原著論文・総説(2010〜)        雑誌名をクリックするとPubMedにリンクします


Yanagida, K. Igarashi, H., Yasuda, D., Kobayashi, D., Ohto-Nakanishi, T., Akahoshi, N., Sekiba, A., Toyoda, T., Ishijima, T., Nakai, Y., Shojima, N., Kubota, N., Abe, K., Kadowaki, T., *Ishii, S., and Shimizu, T.  The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity. JCI Insight, in press.

Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki M., Araki, K., Yamamura, K.-I., Murakami-Murofushi, K., and Ueda, H. (2018) LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. J. Pharmacol. Sci., 136, 93-96.


Tanishima, M. Takashima, S., Honda, A., Yasuda, D., Tanikawa, T., Ishii, S., and MaruYama, T. (2017) Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling. J. Biol. Chem., 292, 17250-17257.

Takara, K., Eino, D., Ando, K., Yasuda, D., Naito, H., Tsukada, Y., Iba, T., Wakabayashi, T., Muramatsu, F., Kidoya, H., Fukuhara, S., Mochizuki, N., Ishii, S., Kishima, H., and Takakura, N. (2017) Lysophosphatidic acid receptor 4 activation augments drug delivery in tumors by tightening endothelial cell-cell contact. Cell Rep., 20, 2072–2086.

Dai, S.-P., Huang, Y.-H., Chang, C.-J., Huang, Y.-F., Hsieh, W.-S., Tabata, Y., Ishii, S., and Sun, W.-H.  (2017) TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice. Sci. Rep., 7:41415.

Lin, S.-H., Steinhoff, M., Ikoma, A., Chang, Y.-C., Cheng, Y.-R., Kopparaju, R.C., Ishii, S., Sun, W.-H., and Chen, C.-C. (2017) Involvement of TRPV1 and TDAG8 in pruriception associated with noxious acidosis. J. Invest. Dermatol., 137, 170-178.


Doi, H., Sato, K., Shindou, H., Sumi, K., Koyama, H., Hosoya, T., Watanabe, Y., Ishii, S., Tsukada, H., Nakanishi, K., and Suzuki, M. (2016) Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[18F]fluoro- and 10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains. Bioorg. Med. Chem., 24, 5148-5157.

Hata, E., Sasaki, N., Takeda, A., Tohya, K., Umemoto, E., Akahoshi, N., Ishii, S., Bando, K., Abe, T., Kano, K., Aoki, J., Hayasaka, H., and Miyasaka, M. (2016) Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Int. Immunol., 28, 283-292.

Takeda, A., Kobayashi, D., Aoi, K., Sasaki, N., Sugiura, Y., Igarashi, H., Tohya, K., Inoue, A., Hata, E., Akahoshi, N., Hayasaka, H., Kikuta, J., Scandella, E., Ludewig, B., Ishii, S., Aoki, J., Suematsu, M., Ishii, M., Takeda, K., Jalkanen, S., and Miyasaka, M. (2016) Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. eLife, 5:e10561.


Igarashi, H., Akahoshi, N., Ohto-Nakanishi, T., Yasuda, D., and *Ishii, S. (2015) The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Sci. Rep., 5,11410.

Yasuda, D., Imura, Y., Ishii, S., Shimizu, T., and Nakamura, M. (2015) The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling. FASEB J., 29, 2412-2422.

Yamaguchi, M., Matsui, M., Higa, R., Yamazaki, Y., Ikari, A., Miyake, M., Miwa, M., Ishii, S., Sugatani, J., and Shimizu, T. (2015) A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. Biochem. Pharmacol. 93, 482-495.

Ishii, S. (2015) Platelet-activating factor (PAF) in infectious diseases. In Bioactive Lipid Mediators: Current Reviews and Protocols (Yokomizo T. and Murakami M. Eds.), pp 95-108.


Harayama, T., Eto, M., Shindou, H., Kita, Y., Otsubo, E., Hishikawa, D., Ishii, S., Sakimura, K., Mishina, M., and Shimizu, T. (2014) Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab. 20, 295-305.

Sumida, H., Yanagida, K., Kita, Y., Abe, J., Matsushima, K., Nakamura, M., Ishii, S., Sato, S., and Shimizu, T. (2014) Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis. J. Immunol. 192, 4361-4369.

Jin, Y., Sato, K., Tobo, A., Mogi, C., Tobo, M., Murata, N., Ishii, S., Im, D.-S., and Okajima, F. (2014) Inhibition of interleukin-1β production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia. J. Neurochem. 129, 683-695.

Hikiji, H., Endo, D., Horie, K., Harayama, T., Akahoshi, N., Igarashi, H., Kihara, Y., Yanagida, K., Takeda, J., Koji, T., Shimizu, T., and *Ishii, S. (2014) TDAG8 activation inhibits osteoclastic bone resorption. FASEB J. 28, 871-879.

Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., Ishii, S., Miwa, M., and Shimizu, T. (2014) Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. FASEB J. 28, 440-452.


Yanagida, K., Kurikawa, Y., Shimizu, T., and Ishii, S. (2013) Current progress in non-Edg family LPA receptor research. Biochim. Biophys. Acta 1831, 33-41.  (Invited Review)

Sumida, H., Nakamura, K., Yanagida, K., Asano, Y., Kadono, T., Tamaki, K., Igarashi, K., Aoki, J., Sato, S., Ishii, S., Shimizu, T., and Yatomi, Y. (2013) Decrease in circulating autotaxin by oral administration of prednisolone. Clin. Chem. Acta 415, 74-80.


Komachi, M., Sato, K., Tobo, M., Mogi, C., Yamada, T., Ohta, H., Tomura, H., Kimura, T., Im, D.-S., Yanagida, K., Ishii, S., Takeyoshi, I., and Okajima, F. (2012) Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci. 103,  1099-1104.


Yanagida, K., and *Ishii, S. (2011) Non-Edg family LPA receptors: the cutting edge of LPA research. J. Biochem. 150, 223-232. (Invited Review)


Sumida, H., Noguchi, K., Kihara, Y., Abe, M., Yanagida, K., Hamano, F., Sato, S., Tamaki, K., Morishita. Y., Kano, M.R., Iwata, C., Miyazono, K., Sakimura, K., Shimizu, T., and *Ishii, S. (2010) LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood  116, 5060-5070.

Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., and *Ishii, S. (2010) The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor. Proc. Natl. Acad. Sci. U. S. A. 107, 17309–17314 (Direct submission).

Hasegawa, S., Kohro, Y., Shiratori, M., Ishii, S., Shimizu, T., Tsuda, M., and Inoue, K. (2010) Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. PLoS One 5, e10467.

Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N., Takamoto, I., Hayashi, Y.K., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., and Kadowaki, T. (2010) Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 464, 1313-1319.

Kihara, Y., Yokomizo, T., Kunita, A., Morishita, Y., Fukayama, M., Ishii, S., and Shimizu, T. (2010) The leukotriene B(4) receptor, BLT1, is required for the induction of experimental autoimmune  encephalomyelitis. Biochem. Biophys. Res. Commun. 394, 673-678. 

Nakamura, M., Yasuda, D., Hirota, N., and Shimizu, T. (2010) Specific ligands as pharmacological chaperones: The transport of misfolded G-protein coupled receptors to the cell surface. IUBMB Life 62, 453-459.

Hirota, N., Yasuda, D., Hashidate T, Yamamoto, T., Yamaguchi, S., Nagamune, T., Nagase, T., Shimizu, T., and Nakamura, M. (2010) Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. J. Biol. Chem. 285, 5931-5940.