama, T., Sasaki, T., Kawamura, K. and Masuda, H. (2001) Endothelial cell proliferation in moderately stenosed rat aorta. 7th World Congress for Microcirculation, 481-484.
  3. kobayashi, M., Hoshi, N., Kawamura, K., Nanjo,H., Sugita, A. and Masuda, H. (2001) Three-dimensional Study of the angiogensis in Long-term Electrically Stimulated Skeletal Muscles. 7th World Congress for Microcirculation, 411-414
  4. Hoshi, N. (2001) Adaptation of capillary endothelial cells of fast skeletal muscle by chronic electrical stimulation. Akita J. Med., 28, 247-261
  5. Hoshi, N., Nanjo, H., Kobayashi, M. and Masuda, H. (2001) Three-dimensional study of capillary remodeling of skeletal muscle induced by special exercise (chronic electrical stimulation). Microcirculation Annual, 17, 121-122
  6. 星　尚人,蝦名寿仁,増田弘毅 (2001) 物理刺激への生体反応の研究の進歩-電気刺激による骨格筋毛細血管の変化-. MB Med. Reha., 8, 47-53.
  7. Sugita, A., Nanjo, H.,Kobayashi, M.,Murakami, M., Asari, Y., Sugiyama, T., Kawamura, K. and Masuda, H. (2001) Arterial Remodeling to Physiological High-Flow. 7th World Cngress for Microcirculation, 569-572.
生理学第一講座
  1. Yamada, K., Ji, J.-J., Yuan, H., Miki, T., Sato, S., Horimooto, N., Shimizu, T., Seino, S. and Inagaki, N. (2001) Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science, 292, 1543-1546.
  2. Yamada, k. and Inagaki, N. (2001) Arole for neuronal KATP channels in metabolic control of the seizure gate. Trends Pharmacol. Sci., 22, 601-602.
  3. Zhou, C.-J., Zhao, L.-X., inagaki, N., Guan, J.-L., Hirabayashi, T., Nakajo, S., Kikuyama, S. and Shioda, S. (2001) ATP-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian Iysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin-sheaths. J. Neurosci. 21,849-857.
生理学第二講座
  1. Miura, A., kawatani, M. and de Groat, WC. (2001) Effects of pituitary adenylate cyclase activating polypeptide on lumbosacral preganglionic neurons in the neonatal rat spinal coed.Brain Res, 895, 223-232.
  2. Miura, A., kawatani, M. and de Groat, WC. (2001) Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons elicited from the lateral funiculus.J. Neurophysiol., 86, 1587-1593.
  3. 河谷正仁,三浦　彰（2001）仙髄副交感神経節前ニューロン(PGN) の放電様式と興奮機構. 自律神経 38, 279-284.
生化学第一講座
  1. Ichihara,T., Komagata, Y., Yang, X.L., Uezato, T., Enomoto, K., Koyama, K.,Miyazaki,J., Sugiyama, T. and Miura, N. (2001) Resistance to fulminant hepatitis and carcinogenesis conferred by overexpression of retinoblastoma protein in mouse liver. Hepatology, 33(4), 948-955.
  2. Kameda, T., Hatakeyama, S., Terada, K. and Sugiyama, T. (2001) Acceleration of the formation of cultured epithelium using Sonic hedgehog expressing feeder cells. Tissue Eng., 7, 545-555
  3. Masuda, Y., Ohnuma, S., Sugawara, J. and Sugiyama, T. (2001) Glycoside in schizophrenic patients sera affects behavior of mouse forced swimming. Tohoku J. Exp. Med.,194(4),223-228.
  4. Masuda, Y., Sugawara, J., Kawarada, Y. and Sugiyama, T. (2001) Lithium affects the reactivities of GaINAcα1-3GaINAc-lipid and fibrinopeptide A in mice. Methods Find Exp. Clin. Pharmacol.,23, 219-221.
  5. Masuda, Y. and Sugiyama, T. (2001) A protein in the cell mall of Helicobactor pylori binds human IgG deprived of sugar chains. Tohoku J. Exp. Med., 194, 65-69.
  6. Masuda, Y. and Sugiyama, T. (2001) A mediates allergic reaction in mice in the acute phase. Peptides, 22(9), 1511-1513.
  7. Masuda, Y., Ohnuma, S. and Sugiyama, T. (2001) α2-Adrenoceptor activity induces the antidepressant-like glycolipid in mouse porced swimming. Methods Find Exp. Clin. Pharmacol.,23, 19-21.
微生物学講座
  1. Sasaki, S., Horie, Y., Nakagomi, T., Oseto, M. and Nakagomi, O. (2001) Group C rotavirus NSP4 induces diarrhea in neonatal mice. Arch. Virol.,146, 801-806
衛生学講座
  1. Fujita, H., Haseyama, T., Kayo, T., Nozaki, J., Wada, Y., Ito, S. and Koizumi, A. (2001) Increased expression of glutathione S-transferase in renal proximal tubules in the early stages of diabetes : a study of type-2 diabetes in the Akita mouse model.Exp. Nephrol., 9, 380-386.
寄生虫学講座
  1. Ohteki, T., Suzue, K., Maki, C., Ota, T., and Koyasu, S., (2001)Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat. Immunol. 2:1138-1143
  2. Suzuki, A., Tsukio-Yamaguchi, M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A., Fukumoto, M., Tsubata, T., Ohashi, P.S., Koyasu, S., Penninger, J.M., Nakano, T., and Mak, T.W., (2001)T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14:523-534
  3. Ohteki, T., Maki, C., and Koyasu, S., (2001)Overexpression of bcl-2 Differentially Restores Development of Thymus-Derived CD4-8+ T Cells and Intestinal Intraepithelial T cells in IRF-1 Deficient Mice.J. Immunol. 166:6509-6513
  4. Ohteki, T., and Koyasu, S., (2001) Role of antigen presenting cells in innate immune response. Archivum Immunologiae et TherapiaeExperimentalis49:47-52 Review
  5. Matsuda, S., Tani, Y., Yamada, M., Yoshimura, K., and Arizono, N., (2001)Type 2-biased expression of cytokine genes in lung granulomatous lesions induced by Nippostrongylus brasiliensis infection. Parasite. Immunol. 23:219-226
  6. Rumbley, C.A., Sugaya, H., Zekavat, S.A., Perrin, P.J., and Phillips, S.M., (2001)Elimination of lymphocytes, but not eosinophils, by Fas-mediated apoptosis in murine schistosomiasis. Am. J. Trop. Med. Hyg. 65:442-449
  7. Sugaya, H., Abe, T. and Yoshimura, K. (2001) Eosinophils in the cerebrospinal fluid of mice infected with Angiostronglus cantonensisare resistant to apoptosis.Int. J. Parasitol.,31, 1649-1658.
  8. Sugaya, H., Graeff-Teixeira, C., Ishida, K., Matsuda, S., Katahira, K. and Yoshimura, K. (2001) Interleukin-5 transgenic mice show an augmented resistance to Angiostrongylus costaricensis. Parasitol. Res.,88, 350-355. DOI 10.1007/s00436-001-0550-y.
内科学第一講座
  1. Pacheco, I., Otaka,M., Jin, M., Komatsu, K., Odashima, M., KOnishi, N.,Sato, T., Kato, S. and Watanabe, S. (2001) FRI67653, a potent suppressant of interleukin-1 and tumor necrosis factor-α production, amelio-rates colonic lesions in experimentally induced acute colitis.J. Gastroenterol. Hepatol., 16, 1105-1111.
内科学第二講座
  1. 加賀義章（2001）再灌流心筋障害時のCa動態に関する実験的研究. 秋田医学28（2）,139-164.
  2. 船木公行（2001）Stynned myocardium における冠灌流圧低下時の局所心筋動態に関する実験的研究.秋田医学28(1), 63-75.
  3. 大本直樹,小林政雄,清水　博,三浦　傳 (2001) 心臓における人工電気刺激様式と冠循環動態に関する実験的研究.秋田医学28(1), 11-23.
内科学第三講座
  1. Hebiguchi, T., Kato, T., Yoshino, H., Mizuno, M., Wakui, H., Komatsuda, A. and Imai, H. (2001) Extremely short small bowel induces focal tubulointerstitial fibrosis. J. Pediatr. Gastroenterol. Nutr.,32(5), 586-592.
精神科学講座
  1. Masuda, Y., Ohunuma, S., Sugawara, J., Kawarada, Y. and Sugiyama, T. (2002) Fragment of human beta-fibrinogen induces a behavioral effect on mouse forced swimming. Peptides. Mar.,23(3), 409-411
  2. Masuda, Y., Ohunuma, S., Sugawara, J., Kawarada, Y. and Sugiyama, T. (2001) Glycoside in schizophrenic patients sera affects behavior of mouse forced swimming. Tohoku J. Exp. Med.,194(4), 223-228.
  3. Masuda, Y., Sugiyama, T. (2001) Lithium affects the reactivities of GalNAcalphal-3GalNAclipid andfibrinopeptide A in mice. Methods Finf Exp. Clin. Pharmacol.,23(5), 219-221.
  4. Masuda, Y. and Sugiyama, T. (2001) A protein in the cell wall of Helicobactor pylori binds human IgG deprived of sugar chains. Tohoku J. Exp. Med., 194(1), 65-69.
  5. Masuda, Y. and Sugiyama, T. (2001) Human fibrinopeptide A mediates allergic reaction in mice in the acute phase. Peptides., 22(9), 1511-1513.
  6. Masuda, Y., Akagawa, Y. and Hishikawa, Y. (2001) Another anti-allergic mechanism : antibody IgE deglycosylation induced by a substance extracted from human urine. Yale. J. Biol. Med.,74(3), 145-149.
  7. Masuda, Y., Ohnuma, S. and Sugiyama, T. (2001) Alpha 2-adrenoceptor activity induces the antidepressant-like glycolipid in mouse foreced swimming. Methods Find Exp.Chin. Pharmacol., 23(1), 19-21.
  8. Masuda, Y., Ishigooka, S. and Matsuda, Y. (2001) Behaviors of mice given forced-swimming. Exp. Anim., 50(4), 331-335.
小児外科学講座
  1. Hebiguchi, T., Kato, T., Yoshino, H., MIzuno, M., Wakui, H., Komatsuda, A. and Imai, H. (2001) Extremely short bowed induces focal tubulointerstitial fibrosis.J. Pediatr. Gastroenterol. Nutr.,32, 586-592.
脳神経外科学講座
  1. Iwakawa, M., Itoh, Y., Tessler, A. and Mizoi, K. (2001) Intraspinal implants of fibrin glue containing glial cell line-derived neurotrophic factor promote dorsal root regeneration into spinal cord. Neurore-habilitation and Neural Repair.,15 : 157-166.
小児科学講座
  1. Komatsu, M.,Takahashi, T., Abe, T., Takahashi, I., Ida, H. and Takada, G. (2001) Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation. BBA,1533(1), 47-54.
産婦人科学講座
  1. Ota, H., Igarashi, S. and Tanaka, T. (1999) Improved fertility through superoxide removal by Toki-shakuyaku-san in mice a preliminary study. Reprod. Fertil. Dev.,11, 451-455.
  2. Kawamura, K., Fukuda, J., Kodama, H., Kumagai, J., Kumagai, A. and Tanaka, T. (2001) Expression of Fas and Fas ligand mRNA in rat and human preimplantation embryos. Mol. Hum.Reprod.,7(5), 431-436.
整形外科学講座
  1. Tomura, Y., Miyakoshi, N., Itoi, E., Abe, T., Kudo, T., Tsuchida, T., Kasukawa, Y. and Sato, K. (2001) Long -term effects of withdrawal of bisphosphonate incadronate disodium (YM175) on bone mineral density, mass structure, and turnover in the Iumbar vertebrae of ovariectomized rats. J. Bone Miner Res., 16, 541-549.
  2. Tsuchida, T., Miyakoshi, N., kudo, T., Tamura, Y., Kasukawa, Y., Suzuki, K. and Sato, K. (2001) Restoring effect of human parathyroid hormone (1-34) on trabecular connectivity in ovariectomized rats.Tohoku J. Exp. Med.,194, 213-221.
  3. Miyakoshi. N., Sato, K., Tamura, Y., Tsuchida, T., Kudo, T. and Kasukawa, Y. (2001) Evaluation of long-term sequential changes in bone mass and strength following withdrawal of incadronate disodium (YM175) in ovariectomized rats. J. Orthop Sci.,6, 167-176.
  4. Yoshida, S. (2001) Effects of Concurrent Administration (YM175) on Cancellous Bone in Rat Tibiae-A Histomorphometric Study. Akita J. Med.,28, 45-54.
泌尿器科学講座
  1. Kojima, N., Sato, M., Suzuki, A., Sato, T., Satoh, S., Kato, T. and Senoo, H. (2001) Enchanced expression of B7-1, B7-2, and intercellular adhesion molecule 1 in sinusoidal endothelial cells by warm ischemia/reperfusion injury in rat liver. Hepatology,34, 751-757.
  2. 鈴木　明,佐藤　滋,土谷順彦,加藤哲郎,佐藤　充,妹尾春樹 (2001) ラット虚血腎における副刺激シグナル系細胞接着分子CD80の発現亢進.　日泌尿会誌93, 33-38.
眼科学講座
  1. 山木邦比古(2001) 網膜・ぶどう膜抗原による実験的自己免疫性ぶどう膜炎、日本眼炎症学会誌3, 3-8.
  2. Abe, T., Nakajima, A., Satoh, N., Ohkoshi, M., Sakuragi, S. and Koizumi, A. (2001) Suppression of experimental autoimmune uveoretinitis by dietary calorie restriction. Jap. j. ophthalmol.,45, 46-52.
  3. Abe, T., Nakajima, A., Satoh, N. and Sakuragi, S. (2001) Fas expression and apoptosis in rats with experimental autoimmune uveoretinitis. Jap. j. ophthalmol., 45, 240-246.
  4. Ohkoshi, M., Abe, T., Satoh, N., Nakajima, A. and Sakuragi, S. (2001) Uveitopathogenic sites in recoverin. Curr. Eye. Res.,22, 304-311.
  5. Matsunaga, M., Abe, T., Satoh, N., Nakajima, A., Ohkoshi, M. and Sakuragi, S. (2001) Uveitopathogenic site of the γ-subunit of cyclic guanosine monophophate phosphodiesterase in Lewis rats. Jap. j. ophthalmol.,45, 570-576.
医療技術短期大学部
  1. Komatsu n, Grigorchuk I, Takashima M, inefuchi H and Yoshizaki K (2000) possible estimation of a parameter corresponding to the compliance of arterial vessels from analysis of the pulse wave. Jpn. Physiol, 50, S61.
  2. Kazuo Ohtomo, kohko fukuha (2001) Immunohistochemical localization and seasonal variation in orexin innervation in hypothalamus of two hibemators, Acta Anat. Nippon 76,115.
  3. Kohko Fukuhara, et al., and Kazuo Ohtomo (2001) Seasonal changes of mitochondrial protein SP-22-immunoreactive neurons of active and hibemating bats, Acta Anat Nippon, 76, 116.
  4. Fukuhara K, Ohtomo K and Yoshizaki K (2000) Change of body temperature respiration and heatr rate during arousa from hibemation in the horseshoe bat and chipmunk and immunoreactivity in the carotid body. Jpn J Physiol, 50, S184.