Around4000BC |
Treatment of toothache with henbane (Mesopotamia) |
Around300BC | Opium, henbane, and mandrake used as “soporific sponges” (Greece) |
1540/1842 | Synthesis of ether (Germany) / Clinical application (U.S., U.K.) |
1772/1799 | Discovery of nitrous oxide (U.K.) / Clinical application (U.K.) |
1804 | World’s first breast cancer surgery using Tsusensan (Japan) |
1805/1839 | Morphine extracted from opium (experiments conducted in dogs) / Clinical application of morphine |
1831/1847 | Discovery of chloroform (U.S., Germany) / Clinical application (U.K.) |
1846 | Neck tumor removal surgery using ether anesthesia (U.S.) ? T.G. Morton |
1853 | Queen Victoria underwent painless childbirth with chloroform (anesthesia spread throughout Europe) |
1862 | Clinical application of cocaine |
1909 | Local anesthesia using procaine |