動物実験施設を利用した各講座の研究業績

秋田大学医学部動物実験施設を使用し得られた研究成果のうち,2000年中に公表され た論文.

原著論文
解剖学第二講座
  1. Imai K, Sato M, Kojima N, Miura M, Sato T, Sugiyama T, Enomoto K, Senoo H (2000) Storage of lipid droplet in and production of extracellular matrix by hepatic stellate cells (vitamin A-storing cells) in Long-Evance cinnamon-like colored (LEC) rats. Anat Rec 258:338-348
  2. 小嶋直介, 三浦光隆, 佐藤 充, 佐藤岳哉, 今井克幸, 妹尾春樹(2000)肝臓星細胞の突起形成のメカニズム,三次元的細胞培養養法,技術部研修報告6:31-35
  3. 三浦光隆, 佐藤 充, 今井克幸, 佐藤岳哉, 小嶋直介, 妹尾春樹(2000)画像ソフトを用いたコンピュータによるビデオ編集,技術部研修報告6:36-39
病理学第一講座
  1. Muto O, Sato Y, Umeki Y, Yoshida K, Yoshioka T, Nishikawa Y, Nakamura T, Mori M, Koyama K, Enomoto K (2000) HGF/SF-induced spreading of MDCK cells correlates with disappearance of Barmotin/7H6, a tight junction-associated protein, from the cell membrane. Cell Biol Int 24:439-446
  2. Imai K, Sato M, Kojima N, Miura M, Sato T, Sugiyama T, Enomoto K, Senoo H (2000) Storage of lipid droplets in and production of extracellular matrix by hepatic stellate cells (vitamin A-storing cells) in Long-Evans Cinnamon - like colored (LEC) rats. Anat Rec 258:338-348
  3. Tokairin T, Nishikawa Y, Doi Y, Watanabe H, Yoshioka T, Su M, Omori Y, Enomoto K (2000) Isolation and culture of rat hepatic sinusoidal endothelial cells by immunomagnetic separation. Cells Hepatic Sinusoid 8: in press
病理学第二講座
  1. 増田弘毅(2000)動脈のリモデリングは血管新生か.治療学7 34:364
  2. 佐藤 勤, 黒川敏昭, 加藤 健, 安井應紀, 宮澤秀彰, 浅沼義博, 南條 博, 小山研二(2000)全肝血行遮断後肝障害に対する prostaglandin E1-肝動脈内持 続投与の効果-. Akita J Med 27: 21-29
  3. Sato T, Kato T, Kurokawa T, Yasui O, Nanjo H, Miyazawa H, Asanuma Y, Koyama K (2000) Continuous infusion of prostaglandin E1 via the superior mesenteric artery can prevent hepatic injury in hepatic artery interruption through passive portal oxygenation. Liver 20: 179-183
薬理学講座
  1. Kurata S, Ishikawa K, Iijima T (1999) Enhancement by arginine vasopressin of the L-Type Ca2+ current in guinea pig ventricular myocytes. Pharmacology 59: 21-33
  2. Fujisawa S, Ono K, Iijima T (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br J Pharmacol 129: 1007-1013
生理学第一講座
  1. Zhao L-X, Zhou C-J, Tanaka A, Nakata M, Hirabayashi T, Amachi T, Shioda S, Ueda K, Inagaki N (2000) Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Biochem J 350:865-872
生化学第一講座
  1. Nagai H, Sugiyama T, Yoshikawa H, Kim Y-S. Yeo S-Y, Konishi N, Matsubara K (2000) Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using new technique. Oncology Report 7: 315-318
  2. Yang X-L, Matsuura H, Fu Y, Sugiyama T, Miura N (2000) MFH-1 is required for bone morphogenetic protein-2-induced osteoblastic differentiation of C2C12 myoblasts. FEBS Letters 470: 29-34
  3. Imai K, Sato M, Kojima N, Miura M, Sato T, Sugiyama T, Enomoto K, Senoo H (2000) Storage of lipid droplets in and production of extracellular matrix by hepatic stellate cells (vitamin A-storing cells) in Long-Evans cinnamon-like colored (LEC) rats. Anat Rec 258: 338-348
  4. Masuda Y, Sugiyama T (2000) The effect of globopentaosylceramide on a depression model, mouse forced swimming. Tohoku J Exp Med 191: 47-54
  5. Masuda Y, Kawarada Y, Sugiyama T (2000) Behavioral effect of mouse fibrinopeptide A on mouse forced swimming. Peptides 21: 459-461
公衆衛生学講座
  1. Hachiya N, Motohashi Y (2000) Examination of LacZ mutant induction in the liver and testis of MutaTM mouse following injection of halogenated aliphatic hydrocarbons classified as human carcinogens.Industrial health 38: 213-220
衛生学講座
  1. Kayo T, Fujita H, Nozaki J, E X, Koizumi A (2000) Identification of two chromosomol loci determining glucose intolerance in a C57BL/6 mouse strain. Comp Med 50:296-302
寄生虫学講座
  1. Yoshimura K, Sugaya H, Aoki M, Ishida K (2000) SCID mice show a similar susceptibility to Angiostrongylus cantonensis as do wild-type mice of the C.B-17 strain. Parasitol Res 86 : 542-550
内科学第一講座
  1. Toyoshima I, Kato K, Sugawara M, Wada C, Okawa S, Kobayashi M, Masamune O, Watanabe S (2000) Massive accumulation of M and H subunits of neurofilament proteins in spinal motor neurons of neurofila ment deficient japanese quail, Quv.Neurosci Lett 287(3): 175-178
内科学第二講座
  1. 木村 元(2000)Ischemic preconditioningとAdenosineの係わり-in vivo rat 心における検討-.秋田医学 26: 225-239
  2. 三ヶ田啓子(2000)Perfusion-Contraction Matching に対する Metabolic Intervention の検討. 秋田医学 37 : (3・4): 201-218
  3. 斉藤 崇, 藤原慶正, 藤原理佐子, 三浦博人, 長谷川仁志, 三浦 傳(2000) 心血管病態と血管の機能的リモデリング-Ca活性化 K channel の発現修飾-. THERAPEUTIC RESEARCH 21(9): 2116-2119
精神科学講座
  1. Masuda Y, Ohnuma S, Sugiyama T (2000) Relationship between antidepressants and glycolipids in the forced swimming test in mice. Methods Find Exp Clin Pharmacol. 22: 667-70.
  2. Masuda Y, Suzuki M (2000) Repeated electroconvulsive shock treatment induces two humoral anti-depressive factors in mouse. Tohoku J Exp Med.192: 283-9.
  3. Masuda Y, Sugiyama T. (2000) The effect of globopentaosylceramide on a depression model, mouse forced swimming. Tohoku J Exp Med. 191:47-54.
  4. Masuda Y, Ishigooka S, Matsuda Y. (2000) Digging behavior of ddY mouse. Exp Anim. 49:235-7.
外科学第一講座
  1. Sato T, Asanuma Y, Hashimoto M, Heianna J, Kusano T, Kurokawa T, Yasui O, Koyama K (2000) Efficacy of hepatic arterial infusion of prostaglandin E1 in the treatment of postoperative acute liver failure-Report of a case. Hepatogastroenterology 47: 846-850
  2. Sato T, Kato T, Kurokawa T, Yasui O, Miyazawa H, Asanuma Y, Koyama K (2000) Continuous infusion of prostaglandin E1 via the superior mesenteric artery can prevent hepatic injury through passive portal oxygenation in hepatic artery interruption. Liver 20: 179-183
  3. Sato T, Asanuma Y, Kurokawa T, Kato T, Yasui O, Kusano T, Koyama K (2000) Prostaglandin E1 continuoue hepatic arterial infusion in the treatment of postoperative acute liver failure: Basic study on hepatic hemodynamics and clinical application. Digestive Surgery 17: 234-240
  4. 佐藤 勤, 黒川敏昭, 加藤 健, 安井應紀, 宮澤秀彰, 浅沼義博, 南條 博 , 小山研二(2000)全肝血行遮断後肝障害に対する Prostaglandin E1 肝動脈内持 続投与の効果. 秋田医学 27: 21-29
  5. 佐藤 勤, 黒川敏昭, 加藤 健, 安井應紀, 浅沼義博, 小山研二(2000) Prostaglandin E1経動脈的持続投与による術後肝不全の治療. 日本 Shock 学会誌 15: 52-55
小児外科
  1. 蛇口達造, 加藤哲夫, 吉野裕顕, 水野 大 (2000) 腸管成長因子としてのアルギニン. 小児外科 32(2): 133-115
  2. 蛇口達造, 加藤哲夫, 吉野裕顕, 水野 大, 萱場広之 (2000) 先天性食堂閉鎖症 の long gap 症例に対する空気注入による食道延長法. 小児外科 32(9) : 939-945
外科学第二講座
  1. 本山 悟, 鈴木裕之, 斉藤礼次郎, 中村征勝, 今野広志, 小川純一(2000)肝虚血時のミトコンドリア内 Bcl-2の変化(プレナリーセッション)
心臓外科
  1. Liu KX, Yamamoto F, SekineS, Goto Y, Kondoh K, Matssukawa M, Kagaya S (2000) Inhibitory Effect of Photooxidation on Intimal Thickening of Vein Graft. Coronary Artery Disease Prevention to Intervention: 233-239 (proceedings)
脳神経外科学講座
  1. Takahashi M, Mineura K, Watanabe K, Kohda K (2000) O6-(fluorobenzyl) guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo. Acta Oncologica 39: 89-95
  2. Okubo A, Kinouchi H, Owada Y, Kunizuka H, Itoh H, Izaki K, Kondo H, Tashima Y, Yoshimoto T, Mizoi K (2000) Simultaneous induction of mitochondrial heat shock protein mRNAs in rat forebrain ischemia. Molecular Brain Research 84: 127-134
小児科学講座
  1. Takahashi I, Takahashi T, Abe T, Watanabe W, Takada G (2000) Distribution of acid sphingomyelinase in human various body fluids. Tohoku J Exp Med 192: 61-66
産婦人科学講座
  1. Ikegami T, Tsuda A, Karube A, Kodama H, Hirano H, Tanaka T (2000) Effects of intrauterine IL-6 and IL-8 on the expression of surfactant apoprotein mRNAs in the fetal rat lung. Eur J Obstet Gynecol Reprod Biol 93: 97-103
  2. Kumagai J, Fukuda J, Kodama H, Murata M, Kawamura K, Itoh H, Tanaka T (2000) Germ cell-specific heat shock protein 105 binds to p53 in a temperaturesensitive manner in rat testis. Eur J Biochem 267: 3073-3078
  3. Kawamura K, Fukuda J, Itoh H, Itoh K, Kodama H, Kumagai J, Kumagai A, Tanaka T (2000) Chaperonin 10 in the Rat Oocytes and Early Embryos: its Expression and Activity for Early Pregnancy Factor. American Journal of Reproductive Immunology 44: 242-248
  4. 櫛引美代子, 吉崎克明, 田中俊誠, 福島峰子 (2000) 当帰芍薬散エキスとその血清の子宮筋収縮に対する作用. 和漢医薬学雑誌 17(4): 170-172
整形外科学講座
  1. Tsuchida T, Sato K, Miyakoshi N, Abe T, Kudo T, Tamura Y, Kasukawa Y, Suzuki K (2000) Histomorphometric evaluation of the recovering effect of human parathyroid hormone (1-34) on bone structure and turnover in streptozotocin-induced diabetic rats. Calcif Tissue Int 66: 229-233
泌尿器科学講座
  1. 立木 裕 (2000) 脊椎損傷ラットにおける下部尿路機能と膀胱で産生される神経成長因子. 秋田医学 27: 57-63
眼科学講座
  1. Yamaki K, Kondo I, Nakamura H, Miyano M, Konno S, Sakuragi S (2000) Ocular and extraocular inflammation induced by immunization of tyrosinase related protein 1 and 2 in Lewis rats. Exp Eye Res 71: 361-369
  2. Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S (2000) Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol 165: 7323-7329
麻酔科学講座
  1. 宮澤一治, 河谷正仁, 西川俊昭 (2000) 猫上頚神経節への半導体レーザー照射が交感神経活動と頚動脈血流量に及ぼす影響. ペインクリニック 21: 553-561
救急医学講座
  1. Nakae H, Inaba H (2000) Electrolyzed oxidized water and hydrocollid dressings promote rapid wound healing in a rat burn wound model. 5th World Congress on Trauma, Shock, Inflammation and Sepsis. Monduzzi Editore: 643-648. (proceeding)
  2. Nakae H, Inaba H (2000) Effect of electrolyzed strong acid aqueous solution irrigation on wound in rat excision model. Artif Organ 24: 544-546
  3. Nakae H, Inaba H (2000) Effectiveness of electrolyzed oxidative water irrigation in burn wound infection model. J Trauma 49: 511-514
老年科
  1. Kato T, Fujita H, Nozaki J, E X, Koizumi A (2000) Identification of two chromosomal loci determining glucose Intolerance in a C57BL/6 mouse strain. Comp Med 50(3): 296-302
医療技術短期大学部
  1. Yoshizaki K, Momiyama H and Hayashida Y (2000) Effects of a dopamine agonist on cytosolic Ca2+ -changes induced by hypoxia in rat glomus cells. Advances in Experimental Medicine and Biology (title: Oxygen Sensing, Molecule to Man) 475: 743-748
  2. Hayashida Y, Yoshizaki K and Kusakabe T (2000) Interplay between the cytosolic Ca2+ increase and potential changes in glomus cells in response to chemical stmuli Advances in Experimental Medicine and Biology (title: Oxygen Sensing Molecule to Man) 475: 691-696.
  3. Yosizaki K and Hayashida Y (1999) Effects of tyramine on cytosolic calcium change in rat glomus cells. Jpn J Physiol 49: S187
  4. Fukuhara K, Yoshizaki K, Ohtomo K (2000) Seasonal changes of several neurochemical agents in the carotid body during hibernation. Acta Anat Nippon, 75: 127
  5. 櫛引美代子, 吉崎克明,  田中俊誠, 福島峰子 (2000) 当帰芍薬散エキスとその血清の子宮筋収縮に対する作用. 和漢医薬学会誌 17(4), 170-172
  6. Ohtomo K, Fukuhara K, and Yoshizaki K (2000) Immunohistochemical study of the carotid body during hiibemation. Advances in Experimental Medicine and Biology (title: Oxygen Sensing, Molecule to Man) 475: 815-822
  7. Ohtomo K, Fukuhara K (2000) Seasonal changes of never fibers in the hypothala-mohypophysial tract of some hibemators. Acta Anat Nippon 75: 109
  8. Narisawa T, Fukuhara Y, Hasebe M, Nomura S, Oshima S, Inakuma T (2000) Prevention of N-methyluitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice. Proc Soc Exp Biol Med, 224(1),116-122
  9. Kumagai J, Fukuhara J, Kodama H, Murata M, Kawamura K, Ito H, Tanaka T (2000) Germ cell specific heat shock protein 105 binds to p53 in a temperature-sensitive manner in rat testis. Eur J Biochem, 267: 3073-3078
  10. Kawamura K, Fukuhara J, Ito H, Kodama H, Kumagai J, Kumagai A, tanaka T (2000) Chaperonin 10 in the rat oocytes and early embryos; its expression and activity for early pregnancy factor. Am J Reprod Immunol, 44: 242-248
  11. Ikegami T, Tsuda A, Karube A, Kodama H, Hirano H, Tanaka T (2000) Effects of intrauterine IL-6 and IL-8 on the expression of surfactant apoprotein mRNAs in the fetal rat lung. Eur J Obstet Gynecol Reprod Biol, 93: 97-103