動物実験施設を利用した各講座の研究業績

秋田大学医学部動物実験施設を使用し得られた研究成果のうち，1999年中に公表された論文．

原著論文
解剖学第二講座
  1. Matano Y, Miura M, Kojima N, Sato M, Imai K, Senoo H (1999) Hepatic stellate cells and extrahepatic stellate cells (extrahepatic vitamin A-storing cells). Cells Hepatic Sinusoid 7：26-27
  2. Li Y-L, Sato M, Kojima N, Miura M, Senoo H (1999) Regulatory role of extracellular matrix components in expression of matrix metalloproteases in cultured hepatic stellate cells. Cell Struct Func 24：255-261
  3. Imai K, Sato M, Kojima N, Miura M, Matano Y, Senoo H (1999) Regulation of extracellular matrix production in the stellate cells - An analysis in the liver of LEC rats -. Cells Hepatic Sinusoid 7：185-186
  4. Sato M, Kojima N, Miura M, Imai K, Senoo H (1999) Intracellular signaling for process elongation in cultured hepatic stellate cells on type?歡ollagen gel. Cells Hepatic Sinusoid 7：32-33
  5. Kojima N, Sato M, Miura M, Imai K, Senoo H (1999) Alteration in distribution of focal adhesion components by signaling inhibitors in hepatic stellate cells and fibroblasts cultured on type ?歡ollagen gel. Cells Hepatic Sinusoid 7：：24-25
  6. Miura M, Sato M, Toyoshima I, Senoo H (1999) Elongation of long, multipolar processes in hepatic stellate cell culture on type?歡ollagen gel by microtubule assembly: Observation utilizing time-lapse video-microscopy. Cells Hepatic Sinusoid 7：17-20
  7. 佐藤　充, 小嶋直介, 三浦光隆, 今井克幸, 李　一雷, 妹尾春樹（1999）?沍^コラーゲンゲル上で培養した肝臓星細胞における突起伸長メカニズム：細胞内シグナル伝達機構. 肝類洞壁細胞研究の進歩11：71-74
病理学第二講座
  1. Masuda H, Zhuang Y-J, Singh TM, Kawamura K, Murakami M, Zarins CK, Glagov S (1999) Adaptive remodeling of internal elastic lamina and endothelial lining during flow-induced arterial enlargement. Arterioscler Thromb Vasc Biol 19：2298-2307
  2. Kobayashi M, Kawamura K, Honma M, Masuda H, Suzuki Y, Hasegawa H (1999) Tunnel capillaries of cardiac myocyte in pressure-overloaded rat heart - an ultrastructural three-dimensional study. Microvascular Research 57：258-272
  3. 佐藤　勤, 草野智之, 黒川敏昭, 南條　博, 川村公一, 安井應紀, 加藤　健, 浅沼義博, 小山研二（1999）肝血行遮断下における酸素供給源としての肝静脈血の役割. 日消外会誌　32：805-811
薬理学講座
  1. Fujisawa S, Iijima T (1999) On the inotropic actions of arginine vasopressin in ventricular muscle of the guinea pig heart. Jpn Pharmacol 81：309-312
生理学第二講座
  1. Sato M (1999) Effect of ouabain on the cytosolic concentrations of calcium in cultured carotid body glomus cells of the rabbit. Brain Res 828：193-196
生化学第一講座
  1. Masuda Y, Miura N, Suzuki M, Akagawa Y, Kawarada Y, Kawagoe M, Sugiyama T, Shimizu T, Hishikawa Y (1999) The fragment of complement 3a lacking the primary 9amino acids induces promoting activity on mouse voluntary running. Tohoku J Exp Med 189：21-27
  2. Narisawa T, Fukaura Y, Terada K, Sekiguchi H (1999) Inhibitory effects of ursodeoxycholic acid on N-methyl-nitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats. J Exp Clin Cancer Res 18：259266
  3. Terada K, Aiba N, Yang XL, Iida M, Nakai M, Miura N, Sugiyama T (1999) Biliary excretion of copper in LEC rat after introduction of copper transporting P-type ATPase, ATP7B. FEBS Lett 448: 53-56
微生物学講座
  1. Nakagomi T, Horie Y, Koshimura Y, Greenberg HB, Nakagomi O (1999) Isolation of a human rotavirus strain with a super short RNA pattern and a new P2 subtype. J. Clin. Microbiol.37：1213-1216
  2. Horie Y, Nakagomi O, Koshimura Y, Nakagomi T, Suzuki Y, Oka T, Sasaki S, Matsuda Y, Watanabe S (1999) Diarrhea induction by rotavirus NSP4 in the homologous mouse model system. Virology 262：398-407
衛生学講座
  1. Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, Lu D, Takata K, Koizumi A, Izumi T (1999) A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse. J Clin Invest 103: 27-37
公衆衛生学講座
  1. Hachiya N, Yajima N, Hatakeyama S, Yuno K, Okada N, Umeda Y, Wakata A, Motohashi Y (1999) Induction of lacZ mutation by 7,12-dimethylbenz[a]anthracene in various of transgenic mice. Mutation Res 444：283-295
  2. Suzuki T, Itou S, Nakajima M, Hachiya N, Hara T (1999) Target organ and timecourse in the mutagenicity of the carcinogenes in Muta Mouse : A summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS, Mutation Res 444：259-268
寄生虫学講座
  1. Aoki M, Ishida K, Sugaya H, Yosimura K (1999) Morbidity and susceptibility of the mouse to Angiostrongylus cantonensis are not related to the H-2 complex. Parasitol Res 85：669-671
法医学講座
  1. Sato A, Gonmori K, Yoshioka N (1999) A case of fatal intoxication with ammonium salfate and a toxicological study using rabbits. Forensin Sci Int 101：141-149
  2. 佐藤　朗, 権守邦夫, 吉岡尚文（1999）窒素, りん酸, カリ混合化学肥料の急性毒性に関する実験的研究. 中毒研究12：415-421
内科学第三講座
  1. Komatsuda A, Wakui H, Ohtani H, Imai H, Miura AB, Itoh H (1999) Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis. Path Intenat 49：513-518
精神科学講座
  1. Yoshimoto M, Higuchi H, Kamata M, Yoshida K, Shimizu T, Hishikawa Y (1999) The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats Eur Neuropsychopharmacol 9：29-35
  2. Takahashi H, Yoshimoto M, Higuchi H, Shimizu T, Hishikawa Y (1999) Different effects of L-type and T-type calcium channel blockers on the hypnotic potency of triazolam and zolpidem in rats. Eur Neuropsychopharmacol 9：317-321
  3. Masuda Y (1999) Mechanism of behavioral adaptation : analyses by a simple model. Med Hypotheses 52：115-117
  4. Masuda Y, Suzuki M, Akagawa Y, Takemura T (1999) Developmental and pharmacological features of mouse emotional piloerection. Exp Anim 48：209-211
  5. Masuda Y (1999) The fragment of complement 3a lacking the primary 9 amino acids induces promoting activity on mouse voluntary running. Tohoku J Exp Med 189：21-27
  6. Masuda Y (1999) Symptoms of patients suffering from somatoform disorders and ifenprodil. Psychosomatics 40：449
外科学第一講座
  1. Shibata S, Asanuma Y, Itoh H, Tashima Y, Nanjo H, Koyama K (1998) Prevention of warm ischemia-reperfusion injury in the pancreas by water-immersion stress. Transplant Proc. 30：202-205
  2. Shibata S, Asanuma Y, Itoh H, Koyama K (1998) The circadian rhythm of HSP 60 in pancreas of rat. Pancreas 17：316-318
  3. Sato T, Kato T, Kurokawa T, Yasui O, Nanjo H, Asanuma Y, Koyama K (1999) Alteration of portal blood by continuous PGE1 infusion via the superior mesenteric artery after hepatic artery interruption. Surgical Forum 50：1-2
  4. Sibata S, Asanuma Y, Shindo Y, Koyama K (1999) The elongation of pancreas preservation time with heat-pretreatment. Low Temp Med 25：129-133
  5. Sawada T, Asamuma Y, Furuya T, Saito K, Koyama K (1999) Tolerance of islet allografts induced by orthotopic liver transplantation. J Surg Res 85：209-216
  6. 佐藤　勤, 浅沼義博, 安井應紀, 黒川敏昭, 加藤　健, 田中淳一, 小山研二（1999）肝血行遮断後の肝非実質細胞障害の検討. 秋田医学26：37-43
  7. 佐藤　勤, 草野智之, 黒川敏昭, 南條　博, 川村公一, 安井應紀, 加藤　健, 浅沼義博, 小山研二（1999）肝血行遮断における酸素供給源としての肝静脈の役割. 日消外会誌32：805-811
  8. 佐藤　勤, 浅沼義博, 小山研二（1999）低温浸漬肝保存における常温下灌流による wash-out 兼酸素化の意義. 秋田医学26：31-35
  9. 加藤　健, 浅沼義博, 佐藤　勤, 田中淳一, 安藤秀明, 安井應紀, 黒川敏昭, 小山研二（1999）肝動脈塞栓術後の肝不全対策：プロスタグランディンE1の上腸間膜動脈持続動注の意義. 日本外科系連合学会誌24：782-786
小児外科
  1. 加藤哲夫, 吉野裕顕, 蛇口達造, 水野　大（1999）家兎胎仔横隔膜ヘルニアの胎内治療とその肺低形成への効果. 日本外科学会誌100：366-372
心臓血管外科
  1. Liu KX, Yamamoto F, Sekine S, Goto Y, Seki K, Kondoh K, Fu Y (1999) Inhibitory effect of methylene blue-induced photooxidation on intimal thickening of vein graft. Ann Thorac Surg 68：84-88
脳神経外科学講座
  1. Itoh Y, Mizoi K, Tessler A (1999) Embryonic central nervous system transplant mediate adult dorsal root regeneration into host spinal cord. Neurosurg 45：849-858
  2. Kinouchi H, Arai S, Kamii H, Izaki K, Kunizuka H, Mizoi K, Yoshimoto T (1999) Induction of Rheb mRNA following middle cerebral artery occlusion in the rat. Neuro Report 10: 1055-1059
  3. Kinouchi H, Huang H, Arai S, Mizoi K, Yoshimoto T (1999) Induction of cyclooxygenase-2 messenger RNA after transient and permanent middle cerebral artery occlusion in rats: comparison with c-fos messenger RNA by using in situ hybridization. J Neurosurg 91: 1005-1012
  4. Iwaya K, Mizoi K, Tessler A, Itoh Y (1999) Neurotrophic agents in fibrin glue mediate about dorsal root regeneration into spinal cord. Neurosurg 44: 589-596
小児科学講座
  1. Ogasawara M, Nakajima W, Ishida A, Takada G (1999) Striatal perfusion of indomethacin attenuates dopamine increase in immature rat brain exposed to anoxia : an in vivo microdialysis study. Brain Res 842：487-490
産婦人科学講座
  1. Ota H, Igarashi S, Ohyama N, Suzuki Y, Tanaka T (1999) Optimal levels of nitric oxide are crucial for implantation in mice. Reprod Fertil Dev 11：183-188
  2. Ikeda M, Kodama H, Fukuda J, Shimizu Y, Murata M, Kumagai J, Tanaka T (1999) Role of radical oxygen special in rat testicular germ cell apoptosis induced by heat stress. Biol Reprod 61：393-399
整形外科学講座
  1. Okada K, Sakusabe N, Kobayashi A, Hoshino N, Sato K (1999) Prevention of lung metastasis by intra-tumoral injection of cepharanthin and staphylococcal enterotoxin B in transplantable rat osteosarcoma. Jpn J Cancer Res 90：928-933
  2. Sakusabe N, Okada K, Sato K, Kamada S, Yoshida Y, Suzuki T (1999) Enhanced sonodynamic antitumor effect of ultrasound in the presence of nonsteroidal anti-inflammatory drugs. Jpn J Cancer Res 90：1146-1151
  3. Miyakosi N, Sato K, Abe T, Tsuchida T, Tamura Y, Kudo T (1999) Histomorphometric evaluation of the effects of ovariectomy on bone turnover in rat caudal vertebrae. Calcif Tissue Int 64：318-324
泌尿器科学講座
  1. 石田俊哉, 下田直威, 佐藤一成, 小川　修, 西澤　理, 加藤哲郎（1999）ラットにおける膀胱虚血の排尿機能と神経成長因子に与える影響. 日泌尿会誌90：564-571
  2. 工藤貴正, 下田直威, 西澤　理, 加藤哲郎（1999）ラットの尿道閉塞ならびに解除時における膀胱機能と神経成長因子. 日泌尿会誌90：651-656
  3. 小友　良, 下田直威, 佐藤　滋, 佐藤一成, 小川　修, 加藤哲郎（1999）ラット膀胱ならびに尿道機能制御に対するATP受容体の役割. 日泌尿会誌90：681-687
眼科学講座
  1. Maeda S, Ishikawa M, Abe T, Konno S, Sakuragi S (1999) Lectin cytochemistry of the lacrimal sac epithelium in experimental dacryocystitis. Jpn J Ophthalmol 43：69-74
麻酔科学講座
  1. Terada H, Ohta S, Nishikawa T, Mizunuma T, Iwasaki Y, Masaki Y (1999) The effect of intravenous or subarachnoid lidocaine on glutamate accumulation during transient forebrain ischemia in rats. Anesth Analg 89：957-961
救急医学講座
  1. Nakae H, Inaba H, Endo S (1999) Usefulness of procalcitonin in Pseudomonas burn wound sepsis model. Tohoku J Exp Med 188：271-273
薬剤部
  1. Suzuki T, Sato E, Tada H, Tojima Y (1999) Examination on local anti-inflammatory activities of new steroids, hemisuccinyl methyl glycolates. Biol Pharm Bull 22：816-821
  2. Suzuki T, Tada H, Sato E, Tojima Y (1999) Examination on biological activities and fates of new steroids, steroid-17-yl methyl glycolate derivatives. Tohoku J Exp Med 187：127-140
  3. Tada H, Yanagiwara S, Itoh K, Suzuki T (1999) Role of diltiazem on tacrolimus pharmacokinetics in tacrolimus-induced nephrotoxic rat. Pharmacol Toxicol 84：241-246
  4. Sakusabe N, Okada K, Sato K, Kamada S, Yoshida Y, Suzuki T (1999) Enhanced sonodynamic antitumor effect of ultrasound in the presence of nonsteroidal anti-inflammatory drugs. Jpn J Cancer Res 90：1146-1151
医療技術短期大学部
  1. Yoshizaki K, Hayashida Y (1998) Responses of cytosolic Ca2+ and pH to natural stimuli as a result of interactions among adjacent glomus cells. Jpn J Physiol 48,　Ｓ175
  2. Hoshino T, Yoshizaki K, Koyano H, Ishikawa K, Terata N, Konno A (1998) An electrophysiological study of pterygoparatine ganglion neurons in the rabbit. Acta Otolaryngol (Stockh) 537, 20-26
  3. Kawaguchi J, Fukuhara K, Yoshizaki K (1999) Effects of culture period on cytoarchitecture and sensitivity to acetylcholine and elevated K+ in cultured superior cervical ganglion cells of rats. J Iwate Med Ass 50, 679-686
  4. Ohtomo K, Fukuhara K (1999) Morphological difference and seasonal changes of immunoreactive fibers of hypothalamohypophyseal tract in the horse shoe bat and chipmunk. Acta Anat Nippon 74, 104
  5. Fukuhara K, Ohtomo K (1999) Distribution of three kinds of peptides in suprachiasamtic nucreus (SCN) of bats, hamsters and chipmunks. Acta Anat Nippon 74, 127
  6. 櫛引美代子, 吉崎克明, 福島峰子, 小松靖弘, 田中俊誠（1998）甘草エキスと甘草血清の子宮筋収縮に対する作用の違い.和漢医薬学雑誌15, 350-351
  7. 林田嘉朗, 吉崎克明（1999）頚動脈小体の化学受容機構モデル. 日本生理学雑誌61, 191-192
  8. 大友和夫, 福原紅子, 吉崎克明（1999）冬眠動物における頚動脈小体の季節変化について. 秋田大学医療技術短期大学部紀要7（2）, 109-116
動物実験施設
  1. Horie Y, Nakagomi O, Koshimura Y, Nakagomi T, Suzuki Y, Oka T, Sasaki S, Matsuda Y, Watanabe S (1999) Diarrhea induction by rotavirus NSP4 in the homologous mouse model system. Virology 262：398-407