動物実験施設を利用した各講座の研究業績

秋田大学医学部動物実験施設を使用し得られた研究成果のうち，1998年中に公表された論文．

解剖学第二講座
  1. Imai K，senoo H (1998) Morpho1ogy of sites of adhesion between hepatic stellate cells （vitamin A-storing cells）and a threedimension al extracellular matrix．Anat Rec 250：430- 437
  2. Sato M, Imai K, Kojima N, Miura M, Senoo H (1998) Induction of cellu1ar processes containing collagenase and retinoid by integrin-binding to type I collagen in hepatic steuate cell culture． Cell Biol Int 22：115-125
  3. Kojima N, Sato M, Miura M, Imai K, Matano Y, Senoo H (1998) Stellate cells (vitamin A- stor- ing cells) change their cytoskeleton and signal transduction system according to extracellular matrix．Histochem Cell Biol 110：121-128
  4. Miura N, Kakinuma H, Sato M, Aiba N, Terada K, Sugiyama T (1998) Mouse forkhead (winged helix) gene LUN encodes a transactivator that acts in the lung．Genomics 50：346-356
  5. 三浦光隆、佐藤充、小嶋直介、妹尾春樹（1998）培養肝臓星細胞における突起の伸長と退縮一ビデ オ記録による経時的追跡一。技術部研修報告4：17-19
病理学第一講座
  1. Morita M, Wang Q, Watanabe H, Doi Y, Mori M, Enomoto K (1998) Analysis of the sinusoidal endothelial cell organization during the deve1opmental stage of the fetal rat liver using a sinusoidal endothelial cell specific antibody, SE-1．Cell Struct Func 23：341-348
病理学第二講座
  1. Zhuang Y-J, Singh-TM, Zarins CK, Masuda H (1998) Sequential increases and decreases in blood flow stimu1ates progressive intimal thicking。Eur J Vasc Endovasc Surg 16：301-310
  2. Singh TM, Abe KY, Sasaki T, Zhuang Y-J，Masuda H, Zarins CK (1998) Basic fibroblast growth factor expression precedes flow induced arterial en1argement．J Surg Research 77： 165-173
  3. Singh TM, Abe KY, Sasaki T, Zhuang Y-J, Masuda H, Zarins CK (1998) Arterial adapation to increased flow requires transfoming growth factor bl．Sugical Forum XLIX：296−298
  4. 増田弘毅、庄永瓜星尚人、村上正代（1998）血流による血管のリモデング。血管と内皮8：231-239
薬理学講座
  1. Wada Y,Shinbo A, Tsukada M, Iijima T, Koizumi A（1997）Electrophysiological evidence of an increase in cold tolerance of cardiac muscles in mice after energy restriction．Mech Ageing Dev 97：35-43
  2. Shinbo A，Iijima T（1997）Potentiation by nitric oxide of the ATP-sensitive K+ current induced by K+ channel openers in guinea-pig ventricular cells．Br J Pharmacol 120：1568-1574
  3. Shinbo A，Ono K，Iijima T（1997）Activation of cardiac ATP-sensitive K＋ channels by KRN4884，a novel K＋ channel opener. J Pharmacol Exp Ther 283：770-777
生理学第一講座
  1. Horimoto N，Nabekura J，Ogawa T（1997）Arachidonic acid activation of potassium channels in rat visual cortex neurons. Neuroscience 77：661-671
生理学第二講座
  1. Imaizumi M, Oguma Y, Kawatani M（1998）Optica1 imaging of the spontaneous neuronal activities in the male rat major pelvic ganglion following denervation of the pelvic nerve． Neuroscience Lett 258：159−1622
  2. Sato M, Kawatani M（1998）DbcGMP raises cytosolic concentrations of Ca2＋ in cultured nodose ganglion neurons of the rabbit．Brain Res 813：203−206
  3. 寺邑敏彦、河谷正仁、佐藤智哉、今泉　満、福田　孝、由利康裕、藤枝信夫、土田正義（1998）会 陰部刺激による排尿反射抑制機構の脊髄損傷後の変化の検討。日本災害医　学雑誌46：682−689
生化学第一講座
  1. Terada K, Nakako T, Yang X-L, Iida M，Aiba N, Minamiya Y, Nakai M, Sakaki T, Miura N, Sugiyama T (1998) Restoration of holoceruloplasmin synthesis in LEC rat after infusion of recombinant adenovirus bearing WND cDNA．J Biol Chem 273：1815-1820
  2. Terada K, Schilsky ML, Miura N, Sugiyama T (1998) ATP7B（WND）protein．Int J Biochem Cell Biol 30：1063-1067
  3. Miura N, Kakinuma H, Sato M, Aiba N, Terada K, Sugiyama T (1998) Mouse forkhead（winged helix）gene LUN encodes a transactivator that acts in the lung．Genomics 50：346-356
  4. Kawarada Y, Miura N, Sugiyama T (1998) Antibody against single-stranded DNA useful for detecting apoptotic cells recognizes hexadeoxynucleotides with various base sequences.
    J Biochem 123：492-498
  5. Awata R, Sawai H, Imai K, Terada K, Seno H, Sugiyama T (1998) Morphological comparison and functional reconstitution of rat hepatic parenchymal cells on various matrices．
    J Gastroenterol Hepatol 13：S55-61
  6. Masuda Y, Takemura T, Sugiyama T (1998) Hypertriglyceridemia associated with the treatment of amitriptyline and maprotiline．Human Psychopharmacol Clin Exp 13：527-528．
  7. Saito H，Minamiya Y，Kitamura M，Saito S，Enomoto K，Terada K，Ogawa J（1998） Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cel1 monolayer．J Immnol 161：1533-1540
生化学第二講座
  1. Tao GZ, Komastuda A, Miura AB, Kobayasi A, Itoh H, Tashima Y（1998）pICln predominantly locaIizes at luminal surface membranes of distal tubules and Henle's ascending limbs．Biochem Biophys Res Commun 247：668-673
衛生学講座
  1. Kayo T, Koizumi A（1998）Mapping of murine diabetogenic gene Mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and β cell developrnent during the perinatal period．J C1in Invest 101：2112-2118
寄生虫学講座
  1. Aoki M, Sugaya H, Ishida K, Yoshimura K（1998）The role of CD4+ and CD8+ T-cells in host morbidity and innate resistance to Angiostrongylus cantonensis in the mouse, Parasitol Res 84： 91-99
  2. Abe T, Sugaya H, Yoshimura K（1998）Analysis of T cell popu1ations and IL-3m RNA expression in mesenteric lymph node cells and intestinal intraepitheIia1 lymphocytes in Strongy- loides ratti-infected mice．J Helminthol 72：1-8
  3. Koyama T, Abe T, Sugaya H, Koizumi A, Yoshimura K（1998）IL-3-depend murine bone marrow derived mast cells express Fas but are resistant to Fas-mediated apoptosis．Akita J Med 25：231−237
  4. Sugaya H, Yoshimura K（1998）Eosinophil activation, apoptosis and pathogeny in Angiostrongylus cantonensis infection in the mouse．IX Int Congr Parasitol：419-424（Proceedings）
法医学講座
  1. Shouji K, Enzan K, Mistuhata H, Yoshioka N（1998）Platelet-activating factor is a key mediator of pulmonary vasocostriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung．Shock9：412-415
内科学第一講座
  1. Toyoshima, Sugawara M, Kato K, Wada C, Hirota K, Hasegawa K, Kowa H, Sheetz MP, Masamune O (1998) Kinesin and cytoplasmic dynein in spinal spheroids with motor neuron disease．J Neurol Sci 159：38-48
  2. Toyoshiima I，Kato K，Sugawara M，Wada C，Masamune O（1998）Kinesin accumulation in chick spinal axnal swenings with β, β′-iminodipropionitrile（IDPN）intoxication． Neurosci Lett 249：103-106
  3. Komatsu M，Toyoshima I，Nakajima K，Kuramitsu T，Hoshino T，Mikami K，Ono T， Chiba M，Gonmori K，Masamune O，(1998) Effects of acetaldehyde on microtubules and hepatic kinesin. A study of the pathogenesis of alcoholic liver disease．Hepatol Res 12： 186-197
  4. Otaka M，Odashima M，Ito S (1998) Role of calcineurin，protein phoshatase 2B，in gastric acid，secretion．Molecular Biological Approach to Gastrointestinal Disease．Axel Springer Japan Publishing Tokyo，pp13-16
  5. 星野孝男、小松口史、三上健一郎（1998）ラット肝星細胞と胆汁酸。肝細胞骨研 究会誌 8： 35-40
  6. Sasahara H，Otaka M，Itoh S，et al．(1998) Effect of preinduction of heat shock proteins on acetic acid-induced small intestinal-lesions in rats．Dig Dis Sci 43：2117-2130
内科学第二講座
  1. 三ケ田啓子、斉藤　崇、鈴木玄、藤原慶正、飯野健二、中島一郎太、田村芳一、三浦　傅（1998） 糖代謝modulatorによる心筋viabi1ity評価に関する基礎的検討一inotropicagent（dobutamine）と の比較。心筋の構造と代謝心筋代謝研究会編-1997, 20：31-39
  2. 島田 薫、松岡一志、長谷川仁志、金野富貴子、寺田 健、津谷裕之、川村公一、増田弘毅、三浦傅 （1998）虚血再濯流障害におけるnitricoxide生合成抑制のタイミングと心筋虚血再濯流障害の関連。 心筋の構造と代謝心筋代謝研究会編-1997, 20：293-300
  3. 長谷川仁志（1998）血管内皮由来弛緩因子／NitricOxide生合成長期持統抑制時の冠動脈微細構築と 心筋構築に関する実験的研究。秋田医学25（1）：91-107
  4. 明石　建，浅沼義博，佐藤　勤，南條　博，小山研二（1998）一過性部分肝血行遮断後の遮断葉、 非遮断葉における壊死と再生についての実験的研究。日本消化　器外科学会誌31：1978-1985
  5. Sato T，Asanuma Y，Yasui O，Kurokawa T，Shibats S，Koyama K（1998）Impaired hepatic mitochondrial function reserve in brain-dead pigs．Tansplantation Proceedings 30：4351- 4355
  6. 粕谷孝光、佐藤 勤、佐藤泰彦、草野智之、浅沼義博、小山研二（1998）熱ストレスによるHeat Shock Protein 72誘導とその肝阻血再灌流障害の軽減効果について，日本消化器外科学会誌31： 2319-2326
精神科学講座
  1. Yoshida K，Higuchi H，Kamata M，Yoshimoto M，Shimizu T，Hishikawa Y（1998）Single and repeated electroconvulsive shock treatment activate dopaminergic and 5-hydroxytryp- taminergic neurotransmission in the frontal cortex of rats．Prog Neuro-Psychopharmacol ＆ Biol Psychiat 22：435-444
外科学第一講座
  1. Shibata S，Asanuma Y，Itoh H，Koyama K（1998）The circadian rhythm of HSP 60 in pancreas of rat．Pancreas17：316-318
  2. Shibata S，Asanuma Y，Itoh H，Tashima Y，Nanjo H，Koyama K（1998）Prevention of warm ischemia-reperfusion injury in the pancreas by water-immersion stress．Transplantation Proceedings 30：202-205
  3. Tanaka J ，Sato E，Saito Y，Kusano T，Koyama K（1998）Preparation of a conjugate of mitomycin C and anti−neural cell　adhesion　molecu1e monoclonal antibody for specific chemotherapy against biliary tract carcinoma．Jpn J Surg 28：1217−1220
外科学第二講座
  1. Motoyama S，Minamiya Y，Saito S，Sait0 R，Matsuzaki I，Abo S，Inaba H，Enomoto K， Kitamura M（1998）Hydrogen peroxide derived from hepatocytes induces sinusoidal endo-　 thelial cell apoptosis in perfused hypoxic rat liver．Gastroenterology 114：153-163
  2. Minamiya Y，Motoyama S，Kitamura M，Saito S，Terada K，Ogawa J (1998). The require- ment of intercellular adhesion molecule-1 for neutrophil respiratory burst in the pulmonary circuIation of rats infused with endotoxin ．Am J Respir Crit Care Med 158：635-642
  3. Minamiya Y，Tozawa K，Kitamura M，Saito S，Ogawa J（1998）P1atelet-activating factor mediates i nterce11u1ar adhesion molecule dependent radical production in the nonhypoxic ischemia rat lung. Am J Respir Cell Mol Biol 19：150-157
  4. Motoyama S，Kitamura M，Saito S，Minamiya Y，Suzuki H，Saito R, Terada K，Ogawa J， Inaba H（1998）Bcl-2 is located predominant1y in the inner membrane and crista of mitoch- ondria in rat liver. Biochem，Biophys Res Commun 249 : 628-636
心臓血管外科学講座
  1. Liu K，Abe T，Sekine S，et a1、（1998）Experimental study on the scavenging effects of ginsenosides on oxygen free radicals using model of heterotopic heart transp1antation in rats． Ann Thorac Cardiovasc Surg 4：188−191
  2. Liu K，Sekine S，Goto Y，Iijima K，Yamagishi K，Kondoh K，Matsukawa M，Abe T（1998） Halofuginone inhibits neointima1 formation of cu1tured rat aorta in a concentration- depen- dent fashion in vitro．Heart Vesseis13：18-23
整形外科学講座
  1. 柏倉　剛、島田洋一、佐藤光三、松永俊樹、堤羊浩、三澤晶子（1998）低頻度周 波数を用いこブロッ ク刺激一機能的電気刺激（functional electrical　stimu1ation；FES）への応用に関して。日パラ医 誌11：90-91
小児科学講座
  1. Ito T，Harada K，Tamura M, Takada G（1998）In　situ morphometric　analysis of the coronary arterial growth in perinatal rats．Early Hum Dev 52：21-26
  2. Ito T，Harada K，Tamura M，Takada G（1998）Increase in pulmonary arterial diameter under prostaglandin El therapy in infants with cyanotic congenital heart discase．Pediatr Cardiol 19： 404-407
    Ito T，0rino T，Harada K，Takada G，（1998）Morpho1ogical maturation of left ventricle in fetal rats：changes in left ventricular volume，mass，wall thickness，and mitral valvular size． Ear1y Hum Dev 53：1-7
産婦人科学講座
  1. 櫛引美代子、福原紅子、福島峰子、小松靖弘、吉崎克明（1998）芍薬及び甘草の 各抽出主成分のラッ ト子宮筋への作用一子宮筋収縮と細胞内カルシウム動態。和 漢医薬学雑誌14：402−403
  2. 櫛引美代子、吉崎克明、福島峰子、小松靖弘、田中俊誠（1998）甘草エキスと甘草血清の子宮筋収 縮に対する作用の違い。和漢医薬学雑誌15：350-351
  3. 櫛引美代子、福島峰子、田中俊誠、吉崎克明（1998）芍薬甘草湯のラット子宮筋収縮抑制作用に対 する性周期の影響。秋田大学医短紀要 6：141-144
  4. 吉崎克明、櫛引美代子、小松靖弘、針生秀樹、福畠峰子（1998）血清薬理学的手　法による漢方薬 作用の解明、Prog Med18：768-773
  5. 太田博孝、畑沢淳一、田中俊誠、五十嵐信一（1998）マウス妊孕能に対する至適　NO濃度の意義。 エンドメトリオージス研究会会誌19：107-110
眼科学講座
  1. Maeda S，Ishikawa M，Abe T，Sakuragi S（1998）Lectin cytochemistry of the rabbit con- junctiva and the lacrimal sac. Jap J OphthalmoI 42：443-449
  2. Satoh N，Abe T，Nakajima A，0hkoshi M，Koizumi T，Tamada H，Sakuragi S（1998） Analysis of uveitogenic sites in phosducin molecule．Curr Eye Res 17：677-686
小児外科学講座
  1. 加藤哲夫、水野大（1998）膵・胆管合流異常と胆道癌一発生機序. 小児外科30：361-364
薬剤部
  1. Suzuki T，Tada H（1998）General and faci1e method for determination of configulation of steroid-17-yl methyl glycolates at C-20 based on kinetic examination. J Chem Soc Perkin Trans1：3831-3836
医療短大
  1. Narisawa T, Fukaura Y, Terada K, Sekiguchi H（1998）Prevention of N-methylnitrosourea- i nduced colon tumorigenesis by ursodeoxychoIic acid in F344 rats．Jpn J Cancer Res 89： 1009-10131
  2. Fukuhara K, Kushibiki M, Kawaguchi T, Fukushima M，Yoshizaki K (1997) Uterine muscle contraction and cytoso1ic ca1cium in cu1tured myometral cells influenced by paeoniflorin and glycyrrhizic acid trisodium. Jpn J Physiol 47, S112
  3. Ohtomo K, Fukuhara K, (1998) Seasonal changes in the immunoreactive fibers of hypothala- mohypophysea1 tract in the horse shoe bat and chipmunk．Acta Anat Nippon73，374
  4. Fukuhara K，Ohtomo K（1998）Changes of several peptides in hypothaIamus of golden hamster，chipmunk and horsc shoe bat through the different hibernation stage. Acta Anat Nippon 73, 373
  5. 吉崎克明、福原紅子、櫛引美代子、福島峰子（ユ997）BayK8644によるラット子宮筋培養細胞内カ ルシウム動態変化に及ぼすペオニフロリンおよびグリチルリチン塩の影響。日本生理学雑誌60，87．
  6. 櫛引美代子、福原紅子、福島峰子小松靖弘、吉崎克明（1997）芍薬および甘草の各抽出主成分のラット子宮筋への作用。和漢医薬学雑誌14，402−403．
動物実験施設
  1. Kurosawa T, Matsuda Y, ，Okamoto M, Mizuno S（1998）Sevoflurane face mask anesthesia in rabbits−A comparision of 3％sevoflurane with 3％ halothane，J Exp Anima Sci 39：1-13